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8,000-Patient study aims to sharpen cancer radiation with Real-Time MRI

NCT ID NCT04075305

Knowledge-focused Sponsor: UMC Utrecht Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, including breast, prostate, lung, and brain tumors. Researchers will track survival, tumor control, side effects, and quality of life to improve future treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 8,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2019

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients receiving treatment and/or imaging on an MR-Linac machine are eligible for enrolment. Patients must meet eligibility criteria and provide informed consent to be enrolled.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient is to undergo or has completed imaging or treatment procedures on an MR-Linac; * Patient provides written, informed consent; * Patient is 18 years old or older. Exclusion Criteria: * MRI exclusion criteria, including * MRI contraindications as per usual clinical care, such as (possible) pregnancy; claustrophobia and metal or electronic implants not compatible with MRI.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm breast cancer breast neoplasm esophageal cancer Esophageal Neoplasms female reproductive organ cancer female reproductive system neoplasm head and neck cancer head and neck neoplasm Head and Neck Neoplasms liver and intrahepatic bile duct neoplasm liver cancer Liver Neoplasms lung cancer lung neoplasm malignant pancreatic neoplasm neoplasm neoplasm of esophagus pancreatic neoplasm prostate cancer prostate neoplasm radiation injury rectal cancer rectal neoplasm urinary bladder carcinoma urinary bladder neoplasm Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bladder cancer Bladder neoplasm Brain cancer Brain tumor Breast cancer Breast tumor Esophageal cancer Esophageal neoplasm Esophageal tumor Esophagus cancer Esophagus neoplasm Esophagus tumor Gynecologic cancer Gynecologic tumor Head and neck cancer Head and neck neoplasms Head and neck tumor Liver cancer Liver metastases Liver neoplasms Lung cancer Lung neoplasm Lung tumor Neoplasms Oligometastases Oncology Pancreatic cancer Pancreatic neoplasms Pancreatic tumor Prostate cancer Prostate neoplasm Prostate tumor Quality of life Radiation toxicity Rectal cancer Rectal neoplasms Rectal tumor Tumor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    18 sites in 9 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Allegheny Health Network

    RECRUITING

    Pittsburgh, Pennsylvania, 15212, United States

  • Austin Health - Olivia Newton-John Cancer Wellness and Research Centre

    NOT_YET_RECRUITING

    Melbourne, Australia

  • IRCCS Ospedale Sacro Cuore Don Calabria

    RECRUITING

    Negrar, Italy

  • Insitut Jules Bordet

    NOT_YET_RECRUITING

    Brussels, Belgium

  • Md Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital

    RECRUITING

    Amsterdam, Netherlands

  • Odense Universitetshospital

    RECRUITING

    Odense, Funen, 5000, Denmark

  • Radboud UMC

    RECRUITING

    Nijmegen, Netherlands

  • Radiotherapeutisch Instituut Friesland (RIF)

    NOT_YET_RECRUITING

    Leeuwarden, Netherlands

  • Radiotherapiegroep

    RECRUITING

    Deventer, Netherlands

  • Sunnybrook Health Sciences Centre/Odette Cancer Centre

    RECRUITING

    Toronto, Ontario, Canada

  • The Christie National Health Service Foundation Trust

    RECRUITING

    Manchester, United Kingdom

  • The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre

    RECRUITING

    London, United Kingdom

  • University Health Network - Princess Margaret Cancer Center

    RECRUITING

    Toronto, Canada

  • University Medical Center Utrecht

    RECRUITING

    Utrecht, 3508GA, Netherlands

  • Università degli Studi di Brescia

    NOT_YET_RECRUITING

    Brescia, Italy

  • Universitätsklinikum Tübingen

    RECRUITING

    Tübingen, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.