Head and neck neoplasms

This study tests a milder combination of chemotherapy, immunotherapy, and radiation for adults aged 65 and older with head and neck cancer who are considered frail. The goal is to see if more patients can complete the full treatment course. The regimen is tailored based on a biom…

This study tests whether giving lower doses of radiation to certain head and neck cancer patients can still effectively treat the cancer while causing fewer side effects. Participants receive chemotherapy and radiation, and doctors use a special PET scan to decide who can get the…

This trial tests a new drug called N17350, a modified enzyme injected directly into tumors, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find the safest and most effective dose, and to see if the drug can shrink or stop tu…

This phase 2 study tests whether adding occasional chemotherapy to the immunotherapy drug pembrolizumab (Keytruda) can improve outcomes for people with recurrent or metastatic head and neck cancer. A blood test that measures tumor DNA helps doctors decide when to give the chemo. …

This early-stage trial is testing a new three-drug combination for people with head and neck cancer that has come back or spread. The drugs include a targeted therapy (zanzalintinib), an immunotherapy (pembrolizumab), and another targeted antibody (cetuximab). The main goal is to…

This study tests whether adjusting the dose of chemotherapy drugs (fluorouracil or capecitabine) based on a person's DPYD gene test can lower the risk of severe side effects. About 100 cancer patients with a specific gene variant will receive either a reduced starting dose or sta…

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This program offers a special PET scan using a radioactive tracer called methionine to help doctors better see and manage central nervous system (brain, spine) and head/neck tumors in children and young adults. The scan provides extra information that can guide treatment decision…

This trial tests whether a cream made from Boswellia serrata (Indian olibanum) gum resin can prevent the painful skin irritation that often occurs during radiation therapy for head and neck cancer. Adults with head and neck cancer scheduled for radiation will apply the 2% cream t…

This study tests whether a special light therapy (photobiomodulation) combined with a mobile health app can improve dry mouth and quality of life in people who have had head and neck cancer and completed radiation. Sixty participants will receive either real light therapy or a sh…

Researchers are testing whether a 12-week Tai Chi program can reduce cancer-related fatigue in people with head and neck cancer who are receiving radiotherapy. The trial enrolls 116 adults who do not exercise regularly. Half join a supervised Yang-style 16-form Tai Chi group alon…

This study tests a new way to give radiation to people with head and neck cancer. The goal is to see if protecting the parts of the throat used for swallowing can help patients eat and drink better after treatment. About 136 adults with certain types of head and neck cancer will …

This study tests whether foot reflexology or a mild electrical nerve stimulation on the ear can reduce pain, dry mouth, fatigue, and sleep problems in people with head and neck cancer who are receiving chemoradiotherapy. Participants are randomly assigned to receive the real trea…

This study tests a program called SNAP that helps head and neck cancer survivors and their caregivers after radiation treatment. The program includes a needs assessment, a personalized care plan, and a mobile app. Researchers want to see if it reduces symptoms for survivors and e…

This study tests whether a daily physical activity routine, started before and continued during radiotherapy, can improve physical function and quality of life for head and neck cancer patients. 80 patients with tumors of the oropharynx, larynx, or hypopharynx will be randomly as…

This study tests whether applying medical ozone gas to mouth sores can reduce pain and severity in people undergoing radiation or chemotherapy for head and neck cancer. Fifty participants will receive ozone therapy, and half will also use a special toothpaste and mouthwash at hom…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

This study is testing whether advanced PET/MR imaging can help doctors personalize radiotherapy for head and neck cancer. Researchers will scan 390 patients before, during, and after treatment to see if imaging details can predict survival and response. The goal is to improve out…

This study looks at the genetic makeup of head and neck tumors from 1,000 people to find markers that predict how well a patient will respond to treatment and their chances of survival. Researchers will also search for new diagnostic markers. The goal is to better understand why …

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study collects leftover tissue samples and additional blood, saliva, and cheek swabs from up to 1,000 people with hearing, balance, smell, taste, voice, or speech disorders. The samples are stored in a biobank for researchers to study the biology of these conditions. No new …