HEAD AND NECK NEOPLASMS

This study is testing a new approach for people with certain head and neck cancers: using lower doses of radiation and chemotherapy, followed by surgery to remove any remaining cancer in the neck. The goal is to see if this gentler treatment can still control the cancer while red…

This study looks at whether adjusting chemotherapy doses based on a patient's DPYD gene test can lower the risk of severe side effects. About 100 adults with certain cancers (like colorectal or breast) will get either a standard or a gene-guided lower dose. The goal is to see if …

This study tests a reduced-intensity treatment plan for adults aged 65 and older with head and neck cancer who are considered frail. Participants receive a personalized combination of chemotherapy and immunotherapy based on their tumor markers, followed by radiation. The goal is …

This study tests whether a blood test that tracks tumor DNA can help doctors decide when to add short bursts of chemotherapy to standard immunotherapy for people with recurrent or metastatic head and neck cancer. About 30 adults will receive pembrolizumab (immunotherapy) plus occ…

This study tests an experimental drug called N17350 for adults with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into tumor lesions every two weeks for up to 12 weeks. Researchers aim to find the safest and most effective dos…

This early-phase study tests a new three-drug combination for people with head and neck cancer that has come back or spread. The goal is to find the safest dose and see if the treatment can shrink tumors or slow the disease. About 36 adults with this type of cancer will take part…

This early-phase study tests a new experimental drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head & neck, or colorectal cancers) that have not responded to standard therapy. The main goals are to check safety, find the ri…

This program gives children and young adults with central nervous system or head and neck tumors access to a special PET scan that uses a tracer called methionine. The scan helps doctors see the tumor more clearly and make better treatment decisions. Anyone under care at St. Jude…

This study looks at whether starting a physical activity program before and during radiotherapy can help head and neck cancer patients maintain their physical function and quality of life. About 80 patients will be randomly assigned to either an exercise group or a standard care …

This study tests whether a heavy lifting strength training program can help head and neck cancer survivors regain muscle strength, reduce fatigue, and improve quality of life. About 60 adults who finished cancer treatment at least one year ago will be randomly assigned to either …

This study tests whether ozone gas therapy, alone or with special toothpaste and mouthwash, can reduce painful mouth sores caused by radiation or chemotherapy. About 50 adults with head and neck cancers who have mouth sores will be randomly assigned to ozone therapy or ozone plus…

This study tests a new way to give radiation to people with head and neck cancer. The goal is to see if protecting the parts of the throat used for swallowing can help patients keep their ability to swallow after treatment. About 136 adults with certain types of head and neck can…

This study tests whether a special light therapy (photobiomodulation) can improve dry mouth, swallowing, and overall quality of life in 60 head and neck cancer survivors who have completed radiation. Participants use a mobile health tool to track symptoms. The goal is to ease lon…

This study looks at whether giving fluoride varnish during regular cancer follow-up visits can help improve oral health for head and neck cancer patients who have had radiation and lack easy access to dental care. About 120 uninsured or underinsured adults will take part. Researc…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover samples from medical care and collect additional blood, saliva, cheek swabs, and small …

This study collects leftover tissue, blood, saliva, and other samples from up to 1,000 people with hearing, balance, smell, taste, voice, or swallowing disorders. The samples are stored in a biorepository for future research to better understand and diagnose these conditions. Par…

This study is testing whether detailed PET and MRI scans can help doctors tailor radiation therapy for people with head and neck cancer. About 390 participants will get scans before and during treatment. The goal is to see if these images can predict survival and treatment respon…

This study looks at the genetic makeup of head and neck tumors to find markers that may predict how well a patient responds to treatment and their long-term outcome. Researchers will analyze tumor tissue from 1000 people with suspected or confirmed head and neck growths. The goal…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…