LIVER METASTASES

This study tests whether a single, high-dose session of MRI-guided radiation can control colorectal cancer that has spread to the liver. About 32 adults with up to 3 small liver tumors will receive this treatment. Researchers will track tumor growth, side effects, and look for MR…

This study tests whether adding a liver-directed chemotherapy (HEPZATO KIT) to an immunotherapy drug combination (Opdualag) is safe and works better than immunotherapy alone for people with metastatic melanoma that has spread to the liver. About 15 participants who have not had p…

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these combinations can change the immune environment inside the liv…

This study tests whether a blood test that looks for cancer DNA (ctDNA) after liver surgery can help doctors decide who needs more chemo. About 120 adults with colorectal cancer that spread to the liver will get standard chemo before surgery, then have their ctDNA checked after. …

This study tests a new approach for people with liver metastases (cancer that has spread to the liver from another part of the body). Doctors will deliver the drug bevacizumab directly into the liver along with standard chemo during a procedure called TACE. The goal is to see if …

This study tests whether adding low-dose radiation to the liver can help immunotherapy work better for people with melanoma or non-small cell lung cancer that has spread to the liver. About 21 participants will receive standard immunotherapy plus liver radiation. The goal is to s…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It includes up to 397 adults with various cancers like pancreas, lung, or prostate cancer. The goal is to see if this approach is safe and improves tumor cont…

This study tests if adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with colorectal cancer that has spread to the liver. About 100 adults whose liver tumors cannot be removed by surgery will receive both treatments. The goal …

This study tests a new way to give radiation for liver cancer in just one session, using real-time MRI to guide the beam and adjust the plan on the spot. It aims to improve survival and reduce side effects. About 62 adults with liver cancer or liver metastases will take part.

This study tests whether adding the drug bevacizumab to standard chemo-immunotherapy can help people with advanced small cell lung cancer that has spread to the liver. About 39 participants will receive the combination for four cycles, then continue two drugs for up to a year. Th…

This study tests whether adding two drugs (serplulimab and bevacizumab) to standard chemotherapy before surgery can improve outcomes for people with colorectal cancer that has spread to the liver. The trial involves 156 adults whose tumors have specific genetic features (RAS/BRAF…

This study tests a personalized vaccine made from a patient's own immune cells, combined with an immunotherapy drug (nivolumab), after surgery to remove liver cancer or colorectal cancer that spread to the liver. The goal is to see if this treatment can prevent the cancer from re…

This study tests whether a single, extremely high dose of radiation delivered by a special MRI-guided machine (MR-Linac) can better control liver tumors that have spread from other cancers compared to the usual high dose. About 114 adults with up to three liver metastases from sp…

This study looks at whether adding an MRI scan to the usual CT scan helps doctors choose the best treatment for people with pancreatic cancer. About 200 patients who are initially thought to be candidates for surgery will be randomly assigned to get either a CT scan alone or a CT…

This study tests a new way to give high-dose radiation to liver tumors that have spread from other cancers. Using real-time MRI guidance, doctors can adjust the radiation beam to protect nearby organs. The goal is to find the highest safe dose that causes few side effects. About …

This study is creating a large database of 2,000 people with metastatic liver cancer (cancer that has spread to the liver from another part of the body). Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and how it …

This study looks at genetic changes in people with colorectal cancer that has spread only to the liver and cannot be removed by surgery. Researchers want to understand why this happens and how liver transplants might help. They will follow 35 patients for up to 5 years to see how…

This study looks at whether taking a small tissue sample (biopsy) right after a tumor-killing procedure (ablation) can detect cancer cells that survived. The goal is to see if this information can help doctors decide on the next treatment. The study involves 200 adults with liver…

This study is collecting data from 1500 people with liver tumors who are getting a treatment called thermal ablation, which uses heat to destroy cancer. The goal is to use artificial intelligence to better predict who will benefit most and how to plan the treatment. This research…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…