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A new way to read CT scans may predict which liver surgery patients will develop Life-Threatening failure

NCT ID NCT07727759

Knowledge-focused Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Aug 19, 2026 · Updated 6 times

Summary

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least three liver segments. The goal is to develop a risk score that helps surgeons identify high-risk patients before the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
What this could lead to
If successful, this could give surgeons a practical tool to identify high-risk patients before liver surgery, potentially reducing life-threatening liver failure.
What could go wrong
This is an observational study, not a treatment trial. The prediction model may not perform as well in real-world settings or may not improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,070 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive adult patients undergoing elective major hepatic resection (three or more Couinaud segments) for benign or malignant liver disease at participating tertiary hepatobiliary referral centers in Egypt. Each center enrolls consecutive eligible patients, in order to minimize selection bias, until the overall target sample size is reached.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Scheduled to undergo major hepatic resection, defined as the removal of three or more Couinaud segments, at a participating center * Availability of a preoperative multiphasic contrast-enhanced CT of the liver of quality sufficient for central core-laboratory analysis * Willing and able to complete postoperative clinical and laboratory follow-up for at least 30 days * Written informed consent Exclusion Criteria: * Minor hepatic resection (fewer than three Couinaud segments) * Significant pre-existing vascular anomaly or vascular pathology (for example, portal vein thrombosis) * Emergency hepatic resection for trauma * Preoperative imaging that fails central quality control * Incomplete follow-up data

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma liver and intrahepatic bile duct neoplasm liver failure Liver Neoplasms nutmeg liver Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carcinoma, hepatocellular Hepatic congestion Liver failure Liver metastases Liver neoplasms Post-hepatectomy liver failure Postoperative complications

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Liver and GIT Hospital, Faculty of Medicine, Minia University

    RECRUITING

    Minya, Minya Governorate, 61519, Egypt

  • Maadi Armed Forces Medical Compound - Department of Liver and Pancreas Surgery and Liver Transplantation

    RECRUITING

    Maadi, Egypt

  • National Liver Institute, Menoufia University

    RECRUITING

    Shibīn al Kawm, Egypt

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