Minia University

This early-phase trial tests whether injecting a medical glue (Histoacryl®) into the pancreas during Whipple surgery can strengthen the connection between the pancreas and intestine and prevent dangerous leaks. The study involves 30 patients with soft pancreases and narrow ducts,…

Researchers are testing whether giving chemotherapy before surgery helps people with clearly resectable pancreatic head cancer or periampullary cancer live longer than going straight to surgery. The trial enrolls 262 participants and randomly assigns them to either mFOLFIRINOX ch…

Pancreatic ductal adenocarcinoma often returns near where it started, even after surgery. This study tests whether a more thorough operation, called total mesopancreatic excision, can improve local disease control and survival. During pancreaticoduodenectomy, surgeons remove the …

This study tests whether injecting the antibiotic moxifloxacin directly into the cornea can help treat bacterial eye infections that don't improve with standard antibiotic drops. About 60 adults with stubborn corneal infections will receive either the injection plus drops or drop…

This trial tests whether preserving the hernia sac as a living flap and stitching it under the mesh can reduce wound and mesh problems after complex ventral hernia repair where the defect has a bony edge. Half of the 180 participants will receive the standard repair plus the sac …

This trial tests whether a technique called socket-shield, which leaves a small piece of the natural tooth root in place, can better preserve bone and gum tissue around a new dental implant compared to the standard method. Adults aged 20-60 who need a front tooth replaced will be…

This trial tests whether giving a proton pump inhibitor (PPI) to children with laryngomalacia—a common birth defect of the voice box—can reduce the chance of food or liquid entering the airway (aspiration). Children aged 6 months to 5 years with recurrent choking or aspiration sy…

This study compares two methods to control bleeding during laparoscopic myomectomy (surgery to remove fibroids from the uterus). One method uses a temporary tourniquet to block blood flow, and the other injects a medicine called epinephrine into the uterus to narrow blood vessels…

This study tests a newer filling material called Cention-N against standard composite resin for repairing cavities in children's first permanent molars. Cention-N releases minerals that may help prevent further decay. One hundred children aged 8-10 with similar cavities on both s…

This study tests whether placing a small tube (stent) in the pancreas during Whipple surgery can prevent a common complication called pancreatic fistula, where digestive fluid leaks out. The trial will compare 100 patients with a soft pancreas who either get the stent or not. The…

This study tests whether adding a medical glue (Glubran 2) to the surgical connection in the pancreas can prevent a serious complication called pancreatic fistula, which is a leak of digestive fluids. About 100 adults undergoing pancreas removal for cancer will be randomly assign…

This study tests a new way to treat a detached Descemet's membrane, a rare complication after cataract surgery. Fifty patients aged 50-70 will be split into two groups: one gets a standard air injection into the eye, and the other gets a modified technique that first deflates the…

This study compares two types of Whipple surgery for people with pancreatic or nearby cancers: the traditional open surgery and a newer keyhole (laparoscopic) approach. About 90 adults with resectable tumors will be randomly assigned to one of the two procedures. The goal is to s…

This study tests a special dressing made from chitosan (a substance from shrimp shells) for treating damaged immature permanent teeth. The goal is to preserve the tooth's nerve and allow the root to finish growing. 26 children and teens with tooth decay or injury will be randomly…

This study tests whether injecting a medical glue (N-butyl-2-cyanoacrylate) into the pancreas during surgery can prevent dangerous leaks. About 90 patients with pancreatic or nearby cancers will receive either standard surgery or surgery plus the glue injection. The goal is to se…

This study tests a more thorough surgery technique for pancreatic head cancer. The goal is to remove more tissue around the tumor to lower the chance of cancer returning. 90 adults with resectable cancer will be followed for 2 years to see if this approach improves survival and r…

This study compares two methods to reduce blood loss during laparoscopic myomectomy, a surgery to remove uterine fibroids. One method temporarily blocks blood flow by clipping the umbilical-uterine trunk; the other injects epinephrine into the uterus. The trial will enroll 66 wom…

This study compares two surgical procedures—trabeculectomy with mitomycin C and slow coagulation trans-scleral cyclophotocoagulation—for lowering eye pressure in patients with open-angle glaucoma that is not controlled by medication. All participants are over 40 and have had cata…

This phase 3 trial tests whether adding a surgical glue called N-butyl-2-cyanoacrylate to standard pancreatic surgery can prevent postoperative pancreatic fistula—a common and serious leak of digestive fluids. About 194 patients with soft pancreas tissue undergoing tumor removal …

Researchers at Minia University are comparing two in-office tooth bleaching systems: one that uses peroxide and one that does not. Fifty adults aged 18 to 45 with healthy front teeth will receive one of the two treatments. Over six months, the team will measure how white the teet…

Researchers at Minia University are testing whether the shape of a single-file rotary dental instrument affects how much debris gets pushed out of the root tip during a root canal, and whether that changes how much pain patients feel afterward. Thirty teeth with irreversible pulp…

This trial tests whether adding nanoparticles to the standard disinfection during root canal retreatment reduces post-operative pain in people with type II diabetes. Participants are adults aged 18 to 40 with a failed root canal in a front tooth and an active infection at the roo…

This trial tests whether different ways of delivering and activating a cleaning solution during root canal treatment can reduce pain afterward. It includes adults aged 18 to 45 who need a first root canal on a canine or premolar tooth with an oval-shaped canal. Participants are r…

This study compares two types of root canal sealers—NeoSEALER Flo and AH Plus—to see which one leads to less pain after treatment and better healing of the area around the tooth root. About 30 adults with infected tooth roots and no other health issues will take part. Pain is mea…

This trial tests two ways of activating cleaning solutions during a repeat root canal procedure to see if one leads to less pain and better healing. Adults with a failed root canal in a single-rooted tooth will be randomly assigned to receive either Xp Finisher R file activation …

This trial investigates whether the type of sealer used during a root canal affects pain after the procedure. It will compare three different sealers—calcium hydroxide-based, bioceramic, and resin-based—in people with single-rooted teeth needing root canal treatment. Participants…

This study compares two inhaled treatments—neostigmine/atropine versus lidocaine—for severe headaches that can occur after spinal anesthesia during C-sections. About 111 women aged 18-35 with moderate to severe headache will be randomly assigned to one of the two treatments. The …

This study tests whether a vacuum sealing drainage (VSD) system can help infected surgical wounds heal faster and with fewer problems compared to standard dressing changes. Thirty women with wound infections after obstetric or gynecologic surgery will be randomly assigned to eith…

This study tests whether using a higher voltage during a nerve-blocking procedure (pulsed radiofrequency) can better relieve pain in people with chronic migraine who haven't responded to at least two preventive medications. One hundred participants will be randomly assigned to re…

This study tests whether taking alpha-lipoic acid, a natural antioxidant, can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 50 adults with solid tumors will receive either alpha-lipoic acid or a placebo alongside their chemo. Researchers will mo…

This study compares two ways of giving breathing support to adults with acute respiratory failure in the ICU. One group gets standard noninvasive ventilation (a mask that helps breathing), while two other groups get that plus a high-flow nasal cannula (a device that delivers warm…

This study looks at whether adding fluoxetine (a common antidepressant) to standard eye patching can improve and maintain vision in people over 10 with lazy eye (amblyopia). Researchers will use special eye scans and brain tests to measure changes. The goal is to find a new way t…

This study follows 420 adults undergoing abdominal wall reconstruction with mesh to identify which patient, surgical, and recovery factors most strongly predict a mesh infection within 90 days. Researchers will track 18 potential risk factors and use statistical analysis to pinpo…

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least thr…

This study reviews 10 years of medical records from 600 adults who had thyroid surgery at Minia University Hospital. The goal is to find out which patients are most likely to develop low calcium levels after surgery, a common complication. By identifying key risk factors, doctors…

This study looks at how often thyroid cancer is found by accident when people with Graves' disease have their thyroid gland removed. Researchers will track 280 adults having this surgery and examine the removed tissue carefully for any cancer, including tiny microcarcinomas. They…

This study looks at how often oxygen levels drop in premature infants when they receive an eye injection of ranibizumab for retinopathy of prematurity (ROP). Researchers reviewed records from 74 infants treated across multiple hospitals, tracking oxygen saturation during the proc…

This study looks at 100 people who have had a Whipple procedure (pancreaticoduodenectomy) for cancers of the pancreas or nearby areas. The goal is to find factors before, during, and after surgery that raise the risk of a pancreatic fistula—a leak of digestive fluid that can caus…

This study looks at how silicone oil, used to hold the retina in place after a retinal detachment, affects the retina's electrical activity. Researchers will measure these signals in 50 people who had surgery for a detached retina. The goal is to better understand how the oil imp…

This study will follow 430 adults having colorectal surgery to understand why some develop a leak where the bowel is reconnected. Researchers will look at factors before, during, and after surgery. The goal is to create a way to predict and prevent this serious complication.