Umc Utrecht

This study follows 40 adults with severe prurigo nodularis, a condition causing intensely itchy skin nodules, as they receive dupilumab treatment. Researchers aim to understand how well the drug controls symptoms long-term and how it affects the immune system in the skin and bloo…

This early-stage study is testing whether using high-intensity focused ultrasound to break apart a tumor can make immunotherapy drugs work better for people with advanced cancer that has stopped responding to standard treatments. The trial will enroll 24 adults to receive one ult…

This study is testing whether a drug called etidronate can slow down or stop the buildup of harmful calcium deposits in the brains of people with Fahr's disease or syndrome. It will enroll 98 adults with the condition to see if the drug improves thinking, movement, and daily life…

This early-stage trial is testing whether adding a more precise form of radiation (MR-guided radiotherapy) to standard chemotherapy before surgery can better control esophageal cancer. The study aims to find the safest and most effective radiation dose for 39 patients with a spec…

This study is testing whether adding progesterone hormone support after IUI fertility treatment helps more couples have babies. It involves over 1,000 couples with unexplained infertility who are undergoing standard fertility treatment. Half will receive the progesterone treatmen…

This early-stage trial is testing if giving a higher, more precise dose of radiation can better control a type of esophageal cancer. It will involve about 30 patients who are already scheduled for standard chemotherapy, radiation, and surgery. The main goal is to find the highest…

This study is testing whether injections of donor stem cells can help heal painful, open sores on the fingers of people with scleroderma. It will involve 20 participants who have ulcers that haven't improved with standard treatments. The main goal is to first check if the treatme…

This study is testing whether artificial intelligence (AI) can help doctors better diagnose the cause of chest pain in people whose heart arteries look clear on standard tests. Researchers will use AI to analyze heart rhythm recordings from 250 patients to spot subtle signs of re…

This study is testing a more precise form of radiation therapy for prostate cancer that aims to avoid damaging the nerves and blood vessels needed for erections. It will involve 70 men with low- or intermediate-risk prostate cancer. The goal is to see if this targeted approach ca…

This study is testing a brain implant system designed to help people with 'locked-in syndrome' communicate. Participants, who are fully conscious but severely paralyzed, will have a small device placed on their brain's surface. The goal is to see if they can learn to control a co…

This study aims to understand how symptoms change over time for people with hip or knee osteoarthritis. Over one year, 600 participants will use a web app to track their pain and function and try different self-care programs. The goal is to build computer models that can predict …

This study is creating a large database of 1,500 men newly diagnosed with prostate cancer in the Netherlands. The goal is to build a platform where future experimental treatments can be tested more efficiently by comparing them to standard care. Researchers will track participant…

This study is creating a large group of 2500 patients whose cancer has spread to their bones. The goal is to collect detailed information to better predict which treatments will relieve pain and improve quality of life. It also sets up a system to quickly test new treatments agai…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study is testing a new online clinic designed to make it easier for family members of people with inherited heart conditions to get genetic counseling and testing. Researchers want to see if this virtual clinic helps more people access these services, how satisfied they are …

This study is creating a large registry to collect detailed information on 1000 adults who have had a spontaneous subarachnoid hemorrhage, a serious type of brain bleed. The goal is to gather data on patient characteristics, treatments received, and long-term recovery to understa…