Umc Utrecht

This early-stage trial tests whether injecting donated stem cells into the muscles around finger ulcers can help heal them in people with scleroderma. The study includes 20 adults with at least one painful, deep finger sore that did not improve with standard treatment. The main g…

This study tests a precise MRI-guided radiation approach for men with low- or intermediate-risk prostate cancer. The treatment targets the tumor while avoiding areas important for erections, aiming to reduce the risk of erectile dysfunction. Seventy men will receive five high-dos…

This early-stage study tests whether using high-intensity focused ultrasound to destroy tumors from the inside can boost the effects of immunotherapy drugs (ipilimumab and nivolumab) in adults with advanced cancer that has stopped responding to standard treatments. The main goals…

This early-phase trial is testing whether giving an extra, higher dose of radiation using MRI-guided technology can improve outcomes for people with a type of esophageal cancer. About 30 participants will receive the standard chemoradiation plus one or two extra radiation boosts.…

This study tests whether etidronate, a drug used for bone disorders, can slow or stop calcium buildup in the brain that causes Fahr's disease. The trial will enroll 98 adults with Fahr's disease or syndrome. Participants will receive either etidronate or a placebo for a year to s…

This study follows 40 adults with moderate-to-severe prurigo nodularis who are starting dupilumab, a targeted therapy. Researchers will track how well the drug reduces itching and skin lesions over time, and also study changes in the immune system and skin tissue. The goal is to …

This study tests a drug that blocks a key immune signal (JAK1) in people with Behçet's disease, myositis, or IgG4-related disease. The goal is to see if it can control disease activity and reduce the need for long-term steroids. About 60 adults will take the drug and be monitored…

This study tests whether adding targeted radiation therapy (SBRT) to standard care helps people with pancreatic cancer that has returned only in the original area live longer and feel better. About 174 adults whose cancer came back after surgery will be randomly assigned to get S…

This early-phase trial tests adding a precise, MRI-guided radiation treatment after standard chemotherapy for people with esophageal adenocarcinoma. The goal is to find the highest safe radiation dose that can improve tumor control without causing severe side effects like fistula…

This study aims to improve diagnosis for people with chest pain but no blocked heart arteries (ANOCA), a condition more common in women. Researchers will use artificial intelligence to analyze ECG recordings during and after a heart function test. The goal is to make diagnosis ea…

This study is testing whether a special PET scan can identify an aggressive form of colorectal cancer called CMS4 without taking tissue samples. About 45 people with colorectal cancer that has spread to the liver will get the scan before surgery. If it works, doctors could use th…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes or be placed on a waiting list. The goal is to fin…

This study tests whether giving radiation and spine-stabilizing surgery on the same day helps people with painful spinal tumors feel better faster. About 100 adults with cancer that spread to the spine will be randomly assigned to same-day treatment or standard care (surgery firs…

This study tests whether filling the bone gap during knee realignment surgery with a synthetic material called AttraX Putty can lower pain after the operation. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a gap fi…

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) can increase the chance of a live birth for couples with unexplained infertility. About 1008 women will be randomly assigned to receive either progesterone or no extra treatment. The go…

This study tests whether a 12-week personalized exercise program, done at home with a trainer via video, can improve quality of life and reduce common side effects like fatigue, anxiety, and nerve pain in cancer survivors. 350 adults who completed cancer treatment within the past…

This study tests a virtual clinic (eCG) that offers genetic counseling and at-home DNA testing for relatives of people with inherited heart conditions. The goal is to see if more family members get tested and feel satisfied compared to the usual in-person approach. About 170 adul…

This study is a registry that gathers detailed information from 1,000 adults who have had a spontaneous brain bleed (subarachnoid hemorrhage). Researchers will analyze treatments and outcomes to identify which approaches work best. No new treatments are tested; the goal is to lea…

This study is collecting information from 2500 people with cancer that has spread to the bones (bone metastases) who are receiving radiation therapy. The goal is to learn why only about 60% of patients get pain relief and to build tools that help doctors predict who will benefit …

This study looks at using a blood test that detects tiny bits of tumor DNA (ctDNA) to guide chemotherapy decisions in people with stage II colon cancer. About 1,320 participants will be randomly assigned to either have their treatment based on the blood test results or receive st…

This study follows 600 people with hip or knee osteoarthritis for one year to understand how their symptoms and daily life change over time. Participants fill out online surveys every two weeks and try different self-care programs focused on physical activity, weight, or sleep. T…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study follows 1,500 men newly diagnosed with prostate cancer to see how different treatments affect their quality of life and side effects over time. Researchers will collect health data and patient surveys to compare standard treatments like surgery and radiation with newer…

This study tests a brain implant that lets people with locked-in syndrome control a computer using their thoughts. Two participants will have electrodes placed on their brain to try typing or selecting words. The goal is to see if they can use the system at home on their own.