BRAIN TUMOR

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to target remaining cancer cells. The goal is to contr…

This study tests whether a focused ultrasound device can safely open the blood-brain barrier in people with non-small cell lung cancer that has spread to the brain. Participants will receive standard immunotherapy while some also get the ultrasound treatment. The goal is to see i…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor called glioblastoma live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned…

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults whose tumor has returned after prior treatment will be randomly assigned to receive Avastin alone or …

This study tests a new way to deliver a standard brain cancer drug (bevacizumab) using focused ultrasound and microbubbles in 10 people whose glioblastoma has returned. The goal is to see if this combination is safe and can help control tumor growth for longer. Participants must …

This study tests a new way to treat aggressive brain cancers that have come back after standard therapy. It combines a targeted drug called cetuximab, given directly into the brain's blood vessels, with a second round of radiation. The goal is to see if this approach can safely s…

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This study tests an experimental drug called zotiraciclib for people with a specific type of brain tumor (glioma) that has returned after treatment. The tumors must have a mutation in the IDH1 or IDH2 gene. The goal is to see if the drug can slow or stop tumor growth. Participant…

This study tests a new oral drug, TNG456, in people with advanced solid tumors that lack a gene called MTAP. The drug aims to slow or stop cancer growth by blocking a protein these tumors rely on. The trial has two parts: first finding the safest dose, then testing how well it wo…

This study is testing proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and how it affects quality of life and side effects. Participants receive targeted proton beams to the tumor area and are fo…

This study tests if a drug called niraparib works better than the standard chemo (temozolomide) for adults with a newly diagnosed, aggressive brain cancer called glioblastoma that has a specific genetic marker (MGMT unmethylated). About 450 people will be randomly assigned to tak…

This study tests if a drug called tranexamic acid (TXA) can reduce blood loss during surgery to remove brain tumors. About 102 adults having a craniotomy will receive either TXA or a placebo during the operation. Researchers will compare blood loss and complications between the t…

This study tests whether sitagliptin, a diabetes drug, can help the immune system fight glioblastoma, an aggressive brain tumor. About 48 adults with progressive grade 4 glioma will receive sitagliptin before surgery to see if it increases cancer-fighting immune cells in the tumo…

This study tests whether a dye called panitumumab-IRDye800 is safe and helps surgeons see brain tumors more clearly during surgery in children aged 6 months to 25 years. The dye makes tumor tissue glow, which may help remove more of the tumor while protecting healthy brain. About…

This study tests a new way of using MRI scans to tell the difference between a brain tumor that has come back and harmless scar tissue caused by radiation. About 101 people with brain tumors that grew after focused radiation will get this special scan before any surgery. The goal…

This study tests a faster MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can clearly tell the difference between a brain tumor coming back and brain damage from radiation therapy. About 90 people will join, including healthy volunteers, people with new …

This study is testing a special PET scan (18F-DOPA) to see if it can better detect and measure several conditions, including congenital hyperinsulinism in children, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 children…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants will take part in virtual coaching sessions over 6 months, learning problem-solving and relaxation techniques. The …

This study tests whether virtual reality (VR) can make cognitive training more engaging and effective for children (ages 8-22) receiving radiation for brain tumors. Participants will be randomly assigned to do brain exercises on an iPad or in VR, and researchers will track how we…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study explores whether people with brain tumors can safely receive radiotherapy without wearing an immobilization mask. Instead, a surface imaging system tracks movement to keep the radiation beam accurate. Twenty adults will try a mask-free session and report on comfort, an…

This study compares two virtual programs for adults with brain tumors who have trouble with thinking or memory. One program combines cognitive rehab with mindfulness training; the other offers brain health education videos. The goal is to see if these programs are practical and l…

This study tests whether daily exposure to bright light can help reduce fatigue and improve thinking skills in children and teens who have been treated for a brain tumor. The study involves 40 participants who will use a light box at home for 6 weeks. The goal is to see if this a…

This early-phase study tests whether letrozole, a drug used for breast cancer, can get into the brain and reach tumor tissue in people with recurrent high-grade gliomas. About 39 adults will take letrozole along with standard treatments. The main goal is to measure drug levels in…

This study is for 100 adults having brain tumor surgery. During the operation, doctors will place a small device called an Ommaya reservoir under the scalp. This device allows them to safely collect spinal fluid samples over time. The goal is to study these samples to find better…

This study involves 20 adults undergoing awake brain surgery for tumors in the hand movement area. Researchers will test different electrical stimulation settings to see which ones help or hinder hand movement. The goal is to improve how surgeons monitor hand strength during surg…

This study aims to create immune organoids—miniature lab-grown models of the immune system—using cells from children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will take blood or tissue samples and turn them into stem cells, then gro…

This study looks at how the body's energy use and immune system may be different in children with autism, epilepsy, brain tumors, or other brain conditions. Researchers will collect blood samples and do behavioral tests in 500 children up to age 17. The goal is to find patterns t…

This study tests a special MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. About 30 adults with suspected or confirmed gliomas will get an MRI before their planned biopsy or tumor removal. The MRI results will be compared with lab…

This study is testing whether a new digital test battery called Mindmore Distance can accurately assess thinking and memory skills in people with neurological conditions like traumatic brain injury, stroke, multiple sclerosis, Parkinson's disease, epilepsy, or brain tumors. Resea…

This study looks at how social, genetic, and environmental factors affect the health of people with meningioma, the most common type of brain tumor. Researchers will survey 3,000 adults to understand why some groups have worse outcomes. The goal is to find ways to improve care fo…

This study aims to find blood markers that show if a child's brain has been injured by cancer treatment. Researchers will collect blood samples from 560 children with brain tumors before and after surgery, radiation, or chemotherapy, and compare them to healthy children. The goal…

This study looks at 100 adults with a new diagnosis of glioblastoma, the most common and aggressive brain tumor. Researchers will measure certain proteins (MMP2 and MMP9) in blood and tumor tissue, and compare them with MRI brain scans. The goal is to learn how these proteins cha…

This study looks at stool samples from 100 children aged 3–18 who are suspected of having a brain tumor. Researchers want to see if changes in gut bacteria can help detect the tumor or track how the disease changes over time. The goal is to learn more, not to test a treatment.

This study uses a smartphone app to track how patients feel before and after brain or spine surgery. Researchers want to learn the normal recovery pattern and how side effects affect well-being. About 400 adults who own a smartphone and are scheduled for surgery will participate.…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study looks at how focused ultrasound affects the fluid around brain tumors. Six adults having brain tumor surgery will have tiny catheters placed to collect samples from areas treated and not treated with ultrasound. The goal is to understand how ultrasound changes the tumo…

This study is creating a large database of brain tumor patients (70,000 people) to help doctors better understand and treat these cancers. It collects medical images, lab results, and patient outcomes. The goal is to improve diagnosis, predict survival, and guide treatment decisi…

This study is tracking 600 people with different types of brain tumors who receive GammaTile radiation therapy during surgery. The goal is to see how well the treatment works and how safe it is in everyday medical practice. Researchers will measure how long tumors stay away and h…

This study is testing a new software that uses fMRI scans to create detailed maps of important brain areas, like those controlling movement and language, before brain tumor surgery. The goal is to help surgeons avoid damaging these critical regions during tumor removal. The study…

This early study tests a new graphene-based electrode for brain mapping during surgery to remove brain tumors. Ten adults with glioma will have the device used alongside standard monitoring to check its safety and how well it records brain signals. Some participants who are awake…

This study aims to collect and store biological samples (like tumor tissue or blood) from 500 adults with confirmed brain tumors. The samples will be used for future research to better understand brain tumors. No treatment or experimental therapy is given—this is purely a sample …

This study tests the drug troriluzole in people with recurrent glioblastoma, a type of brain cancer. Participants take the drug before surgery to see how it affects brain activity and glutamate levels in the tumor. The goal is to learn more about the drug's effects, not to treat …