BRAIN TUMOR

This study follows 160 patients of any age who have or will receive a CODMAN CERTAS Plus programmable valve to treat hydrocephalus (fluid buildup in the brain). The goal is to see if the valve is placed correctly and works as intended 30 days after surgery. This is an observation…

This study tests whether a higher dose of proton radiation can safely control high-grade meningiomas, which are aggressive brain tumors. About 21 adults with specific tumor types after surgery will receive intensity-modulated proton therapy (IMPT). The goal is to find the highest…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This study tests whether using focused ultrasound to temporarily open the blood-brain barrier can safely deliver the chemotherapy drug doxorubicin to treat a rare and aggressive childhood brain tumor called DIPG. About 10 children aged 5 to 18 who have completed radiation therapy…

This study tests whether using focused ultrasound to temporarily open the blood-brain barrier can safely deliver the chemotherapy drug doxorubicin to treat a rare and aggressive brain tumor called DIPG in children and young adults aged 5 to 21. The approach aims to improve drug a…

This early-phase study tests a genetically engineered virus (rQNestin34.5v.2) that targets and kills brain tumor cells. About 62 adults with recurrent malignant glioma will receive the virus injected directly into the tumor, sometimes with a drug called cyclophosphamide to boost …

This study tests a new MRI technique called magnetic resonance fingerprinting (MRF) to improve how brain tumors are diagnosed and assessed. Researchers will compare MRF data with standard tests, treatment details, and biopsy results in 172 people with brain tumors. The goal is to…

This study tests a special proton radiation method for children aged 3 to 18 with brain tumors that need radiation to the brain and spine. The new approach spares parts of the backbone to reduce side effects like low blood cell counts and slowed growth. Researchers will check if …

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can be used at home to boost recovery of memory, language, and thinking skills in people with stroke, brain tumors, or neurodegenerative conditions like Parkinson's or Alzheimer's. Participants …

This study looks at how radiation therapy affects the brain in children with medulloblastoma, a type of brain tumor. Researchers use special PET scans to measure inflammation in different brain areas over time. The goal is to understand how radiation causes long-term changes in t…

This study looks at 88 children having brain tumor surgery who also have epilepsy. Doctors want to know which anesthetic drug—fentanyl or ketamine—better helps them see seizure signals on brain monitors during the operation. The goal is to improve how surgeons find and remove the…

This study aims to understand how the brain processes spoken language by recording brain activity in people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Researchers will compare brain signals from English, Spanish, and Mandarin speakers…

This study follows over 1,500 young adults who survived childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma. Researchers measure physical frailty—a set of five fitness tests—over five years to see if it predicts future health problems. The goal is to identify surv…

This study is testing whether advanced PET and MRI scans can better measure oxygen levels, blood flow, and metabolism in high-grade brain tumors and cervical cancers. About 20 adults with newly diagnosed or recurrent tumors will receive two types of scans. No treatment is given; …

This study looks at how proton beam radiation therapy (PBRT) changes brain connections in children and young adults (ages 6-25) treated for brain tumors. Researchers use resting-state MRI scans and thinking tests to compare patients with healthy volunteers. The goal is to underst…

This study looks at whether adding a breath-holding task during fMRI scans can improve the accuracy of mapping essential brain areas in people with brain tumors. Researchers will compare standard fMRI results with those adjusted using breath-hold data. The goal is to reduce false…

This study looks at how the location of a tumor in the cerebellum affects a person's thinking, memory, and coordination before and after surgery. Researchers will compare people with cerebellar tumors to those with tumors in other parts of the brain. The goal is to better underst…

This study looks at how surviving a pediatric brain tumor affects children's thinking, memory, and behavior over time. Researchers will track 42 children who have finished treatment for certain brain tumors to understand these late effects. The goal is to gather information that …

This study looks at whether adding a weekly check by a specially trained radiation technologist (MERM) to the usual doctor visits can help find side effects from proton therapy more often. About 92 adults with brain or upper throat tumors will take part. The goal is to see if thi…