BRAIN TUMOR

This early-phase trial tested an experimental drug called CUDC-907 in 26 children and young adults (ages 1-21) whose solid tumors, brain tumors, or lymphoma had stopped responding to standard treatments. The main goal was to find safe dosing and identify side effects. Researchers…

This small pilot study tested whether adding a focused ultrasound device (NaviFUS) to standard chemotherapy (bevacizumab) could help control recurrent glioblastoma, an aggressive brain cancer. Six adults whose cancer returned after prior treatment took part. The main goals were t…

This early-phase study tested the safety of combining two drugs (pembrolizumab and vorinostat) with standard chemotherapy and radiation in 21 people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to find the highest safe dose of vorinostat in this com…

This study looked at whether a sedative called dexmedetomidine can protect the brain during surgery to remove a brain tumor. 56 adults having brain tumor surgery received either the drug or a placebo. The goal was to see if the drug reduces brain injury and helps with recovery.

This study looked at whether a type of PET scan (18F-DOPA-PET) can help doctors tell the difference between brain tumors and non-cancerous brain lesions. Researchers analyzed scans from 74 patients with suspected brain tumors. The goal was to find the best way to use this scan to…

This study tested a new MRI contrast agent called RVP-001 in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and effective at highlighting these lesions without using gadolinium, a metal that can build up in the bo…

This study tested a new imaging technique that combines a special tracer called [18F]PARPi with PET and MRI scans to get clearer pictures of brain tumors. Five adults with new or suspected returning brain tumors took part. The goal was to see how well this method shows tumor acti…

This study looked at whether a 12-week physical activity program can improve memory and attention in children ages 8-17 who had radiation for a brain tumor at least 2 years ago. Participants were split into two groups: one started the exercise program right away, the other contin…

This study tested a counseling program called CALM (Managing Cancer and Living Meaningfully) for people with malignant brain cancer. The goal was to see if it's practical and helpful for reducing distress like depression and anxiety about death. 60 participants were offered eithe…

This study tested whether watching 360° virtual reality movies can help lower fear and anxiety in cancer patients before they start radiation treatment. 292 adults with breast, lung, prostate, head and neck cancer, or a brain tumor took part. Researchers measured their stress lev…

This study looked at whether online training can improve how emergency room doctors interpret CT scans of the head. 173 ER doctors from 6 UK hospitals took part. Some received training right away, while others served as a control group. The goal was to see if training helps them …

This study followed 155 children who had proton radiation for brain or central nervous system tumors. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment. Parents and children filled out questionnaires …

This study tested a new, highly sensitive ultrasound method to map brain activity during surgery. 23 adults having brain tumor or lesion surgery participated. The goal was to see if this ultrasound technique could show which brain areas are active, compared to standard methods li…

This study tested whether a telehealth program called C-SMART is practical and well-liked by people with primary brain tumors who have mild memory or thinking problems. Researchers enrolled 32 participants (18 patients and 14 caregivers) to see if they could complete the program …

This study enrolled 1214 people with brain or spinal cord tumors to collect medical information, blood, urine, spinal fluid, and tumor tissue samples. The goal was to better understand these tumors and identify new areas for research. Participants also received guidance on managi…