LIVER CANCER

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. AGX101 is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to check for sid…

This study looks at 200 adults with liver cancer to compare two ways of using a special dye during surgery. The dye helps surgeons see and remove only the diseased part of the liver. One method injects the dye through an artery, the other through a vein. The goal is to see which …

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) can help children and young adults with a rare liver cancer that has returned or not responded to standard treatment. About 18 participants will receive the drug, and researchers will measure how well it shr…

This early-phase trial tests a new treatment called CARE T cells for children whose solid tumors (like liver cancer or Wilms tumor) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding special genes to help them recog…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people will take part, and researchers will track whether tumors shrink and how long the benefit lasts. The goal i…

This study tests a new gel that hardens at body temperature to block blood flow to liver tumors during chemoembolization. About 216 adults with liver cancer will be randomly assigned to receive either the new gel or standard gelatin sponge particles alongside chemotherapy. The go…

This early-phase study tests a new drug, SON-DP, in about 96 adults with advanced solid tumors, including liver and gastric cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors or slow their growth. Participants must have measurab…

This study tests a new radiation technique called vGRID SBRT for people with liver cancer that cannot be surgically removed. The goal is to find the highest safe dose of radiation that can shrink tumors while keeping side effects low. About 18 adults with advanced liver cancer wi…

This early-stage trial tests a new mRNA vaccine designed to help the immune system fight advanced liver cancer. It is for people whose cancer has not responded to standard treatments. The main goal is to check safety, and researchers will also see if the vaccine can shrink tumors…

This study tests if adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with colorectal cancer that has spread to the liver. About 100 adults whose liver tumors cannot be removed by surgery will receive both treatments. The goal …

This study tests a new way to give radiation for liver cancer in just one session, using real-time MRI to guide the beam and adjust the plan on the spot. It aims to improve survival and reduce side effects. About 62 adults with liver cancer or liver metastases will take part.

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electric pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink tu…

This study tests a drug called 177Lu-PSMA-617 in people with liver cancer that has spread and shows a specific marker (PSMA) on scans. The drug delivers radiation directly to cancer cells. The trial aims to see if this approach is safe and can help control the disease. About 10 a…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study aims to improve how doctors see digestive system cancers (like liver, stomach, and pancreatic cancer) using special PET/CT imaging probes. Researchers will test these probes in 400 adults to measure how they spread in the body and how well they find tumors. The goal is…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like bladder, lung, liver, and ovarian cancer better than current methods. About 400 adults with confirmed or s…

This study tests a new ultrasound method to find liver cancer earlier and more accurately. About 328 adults at risk for liver cancer will get both standard and new ultrasound scans. The goal is to see if the new method can spot tumors that standard ultrasound might miss, helping …

This study compares two ways to screen for liver cancer in people with cirrhosis who are at high risk. About 944 participants will either get a standard ultrasound every six months or an ultrasound plus a quick MRI (Fast-MRI). The goal is to see if adding Fast-MRI finds more earl…

This study tests a new imaging probe that makes liver cancer cells glow when viewed with a special camera. Researchers will apply the probe to liver tissue removed during surgery and check if it can accurately show where the cancer ends. The goal is to help surgeons remove all ca…

This study tests whether a blood test (GALAD) is better than ultrasound for finding liver cancer early in 5500 people with cirrhosis or chronic hepatitis B. Participants will be randomly assigned to one of two screening methods every six months. The goal is to see which approach …

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at how two types of liver cancer treatments—radiology-guided therapies and focused radiation—affect patients' quality of life. Researchers will track changes in well-being using surveys before and after treatment. The study includes 78 adults with liver cancer wh…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study is creating a large database of 2,000 people with metastatic liver cancer (cancer that has spread to the liver from another part of the body). Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and how it …

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, like cell clusters and mouse tumors, to better understand these diseases and test new treatments. The goal is to impro…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, researchers check participants' health each year for 15 years to watch for any long-term side effects. The goal is to make sure th…

This study creates a collection of blood, urine, stool, and other samples from up to 9,150 people with cholestatic liver diseases like primary biliary cholangitis and primary sclerosing cholangitis. Researchers will use these samples and health data to better understand how these…

This study is testing a new type of CT scan called HyperSight, which is built into a radiation therapy machine. The goal is to see if it produces clearer images than current scans, which could help doctors target tumors more accurately. About 50 adults with various cancers (head …

This study is testing whether using a radiofrequency device to heat the edges of the liver after tumor removal can lower the chance of cancer coming back. About 720 adults with liver cancer (either from colorectal cancer or primary liver cancer) will be randomly assigned to recei…

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …

This study looks at whether a special ultrasound (contrast-enhanced ultrasound) can better show if liver cancer treatment (radioembolization) killed the tumor, compared to standard CT or MRI scans. About 30 adults with liver cancer will get an ultrasound within two weeks of their…

This study is developing an AI method to track the movement of tumors and nearby organs during radiation therapy without using physical markers. Researchers will use data from 300 patients receiving radiation for various cancers or heart arrhythmias to train and test the system. …

This study is observing 50 adults with advanced cancers (lung, breast, colorectal, liver, stomach) who are starting immunotherapy. Researchers will track ctDNA levels in the blood to see if changes can predict early whether the treatment is working. They will also look at other m…

This study is creating and testing an educational tool to help people understand how to prevent liver cancer. About 40 adults from a clinic who have not been diagnosed with liver cancer will review the materials and share their thoughts. The goal is to make sure the information i…

This study tests whether a large language model (a type of AI) can help junior doctors write more accurate and efficient cancer treatment reports. 40 junior doctors will be split into two groups: one uses AI assistance, the other uses traditional methods. Their reports will be sc…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genes in the samples and link them to patient health details. The study does not provide any treatment, but pa…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study is collecting data from 1500 people with liver tumors who are getting a treatment called thermal ablation, which uses heat to destroy cancer. The goal is to use artificial intelligence to better predict who will benefit most and how to plan the treatment. This research…

This study aims to develop a new 4D-MRI imaging technique that creates 3D movies of the lungs and liver during breathing. The goal is to help doctors better target tumors in cancer patients receiving radiation therapy, especially when tumors move with breathing. The study will te…

This study aims to understand how the immune system and genes change in people with advanced liver cancer during immunotherapy. Researchers will collect blood and tumor samples from 50 participants before and during treatment. The goal is to find biomarkers that predict how well …

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study aims to improve a liver cancer treatment called TARE, which delivers radiation directly to tumors through blood vessels. Researchers will create computer models of each patient's liver blood flow to predict where the radiation goes. The goal is to help doctors plan tre…

This study explores whether emotional distress, like anxiety or depression, impacts how well liver cancer patients respond to immunotherapy. Researchers will follow 651 newly diagnosed adults with liver cancer who are starting treatment. The goal is to see if those with emotional…