LIVER CANCER

This study tests whether a special X-ray tracking system called KIM can make radiation treatment for liver cancer more accurate. About 32 adults with liver cancer who cannot have surgery or other standard treatments will receive focused radiation (SABR) while the KIM system track…

This study tests a new treatment for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, called T cells, which are genetically modified in a lab to better recognize and attack cancer cells. The main goa…

This study tests a new technique called irreversible electroporation (IRE) for people with liver cancer whose tumors are near major blood vessels and cannot be surgically removed. IRE uses high-voltage electrical pulses to destroy cancer cells without harming nearby blood vessels…

This early-stage study tests a combination of the immunotherapy drug nivolumab with a procedure called drug-eluting bead chemoembolization (deb-TACE) in 20 adults with advanced liver cancer. The goal is to see if the combination is safe and tolerable. Participants receive both tr…

This early-stage study tests a new drug called SH006, given in combination with other treatments, for people with advanced solid tumors (including liver cancer) who have not responded to standard therapy. The main goals are to check safety, find the best dose, and see if the drug…

This study tests whether the immunotherapy drug nivolumab can delay or prevent liver cancer from returning in patients who have already had surgery or ablation to remove their tumors. About 545 participants at high risk of recurrence will receive either nivolumab or a placebo. Th…

This early-phase study tests a new treatment called GAP T cells for children and young adults with a type of liver cancer that has returned or not responded to standard therapy. The treatment involves taking a patient's own immune cells, adding a gene to help them recognize and a…

This early-stage trial tests a new treatment called AGAR T cells for children whose solid tumors (like liver cancer or rhabdomyosarcoma) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding genes to help them recogniz…

This study tests a precise type of radiation called SBRT for people with liver cancer or tumors that spread to the liver from other cancers. About 280 adults who cannot join other trials will receive SBRT. The goal is to see how well it controls tumor growth and what side effects…

This study tests a new way of giving the drug regorafenib to people with advanced liver cancer. Instead of starting at a high dose, the dose is slowly increased over the first two treatment cycles to find the highest dose each person can handle without severe side effects. The go…

This study tests a treatment called Eye90 microspheres for people with liver cancer that cannot be removed by surgery. The tiny beads deliver radiation directly to tumors to shrink them. The trial involves 120 participants and measures how well the tumors respond and how safe the…

This study is testing a new blood test called Oncoguard™ Liver to see how well it finds liver cancer early in people who are at high risk, such as those with cirrhosis or hepatitis B. About 3,000 adults will take part, and the test's accuracy will be compared to standard ultrasou…

This study tests whether High-Intensity Focused Ultrasound (HIFU) can safely relieve symptoms like pain from abdominal tumors that cannot be removed by surgery. About 38 adults with benign or malignant tumors will receive a single HIFU session, which uses focused ultrasound waves…

This study tests whether a nurse-led pre-surgery program can help liver cancer patients get stronger, eat better, and feel calmer before their operation. About 92 adults having liver surgery will either receive the program (which includes exercise, nutrition support, and mental h…

This study looks back at the medical records of 2500 liver cancer patients treated at a major hospital in Taiwan between 2019 and 2024. Researchers want to see how well newer drugs like Pembrolizumab, Atezolizumab, and Lenvatinib work compared to the older drug sorafenib. They wi…

This study tests whether a special pressure-enabled catheter delivers radioactive tracer more precisely to liver tumors than a standard catheter. Twenty adults with liver cancer who are scheduled for radioembolization will receive both catheters during the mapping procedure. The …

This study is for adults with liver cancer who have had or plan to have immunotherapy. Researchers will collect blood, urine, stool, and tissue samples, along with medical records, to build a large database. The goal is to learn more about how liver cancer develops and responds t…

This study collects fresh tumor samples from 416 adults with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) to develop and train a live tumor diagnostic platform. The goal is to see how accurately the platform can predict whether a pa…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study looks at tissue from liver tumors that were destroyed by heat or cold (ablation). The goal is to see if a special test can tell whether the treatment fully killed the cancer or if new cancer cells are growing. Standard CT scans can't always tell the difference between …

This study tests whether a special catheter (TriNav) helps doctors better match the test dose with the actual treatment dose during a liver cancer procedure called radioembolization. About 19 adults with liver tumors that cannot be removed by surgery will take part. The goal is t…

This study collects leftover tissue, blood, and other body fluids from up to 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples in future lab studies to learn more about what causes these cancers…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. No extra procedures are d…

This study collects blood and tumor tissue from 360 people with early-stage liver cancer who had surgery to remove their tumors. Researchers look for specific markers in these samples to better predict if the cancer will return and to guide future immune-based treatments. The goa…

This study looks at whether combining detailed MRI scans, whole genome sequencing, and digital pathology can help doctors choose the best treatment for people with liver cancer. Researchers will study 200 adults who are scheduled for liver surgery. The goal is to see if these adv…