LUNG NEOPLASM

This study looks at two standard treatments for early-stage lung cancer: surgery and a precise type of radiation called stereotactic radiotherapy. Doctors want to find out if one is better than the other at helping patients live longer and feel better. About 670 adults with stage…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare cancers will receive the drug combinat…

This study tests new antibody-drug conjugates (ADCs) for people with advanced squamous lung cancer that stopped responding to standard immunotherapy or chemotherapy. ADCs work like guided missiles, delivering a powerful drug directly to cancer cells. The study will compare these …

This study tests a 6-week program combining bright light exposure with specific exercises to improve sleep, mood, and quality of life in people with lung or esophageal cancer. Researchers will track 200 participants' sleep patterns, symptoms, and survival rates for one year. The …

This study tests whether special lung scans (like CT and X-ray videos) can help doctors avoid damaging healthy lung tissue during radiation therapy for lung cancer. About 15 adults with stage II-IV lung cancer will get extra scans before and after their standard treatment. The go…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study builds a living collection of lab-grown mini tumors (organoids) from 150 lung cancer patients. Researchers will test how these organoids respond to chemotherapy and targeted drugs, comparing results to how the patient's actual tumor responds. The goal is to see if orga…