ESOPHAGUS CANCER

This early-stage trial tests a new drug (CA-4948) combined with standard chemotherapy and immunotherapy for people with untreated stomach or esophageal cancer that cannot be removed by surgery. The study includes two groups: one for HER2-negative cancer and one for HER2-positive …

This study tests a new way of giving chemotherapy to people with certain gastrointestinal cancers, like colorectal or stomach cancer. The approach adjusts the dose of one chemotherapy drug (5-FU) based on how well each person tolerates the starting dose. The goal is to see if thi…

This study tests whether combining two targeted drugs, afatinib and palbociclib, can shrink tumors in people with advanced esophageal cancer that has come back or spread after prior treatment. About 45 adults aged 18 to 75 will take part. The goal is to find the safest dose and s…

This study aims to find the best treatment plan for people with esophageal or esophagogastric junction cancer that cannot be removed by surgery. It will test adding immunotherapy (PD-1/PD-L1 antibodies) or targeted drugs to the standard chemoradiotherapy. About 2000 adults with s…

This study tests whether a special vacuum device placed inside the body can prevent dangerous leaks where the esophagus is reconnected to the stomach after cancer surgery. About 44 adults having minimally invasive esophageal cancer surgery will receive this preventive treatment. …

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can stop the cancer from growing for at least 6 mo…

This study aims to improve how doctors see digestive system cancers (like liver, stomach, and pancreatic cancer) using special PET/CT imaging probes. Researchers will test these probes in 400 adults to measure how they spread in the body and how well they find tumors. The goal is…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study is collecting survey responses from 1,000 people who have had or will have surgery for esophageal cancer or other upper digestive problems. The goal is to create a standard way to measure symptoms and recovery after treatment. The information will help doctors better m…

This study looks back at the medical records of 4000 people who had surgery for esophageal cancer. The goal is to learn how the edges of removed tissue (called margins) relate to how long patients live. No new treatments are given; instead, researchers hope to find patterns that …

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study uses artificial intelligence to analyze patient data—like medical history, scans, and lab results—to predict how well esophageal cancer responds to chemotherapy and immunotherapy before surgery. Researchers aim to identify which patients achieve a complete response and…