QUALITY OF LIFE

This study looks at three ways to correct nearsightedness in children: regular glasses, special glasses that blur side vision, and rigid contact lenses worn overnight. Researchers will track 90 kids aged 7-17 for one year to see which method improves quality of life most, works b…

This study tests whether smartphone apps and text messages can help African American adults aged 50 and older better manage their blood pressure and stick to their medications. High blood pressure is a major health issue for this group, and the goal is to see if technology can ma…

This study tests a program to help veterans manage pain and reduce risky substance use after leaving the military. About 1,800 veterans will be assigned to either standard training for case managers or extra support to adopt a new care pathway. The goal is to see if extra support…

This study compares two types of surgery (Parks and Bacon) for people with very low rectal cancer. The goal is to see which method leads to better bowel function and quality of life one year after surgery. About 256 adults aged 18–75 with tumors close to the anal opening will tak…

This study tests whether giving ICU patients extra protein and activating their muscles early with electrical stimulation can prevent severe muscle loss. About 40 critically ill adults on breathing machines will take part. The goal is to see if this approach helps patients keep m…

This study tests whether starting dialysis twice a week instead of the standard three times a week can reduce hospital visits and improve well-being in older adults (60+) with kidney failure who still produce some urine. About 428 participants will be followed for up to 2 years. …

This study tests whether special air cleaners and ventilators can improve indoor air quality and help control asthma in children and adults living in low-income homes. Over one year, 80 households will receive either active or placebo devices. Researchers will measure lung functi…

This study tests whether a treatment plan called total neoadjuvant therapy (TNT) can help about half of rectal cancer patients avoid surgery and keep their rectum. Participants receive chemotherapy and radiation before deciding if they need surgery. Those who respond very well ar…

This study looks at whether giving patients more oxygen during and right after major surgery can lower the chance of wound infections and other complications. About 7,800 adults having planned surgeries will be randomly assigned to receive low, medium, or high oxygen levels. The …

This study is testing whether adding the drug adebrelimab to standard chemotherapy before surgery can help eliminate or shrink esophageal cancer more effectively. About 25 people with stage II or III esophageal squamous cell carcinoma will receive the combination, then have surge…

This study tests whether a vacuum-sealed dressing (negative pressure wound therapy) can reduce wound complications like infection or reopening after emergency abdominal surgery. About 720 adults with a large midline incision will be randomly assigned to get either the vacuum dres…

This study compares a single, high-dose radiation session to multiple sessions for people whose cancer has spread to up to 5 spots. The goal is to see if one session works just as well with fewer side effects and better quality of life. About 598 adults with stable or slowly grow…

This study looks at whether a dual bronchodilator (a type of inhaler that opens airways) can improve both breathing and heart function in people newly diagnosed with moderate-to-severe COPD. Researchers will measure exercise capacity, quality of life, and lung function over 12 we…

This study tests whether a home blood pressure monitoring program with health coaching can help rural adults better control their high blood pressure. About 334 participants will either get the coaching program or a standard health app. The goal is to see if blood pressure and me…

This study tests whether simple, low-cost changes like adding shade, painting roofs, and improving airflow can reduce heat-related health problems and improve quality of life in rural Pakistan. About 7,128 people from villages in Matiari will take part. Some families will receive…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in people with severe brain injuries. About 3,300 adults on ventilators in intensive care will be randomly assigned to recei…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests a 12-week wellness program for 50 residents of a transitional housing estate in Hong Kong. Participants will do light exercise, gardening, and attend health talks to see if it improves their quality of life, happiness, and daily activities. The program is designe…

This study tests if a special type of yoga, called trauma-adapted yoga, can help teenagers with ADHD or PTSD. About 180 teens will either do yoga plus their usual care or just their usual care. Researchers will check if yoga improves symptoms like stress, focus, and pain.

This study tests whether a 12-week digital MediYoga program—combining deep breathing, gentle yoga, and meditation—can improve quality of life, blood pressure, and heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get online suppor…

This study tests a new digital follow-up program for people who have had early-stage colorectal cancer. The program uses a smartphone app to monitor symptoms, fear of cancer returning, and quality of life, and provides personalized care. About 400 participants will be split into …

This study looks at how getting a full set of fixed dental implants changes people's daily lives and well-being. Researchers will ask 100 adults with no teeth how their oral health affects their quality of life before and after treatment. The goal is to understand the real-world …

This study tests a special support program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The goal is to see if this program can improve quality of life and reduce depression compared to usual care. The study will involve 120 women and …

This study tests whether a non-invasive technique called transcranial magnetic stimulation (TMS) can help people recover movement after brain tumor surgery. Six adults with lasting motor problems will receive TMS once a day for three days. Researchers will measure muscle strength…

This study is testing a new rehabilitation program that uses multiple senses (like hearing and touch) to help people with ultra low vision. The goal is to improve their visual ability, hand-eye coordination, and quality of life. The study will involve 36 participants with very po…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study looks at how stereotactic radiosurgery (a precise type of radiation) affects quality of life and tremor severity in people with essential tremor or Parkinson's tremor whose medications aren't enough. About 60 participants will fill out questionnaires and have their tre…

This study looks at how different treatments affect quality of life in men with good-prognosis metastatic testicular cancer. Some will have surgery (RPLND) and others will get chemotherapy. The goal is to see which approach causes fewer side effects and better long-term well-bein…

This study tests a special gel and mouthwash (XCM-OM118) in 63 head and neck cancer patients getting radiation, with or without chemo. The goal is to see if it lowers the chance of severe mouth sores and improves quality of life. Patients use the product during radiation and late…

This study compares early pain after two types of weight-loss surgery: robotic sleeve gastrectomy and laparoscopic sleeve gastrectomy. About 91 people who qualify for sleeve gastrectomy will be randomly assigned to one of the two procedures. The main goal is to see if robotic sur…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty terminally ill patients will receive either two doses of LSD or a very low-dose active placebo. The goal is to improve psycholog…

This study tests a device called Patient-Controlled Transcutaneous Electrical Acupoint Stimulation (PC-TEAS) to see if it can improve quality of life for people with long-term cancer pain. About 290 adults with cancer pain will use the device at home as needed. Researchers will m…

This study is testing whether a special snack rich in plant nutrients and fiber can improve common menopause symptoms like hot flashes, night sweats, mood changes, and sleep problems. About 20 women aged 40-55 who are not on hormone therapy will eat the snack or a placebo daily f…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in women waiting for IVF treatment. 120 participants will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no treatment. The goal…

This study tests whether a 24-week Frame Running training program can improve physical function, daily activity, and quality of life in children aged 8-18 with cerebral palsy or other physical disabilities. Participants start with a low-intensity 12-week period, then move to a hi…

This study tests a program called CAPABLE Transplant to help people with kidney failure who are waiting for a transplant. The program aims to solve problems like depression, physical weakness, or lack of support that keep them from being active on the waitlist. About 43 adults wi…

This study compares underwater exercise to regular aerobic exercise in 100 adults with muscle weakness and low quality of life. Participants will do either water-based or land-based aerobic workouts. Researchers will measure changes in pain, grip strength, and psychological well-…

This study looks at whether extending the nightly fasting period (not eating for a longer stretch overnight) can improve memory, focus, sleep, and overall well-being in breast cancer survivors. Researchers will compare this approach to health education alone. The study involves 6…

This study compares four mouthwashes (Bone Bioactive Liquid, Hyaluronic Acid, Chlorhexidine, and Warm Saline) to see which one helps the healing of wisdom tooth extraction sockets. One hundred adults who need a lower wisdom tooth removed will be randomly assigned to use one of th…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical and mental health in women veterans aged 18-45. Participants will play VR games that involve physical movement, and researchers will measure changes in depression, anxiety, PTSD, …

This study tests if a special website can help people who survived a cardiac arrest outside the hospital. The goal is to improve their quality of life, mood, thinking, and social connections. About 106 survivors will use the web app and report how they feel.

This study is testing whether a pulmonary rehabilitation program can help people with advanced non-small-cell lung cancer maintain muscle mass, improve lung function, and reduce inflammation. About 94 participants will take part while receiving standard cancer treatments like che…

This study tests whether a minimally invasive procedure called alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18–45 with ovarian endometriomas. Participants are randomly assigned to receive the procedure or no treatment (expectant managemen…

This study looks at whether a fermented whey and fiber supplement can ease digestive discomfort in recreational athletes. Researchers will compare the supplement to a placebo in two groups: athletes without stomach issues and those who often have gut problems. The goal is to see …

This study looks at whether combining pain education with therapeutic exercise can reduce pain and improve quality of life in women with endometriosis. Researchers will track how well participants stick with the program and measure changes in pain, negative thoughts about pain, a…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help patients with endometrial or cervical cancer use fewer opioids and feel better. About 120 participants will be randomly assigned to use the app or not. The goal is to see if …

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called overlap syndrome. Researchers will measure mem…

This study tests whether taking a collagen supplement for 8 days can improve quality of life, appetite, mood, and blood sugar control in overweight or obese adults aged 18-65. Participants will take the supplement or a placebo, fill out questionnaires, and wear a continuous gluco…

This study looks at three different hand therapies—mirror therapy, brain stimulation, and robotic hand training—added to standard rehab for stroke patients. The goal is to see which one works best for improving arm movement, reducing pain, and boosting quality of life. About 120 …

This study tests a 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the program is free.

This study looks at whether adding kinesiotaping (a special tape) to prenatal stretching exercises can reduce low back pain, improve movement, and enhance quality of life in pregnant women. About 34 women between 20-34 weeks of pregnancy and aged 18-35 will take part. Participant…

This study looks at whether a structured exercise program can help recreational video game players react faster and click more accurately. Researchers will measure changes in reaction time and mouse accuracy in 15 college students who play at least one hour of video games per wee…

This study looks at whether adding Brandt-Daroff exercises (simple head movements done at home) to the standard GANS maneuver can better reduce dizziness and improve quality of life in people with BPPV, a common inner-ear condition that causes brief spinning sensations. Researche…

This study tests whether cannabidiol (CBD) suppositories can reduce pain during sex and improve well-being and quality of life. Fifty adults who experience sexual pain and have used CBD before without allergic reaction will be randomly assigned to different doses. The treatment l…

This study tests whether Jing Si Herbal Tea, taken twice daily, can improve quality of life and sleep for people with dementia and their caregivers. Researchers will first test the tea's feasibility in 100 people with dementia, then run a larger placebo-controlled trial with 200 …

This study tests whether regular, friendly phone calls can improve mental health and reduce loneliness in older adults who are homebound. About 400 people aged 65 and older will receive either supportive calls from trained helpers or no calls during the study. The goal is to see …

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain education, can help women aged 18 to 48 who have migraines. Researchers will measure changes in headache-related disability, pain sensitivity, and quality of life. The goal …

This study will test a health and wellness product in 133 adults aged 21-75 who are either taking a GLP-1 medication or trying to lose weight. Participants will report their digestive symptoms and quality of life through surveys and provide biomarker samples. The goal is to see i…

This study tests whether a single dose of the steroid dexamethasone given during hip replacement surgery can improve patients' quality of life and reduce pain for up to three months after the operation. About 224 adults aged 60 and older having elective hip replacement will recei…

This study aims to find out which ovarian stimulation method is more comfortable and satisfying for women undergoing IVF. About 60 women will try both a new approach (using CFA and PPOS) and the standard approach, then report their experiences. The goal is to improve quality of l…

This study looks at whether using a handheld breathing device (oscillating PEP) helps children (ages 8+) and adults with bronchiectasis feel better day-to-day. Researchers will ask 60 participants about their quality of life before and after using the device. The goal is to see i…

This study looks at whether combining Swiss ball exercises with deep breathing can reduce stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) in pregnant women. About 42 pregnant women with mild to moderate leakage will be split into two groups: one…

This study compares a modified double-J ureteral stent to a standard one in 40 adults with kidney or ureteral stones. The new stent has a thinner loop at the bladder end, which may reduce common side effects like pain, blood in urine, and discomfort when urinating. The goal is to…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause, which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks and report how their symptoms and quality of life change. The goal is to …

This study tests a coaching program for pregnant or new-mom doctors in training. About 48 participants will either get coaching (one-on-one and group sessions) or not. Surveys over 7 months will measure burnout, well-being, and confidence. The goal is to see if coaching helps the…

This study is testing whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help Black teenagers and young adults with sickle cell disease cope with stress related to racism. About 30 participants aged 14-21 will take part in a 10-session group therapy…

This study tests a mobile app called Stappvoorstap for adults on mental health waiting lists in the Netherlands. Over 4 weeks, participants use the app to track stress, learn coping skills, and access relaxation exercises. The goal is to see if the app can reduce stress and impro…

This study looks at whether hearing aids can improve the quality of life for cancer patients who develop hearing problems from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing loss will be offered a hearing aid. Researche…

This study tests if dry needling—inserting thin needles into muscles—can help people with chronic low back pain feel better and improve their quality of life. Researchers will compare three different dry needling sessions in 42 adults aged 18 to 65. The goal is to see if the appr…

This study compares two types of exercise training—Dynamic Neuromuscular Stabilization (DNS) and Pelvic Floor Muscle Training (PFMT)—in women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 51 women will be randomly assigned to one o…

This study is testing a smartphone app powered by artificial intelligence to help people with oral cancer return to work and manage physical and emotional challenges. Researchers will compare 650 patients who use the app with those who receive standard care. The goal is to see if…

This study looks at children with large birthmarks (congenital melanocytic nevi) who choose to have them surgically removed. The goal is to see if removal improves their quality of life and reduces feelings of being stigmatized. About 100 children aged 9 months to 16 years will b…

This study tests whether a tailored physical activity program can help preserve exercise capacity, heart function, memory, and quality of life in adults (ages 18-85) with Hodgkin or non-Hodgkin lymphoma or stage I-III breast cancer who are undergoing chemotherapy or other cardiot…

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, combined with practical heat-safety advice, can reduce heat-related illnesses and improve quality of life. Over 7,000 people in low-income neighborhoods of Karachi, Pakist…

This study looks at how sleep troubles impact memory, focus, and quality of life in women treated for breast cancer. Researchers will track sleep patterns using a wrist monitor and ask participants about their thinking and well-being. The goal is to better understand these links …

This study looks at how inner strengths like resilience, gratitude, and acceptance help older adults (60+) feel better and cope with stress. Researchers will measure quality of life, loneliness, and emotional well-being in 110 participants living in Spain. The goal is to shift th…

This study is collecting blood samples from 5000 people having heart, colorectal, vascular, or lung surgery to find biological markers that can predict serious complications like infections, kidney injury, or death within 30 days. The goal is to improve risk assessment and guide …

This study follows 100 people whose pilonidal cyst came back after surgery or laser treatment. Researchers will use questionnaires to measure how the recurrence affects quality of life, pain, and daily activities. The goal is to better understand the burden of this condition.

This study is translating and testing a questionnaire called the Parkinson's Disease Dyskinesia Scale (PDYS-26) into Turkish. The questionnaire measures how involuntary movements (dyskinesia) affect daily life in people with Parkinson's disease. Researchers will enroll 130 patien…

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers want to understand their physical and emotional distress, financial burden, and care needs over one year. The goal is to create a tool that can predict who is at high risk for severe s…

This study looks at how a brief full-body cold-water bath, compared to a warm bath, influences decision-making, mood, and physical responses. Researchers will measure things like risk-taking, food choices, heart rate, and stress hormones in 40 healthy adults. The goal is to under…

This study surveys 400 men undergoing fertility treatment due to low sperm quality. Researchers want to understand men's emotional and social experiences, and whether they feel overlooked by doctors. They will also check if low testosterone affects quality of life. Results will b…

This study looks at what makes life better for people aged 60 and older living in nursing homes in Hanoi, Vietnam. Researchers will interview 176 residents to see how things like health, independence, and support from others affect their quality of life. The goal is to use this i…

This study looks at how women's feelings about artificial intelligence relate to their anxiety levels and quality of life while undergoing infertility treatment. About 191 women aged 18-45 with infertility will answer questionnaires. The goal is to understand these connections to…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track insomnia over the first year using questionnaires to see how it develops and what factors—like treatment or emotional distress—may trigger or worsen it. The goal is to…

This study is translating and testing a quality-of-life questionnaire (AQUAREL) for Turkish-speaking people with pacemakers or similar heart devices. Researchers will enroll 120 patients to check if the Turkish version is accurate and reliable. The goal is to give doctors a bette…

This study looks at how well a heart procedure called catheter ablation improves quality of life for people with a fast heart rhythm (ventricular tachycardia) who also have an implantable defibrillator. Researchers will ask 70 adults to fill out questionnaires about their health …

This study looks at how immunotherapy for advanced cancer changes a person's physical fitness and quality of life. About 67 adults with solid tumors will take fitness tests and answer questionnaires before starting treatment and again 12 weeks later. Researchers will also track l…

This study follows 800 adults who spent at least 48 hours in the ICU to track how many develop ongoing pain. Researchers will call participants at 90 and 180 days after leaving the ICU to ask about pain, sleep, mood, and quality of life. A smaller group will also have a detailed …

This study explores the link between mental health and symptom severity in 200 adults with graft-versus-host disease (GvHD), a complication after bone marrow transplant. Researchers will use questionnaires to measure depression, anxiety, and quality of life. The goal is to see if…

This study tests whether an 8-week online education program based on logotherapy (finding meaning in life) can increase physical activity and improve quality of life in middle-aged office workers. About 200 participants aged 35-60 with sedentary jobs will be randomly assigned to …

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their own healthcare. The app includes a digital medical passport, educational information, community suppor…

This study looks at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults using standard questionnaires. No new treatments are te…

This study is testing whether a program called CAPABLE can help homebound older adults who feel socially isolated or lonely. The program works with home-based primary care to improve daily function and quality of life. Researchers will enroll 450 participants from Johns Hopkins H…

This study follows 1500 people for 5 years after breast cancer surgery to see how their quality of life changes. Participants fill out questionnaires about their physical and emotional well-being. The goal is to better understand the long-term effects of surgery and help improve …

This study looks at whether providing meal kits and nutrition education can improve diet, mental health, and quality of life for adults aged 40 and older with lower incomes. About 120 participants will receive either meal kits plus classes or standard nutrition materials. Researc…

This study follows 250 people with chronic diverticular disease to see if elective surgery improves their quality of life compared to those who continue with conservative treatment. Participants will fill out questionnaires about their symptoms and well-being. The goal is to help…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study follows 384 women who receive Silimed smooth breast implants for breast augmentation. Researchers will track any side effects or complications over 10 years, and measure how satisfied patients are with the results. The goal is to confirm the implants are safe and work …

This study looks at how small-fiber neuropathy (nerve damage causing pain, burning, and tingling) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's, comparing those with and without nerve pain. The …

This study follows 327 adults aged 65 and older who have surgery to remove gastrointestinal cancers. Researchers track their physical function, quality of life, and cancer outcomes for up to 5 years. The goal is to identify factors that predict decline, helping doctors better sup…

This study looks at how the daily independence of young children with rare genetic disorders affects their families' mental health and quality of life. Researchers will assess 45 children aged 0-4 and their caregivers using questionnaires. The goal is to help doctors provide bett…

This study follows 632 women who received Silimed breast implants (textured or polyurethane-coated) for augmentation. Researchers will track side effects and patient satisfaction over 10 years. The goal is to better understand the long-term risks and how happy women are with thei…

This study tests whether a digital dashboard can help home visitors in Rwanda deliver mental health support more effectively. The program, called Sugira Muryango, aims to improve family well-being and reduce violence. About 1,800 caregivers and officials will take part to see if …

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study is for women who have had the first stage of implant-based breast reconstruction and have surgical drain tubes in place. It aims to see if showering 48 hours after surgery increases the risk of infection or affects quality of life. Half of the 100 participants will be …

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study aims to understand how two mental practice techniques—imagining movements and watching others perform movements—affect muscle activity in stroke survivors. Researchers will measure electrical signals in arm and hand muscles of 28 participants during these exercises to …