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New study tests freezing vs heating nerves to stop war wound pain

NCT ID NCT07416448

Symptom relief Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The goal is to see which method better reduces pain, improves function, and lowers the need for painkillers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Sustained combat-related trauma * Clinically significant neuroma-associated pain localized to a peripheral nerve or neuroma * Moderate to severe pain (score ≥ 4 on a standardized numeric pain rating scale) * Medically stable and able to undergo a percutaneous interventional procedure * Able to understand and provide written informed consent * Willing and able to comply with study procedures, including follow-up assessments and patient-reported outcome measures * May be receiving standard analgesic therapy, including opioids, if usage can be monitored * No planned surgical intervention at the neuroma site during the study period that could interfere with pain assessment Exclusion Criteria: * Age under 18 years * Pregnant or breastfeeding * Severe uncontrolled medical comorbidities that preclude safe participation * Active infection at or near the proposed intervention site * Known coagulopathy or use of anticoagulants that cannot be safely withheld * Previous cryoablation or radiofrequency ablation at the target neuroma within the past 6 months * Inability to provide informed consent or comply with study procedures * Participation in another interventional clinical trial that could interfere with study outcomes * Known allergy or intolerance to materials used during the procedures

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Conditions

The condition(s) this trial relates to.

agnosia depressive disorder Hypesthesia major depressive disorder neuralgia neuroma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression in adults Functional outcome Hypoesthesia Neuroma Neuropathic pain Pain management Quality of life

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Communal enterprise "Yuri Semenyuk Rivne Regional Clinical Hospital" of Rivne Regional Council

    RECRUITING

    Rivne, 33003, Ukraine

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