NEUROPATHIC PAIN

This study is creating and testing a Thai version of a questionnaire called PainPREDICT, which will be built into a mobile app. The goal is to help doctors and patients screen for painful nerve damage caused by diabetes more easily and accurately. Researchers will test the app wi…

This study compares two different nerve-blocking techniques to prevent chronic pain after minimally invasive chest surgery. Researchers want to see if a newer ultrasound-guided nerve block works better than the standard surgical nerve block at reducing long-term pain. The study w…

This study is testing two minimally invasive procedures to help manage severe, acute chest pain in adults who have suffered combat-related injuries in Ukraine. It aims to see if using extreme cold (cryoablation) or controlled heat (radiofrequency ablation) to block pain signals f…

This study is testing whether a special electrical skin patch can safely reduce chronic nerve pain in people with spinal cord injuries. Thirty participants will be randomly assigned to receive either the real patch or a placebo patch for two weeks, while continuing their standard…

This study is testing if a temporary spinal cord stimulator can help people with type 2 diabetes who have painful nerve damage in their legs. Researchers want to see if the device can reduce pain and also improve blood circulation in the lower limbs. The study involves 25 partici…

This study is testing whether playing a virtual reality walking game can help reduce chronic nerve pain in adults with incomplete spinal cord injuries. Researchers believe the VR experience may correct a mismatch between what the brain expects and what the body feels, which could…

This study is testing a new self-hypnosis software program designed for use with a virtual reality headset. Researchers want to see if it is safe, easy to use, and might help reduce chronic pain in adults living with HIV. The study will involve about 25 participants who will try …

This study is testing whether a combination of visual body illusions and a gentle, non-invasive form of brain stimulation can help reduce chronic nerve pain in people with spinal cord injuries. Researchers want to see if this approach can lessen pain severity and improve daily li…

This study aims to find out if cannabis compounds (THC, CBD, or both) can help reduce chronic nerve pain in Veterans. It will compare these treatments against a placebo in 320 Veteran participants who are not current cannabis users. The goal is to provide clearer evidence on whet…

This study is testing whether a non-invasive brain stimulation technique can reduce severe, treatment-resistant nerve pain in people with spinal cord injuries. Researchers will use a magnetic coil placed on the scalp to stimulate two different brain areas, comparing which locatio…

This study compares two existing pain relief methods for people with postherpetic neuralgia, the nerve pain that can linger after shingles. Researchers will look back at 50 patients who received either an ultrasound-guided nerve block or a radiofrequency treatment as part of thei…

This study is testing whether a non-invasive brain stimulation technique called 'deep rTMS' can reduce pain for people with chronic neuropathic pain or fibromyalgia. 70 participants will be randomly assigned to receive either the real magnetic stimulation or a sham (fake) treatme…

This study is testing a special spinal cord stimulator for people with long-lasting nerve pain caused by chemotherapy. The device is implanted and works by automatically adjusting electrical pulses to the spinal cord in real-time, aiming to reduce pain. Researchers will measure c…

This study is testing whether adding ultrasound-guided injections to a home exercise program helps people with chronic, painful frozen shoulder. Researchers will compare two different injection approaches to see which one works better at reducing pain and improving shoulder movem…

This study is testing whether a 12-week supervised strength training program can reduce chronic pain in people with multiple sclerosis (MS). Researchers will compare pain levels in 116 participants who either start the exercise program right away or continue with their usual care…

This study is testing whether a non-invasive brain stimulation therapy can reduce chronic nerve pain for people with spinal cord injuries. Researchers will compare two different stimulation targets in the brain against a placebo treatment. The goal is to see if this therapy can e…

This study aims to find out which common over-the-counter painkillers (like diclofenac or meloxicam) work best for adults with frozen shoulder when combined with simple home exercises. Researchers will enroll 120 adults with shoulder pain and stiffness to test different medicatio…

This study is testing whether a portable, home-use device that delivers mild electrical stimulation to the brain can help people with long-term nerve or body-wide pain. It is for people who got short-term relief from a similar hospital treatment. Participants will use the device …

This study is testing whether playing an immersive virtual reality walking game can reduce chronic nerve pain in adults with complete spinal cord injuries. Researchers believe the game may help by creating a visual illusion of walking, which could correct a mismatch in brain sign…

This study is testing whether a high-concentration capsaicin (the compound that makes chili peppers hot) skin patch can relieve chronic pain at the tailbone (coccygodynia). It will involve 188 adults in France who have had this pain for over 3 months and have not gotten enough re…

This study aims to find out which of three newer therapies works best to improve arm and hand function, reduce pain, and boost quality of life for people recovering from a stroke. Researchers will compare mirror therapy, a non-invasive brain stimulation technique, and robot-assis…

This study is testing whether combining spinal cord stimulation (a device that sends electrical pulses to the spinal cord) with a comprehensive rehabilitation program can better manage chronic nerve pain in the legs. The program includes physical therapy, psychological counseling…

This study is testing whether a non-invasive magnetic brain stimulation therapy can reduce chronic nerve pain in people with spinal cord injuries. It will involve 60 participants who have had pain for at least six months. The therapy targets a specific brain area to see if it eas…

This study in Ukraine aims to find out which of two minimally invasive procedures works better for reducing severe nerve pain caused by combat injuries. Fifty adult patients with this type of pain will be randomly assigned to receive either a 'freezing' (cryoablation) or a 'heati…

This study is testing which of two steroid injection methods works better for people with long-term back and leg pain that hasn't improved with physical therapy or medications. Researchers will compare a newer 'transgrade' injection technique against the standard 'interlaminar' m…

This study is testing a new oral medication called EC5026 to see if it is safe and tolerable for people with chronic nerve pain caused by a spinal cord injury. Researchers will enroll 36 adults who have had this pain for over a year and have not gotten enough relief from other st…

This study is testing whether training leg reflexes can reduce chronic nerve pain in people with spinal cord injuries. Researchers are recruiting 15 people with this type of pain to participate in about 50 training sessions over 6.5 months. The goal is to see if this specific tra…

This study is testing whether a skin patch containing capsaicin, the compound that makes chili peppers hot, can reduce chronic nerve pain in teenagers. It will compare the capsaicin patch to a placebo patch in 46 teens aged 12 to 17 who have had pain for over 3 months following s…

This study is testing whether two dietary supplements (PEA and Scutellaria) combined with a specific exercise program can help reduce nerve pain and damage caused by chemotherapy. It will observe 40 adults who have finished chemotherapy and are experiencing significant nerve pain…

This study is testing a specific nerve surgery called RPNI to see if it can reduce long-term pain and improve mobility for people who have had a major leg amputation. Researchers will follow 20 patients for two years after their surgery. They will measure pain levels, how well pa…

This study is testing whether giving vitamin D supplements to cancer patients who are deficient can reduce nerve pain caused by a common chemotherapy drug called taxane. About 80 patients scheduled for this chemo will be randomly assigned to either receive prescribed vitamin D or…

This study aims to understand how daily pain, mood, and activities are connected, especially as acute pain transitions to chronic pain. Researchers will enroll 800 people with acute pain, chronic pain, or no pain to use a smartphone app (SOMA) for four months to track their daily…

This study aims to understand how spinal cord stimulation (SCS) works to relieve chronic nerve pain. Researchers will measure specific chemicals in the blood and spinal fluid of 30 patients before and after they receive SCS treatment. The goal is to learn which body signals are l…

This study aims to collect detailed information from 4,500 patients before and after various brain and spine surgeries. The goal is to identify which factors best predict a patient's recovery and quality of life after their operation. By standardizing how outcomes are measured ac…

This study aims to understand how ginger might affect the connection between the gut and brain in people with sciatica nerve pain. Eighty participants with chronic sciatica will take either ginger or a placebo daily for eight weeks. Researchers will measure changes in gut bacteri…

This study aims to validate a new scoring tool designed to predict which cancer patients are most likely to develop long-term nerve pain as a result of their treatments, like surgery or chemotherapy. Researchers will enroll 625 participants, including cancer patients and healthy …

This study aims to understand how different types of spinal cord stimulation (some with a tingling sensation, some without) relieve chronic nerve pain. Researchers will use brain scans and pain tracking in 90 patients to learn how these treatments work in the body and to identify…

This study aims to understand how neuropathic (nerve) pain affects the ability to care for oneself and overall quality of life in people with Type 2 diabetes. Researchers will survey 128 adult volunteers with Type 2 diabetes, asking questions about their pain levels, daily activi…

This study aims to understand how common nerve pain is in children and teenagers who have had a limb amputated. Researchers will observe 50 participants, asking them questions about phantom limb pain, residual limb pain, and how it affects their daily life and independence. The g…

This study aims to better understand the specific sensations of chronic shoulder pain and how they relate to a sensitized nervous system. Researchers will observe 82 adults with shoulder pain lasting at least 3 months, using questionnaires and movement measurements. The goal is t…

This study aims to understand the relationship between a specific pain questionnaire (PainDETECT), where patients feel pain, and their final diagnosis. Researchers will observe 150 adults visiting a sports medicine clinic for pain, recording their questionnaire answers and diagno…