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Massive study aims to predict brain surgery success

NCT ID NCT06724029

Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes are measured, the study hopes to improve surgical decisions and give patients clearer guidance before their operation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 4,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients older than 18 years old, with neurosurgical pathology

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and extra axial tumors excluding the skull base (anterior, middle and posterior fossa; sellar and parasellar region) * Basicranial pathology: tumors originating from the anterior cranial fossa, middle cranial fossa and posterior cranial fossa, sellar region with or without supratentorial/parasellar development. * Vascular pathology: aneurysms, AVMs, cavernomas, other pathologies (Moyamoya disease, dural fistulas, nontraumatic hematomas) * Traumatic pathology: diffuse damage (nonvisible diffuse damage, diffuse damage, diffuse damage with edema, diffuse damage with shift) and focal damage (acute/subacute/chronic subdural hematoma, extradural hematoma, subarachnoid hemorrhage, intraparenchymal hematoma, fractures); hydrocephalus. The inclusion criterion for chronic subdural hematoma is recent bleeding for TBI with CT finding of chronic subdural hematoma candidate for evacuation surgery. * Spinal pathology: degenerative cervical (anterior/posterior), myelopathic, and trauma pathology; instrumented, uninstrumented thoracolumbar pathology (disc pathology, canal pathology), and trauma pathology; oncologic spinal pathology. * Functional pathology: Parkinson's disease, spasticity, trigeminal neuralgia, craniofacial pain/algia, neuropathic pain, tremor, dystonias, obsessive compulsive disorder, drug-resistant epilepsies, depression. Normotensive hydrocephalus. * Peripheral nervous system pathology: peripheral nerve compression syndromes, peripheral nerve and plexus tumors, brachial plexus and peripheral nerve trauma (contusion and section) * Malformative pathology: Chiari malformation type 1 and craniostenoses including both those framed in malformative syndromes and those not framed in malformative syndromes (monosutural craniostenoses: trigonocephaly, plagiocephaly, scaphocephaly; multisutural craniostenoses). Malformative hydrocephalus. * For cognitive and psychological assessment: age 18 years or older; adequate understanding of Italian language; diagnosis of glioma, meningioma, vascular pathology, spinal pathology Exclusion Criteria: * For cognitive and psychological assessment: patients with psychiatric diseases in history and/or taking psychotropic drugs; presence of overt cognitive decline (not due to the injury) in history; patients younger than 18 years old.

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Conditions

The condition(s) this trial relates to.

Aneurysm arteriovenous hemangioma/malformation arteriovenous malformations of the brain Chiari malformation type I Depression depressive disorder Drug Resistant Epilepsy dystonic disorder Facial Pain Hematoma, Epidural, Spinal Hematoma, Subdural hydrocephalus Moyamoya disease Muscle Spasticity neuralgia normal pressure hydrocephalus obsessive-compulsive disorder Parkinson disease skull base neoplasm subarachnoid hemorrhage Tremor trigeminal neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aneurysms Arteriovenous malformations Cavernomas Chiari malformation type 1 Craniofacial pain Depression Drug resistant epilepsy Dural fistulas Dystonias Extradural hematoma Hydrocephalus Moyamoya disease Neuropathic pain Normal pressure hydrocephalus Obsessive compulsive disorder Parkinson'S disease Skull base tumors Spasticity Subarachnoid hemorrhage Subdural hematoma Tremor Trigeminal neuralgia Tumors of peripheral nerves

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 1. ASST Papa Giovanni XXIII

    ACTIVE_NOT_RECRUITING

    Bergamo, BG, 24127, Italy

  • A.R.N.A.S. Ospedali Civico di Palermo

    RECRUITING

    Palermo, 90127, Italy

  • ASL Roma 1

    RECRUITING

    Roma, 00135, Italy

  • ASST Cremona

    ACTIVE_NOT_RECRUITING

    Cremona, CR, 26100, Italy

  • ASST Fatebenefratelli Sacco

    ACTIVE_NOT_RECRUITING

    Milan, Italy

  • ASST Lariana, Ospedale S. Anna

    ACTIVE_NOT_RECRUITING

    Como, CO, 22100, Italy

  • ASST Ovest Milanese

    ACTIVE_NOT_RECRUITING

    Legnano, 20025, Italy

  • ASST Santi Paolo e Carlo

    RECRUITING

    Milan, 20153, Italy

  • ASST della Valtellina ed Alto Lario

    ACTIVE_NOT_RECRUITING

    Sondrio, SO, 23100, Italy

  • Azienda Ospedaliero Universitaria Careggi

    RECRUITING

    Florence, Italy

  • Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"

    RECRUITING

    Catania, Italy

  • Azienda Ospedaliero Universitaria di Parma

    ACTIVE_NOT_RECRUITING

    Parma, Italy

  • Azienda Sanitaria Universitaria Friuli Centrale di Udine

    RECRUITING

    Udine, 33100, Italy

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    ACTIVE_NOT_RECRUITING

    Milan, 20122, Italy

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    RECRUITING

    Milan, 20133, Italy

  • Fondazione IRCCS Policlinico San Matteo

    ACTIVE_NOT_RECRUITING

    Pavia, PV, 27100, Italy

  • Fondazione IRCCS San Gerardo dei Tintori

    ACTIVE_NOT_RECRUITING

    Monza, MB, 20900, Italy

  • Fondazione Poliambulanza Istituto Ospedaliero

    ACTIVE_NOT_RECRUITING

    Brescia, BS, 25124, Italy

  • Fondazione Policlinico Universitario Gemelli di Roma

    RECRUITING

    Roma, 00168, Italy

  • IRCCS Istituto Clinico Humanitas

    ACTIVE_NOT_RECRUITING

    Rozzano, 20089, Italy

  • Istituto Clinico Città Studi

    ACTIVE_NOT_RECRUITING

    Milan, Italy

  • Ospedale Alessandro Manzoni

    ACTIVE_NOT_RECRUITING

    Lecco, 23900, Italy

  • Ospedale F. Spaziani di Frosinone

    RECRUITING

    Frosinone, 03100, Italy

  • Ospedale Moriggia Pelascini

    ACTIVE_NOT_RECRUITING

    Gravedona, Como, 22015, Italy

  • Ospedali Riuniti di Livorno -Azienda USL Toscana nord ovest

    RECRUITING

    Livorno, Italy

  • Policlinico di Monza

    RECRUITING

    Monza, 20900, Italy

  • Spedali Civili Brescia

    ACTIVE_NOT_RECRUITING

    Brescia, BS, 25123, Italy

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