HYDROCEPHALUS

This study looks at how safe and effective the Polaris® 24 adjustable valve is for people with hydrocephalus, a condition where fluid builds up in the brain. About 126 patients will be enrolled to track any serious side effects and how often the valve needs to be replaced. The va…

This program gives children under 26 with brain conditions like cerebral palsy or stroke access to umbilical cord blood infusions. The cord blood is given through an IV and may help the brain repair itself. It is not a cure, but aims to improve symptoms and quality of life.

This study tests a new MRI technique to measure how cerebrospinal fluid (CSF) flows in the brain. Researchers will compare CSF flow in healthy people and those with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understa…

This study is testing a small, wireless sensor that sticks to the skin over a shunt tube to see if fluid is flowing properly. It uses gentle warmth to measure temperature changes without breaking the skin. About 55 children and adults with hydrocephalus and working shunts will ta…

This study tests a new wireless, bandage-like sensor called FlowSense that measures fluid flow in the brain for people with hydrocephalus. The sensor is placed on the neck to check if a shunt is working without needing X-rays or hospital equipment. Researchers will compare its re…

This study watches 148 adults with acute brain injury who have a drainage tube in their head. Researchers want to see if changes in a natural chemical called lactate in the brain fluid can signal an infection early. The goal is to find better ways to detect and manage these serio…

This study aims to confirm whether high sugar levels in the fluid around the brain and in the blood soon after a brain aneurysm rupture are linked to needing a permanent shunt. Researchers will measure sugar levels daily in 160 adults who have a temporary drain placed. Participan…

This study follows 140 people with early signs of normal pressure hydrocephalus (NPH) to see if brain scans and fluid tests can predict who will get worse and need a shunt. It also looks at how symptoms change over time in people with and without surgery. The goal is to better un…

This study tests a non-invasive light-based device to monitor blood flow and oxygen use in the brains of premature infants who have had a brain bleed or developed fluid buildup (hydrocephalus). Researchers will compare these babies to healthy newborns and those with other causes …

This study uses leftover spinal fluid from 10 patients with normal pressure hydrocephalus to see how different mixtures of local anesthetics and additives form crystals over time. Researchers will grade the amount of crystallization and measure pH changes. The goal is to better u…

This study is collecting information from 4,500 people who have had brain surgery for conditions like aneurysms, tumors, or epilepsy. The goal is to find out what factors help predict recovery, such as thinking skills and emotional health. By standardizing how outcomes are measur…

This study is testing a new device that measures pressure around the brain from outside the head, avoiding the need for risky surgery. Researchers will collect data from 581 patients who already have standard surgical monitors, to help develop a safer, non-invasive alternative. T…

This study looks at whether giving antibiotics for the entire time a brain drain (EVD) is in place prevents infections better than just a single dose before placement. About 84 adults with certain brain conditions will take part. The goal is to find out if longer antibiotic use i…