Obsessive compulsive disorder

This pilot study tests whether transcranial magnetic stimulation (TMS) is safe and tolerable for teenagers aged 13 to 17 with obsessive-compulsive disorder (OCD) who have not improved enough with standard treatments. Participants receive TMS sessions five days a week for three we…

This trial tests whether a noninvasive technique called transcranial temporal interference stimulation (tTIS) can reduce symptoms in people with obsessive-compulsive disorder (OCD). The stimulation targets the nucleus accumbens, a deep brain region linked to OCD, using electric f…

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants a…

This study tests whether adding cognitive behavioral therapy (CBT) can help children and teens with obsessive-compulsive disorder (OCD) safely stop their medication without symptoms returning. Participants first receive CBT for 12 to 18 weeks, then continue with maintenance sessi…

This trial tests whether a wearable headband called ATTN201 can safely reduce obsessive-compulsive disorder (OCD) symptoms. The device delivers low-intensity focused ultrasound to a deep brain region involved in OCD, without surgery. Forty adults with moderate-to-severe OCD will …

This study tests whether a 6-week digital mindfulness program, delivered through a mobile app, can help people with obsessive-compulsive disorder (OCD) manage their symptoms. The trial compares the digital therapy alone, standard medication alone, and a combination of both in 150…

This study tests a new way to treat severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Researchers will use brain mapping to guide the placement of four electrodes that deliver mild electrical pulses to specific brain areas. The goal is to see …

This study tests if deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Ten participants will have a device implanted in their brain and be randomly assigned to receive real or sham stimulation. …

This study is testing whether adding stimulation to the front part of the brain can improve standard deep brain stimulation (DBS) for severe obsessive-compulsive disorder (OCD). Fifteen adults with OCD that hasn't improved with other treatments will get DBS plus an extra set of e…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people with obsessive-compulsive disorder (OCD) who haven't gotten better with medication. The treatment targets a specific brain area linked to OCD. Researchers will measure symptom changes …

This study is testing whether a noninvasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can boost the effects of a type of talk therapy (Exposure and Response Prevention) for people with obsessive-compulsive disorder (OCD) that hasn't im…

This study tests whether a therapist-guided online cognitive-behavior therapy program can help reduce obsessive-compulsive disorder (OCD) symptoms in children and teens with autism. About 220 participants will receive the online treatment or a comparison condition. The goal is to…

This study tests if a non-invasive brain stimulation technique called TMS can improve the effects of exposure therapy for obsessive-compulsive disorder (OCD) in people aged 12 to 21. Fifty participants will receive either real or fake TMS before therapy sessions over two weeks. T…

This study tests a brain-training method called neurofeedback to see if it can help people with obsessive-compulsive disorder (OCD) and post-traumatic stress symptoms feel better overall. Twenty adults on a therapy waitlist will try the training, and researchers will check for ch…

This study explores whether personalizing therapy for anxiety—by matching people to cognitive, behavioral, or mindfulness-based approaches—can improve outcomes. Researchers will look for baseline predictors of success and compare brief video-based skill training to four sessions …

This study tests a new drug called RR-HNK (related to ketamine) to see if it safely reduces obsessive-compulsive disorder (OCD) symptoms. About 45 adults with OCD who haven't improved with standard treatments will receive two doses of the drug or a placebo. The main goal is to me…

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usuall…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty adults with moderate to severe OCD who haven't improved with standard treatments will receive either a low, medium, or high dose …

This study tests whether a special helmet that delivers focused ultrasound can safely and effectively calm overactive brain circuits in people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Participants receive two sessions of this …

This study tests a 20-25 minute online program called Project EMPOWER-OCD for caregivers of people with OCD. The program teaches caregivers how to reduce accommodating behaviors that can accidentally make OCD worse. Researchers want to see if it lowers caregiver stress and improv…

This study tests whether a special kind of talk therapy, called Emotion-Focused Acceptance and Commitment Therapy (ACT), can reduce symptoms of Obsessive-Compulsive Disorder (OCD). About 36 adults with OCD will be randomly assigned to either ACT group therapy or a supportive grou…

This study tests whether adding dextromethorphan (a cough suppressant) to fluoxetine (an antidepressant) can safely reduce symptoms of obsessive-compulsive disorder (OCD) and related conditions like body dysmorphic disorder. About 60 adults in California will take the combination…

This study tests a computer-based training program called CBM-I for adults with obsessive-compulsive disorder (OCD). The training aims to change how people interpret situations, which may reduce OCD symptoms. Participants will be randomly assigned to either the training or a cont…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, such as depression, anxiety, or PTSD, and assign them to practi…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with obsessive-compulsive disorder (OCD) who haven't gotten better with standard treatments. Over 7 days, 30 participants will receive 28 sessions of brain stimulation targeting areas linke…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This Stanford study tests how ketamine quickly reduces OCD symptoms by blocking opioid receptors with naltrexone. 150 adults with OCD who haven't responded to standard treatments will receive ketamine plus either naltrexone or a placebo. The goal is to see if the opioid system is…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests a non-invasive brain stimulation technique called TMS for adults with obsessive-compulsive disorder (OCD) who did not improve enough with standard exposure therapy. 250 participants will receive either real or sham TMS combined with therapy for 5-7 weeks. The goa…

This study tests whether MDMA (the active ingredient in ecstasy) combined with talk therapy can safely reduce OCD symptoms. About 40 adults with OCD who have not improved with standard treatments will receive either MDMA or a comparison drug during therapy sessions. The goal is t…

This study tests whether virtual reality (VR) can help people with obsessive-compulsive disorder (OCD) by letting them face their fears in a safe, computer-generated world. 62 inpatients will be randomly assigned to standard therapy plus VR exposure, VR cognitive games, or standa…

This study tests whether a short, culturally adapted form of cognitive behaviour therapy (CaCBT) can help people with obsessive-compulsive disorder (OCD) in Pakistan. Researchers will enroll 166 adults with OCD and measure changes in symptoms, depression, and anxiety. The therapy…

This study tests whether a drug called psilocybin, given alongside talk therapy, can help people with severe obsessive-compulsive disorder (OCD) who haven't gotten better with standard treatments. Fifteen adults will receive three eight-hour sessions under the influence of psiloc…

This study is testing whether virtual reality (VR) can help people with obsessive-compulsive disorder (OCD) face their fears in a safe, controlled way. Thirty adults with OCD will try five weekly VR sessions that expose them to situations that trigger their symptoms. The goal is …

This study tests a new, faster version of transcranial magnetic stimulation (TMS) for obsessive-compulsive disorder (OCD). Twenty adults with OCD who haven't improved enough with standard treatments will receive six TMS sessions each day for five days. The goal is to see if this …

Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive an…

This observational study aims to understand why some people are more impulsive or compulsive than others. Researchers will use brain scans, genetic tests, and behavioral surveys in 1,100 participants aged 6 to 80, including those with ADHD, OCD, autism, and conduct disorder. The …

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study aims to build a comprehensive 'physiological brain atlas' by collecting electrical and other data from patients undergoing stereotactic brain surgery for conditions like Parkinson's disease, OCD, and epilepsy. The goal is to map this information onto a standard brain t…

This study investigates how the gut-brain axis—the communication network between gut bacteria and the brain—might be involved in pediatric obsessive-compulsive disorder (OCD). Researchers will compare gut microbiome, blood metabolites, brain imaging, and EEG data from children wi…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study is observing 400 adults with OCD who are receiving exposure therapy. Researchers will use machine learning to analyze self-reports, behavior, and physiological data from therapy sessions. The goal is to identify which mechanisms lead to better outcomes, so therapy can …

This study is testing whether a carbon dioxide (CO2) challenge can predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults and measure their reaction to breathing CO2-enriched air before star…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at medical records from over 150,000 people who received NeuroStar TMS (a non-invasive brain stimulation treatment) for depression, OCD, or anxiety. Researchers want to find out which patient traits and treatment settings lead to the best results. No new treatmen…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study is a registry that will follow up to 1,000 adults with treatment-resistant depression or obsessive-compulsive disorder (OCD) who receive electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine/esketamine. Researchers will collect data from…

This study tests whether a short, safe ear-water stimulation (caloric vestibular stimulation) can temporarily improve insight in people with obsessive-compulsive disorder, body dysmorphic disorder, or illness anxiety. Sixteen adults with strongly held beliefs will receive the sti…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study uses brain wave recordings (EEG) and computer models to better understand why people with OCD feel compelled to repeat certain actions. Researchers will compare 50 adults with OCD to 50 healthy volunteers. The goal is to find more precise brain patterns linked to compu…

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …