OBSESSIVE-COMPULSIVE DISORDER

This study tests whether deep brain stimulation (DBS) can help people with severe, treatment-resistant obsessive-compulsive disorder (OCD). Ten participants will have a DBS device implanted and will be randomly assigned to receive real or sham stimulation. Researchers will track …

This study tests a precise brain stimulation technique for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Researchers will map brain activity and implant electrodes to deliver targeted electrical pulses, comparing active stimula…

This study tests a new drug called RR-HNK to see if it can safely reduce OCD symptoms. About 45 adults with OCD who haven't been helped by standard treatments will receive either the drug or a placebo. The goal is to measure changes in obsessions and compulsions using a standard …

This study tests a short, culturally adapted version of cognitive behavior therapy (CaCBT) for people with obsessive-compulsive disorder (OCD) in Pakistan. About 166 adults with OCD will receive the therapy, and researchers will measure changes in OCD symptoms, depression, and an…

This study tests whether adding dextromethorphan (a common cough suppressant) to fluoxetine (an antidepressant) can reduce symptoms of obsessive-compulsive disorder (OCD) and related conditions like body dysmorphic disorder and health anxiety. About 60 adults in California will t…

This study looks at whether a noninvasive brain stimulation technique called rTMS, combined with a specific type of therapy (Exposure and Response Prevention), can reduce OCD symptoms in people who haven't gotten better with standard treatments. About 48 adults with OCD will rece…

This study tests whether virtual reality (VR) can help people with obsessive-compulsive disorder (OCD) by letting them safely face their fears in a computer-generated world. Thirty adults with OCD will first wait five weeks, then receive five VR therapy sessions over five weeks. …

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce OCD symptoms. Thirty adults with moderate-to-severe OCD who haven't improved with standard treatments will receive a low, medium, or high dose in chocolate. The goal is to see if it e…

This study tests a new way to treat obsessive-compulsive disorder (OCD) using a type of brain stimulation called rTMS. Twenty adults with OCD will receive six sessions of rTMS each day for five days, targeting a specific brain area. The goal is to see if this treatment reduces OC…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for guided exerc…

This study tests a non-invasive brain stimulation method called accelerated intermittent Theta Burst Stimulation (iTBS) for adults with obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Over 7 days, 30 participants will receive 4 sessions per day,…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce obsessive-compulsive disorder (OCD) symptoms in adults who have not responded to at least two medications. The treatment targets a specific brain area linked to OCD. Researchers will measur…

This study tests whether using smartphone-based personalized assessments can make cognitive-behavioral therapy (CBT) more effective for children with obsessive-compulsive disorder (OCD). About 30 youth aged 8-17 with moderate OCD will either receive standard CBT or CBT guided by …

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help people with severe obsessive-compulsive disorder (OCD) who haven't gotten better with standard treatments. Fifteen adults aged 18-65 will receive 12 therapy sessions…

This study tests a digital program called Cognitive Bias Modification for Interpretation (CBM-I) in adults with obsessive-compulsive disorder (OCD). The program aims to change how people automatically interpret situations, which may reduce OCD symptoms. Participants will be rando…

This study tests whether virtual reality (VR) can help people with obsessive-compulsive disorder (OCD) face their fears in a safe, controlled way. About 62 inpatients will be randomly assigned to standard therapy plus VR exposure, VR brain training, or standard therapy alone. The…

This study tests whether an online, therapist-guided cognitive-behavior therapy can help children and teens with autism who also have obsessive-compulsive disorder (OCD). The goal is to reduce OCD symptoms and improve daily functioning. About 220 participants will be enrolled, an…

This study tests whether combining MDMA with cognitive behavioral therapy (CBT) can safely reduce OCD symptoms. It involves 40 adults with OCD who have not responded to standard treatments. Participants will receive either MDMA or a comparison drug during therapy sessions, and th…

This study looks at existing medical records from over 156,000 people who received NeuroStar TMS for depression, OCD, or anxiety. Researchers want to find out which patient traits and treatment settings lead to the best results. No new treatments or visits are required—just analy…

This study aims to see if a carbon dioxide (CO2) challenge can help doctors identify patients with anxiety, OCD, PTSD, or panic disorder who are unlikely to improve with exposure-based therapy. Researchers will enroll 600 adults aged 18-70 and measure their response to CO2 before…

This study follows 1,000 adults with hard-to-treat depression or OCD who receive advanced treatments like brain stimulation or ketamine. Researchers will collect data from brain scans, cognitive tests, and voice recordings to find markers that predict which treatment works best f…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different parts of the prefrontal cortex and test how it changes behavior. The goal is to understand which brain cir…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, including depression, anxiety, and PTSD. Participants will lear…

This study aims to better understand why people with Obsessive-Compulsive Disorder (OCD) feel driven to repeat certain behaviors. Researchers will use brain wave recordings (EEG) and computer models to look at how different parts of the brain work together in 50 adults with OCD a…

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. About 240 adults aged 18-55 who struggle with emotion regulation will be …

This study aims to figure out why exposure therapy helps some people with OCD but not others. Researchers will track 400 adults with OCD during therapy sessions, using surveys, behavior observations, and wristwatch sensors to measure body responses. The goal is to identify which …

This study is creating a shared database of information from up to 100 children who have had or will have deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By combining data from multiple hospitals, researchers hope to learn which children…

This study looks at whether a child's genes can predict if they will have a rare but serious side effect from common antidepressants (SSRIs) called behavioral disinhibition, which can cause agitation or impulsivity. Researchers will collect saliva samples from 120 children and yo…

This study is collecting information from 4,500 people who have had brain surgery for conditions like aneurysms, tumors, or epilepsy. The goal is to find out what factors help predict recovery, such as thinking skills and emotional health. By standardizing how outcomes are measur…

This study looks at how ketamine affects the brain to quickly reduce symptoms of obsessive-compulsive disorder (OCD). Researchers will measure changes in OCD severity using a standard scale. The study involves 150 adults aged 18-65 with OCD who have not responded to at least one …

This study explores whether a safe, non-invasive technique called caloric vestibular stimulation (using warm or cool water in the ear) can temporarily improve how well people with obsessive-compulsive disorder, body dysmorphic disorder, or illness anxiety disorder recognize their…

This study aims to understand why some people are more impulsive or compulsive than others by looking at brain structure, chemistry, and genetics. Researchers will enroll up to 1,100 participants aged 6 to 80, including those with conditions like ADHD, OCD, or autism, as well as …

This study looks at whether adding a second type of brain stimulation (cortical stimulation) to standard deep brain stimulation (DBS) can better treat severe obsessive-compulsive disorder (OCD). Researchers will record brain signals and test symptom changes in 15 adults with OCD …