OBSESSIVE-COMPULSIVE DISORDER

This study tests a non-invasive procedure called ExAblate MR-guided focused ultrasound for people with moderate to severe obsessive-compulsive disorder (OCD) who haven't gotten better with therapy or medication. The treatment uses sound waves to target a small area in the brain t…

This small study will test whether deep brain stimulation (DBS) in two different brain areas can ease symptoms in 4 people with severe, treatment-resistant obsessive-compulsive disorder (OCD). Participants will have electrodes placed in both areas and will be monitored to see whi…

This study tests a self-help cognitive behavioral therapy (CBT) manual adapted for people with OCD in Pakistan. About 108 adults with OCD will use the manual with guidance from a therapist. The goal is to see if this approach is practical, acceptable, and helps reduce OCD symptom…

This study tests whether provoking OCD symptoms right before a gentle brain stimulation technique (tDCS) can boost its effects. About 178 adults with treatment-resistant OCD will receive either tDCS alone or tDCS preceded by symptom provocation. The goal is to see if the combined…

This study tests whether valbenazine can safely reduce symptoms in adults with moderate-to-severe obsessive-compulsive disorder (OCD). Thirty participants will receive both the drug and a placebo at different times to compare effects. The main goal is to see if OCD severity score…

This study tests a single, self-guided online session designed to reduce stress and unhelpful behaviors in caregivers of people with OCD. The program aims to be more accessible than traditional treatments by removing barriers like cost and travel. Researchers will enroll 110 care…

This early-phase study will give 20 adults with obsessive-compulsive disorder (OCD) either a low or high dose of psilocybin, the active ingredient in magic mushrooms, in four supervised sessions. Researchers will track changes in OCD symptoms, brain activity, and safety over 12 w…

This study looks at why people with OCD have strange or uncomfortable feelings (called sensory phenomena) and whether a type of brain stimulation can help. Researchers will use brain scans and EEG to compare people with OCD and healthy volunteers. They will also test if low-frequ…

This study looks at whether brain scans can predict and track how well a type of therapy called Exposure and Response Prevention (ERP) works for children and teens with OCD. Thirty participants aged 10 to 17 will receive 14 weeks of ERP therapy and have their brain activity measu…

This study looks at how often obsessive-compulsive symptoms occur in adults with substance use disorder compared to similar people without it. Researchers will interview 102 participants aged 18-50 and use standard questionnaires to measure symptoms, addiction severity, and quali…