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A Two-Year watch: can brain scans and surveys predict depression and anxiety in teens?

NCT ID NCT07744490

Knowledge-focused Sponsor: Shanghai Mental Health Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biological samples to track who develops these disorders and what factors might predict that. The goal is to identify early warning signs that could lead to better prevention and support for young people at risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to identify children and teens at risk for depression, anxiety, or OCD before full-blown disorders develop, enabling earlier support and prevention.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test any intervention. The findings may not apply to all populations, and the two-year follow-up may be too short to capture all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Approximately 200 children and adolescents aged 7-17 years who are at elevated risk for depressive disorders, anxiety disorders, or obsessive-compulsive disorder will be enrolled. Elevated risk is defined by a relevant family history or clinically significant subthreshold emotional or repetitive behavioral symptoms. Participants will not meet the full diagnostic criteria for the target disorders at baseline and will be followed prospectively for two years.

Ages

7 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 7-17 years at enrollment. 2. Meeting at least one of the following conditions: Having at least one first-degree relative with a depressive disorder, anxiety disorder, or obsessive-compulsive disorder; or exhibiting clinically relevant but subthreshold depressive, anxiety, obsessive-compulsive, or repetitive behavioral symptoms. 3. Not meeting the full diagnostic criteria for a depressive disorder, anxiety disorder, or obsessive-compulsive disorder at baseline, as assessed using the K-SADS-PL. 4. Willing and able to participate in the scheduled assessments and follow-up visits. 5. Written informed consent provided by a parent or legal guardian and assent provided by the participant Exclusion Criteria: 1. A current or previous diagnosis of a depressive disorder, anxiety disorder, or obsessive-compulsive disorder. 2. A severe psychiatric condition requiring immediate clinical intervention, including acute suicide risk, a psychotic disorder, or a bipolar disorder. 3. A major neurological disorder, severe head injury, or serious or unstable medical condition that may interfere with study participation. 4. Intellectual or cognitive impairment that prevents the participant from understanding or completing the study assessments. 5. Inability or unwillingness of the participant or legal guardian to comply with the study procedures.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression major depressive disorder obsessive-compulsive disorder obsessive-compulsive personality disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety disease Depression - major depressive disorder High risk Obsessive compulsive disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai Mental Health Center

    Shanghai, 200030, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.