Psychiatric disorder

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

Researchers are testing Actívatexto, a mobile program that combines text messages, wearable activity trackers, and nicotine replacement therapy. The trial enrolls Latino adults who smoke at least three days a week, want to quit in the next month, and currently get less than the r…

This early-phase trial tests whether transplanting healthy donor gut bacteria (washed microbiota transplantation) can improve autism and ADHD symptoms in 80 children aged 3-17. The approach targets the 'gut-brain axis,' since many children with autism have gut microbiome imbalanc…

This study tests a new drug called ARO-MAPT-SC in healthy people and those with early Alzheimer's. The goal is to check if it is safe and how the body processes it. Participants receive either the drug or a placebo by injection under the skin. The trial is still in early stages, …

This early-phase trial will test whether a special form of resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for three months. The study will also measure how the drug …

This study tests whether the insomnia medication lemborexant (Dayvigo) can lower blood markers of brain damage in adults aged 40–65 with insomnia. Twenty participants will take the drug or a placebo for two weeks each, then have their blood tested for proteins linked to Alzheimer…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effect…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

Researchers are testing whether a home-use pulsed electromagnetic therapy device can slow cognitive decline in people with mild to moderate Alzheimer's disease, Lewy body dementia, or vascular dementia. About 48 participants will use the device three times a day for 15 minutes ov…

Many young children show signs of mental health problems, but few get evaluated or treated early. This study tests a program called NTRI-MH that trains peer family navigators to help caregivers of Head Start preschoolers find and engage with mental health services. Researchers wi…

This early-stage trial is testing the drug vorinostat in 15 girls and young women with Rett syndrome, a rare genetic disorder that affects brain development. Each participant will receive placebo and two different doses of vorinostat, acting as their own control. The study aims t…

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

This study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…

This phase 2 trial tests an experimental drug called efimosfermin alfa in adults with alcohol-related liver disease. The study aims to see if the drug can improve liver health, measured by liver stiffness and a standard liver disease severity score. Participants receive either th…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This early-stage trial is testing a long-acting injectable form of the drug cariprazine, called AX251, in 48 adults with stable schizophrenia. The study aims to see how the drug moves through the body and whether it is safe when given as a single shot at different doses. If resul…

This trial tests whether Caplyta, a drug already used for other conditions, can reduce symptoms of social anxiety disorder in adults. Researchers will give 40 adults either Caplyta or a placebo every day for 8 weeks, with weekly clinic visits to track changes. The main question i…

This study tests whether adding accelerated transcranial magnetic stimulation (aTMS) to the standard smoking-cessation drug varenicline helps adults quit nicotine products like cigarettes and vapes. Thirty participants will take varenicline daily for 12 weeks and receive either r…

This early study is testing whether a washed fecal transplant (WMT) can improve ADHD symptoms and related issues like sleep problems in children aged 3-17. The idea is that changing the gut bacteria might help the brain via the gut-brain axis. Fifty children will receive the tran…

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, a…

This Phase 2 study tests an investigational drug called emraclidine in about 268 adults with schizophrenia. The trial has two parts: Part A looks at how the drug moves through the body and its safety at different doses, while Part B measures whether it improves symptoms like hall…

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This early-stage trial tests a drug called ALN-APP (mivelsiran) in 60 adults with mild cognitive impairment or mild dementia due to early-onset Alzheimer's disease. The drug is given via a spinal injection to see if it safely lowers certain proteins linked to Alzheimer's in the b…

This Phase 2 trial is testing whether HB-1, a tablet combining two blood pressure medications (telmisartan and verapamil), can safely reduce PTSD symptoms. About 200 adults aged 18-65 with PTSD will receive either HB-1 or a placebo daily for 12 weeks. The main goal is to see if H…

This study tests whether a drug called dexmedetomidine, which promotes sleep, can prevent delirium (sudden confusion) in patients aged 60 and older after heart surgery. Delirium is common in the ICU and can lead to longer hospital stays and worse recovery. The trial will compare …

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This phase 3 study is testing the long-term safety of KarXT, a new drug for managing mania in people with bipolar I disorder. About 450 participants, including those who completed earlier studies and new volunteers, will take KarXT along with standard mood stabilizers like lithiu…

This study looks at whether giving free reading or distance glasses to older adults in rural areas can slow down memory and thinking problems. About 964 people aged 60-79 with poor eyesight but normal hearing and memory will take part. Half will get glasses, and the other half wi…

This phase 3 trial tests whether KarXT (a combination of xanomeline and trospium chloride) can prevent relapse in people with schizophrenia. Participants who have had a recent hospitalization for schizophrenia and still have symptoms will receive KarXT or a placebo. The study mea…

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This study tests whether adding smartphone-based self-monitoring and micro-interventions to standard behavioral therapy helps people with bulimia nervosa or binge eating disorder. Participants will use an app to track their eating and practice therapeutic skills, with some receiv…

This study tests whether the drug lumateperone can improve mood and reduce inflammation in adults with bipolar depression who also have obesity. Over about six weeks, participants take lumateperone daily and undergo mood assessments and an MRI to estimate brain age. The goal is t…

This trial tests whether a single day of accelerated transcranial magnetic stimulation (TMS) can reduce depressive symptoms in adults with treatment-resistant depression. Participants are randomly assigned to receive one of two active TMS protocols—targeting the precuneus or the …

This early study tests a small, wireless brain implant designed to help people with severe speech problems communicate by thought. Four adults with conditions like locked-in syndrome or ALS will get the implant and learn to control it. The main goal is to see if the device is saf…

This trial tests whether a structured sensory-based occupational therapy program can improve daily functioning, sensory processing, gross motor skills, and eating behaviors in children with autism spectrum disorder. Forty children aged 3 to 9 years will receive either face-to-fac…

This early-stage study tests whether the psychedelic drug DMT, combined with psychotherapy, can help people with alcohol use disorder. 63 participants will receive either a moderate or low dose of DMT, or a placebo, and their safety and desire to drink will be measured. The goal …

This study tests if semaglutide, a drug used for diabetes, can help veterans with alcohol use disorder drink less. About 622 veterans will get either the drug or a placebo shot for 28 weeks. The goal is to see if it safely reduces heavy drinking and improves health.

This study tests a new therapy program called PSYCHOPATHY.COMP for male prison inmates with psychopathy. The goal is to see if 20 weeks of compassion-focused sessions can reduce psychopathic traits and improve emotional control. Researchers will compare the therapy to usual priso…

This trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder (GAD). About 384 participants will receive either the drug or a placebo daily for 8 weeks. The main goal is to see i…

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

This trial tests whether a structured group therapy, blending EMDR and sensorimotor techniques, can help adults with trauma-related symptoms in a primary care setting. Participants are randomly assigned to either this group intervention or usual care. The study measures changes i…

This study compares a once-monthly injectable buprenorphine to the standard daily sublingual tablet (with naloxone) for treating opioid use disorder in 952 veterans. The goal is to see which formulation better keeps people in treatment and helps them stay opioid-free over 48 week…

This trial tests whether a non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can enhance the effects of standard anxiety medication in adults with generalized anxiety disorder. Participants are randomly assigned to receive cTBS targeting on…

This study is testing the long-term safety of a new medication called LB-102 for adults with stable schizophrenia. About 900 participants will take the drug for 52 weeks to see what side effects occur. The goal is to make sure the drug is safe enough for ongoing use to control sc…

This phase 2 trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce binge-eating episodes and help with weight loss in adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or the existing drug li…

This trial tests whether citicoline, a neuroprotective agent, can prevent or slow cognitive decline in older adults who develop delirium while hospitalized for a hip fracture. Delirium is a common complication that can lead to lasting memory and thinking problems. Participants wi…

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

Researchers at Duke University are testing emPath, a digital platform that community outreach workers can use to connect adults with opioid use disorder to telemedicine visits and medication treatment. The pilot study enrolls 80 people in Durham, North Carolina, including 50 adul…

This clinical trial is testing whether a faster, more intensive schedule of a brain stimulation treatment called intermittent theta burst stimulation (iTBS) works better than the standard schedule for adults with major depressive disorder. Participants will be randomly assigned t…

This Phase 3 trial evaluates the long-term safety and tolerability of an experimental drug called ITI-1284, taken under the tongue, for people with generalized anxiety disorder (GAD) who have not responded to previous treatments. Participants receive ITI-1284 either alone or alon…

This trial tests whether a monitor that measures muscle response can guide the dose of the muscle relaxant atracurium in intensive care unit patients who need a continuous drip for more than 48 hours. Researchers will compare a group whose dose is adjusted using the monitor to a …

This pilot study tests whether transcranial magnetic stimulation (TMS) is safe and tolerable for teenagers aged 13 to 17 with obsessive-compulsive disorder (OCD) who have not improved enough with standard treatments. Participants receive TMS sessions five days a week for three we…

This trial tests whether a daily synbiotic supplement, which combines prebiotics and beneficial bacteria, can improve gut health and mental well-being in people with obesity. Researchers will give 120 adults with a BMI between 30 and 40 either the supplement or a placebo for 12 w…

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This study tests whether drugs that target tau protein, alone or with donanemab, can reduce tau buildup and slow memory decline in people aged 50-80 with early Alzheimer's. Participants will receive treatment for 30 months and undergo brain scans and cognitive tests. The goal is …

This study tests whether solriamfetol, a medication taken once daily, can reduce symptoms of attention deficit hyperactivity disorder (ADHD) in adolescents aged 12 to 18. Over six weeks, participants receive either solriamfetol or a placebo to compare changes in ADHD symptoms. Th…

This phase 3 trial tests whether solriamfetol, taken once daily, can reduce ADHD symptoms in children aged 6 to under 12. Over 6 weeks, researchers compare the drug against a placebo using a standard rating scale. The goal is to see if solriamfetol is a safe and effective treatme…

This study tests whether adding the drug brenipatide to standard treatment can delay the return of bipolar symptoms compared to a placebo. About 400 adults with bipolar I or II will self-inject the study drug or placebo for at least 6 months. The main goal is to see how long it t…

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This Phase 3 study tests whether KarXT, a combination of two drugs, can safely reduce manic symptoms in people with Bipolar-I disorder. About 274 participants hospitalized for mania will receive either KarXT or a placebo. The main goal is to see if KarXT improves scores on a stan…

This early-stage trial tests an experimental gene therapy called VY1706 in people with early Alzheimer's disease. The goal is to see if it is safe and tolerable, and whether it can reduce tau protein buildup in the brain, a hallmark of the disease. Participants receive one of thr…

This study tests a new group program called PEDAL for people with bipolar disorder. It combines standard group education with digital tools like an app-based mood diary and online resources to help manage rapid mood swings. The trial will involve 120 participants across five site…

This Phase 2 trial tests whether adding brenipatide to standard buprenorphine treatment helps people with opioid use disorder stay off opioids longer. About 465 participants will receive either brenipatide or a placebo injection alongside their usual medication. The study measure…

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This trial tests whether a noninvasive technique called transcranial temporal interference stimulation (tTIS) can reduce symptoms in people with obsessive-compulsive disorder (OCD). The stimulation targets the nucleus accumbens, a deep brain region linked to OCD, using electric f…

This study is testing whether a private Facebook group, called Wiidookaage'Win, can help Native American women in Minnesota stay off opioids. The group includes social support, mindfulness, and cultural practices. Sixty women who are already on medication for opioid use and have …

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking…

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This early-stage trial tests whether adding special cells (DUOC-01) into the spinal fluid is safe for children with inherited metabolic diseases that damage the brain. Participants are ages 1 week to 21 years and are already receiving a standard umbilical cord blood transplant. T…

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This trial tests two experimental drugs, donanemab and RG6289, in people who carry a specific genetic mutation that causes an inherited, early-onset form of Alzheimer's disease. The study first gives donanemab to clear amyloid plaques from the brain, then randomly assigns partici…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This pilot study tests whether an antioxidant cocktail called Rett-T can improve motor function in children and adolescents with Rett syndrome, a rare genetic disorder that affects movement and coordination. Participants, aged 2 to 21 and at least partially able to walk, will rec…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether giving pasteurized donor human milk to full-term babies of mothers with diabetes during the first five days of life can reduce the number of infants admitted to the neonatal unit for low blood sugar. About 1,444 mothers and their newborns will be randomly…

Researchers are studying whether a combination of blood tests, retinal imaging, and brain scans can improve the detection and staging of Alzheimer's disease in Chinese adults. The study enrolls 300 people, including those with probable Alzheimer's dementia and those without. Part…

Researchers are studying whether a blood test called HepQuant DuO can measure liver function over time in people with alcohol-related liver disease. Participants drink a natural compound called cholate, then give two blood samples at 20 and 60 minutes. The study follows about 40 …

Researchers at Gødstrup Hospital are studying whether balance and dizziness problems in young children come from the inner ear's balance system. The study includes 30 children aged 6 months to 10 years who have delayed gross motor development or dizziness and balance issues. Chil…

Researchers at the University of California, San Francisco are testing whether a device called NIRSIT can measure depression severity by shining near infrared light through the forehead to track blood oxygen levels in the frontal lobe. The study compares adults diagnosed with Maj…

This study is testing a smartphone app that records and analyzes speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

Researchers are building AI models that score standard physical and cognitive screening tests from video and audio, and that predict results a person did not obtain. The study enrolls adults 18 and older and follows them for life, linking records to a long-term aging study to che…

This study tests whether a radioactive tracer called 18F-S16/T807 can help diagnose tau-related brain diseases. Tau is a protein that builds up abnormally in conditions like Alzheimer's and other neurodegenerative disorders. Researchers will give 500 adults a single injection of …

This trial tests whether PET/CT scans using special radioactive tracers can detect amyloid protein buildup in various diseases, including cardiac amyloidosis. Researchers will give each participant a single injection of one of several tracers, then perform imaging to measure how …

This study tests a new radioactive tracer called [18F]NIDF that binds to tau tangles in the brain, which are linked to Alzheimer's and other neurodegenerative diseases. Researchers will give the tracer to 20 healthy volunteers and patients, then use PET scans to see how well it h…

This study tests a radioactive tracer called 18F-AIPF-1026 that binds to monoamine oxidase A (MAO-A), an enzyme linked to depression, anxiety, and heart injury. About 200 adults with these conditions will receive a single injection of the tracer and then undergo PET/CT or MRI sca…

This study tests whether a special imaging agent called 18F-FPyCO/SMBT-1 can help diagnose Parkinson's disease and related conditions by detecting a brain enzyme called MAO-B. About 200 adults with suspected or confirmed Parkinson's will receive a single injection of the agent an…

This study tests whether PET/CT scans using two radioactive tracers, 18F-92/AV45 and 11C-PIB, can detect beta amyloid buildup in the brain. Researchers will enroll 500 adults with suspected or known neurodegenerative diseases linked to amyloid. Each participant receives one injec…

This study is testing a new imaging agent called [18F]FT8 to see if it can help doctors better see and diagnose amyloidosis, a disease where abnormal proteins build up in organs like the heart. The study will involve 20 patients with amyloidosis and 5 healthy volunteers. Research…

Researchers are testing whether a three-session couples motivational interviewing program helps male couples reduce illicit drug use and behaviors that raise HIV transmission risk. The trial enrolls 360 male couples where at least one partner is HIV negative and at least one has …

People who need emergency surgery after a traumatic event like a car crash or fall face a higher risk of developing post-traumatic stress disorder. This trial tests whether giving the sedative dexmedetomidine during surgery, with or without adding a non-invasive ear stimulation c…

This study works with 300 women in rural Kentucky jails who have opioid or stimulant use disorders. The goal is to lower their risk of overdose when they return to their communities. The program offers support and connects them to treatment options before and after release.

This study tests a brain health service designed to assess and reduce dementia risk in people aged 55 to 85 who have subjective cognitive decline (memory concerns without objective impairment). Participants are randomly assigned to either a personalized 6-month program—combining …

This pilot study will test whether teaching people aged 50 to 75 how to cook healthy meals can reduce their risk of type 2 diabetes and dementia. Forty participants at higher risk will either attend weekly cooking classes with at-home practice or receive nutrition handouts. The s…

This trial tests a police education program called SHIELD 2.0 in nine counties in Appalachian Kentucky. The program trains local behavioral health workers to teach police how to refer people who use drugs to treatment and social services instead of arresting them for low-level po…

This study tests two counseling programs—one focused on motivation and coping skills, the other on strengths and advocacy—to prevent opioid misuse in 300 homeless youth aged 14-24. Participants are randomly assigned to one of the programs or standard services, and tracked for two…

This study tests whether the experimental drug trontinemab can prevent or delay memory loss and dementia in people who have early biological signs of Alzheimer's but no cognitive symptoms. Participants receive either trontinemab or a placebo intravenously for several years. The g…

Researchers at Yale University are studying how to expand opioid agonist therapy (OAT) in prisons and probation systems in Tajikistan, Kyrgyzstan, Moldova, and Georgia. OAT uses medicines like methadone or buprenorphine to treat opioid dependence and can lower HIV transmission am…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This trial tests whether a nighttime care routine called the Triple Sleep-Promotion Protocol can lower the chance of delirium in adults staying in intensive care units (ICUs). Delirium, a state of sudden confusion, is common in ICUs and may be linked to broken sleep and frequent …

This study tests whether a non-invasive brain stimulation technique called TMS, given within two weeks of a traumatic event, can prevent chronic PTSD. Researchers will measure changes in brain activity linked to fear and threat. The goal is to see if early intervention can reduce…

This trial tests whether immersive virtual reality (VR) nature scenes can prevent delirium in intensive care unit (ICU) patients on ventilators. Half of the 300 participants will watch nature videos through a VR headset for 20 minutes daily, while the other half watches the same …

Researchers at Duke University are testing FlexED, a smartphone-based gamified intervention designed to help young women aged 18 to 25 who are at risk for eating disorders. The program uses interactive exercises and games based on Acceptance and Commitment Therapy to teach psycho…

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This study tests whether mindfulness-based cognitive therapy (MBCT) delivered through video calls can prevent depression from coming back. 315 adults with recurrent depression in partial remission will be randomly assigned to group MBCT, a self-help manual with minimal video supp…

This study tests whether a nature-based healing meditation program can help friends and family caregivers who are grieving the loss of a loved one to cancer. The program includes six audio meditation modules available online. Researchers will measure how feasible and acceptable t…

This study tests whether a dietary supplement called AP-Brain can improve cognitive function in healthy adults aged 18-39 who feel they have attention problems. Participants will take different doses of AP-Brain or a placebo for 56 days and complete memory and attention tests. Th…

Researchers at Virginia Commonwealth University are testing whether adding high-definition transcranial direct current stimulation (HD-tDCS) to cognitive behavioral therapy can help people with cocaine use disorder. The trial enrolls 36 adults aged 18 to 65 who meet criteria for …

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

Researchers at Hannover Medical School are testing whether intermittent theta-burst stimulation (iTBS), a non-invasive brain stimulation technique, can reduce negative symptoms and improve thinking in people with schizophrenia. The trial enrolls 60 adults aged 18 to 65 with a sch…

This study is testing whether a dietary supplement called AP-Brain can improve memory and thinking in healthy adults aged 40 to 79 who feel their memory is slipping. Participants will take different doses (1g, 3g, or 5g) or a placebo for 56 days and complete computer-based memory…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

This Phase 3 trial tests whether fenfluramine (Fintepla) can reduce behavioral and emotional symptoms in people with Rett syndrome. About 200 participants will receive either the drug or a placebo for 14 weeks. The study measures changes in behavior, sleep, and overall condition …

Researchers are testing whether transcranial random noise stimulation (tRNS), a non-invasive brain stimulation technique, can improve behavioral and psychological symptoms in people with early Alzheimer's disease. The trial enrolls 40 participants who receive either active tRNS o…

This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for weeks, participants receive multiple treatments over just 5 days. The goal is to see if this faster approach is saf…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

Researchers test whether adding rectal ozone therapy to usual care can reduce numbness and tingling in people with chemotherapy-induced peripheral neuropathy. The trial enrolls 42 adults whose cancer is stable or in remission and who have had persistent numbness or tingling for a…

Researchers compare two bladder medications, tolterodine and mirabegron, against placebo in women aged 60 and older who have urgency incontinence. The trial measures nighttime urination frequency, incontinence episodes, sleep quality, and thinking skills over six months. The goal…

Researchers are testing whether playing video games can reduce anxiety in adolescents aged 11 to 15 with elevated anxiety symptoms. The trial compares an action game designed to boost attention control, a casual puzzle game, and no game at all. Teens play at home online for six w…

This early-phase study tests whether a noninvasive brain stimulation technique called rTMS can help people with impulse control disorders, specifically excessive eating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30 to receive personalized, accelerated rTMS s…

Researchers are testing whether an accelerated protocol of transcranial magnetic stimulation using the BTL-699-2 device can reduce anxiety symptoms in adults with generalized anxiety disorder. The trial enrolls 40 adults aged 22 and older who receive 16 stimulation sessions over …

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

Many people who care for a family member with dementia struggle with sleep. This trial tests an 8-week program that combines a sleep self-help manual, cartoon videos, and weekly telephone coaching. Researchers randomly assign 120 caregivers to either the sleep program or an educa…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

Researchers at Penn State are testing whether the BaSICS program reduces anxiety, depression, and suicide risk in 11- to 14-year-olds from low-income families who are waiting for mental health services. The program teaches coping skills, healthy identity development, and collecti…

Researchers are testing an experimental drug called tezampanel to see if it is safe and can ease opioid withdrawal symptoms in adults with opioid use disorder. The trial enrolls 40 people who are seeking treatment and have recent opioid use. Participants stay in a research center…

This study tests whether giving coloring activities (nature scenes, geometric shapes, word searches, or free drawing) to adults waiting in the emergency department can lower their self-reported pain and anxiety. Researchers will measure changes using standard questionnaires. If e…

Researchers in South Punjab, Pakistan, are testing whether supervised aerobic exercise improves depression treatment. Adults aged 18 to 55 with moderate to severe depression receive either the antidepressant sertraline alone or sertraline plus three weekly sessions of cycling or …

Researchers are testing a two-day group therapy program for military couples where one partner has PTSD. The program, called AIM-CBCT for PTSD, teaches couples skills to manage PTSD symptoms and improve their relationship. They compare it with a standard relationship education pr…

Researchers are testing whether a 12-week home cycling program can help adults with alcohol use disorder and alcohol-related liver disease drink less and crave alcohol less. Thirty participants join either the exercise program plus standard care or standard care alone. The study …

Researchers test whether a non-invasive brain stimulation called tACS can help people with schizophrenia better tell themselves apart from others. The trial delivers 10 Hz current to the medial prefrontal cortex for 20 minutes daily over five days. Participants include patients w…

This trial is testing whether a digital therapy app called NDTx-03, used alongside usual care, can help children and adolescents aged 10 to 18 with autism spectrum disorder or social communication disorder better recognize and respond to social situations. The app combines cognit…

This study tests whether personalizing the Healthy Minds Program app can improve well-being in people with mild depression. About 1500 participants will use the app for 4 weeks, with some getting personalized features like tailored module order or supportive text messages. The go…

This trial tests whether cannabidiol (CBD) can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Participants take either CBD or a placebo for 8 weeks, and researchers measure changes in PTSD symptoms using standard clinical assessments. The study aims to see if…

Researchers are testing a home-use pulsed electromagnetic therapy device in 40 people with mild to moderate Alzheimer's disease. Participants use the device three times a day for 15 minutes over 120 days. The study measures changes in thinking and memory using standard tests, wit…

This study tests whether a new drug called TSND-201 can safely reduce PTSD symptoms in adults. About 300 people with PTSD will receive either one of two doses of TSND-201 or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to see if the drug helps…

This study tests whether a quick form of brain stimulation called SAINT can reduce symptoms of postpartum depression better than a fake treatment. It will include 192 women who are up to 12 months after giving birth and whose depression hasn't improved with standard care. The mai…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the drug combo or a placebo for 14 weeks. The main goal is to se…

This study tests whether a simple injection of dextrose (sugar water) into the neck can reduce symptoms like anxiety, brain fog, and depression in people with PTSD who haven't improved after trying multiple medications and therapies. About 50 adults will receive either the dextro…

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety or depression. It compares IBTT to a well-known therapy called the Unified Protocol (CBT-based). The goal is to see if IBTT is more engaging and effectiv…

This study tests whether cannabidiol (CBD) can reduce the need for strong painkillers (opioids) in people with end-stage prostate cancer that has spread and no longer responds to standard treatments. About 58 participants will receive either CBD or a placebo three times daily for…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

Researchers at Chang Gung Memorial Hospital are testing whether intermittent theta burst stimulation, a non-invasive form of brain stimulation, can help autistic people with minimal verbal ability or intellectual disability regulate their emotions and behavior. The study enrolls …

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults will receive either the drug combo or a placebo for 14 weeks. The main goal is to see if agitation symptoms improve, as…

This study tests whether playing gentle sounds during deep sleep can improve thinking and emotional control in young adults (ages 18-25) with anxiety, depression, and sleep problems. Participants will spend two nights in a sleep lab, once with tones and once without, and complete…

Researchers are testing an oral drug called LPCN 1154A as a possible treatment for severe postpartum depression. The trial enrolls women aged 15 to 45 who gave birth within the past 18 months and developed depression during pregnancy or shortly after delivery. Participants receiv…

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

This study tests whether four short, guided conversations with a trained nurse can lower anxiety and improve breastfeeding confidence in mothers who have a planned C-section. About 160 women will be randomly assigned to either standard care or standard care plus these nurse-led c…

This study tests a medicated skin patch (dexmedetomidine) to see if it can reduce agitation in people with Alzheimer's dementia. About 150 adults living in care facilities will receive either the patch or a placebo for 96 hours. The goal is to measure changes in agitated behavior…

Researchers in Vietnam are testing a peer-counseling program called Friendship Bench for women who use methamphetamine and have common mental health problems like depression, anxiety, or stress. The program trains peer workers to lead six weekly one-on-one sessions that help part…

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study is testing the long-term safety of a combination of two drugs, KarXT and KarX-EC, for treating agitation in people with Alzheimer's disease. It is an open-label extension, meaning everyone knows they are getting the treatment. The study enrolls 600 participants who hav…

Researchers are testing whether a home-based program combining adapted exercise and mindfulness training can improve walking ability and sleep quality in people with rare neurodegenerative diseases such as leukodystrophy, ataxia, and adrenomyeloneuropathy. The study enrolls about…

Researchers are testing a once-weekly tablet of brexpiprazole against placebo in adults hospitalized for an acute episode of schizophrenia. The trial enrolls about 450 people aged 18 to 74 who need hospital care for a relapse. Over seven weeks, participants receive either the act…

Researchers are testing whether ketamine infusions combined with mindfulness-based cognitive therapy improve quality of life more than mindfulness therapy alone in adults who have both chronic pain and posttraumatic stress disorder. The pilot study enrolls 30 veterans and civilia…

Researchers are testing an experimental drug called OSU6162 in adults with bipolar disorder who are in a depressive phase and already taking a mood stabilizer. The trial aims to see whether the drug reduces depressive symptoms over eight weeks. Participants receive flexible doses…

This study tests whether squeezing a stress ball during wound cleaning (debridement) helps reduce pain, distress, and changes in heart rate or blood pressure in people with diabetic foot ulcers. About 84 adults with type 2 diabetes will be randomly assigned to use a stress ball o…

This phase 2 trial tests whether low intensity focused ultrasound, aimed at a deep brain region called the amygdala, can ease PTSD symptoms in 60 veterans. The treatment is non-invasive and uses sound waves similar to diagnostic ultrasound. Researchers will measure symptom change…

This early-stage study tests whether a single 25 mg dose of psilocybin can help people who still feel emotionally flat or uninterested in things despite taking antidepressants. About 90 adults aged 18-65 will receive either psilocybin or a placebo, and researchers will use brain …

Care homes face shortages of trained staff, and more than half of residents have some form of dementia. Researchers are testing whether retired volunteers can lead a group music and discussion program called Making Connections Thru Music. The study enrolls 196 people: volunteers …

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can ease depression in people with bipolar II disorder who haven't improved with standard treatments. About 90 adults aged 19-65 will receive either the full dose or a very low placebo dose, and their…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

Researchers are testing a digital app called BRAIN that uses artificial intelligence to personalize cognitive stimulation for people with dementia. The app tailors activities to each person's interests and background, aiming to improve engagement, quality of life, and relationshi…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

This study tests whether a safe, at-home brain stimulation device called tDCS can help people with depression that hasn't improved with standard treatments. Ten participants will use the device at home under remote supervision for two weeks. The goal is to see if the approach is …

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder symptoms in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete tests and questionnaires. The goal is to see if one compound he…

Researchers at San Diego State University are testing an 8-week online program that teaches intuitive eating principles to pregnant women with obesity. The program includes weekly video modules and workbook exercises, with optional office hours. The study will compare participant…

Researchers are testing whether adding the experimental drug OSU6162 to an SSRI or SNRI antidepressant helps adults whose depression has not improved with those drugs alone. The trial enrolls 180 people aged 25 to 75 who meet criteria for major depressive disorder and have not re…

This trial tests whether adding personalized feedback makes an ultra-brief online program more effective for adults with depression and anxiety. The program, called Things You Do, teaches skills to increase healthy actions like meaningful activities, healthy thinking, and social …

Researchers are testing nursing care built on the Salutogenesis Model, which aims to strengthen a person's sense of coherence: how understandable, manageable, and meaningful life feels. The study enrolls 73 adults with mild to moderate dementia and assigns them to face-to-face se…

This study tests whether a midwife-led digital follow-up program can reduce postpartum depression and improve breastfeeding success in women who had a C-section. About 104 women will either get the digital program or standard care. The goal is to see if extra support through phon…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

Researchers at the University of Missouri-Columbia are studying whether improving insomnia can lead to better alcohol outcomes in heavy-drinking adults. The trial enrolls 256 adults who meet criteria for alcohol use disorder and insomnia disorder. Participants receive five weekly…

Researchers are testing a computer-based program that aims to change how anxious children interpret ambiguous situations as threatening. The trial enrolls 72 youth ages 10 to 17 with generalized, separation, or social anxiety disorder. Participants are randomly assigned to either…

Researchers at the University of South Florida are testing whether stroke survivors with chronic aphasia can improve their spontaneous speech by listening to recordings of themselves and correcting mistakes. Participants complete language tasks and then use tablets and headphones…

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is…

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

This study tests whether a brain-training technique called neurofeedback can help people with opioid use disorder who are on methadone feel more pleasure and recall positive memories. Participants learn to control their brain activity using real-time fMRI scans, a method that has…

This study tests whether a therapist-guided online cognitive-behavior therapy program can help reduce obsessive-compulsive disorder (OCD) symptoms in children and teens with autism. About 220 participants will receive the online treatment or a comparison condition. The goal is to…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

People with treatment-resistant schizophrenia often take clozapine, a drug that can cause serious weight gain and metabolic problems. This pilot study tests whether a daily infusion made from the leaves of the Nitraria retusa plant can reduce those side effects. Thirty patients w…

This study tests a smartphone app called GAINS that guides caregivers step-by-step through teaching life skills to children with autism, similar to how a GPS gives driving directions. The app breaks down complex tasks into simple steps and provides audio and visual cues. Research…

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must…

This study compares two strategies for veterans struggling with Cognitive Processing Therapy (CPT) for PTSD: using CPT skills to work through challenges, or switching to a different therapy called Present Centered Therapy. The goal is to see which approach reduces dropout and imp…

This study tests whether low-intensity focused ultrasound (LIFU) can safely calm overactive brain areas linked to alcohol cravings. Twenty-five adults with alcohol use disorder will receive LIFU while researchers monitor side effects and measure brain activity changes with fMRI. …

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

VoiceLove is a phone app that lets family members and ICU patients share messages and information securely. Researchers at Vanderbilt University Medical Center are comparing the app with usual care to see whether it improves communication, family engagement, and delirium in criti…

This study tests whether a gentle brain stimulation technique called tDCS, given while doing social learning tasks on a computer, can reduce anxiety and improve social skills in adults with autism. Twenty high-functioning adults will receive both real and fake (sham) stimulation …

Researchers are testing whether four weeks of intensive motor speech therapy can improve speech accuracy in children who have childhood apraxia of speech along with a rare genetic condition. The study enrolls up to 20 children aged 3 to 16. Each child receives 12 sessions of eith…

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI stimulation to deep brain areas linked to addiction or a sham (fake) treatment during a …

This study tests whether involving a romantic partner in PTSD therapy helps veterans function better in daily life. About 420 post-9/11 veterans with PTSD and their partners will take part. The treatment, called Partnered PE, adds partner support to standard exposure therapy to i…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests whether a medication called SPN-812 (viloxazine) can safely reduce ADHD symptoms in children aged 4 to 5. About 286 kids will receive either the drug or a placebo for 6 weeks. The goal is to see if the drug improves attention and reduces hyperactivity better than…

Researchers test whether an AI chatbot called Pai.ACT can help parents of young children with neurodevelopmental disorders like autism and ADHD. The chatbot delivers acceptance and commitment therapy, a type of talk therapy, and adapts its exercises to each parent's needs. The tr…

This study tests an experimental drug called evenamide for people with schizophrenia that hasn't improved with standard antipsychotics. About 400 adults will receive either evenamide or a placebo added to their current medication for 12 weeks. The goal is to see if evenamide redu…

This study tests a 10-session meditation practice combined with real-time brain feedback to help ease depression. Twenty-seven adults with moderate depression will participate. The goal is to see if this approach can improve mood and reduce symptoms.

This study tests whether taking vitamin D daily for 8 weeks helps healthy adults keep their thinking, simple physical tasks, and mood steady during very stressful situations. 52 participants will take either vitamin D or a placebo, then perform tasks while wearing a belt that giv…

This study explores whether a virtual reality mindfulness meditation program is practical and well-liked by older adults with mild to moderate cognitive impairment living in long-term care homes. About 36 participants will try up to 8 VR sessions over 4 weeks, and researchers wil…

Researchers test whether ultrasound-guided electrical stimulation of the gluteal nerves can improve hip muscle strength in people who have had low back pain. The study enrolls 24 adults with a history of low back pain and signs of gluteal muscle weakness. Participants receive ele…

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

Researchers are testing a group-based ketamine-assisted psychotherapy program designed for Spanish-speaking adults with depression. The trial enrolls 10 adults who have major depressive disorder and a Montgomery-Asberg Depression Rating Scale score of 20 or higher. Participants r…

This study tests a two-week intensive summer treatment program for 70 adolescents aged 12-18 with obsessive-compulsive disorder (OCD) in Iceland. The program uses daily cognitive-behavioral therapy with exposure and response prevention in a group setting. Researchers will measure…

This study will test whether Emotional Freedom Technique (a type of tapping) and music therapy can reduce stress, anxiety, and depression in women with a high-risk pregnancy due to early rupture of membranes. About 177 women will be randomly assigned to receive these therapies or…

Researchers are testing whether a form of magnetic brain stimulation called intermittent theta-burst stimulation (iTBS) can improve anhedonia, the inability to feel pleasure, in people with major depression. The study compares stimulating two brain areas at once (the left dorsola…

Autistic teens are three to four times more likely to experience depression than their non-autistic peers, yet almost no depression treatment research has focused on autistic youth with below average cognitive abilities. This small study tests a 12-session behavioral activation t…

Researchers are testing an internet-delivered form of acceptance and commitment therapy for people aged 15 to 24 who have PTSD and chronic pain. Participants work through online modules on trauma education, facing avoided memories and situations, mindfulness, and acceptance, with…

Researchers are testing whether a personalized form of transcranial magnetic stimulation (TMS) changes reward-related brain activity more than standard TMS in adults who smoke cigarettes. Participants receive 15 TMS sessions over three weeks, with brain scans used to pick the sti…

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study tests whether a therapy called Sensory Motor Arousal Regulation Treatment (SMART) works better than standard care for youth aged 7-17 who have experienced trauma and struggle with self-regulation. The trial will involve 120 participants randomly assigned to SMART or us…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

This study tests if using a small device that sends a mild electrical pulse to the earlobes (called cranial electrotherapy stimulation) along with life coaching can reduce burnout and moral distress in healthcare workers who treat cancer patients. About 40 doctors, nurses, and ot…

This study tests a brief behavioral sleep program for depressed teens aged 12-18 who sleep less than 7 hours or have irregular sleep. The program uses two sessions and smartphone tools to help teens set sleep goals. Researchers will compare it to a simple sleep education session …

This study tests a new type of mental training for people with borderline personality disorder (BPD). The training teaches a skill called 'reappraisal-by-distancing' to help control emotions. Researchers will use brain scans to see if the training changes brain activity and will …

This study tests whether a brief motivational interviewing session during a primary care visit can reduce alcohol and cannabis use among diverse teens aged 12 to 17. Researchers will enroll 500 participants who are at risk for substance use and track changes in how often they dri…

This study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…

This study tests if reading a personal narrative book, in addition to standard care, can help women of childbearing age manage anxiety, depression, and negative thinking before a hysterectomy. About 156 women will either receive standard information or also read a book. The goal …

This study tests whether a 7-session playback theatre program can improve mental health in adolescents and young adults aged 13 to 24 with mild to moderate depression. Participants will attend weekly 90-minute sessions led by trained social workers and music therapists. The goal …

This pilot study at St. Jude Children's Research Hospital is testing whether a daily dose of extended-release methylphenidate (Ritalin) can safely improve attention, thinking, and school performance in children aged 8 to 17 with sickle cell disease. The trial will enroll 72 parti…

Many smokers are not ready to set a quit date, so traditional cessation programs miss them. This trial tests whether counseling focused on practice quitting, where smokers try not smoking for short periods without pressure to quit forever, helps them make a real quit attempt late…

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

This study looks at whether eating pecans every day for three months can improve memory, mood, and brain function in people aged 50 and older with mild cognitive impairment. Sixty participants will be randomly assigned to eat either pecans or pretzels as a snack. Researchers will…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study follows 200 people with postpartum depression who are starting zuranolone (Zurzuvae). Researchers will use online surveys to track symptom changes at 15, 45, and 90 days. The goal is to see how symptoms improve in everyday conditions, not in a controlled lab setting.

This study tests whether an 8-week mindfulness program can reduce anxiety and depression in adults with mild emotional distress. Participants are randomly assigned to either mindfulness training or progressive muscle relaxation. Researchers use brain scans to see if mindfulness c…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have eating disorders. Participants will be randomly assigned to ACT, supportive diabetes counseling, or a waitlist. The goal is to see if …

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests an experimental drug called azetukalner in 450 adults with moderate-to-severe major depression. Participants take the drug or a placebo daily for 6 weeks to see if it reduces depression symptoms like low mood and loss of pleasure. The goal is to find a new treatm…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study tests whether adding a peer coach or parent coach to standard eating disorder therapy helps teens aged 12-18 recover faster. 70 participants will receive 12 weeks of therapy plus either a parent coach with patient education materials or patient coaching with parent edu…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study tests whether a culturally adapted version of Dialectical Behavior Therapy skills training (DBT-A-ST) helps teens aged 12-18 with emotional disorders like depression, anxiety, or ADHD. Participants are randomly assigned to either the DBT group or a standard support gro…

This study tests a four-day intensive therapy called Bergen Four-Day Treatment (B4DT) for people with obsessive-compulsive disorder (OCD). About 35 patients will receive the therapy, which involves exposure and response prevention exercises over four days, followed by three month…

This study is testing whether playing special brain-controlled games at home can help school-aged children (ages 7 to 11) with mild to moderate ADHD pay better attention and feel less hyperactive. About 146 children will play these neurofeedback games over several weeks, and rese…

This study tests whether using a stress ball for 15 minutes before retrograde intrarenal surgery (a type of kidney stone procedure) can lower patients' anxiety and fear, and improve heart rate and blood pressure. Sixty-six adults scheduled for elective surgery will be randomly as…

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. Ab…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and interpersonal therapy (IPT)—for postpartum depression in mothers whose babies are in the NICU. About 72 mothers will receive either 4 weeks of one therapy or 8 weeks of both, to see which approach r…

This study tests a non-invasive device that stimulates the vagus nerve before meals in teens and young adults (ages 14-22) with anorexia or similar eating disorders. Over 4 weeks, participants receive either real or sham stimulation to see if it boosts meal satisfaction, calorie …

This study tests a short, three-session online program designed to help caregivers of people with advanced prostate cancer manage their fear that the cancer will progress. The program teaches techniques like detached mindfulness to help caregivers relate to worrying thoughts in a…

This study tests whether the drug KarXT can reduce symptoms of mania in people with Bipolar I disorder who are currently hospitalized for a manic episode. About 274 participants will receive either KarXT or a placebo for 3 weeks while staying in the hospital. The main goal is to …

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study tests a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and chronic pain. 240 adults will receive one of four types of brain stimulation or a fake treatment for two weeks. Researchers will check if it reduces pain…

This study looks at how psilocybin (the active ingredient in magic mushrooms) affects mood and pain in people with both chronic low back pain and depression. About 40 adults will receive either a single high dose of psilocybin or a control drug. Researchers will track changes in …

This trial tests whether a four-week improv comedy program can reduce anxiety and improve mental well-being in Chinese young adults in Hong Kong who have mild-to-moderate anxiety but no diagnosed mental disorder. Participants attend weekly three-hour improv workshops and complete…

This study tests an internet-based therapy program called the Sleep Course, designed to help public safety personnel (like police, firefighters, and paramedics) who have trouble sleeping. The program teaches skills to manage sleep difficulties and includes optional support from a…

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

This pilot study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can safely improve memory in people with mild-to-moderate Alzheimer's disease. The treatment targets the precuneus, a brain region important f…

This early-stage study at Johns Hopkins is testing whether giving both psilocybin and MDMA together is safe and can help reduce PTSD symptoms in military veterans. Forty veterans with PTSD will receive the drugs in a controlled setting. The study tracks side effects, suicidal tho…

This study tests whether combining home-based brain stimulation (tDCS) with virtual speech therapy can improve communication in adults with primary progressive aphasia, a language disorder often caused by Alzheimer's disease. Eighty participants will receive either active or plac…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This Phase 3 trial tests whether the drug KarXT can safely reduce psychosis (hallucinations and delusions) in people with Alzheimer's disease. About 500 participants aged 55 to 90 with mild to severe Alzheimer's and moderate to severe psychosis will receive either KarXT or a plac…

This study tests an 8-week program called MH-POWER designed to help autistic college students manage stress, anxiety, and depression. The program combines cognitive behavioral therapy, acceptance and commitment therapy, and habit formation through weekly group sessions and daily …

This study tests a special type of talk therapy called Multi-Modal Cognitive Processing Therapy (MMCPT) for people with posttraumatic stress disorder (PTSD). Sixty adults with PTSD will either receive 12 weekly therapy sessions or standard care. Researchers will track changes in …

This study adapts a group therapy program called Regulating Together for children aged 8-12 with autism and intellectual disability who struggle with emotions like irritability and aggression. The therapy uses relaxation, mindfulness, and parent training to help kids regulate the…

This trial tests a program called Teachers Leading the Frontlines (Tealeaf) that trains elementary and middle school teachers in North Carolina to support students with mental health needs, such as depression, anxiety, and behavior challenges. Teachers learn to identify students …

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This pilot study tests whether adding socialization support to Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) helps reduce posttraumatic stress symptoms in youth aged 10-15 who have experienced child maltreatment. Participants receive the enhanced therapy, and researchers m…

This study tests whether an immersive virtual reality program using nature scenes can improve cognitive and emotional well-being in older adults with mild to moderate cognitive impairment. Participants will attend 10 group sessions that combine virtual nature environments with mi…

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This trial tests FlexED, a digital game-like intervention for young women aged 15–25 with eating disorders. Over seven 20-minute sessions on a mobile phone, users follow an avatar through a story and complete interactive exercises based on Acceptance and Commitment Therapy (ACT).…

This study at the University of Pennsylvania is testing whether personalized brain stimulation can reduce negative emotions in people with depression and anxiety. Researchers will use brain scans to map each participant's negative emotion patterns, then apply different types of t…

This study compares two versions of a smartphone app called Living Free from Tobacco (LiFT) to help young adults ages 18-30 quit using nicotine and tobacco products. About 140 participants will use one of two app versions: one focuses on building mental flexibility to support qui…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This study tests whether a single early meeting with a psycho-oncology counselor can reduce anxiety and depression and improve quality of life in people recently diagnosed with cancer. About 148 patients will be randomly assigned to either receive this counseling plus standard ca…

This study tests whether a daily medication called vortioxetine can safely reduce depression symptoms in Japanese teenagers aged 12 to 17 with major depressive disorder. About 180 participants will receive either the drug or a placebo for 14 weeks, with follow-up for 4 more weeks…

This study tests whether a drug called pimavanserin can reduce rigid, repetitive behaviors in people with autism. About 30 adolescents and adults aged 12 to 40 will receive either the drug or a placebo, then switch. The goal is to see if it improves flexibility and reduces compul…

This study tests a digital therapy that combines unconscious exposure to trauma-related images with bilateral eye movements to reduce intrusive memories in people with PTSD. About 123 participants who experience at least 5 intrusive memories per week will be randomly assigned to …

This Phase 3 trial tests whether a daily pill called azetukalner can safely reduce depression in people with bipolar I or II disorder. About 400 adults currently in a depressive episode will take either the drug or a placebo for 6 weeks. Researchers will measure mood changes usin…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This study tests whether adding a 12-week exercise program (daily walking plus two weekly combined aerobic and strength sessions) to standard antidepressant treatment can improve depression symptoms in 124 adults with major depressive disorder. Researchers will also use brain sca…

This study tests whether teaching carers of children with global developmental delay to give aromatherapy massages can improve their caregiving experience and reduce stress. Around 30 carers in Hong Kong will attend an 8-hour training session, then give their child a 10 to 15 min…

This phase 2 trial tests whether DT-101 can ease depression symptoms in adults with major depressive disorder who are already on antidepressant medication. About 118 participants will receive either DT-101 or a placebo, and researchers will track changes in depression scores over…

This study tests whether a brain-computer interface (BCI) that reads your brain waves while you play a video game can deliver targeted magnetic stimulation to improve focus and thinking. Researchers will enroll 180 adults, including those with mild cognitive impairment, to compar…

This study tests a drug called DT402 (a form of MDMA) in 20 adults with autism spectrum disorder. The goal is to see if it can reduce the severity of social and communication problems. Participants will take the drug and report their experiences using simple rating scales. It is …

This study tests a new approach to reduce intrusive memories in people with PTSD. Participants are briefly exposed to trauma cues without realizing it, then play Tetris. The idea is to disrupt memory reconsolidation without needing to consciously recall the trauma. The trial will…

This study looks at whether a low dose of ketamine, given as an IV infusion, can quickly improve depressive symptoms in adults who have been in the intensive care unit (ICU) for at least 6 days. About 50 participants will receive either ketamine or a placebo on two days in a row.…

Researchers are building a large database of cognitive, behavioral, lifestyle, and genetic information from people with neurodegenerative diseases such as Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. The goal is to find biomarkers that help do…

Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive an…

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

Researchers are using PET scans to measure mitochondrial Complex-I and glucose metabolism in the brains of people with alcohol use disorder and healthy volunteers. The study aims to see whether these markers differ between the two groups and whether they relate to alcohol craving…

This observational study aims to understand why some people are more impulsive or compulsive than others. Researchers will use brain scans, genetic tests, and behavioral surveys in 1,100 participants aged 6 to 80, including those with ADHD, OCD, autism, and conduct disorder. The …

DREAM-10 is a 10-year observational study that follows 1,000 adults aged 30 to 60 who have imaging signs of cerebral small vessel disease but no known dementia. Researchers collect clinical data, memory and thinking tests, brain MRI scans, and detailed eye imaging to track how th…

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at how exercise affects the way people with PTSD learn and remember emotional information. One hundred adults with PTSD from interpersonal violence will do either moderate or light cycling after recalling a traumatic memory. Researchers will measure anxiety, hear…

This early-stage study looks at how a new drug called ABBV-932 moves through the body when taken with another drug, itraconazole. Twenty healthy adults will take both drugs and have their blood levels measured. The goal is to check for side effects and see if itraconazole changes…

Researchers are following thousands of people with Alzheimer's disease who receive lecanemab-irmb in routine care to see how often serious brain side effects occur. The study uses a national registry to track brain swelling, small bleeds, seizures, allergic reactions, strokes, an…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

Researchers are testing whether PT150, an experimental drug that blocks the body's stress hormone receptor, can reduce the physical and behavioral effects of stress and alcohol in people with alcohol use disorder. The study enrolls 34 adults who are not seeking treatment. Partici…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depressi…

This study is testing whether simple saliva tests done at home can accurately show when someone has not used cannabis. Researchers will enroll 200 people aged 18-30 who use cannabis at least once a week. Participants will provide saliva and urine samples over 3-4 weeks, and resea…

This study looks at whether fidgeting—specifically using a smart fidget ball—can help adults with ADHD pay better attention and manage emotions. Researchers will measure processing speed, memory, and heart rate in 109 adults with ADHD. The goal is to see if simple movements can b…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study is testing whether a smartwatch can detect when someone uses opioids or experiences withdrawal. Researchers will collect biometric data from 420 people with opioid use disorder who wear the watch for 14 days. The goal is to train a machine learning algorithm to recogni…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study aims to understand why some people with depression don't get better with standard medications. Researchers will use brain scans to compare dopamine receptors in 45 people: those with treatment-resistant depression, those whose depression responds to treatment, and heal…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they w…

Researchers want to know why older adults get distracted more easily. They are focusing on a small brain region called the locus coeruleus and its connections to other brain networks. The study will test whether two weeks of at-home tablet attention games can improve focus and st…

This study looks at how a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) affects symptoms and blood markers in people with treatment-resistant depression. Fifty patients will receive iTBS sessions over four weeks, while fifty healthy v…

This study is testing how well a culturally adapted screening and brief counseling program works for American Indian and Alaska Native adults who have chronic pain or misuse opioids. Researchers will work with three clinics to see if the program is easy to use and helpful. The go…

This study uses a special PET imaging tracer to measure how much energy the brain uses in people with cocaine use disorder compared to healthy controls. The goal is to see if energy use in key brain regions, like the orbitofrontal cortex and midbrain, differs in addiction. This c…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will ask 150 older adults (70+) to wear a watch that tracks sleep and to give blood samples. The goal is to fi…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

Researchers at Emory University are testing whether a six-week course of the amino acid leucine changes glutamate levels and brain circuit activity in people with midlife depression. The trial enrolls 75 adults with moderate to severe depression and signs of inflammation. Partici…

This study looks at how the brain processes threats in people with PTSD. Researchers will use a mild electrical current (tACS) to gently stimulate brain areas and measure changes in brain activity and anxiety. The goal is to understand the brain mechanisms behind PTSD, not to tes…

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

This study tests an online training program called DERA for community health workers. The goal is to see if it improves their knowledge about dementia, reduces stigma, and boosts their confidence in helping people with dementia. About 100 community health workers will take the tr…

Researchers at the University of Idaho are studying whether an 8-week mindfulness program focused on self-compassion or 8 weeks of vitamin D supplements can reduce stress in mothers of preterm infants. The trial enrolls 500 mothers and measures stress hormones, self-compassion, a…

This study looks at whether a guided self-help workbook can help autistic adults feel better. Ten participants will use the workbook with a trained supporter over 4-6 sessions. They will fill out wellbeing questionnaires and share their thoughts in interviews. The goal is to see …

Researchers are studying whether blood proteins and metabolites can predict who responds to transcranial magnetic stimulation (TMS) for treatment-resistant depression. About 55 adults whose depression has not improved with at least two antidepressants receive 20 sessions of inter…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

Researchers are observing children aged 1 to 16 who receive all their nutrition through a gastrostomy tube. The study checks how the mix of gut bacteria changes after the children switch to Compleat Paediatric Nature Mix, a formula made from food-derived ingredients. Over six mon…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study investigates repetitive behaviors—like repeating words or actions—in people with Alzheimer's disease. Researchers want to understand how common these behaviors are, what types occur, and whether they are linked to memory problems or lack of awareness of the condition. …

This study follows 150 people diagnosed with methamphetamine-induced psychotic disorder for one year. Researchers will track factors like medication adherence, social support, and insight into illness to see how they relate to changes in psychiatric symptoms. The goal is to bette…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study looks at how cannabidiol (CBD) influences stress in 160 people aged 18-25 who experienced early life trauma. Participants receive either CBD or a placebo, then undergo brain scans and stress tests. The goal is to understand the brain and hormone changes behind CBD's st…

Researchers at the University of Rochester are testing a program called FMF Connect Pro that trains mental health providers to screen for prenatal alcohol exposure, diagnose fetal alcohol spectrum disorders, and support caregivers through a companion app. The study compares two t…

This study aims to improve pain relief after cesarean sections by looking at how a mother's genes affect her response to opioids. Researchers will enroll 700 women and track genetic markers linked to side effects like breathing problems and nausea. The goal is to create a persona…

This study aims to understand how ketamine produces rapid antidepressant effects by using a special brain scan (GluCEST) to measure changes in glutamate, a key brain chemical. Ten adults with treatment-resistant depression will receive a single ketamine infusion and undergo imagi…

Researchers are studying how attachment styles and social cognition relate to post-traumatic stress disorder in French military personnel. The trial compares military personnel with PTSD to those without it, looking at biological, psychological, and social factors that may contri…

This study will compare symptoms of sluggish cognitive tempo (also called cognitive disengagement syndrome) in 100 adults with Functional Neurological Symptom Disorder against healthy controls. Participants will fill out questionnaires about daydreaming, confusion, and slow think…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study looks at whether a trauma-informed approach can improve smoking cessation support for pregnant women, especially those from racial and ethnic minority groups. Researchers will interview clinicians and pregnant women to understand their needs and experiences. The goal i…

This study looks at how ketamine, a fast-acting antidepressant, affects the brain. Researchers want to understand if a specific brain receptor (AMPA) is key to its effects. Seventy adults with treatment-resistant depression will take part, receiving ketamine and a drug that block…

This study looks at anxiety levels in 100 living liver donors before and after their surgery. Participants will fill out questionnaires to measure their worry and stress. The goal is to better understand how anxiety affects recovery and to improve care for future donors.

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study looks at whether using a conversational AI to collect medical history can make people with depression feel more understood by their doctors. About 130 adults with moderate to severe depression will try the AI at home before a regular visit and rate how empathetic the e…

Researchers at Ariel University are studying how the level of food processing and nutritional quality affect how much people eat, how fast they eat, how full they feel, and their blood sugar. Forty adults in Israel with a body mass index between 20 and 40 will eat three laborator…

This study tests a stepped care program called the Trauma Resilience and Recovery Program (TRRP) for people hospitalized after a traumatic injury. It includes education, symptom tracking, and referrals to mental health services. Researchers will follow 350 participants for 12 mon…

Researchers at Yale University are using PET brain scans to measure two types of opioid receptors, mu and kappa, in people with alcohol use disorder and in healthy volunteers. Participants with alcohol use disorder complete detoxification and then undergo scans within the first d…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study adapts a parenting program called 'Proud of Baby and Me' for new mothers who are receiving medication for opioid use disorder. The goal is to see if the program helps mothers stay in treatment, reduce stress, and improve bonding with their baby. Ten women will particip…

Researchers at Georgia State University are studying how transcranial magnetic stimulation (TMS) affects reading speed and accuracy. About 50 adults with typical reading skills will receive either excitatory, inhibitory, or sham stimulation to a brain region called the supramargi…

This study collects blood or brain tissue from families with two or more members diagnosed with Alzheimer's or dementia. The goal is to build a large DNA bank that researchers can use to find genes linked to the disease. No individual results are returned, but the data may lead t…

This study will give 22 occasional cannabis users oral THC, CBD, both, or a placebo to measure how these substances appear in blood and saliva, and how they affect thinking and behavior. The goal is to better understand drug detection and impairment from oral cannabinoids. It is …

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This observational study looks at how the brain responds when watching others perform actions, focusing on the mirror neuron system. Researchers will measure brain activity in healthy adults and infants, including those at risk for developmental delays, using EEG and fNIRS. The g…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study uses PET and MRI brain scans to see if antipsychotic medication causes lasting changes in dopamine receptors in people with schizophrenia. Researchers will compare three groups: healthy volunteers, patients who have never taken antipsychotics, and patients who have bee…

This study looks at whether a group support program is practical and helpful for female partners of men who have viewed child sexual abuse material. Researchers will check if 15-20 women can be recruited within a year and if they find the program useful. The goal is to understand…

This observational study follows 500 people with atypical parkinsonian syndromes, including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration. Researchers track motor and non-motor symptoms and imaging changes every …

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study tests a 10-week parenting program called Parenting in 2 Worlds (P2W), designed specifically for urban American Indian families. Researchers will compare it to a general health program in four U.S. cities with 1,440 parent-teen pairs. The goal is to see if P2W improves …

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This study looks at whether obese children with autism spectrum disorder differ from those without autism in fitness and heart health. Researchers will review medical records of 200 children aged 6 to 18, including step test results, handgrip strength, body measurements, and bloo…

This early-stage study is testing an experimental drug called LY3439539 in 30 people with mild-to-moderate Alzheimer's disease. The main goal is to see if the drug changes certain proteins in the spinal fluid that are linked to Alzheimer's. Participants will receive the drug thro…

This study uses a special PET scan with a radioactive tracer called AV-1451 to look at tau protein buildup in the brains of 100 older adults with mild cognitive impairment or Alzheimer's disease. The goal is to see how tau patterns relate to other brain changes and thinking abili…

This study is testing a program that helps teachers and parents work together to support preschoolers who have trouble with social communication. The program is run by preschool staff and uses proven teaching methods. Researchers want to see if the program is easy to use and if f…

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not seeking treatment. Participants will smoke either placebo, low-dose, or high-dose THC ca…

This study looks at whether a blood marker called phosphatidylethanol (PEth), which reflects alcohol use over the past few weeks, can predict complications after surgery. Researchers will test PEth levels in 170 adults having elective surgery at University Hospitals Cleveland Med…

Researchers are studying tiny particles released by brain cells into the blood, called glial extracellular vesicles, to see if they carry signs of inflammation that change as Alzheimer's disease advances. They will follow 48 people across three stages of the disease, from mild fo…

This study explores whether a short substance use questionnaire and brief counseling session can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 participants will fill out a screening tool and, if needed, receive supportive counseling during…

Researchers at Duke and UNC are building a long-term research group of 500 adults to study how memory and thinking change with age. Participants range from healthy younger adults to those with mild cognitive impairment or dementia. Over time, they will provide blood, urine, and s…

This early-stage study will test how a hemp-based CBD lotion with a small amount of THC is absorbed by the body. Twenty healthy adults will use the lotion in a clean, controlled environment. Researchers will measure cannabinoid levels in saliva, blood, and urine over time to unde…

This study follows 450 people with treatment-resistant depression who are starting or continuing treatment with either IV ketamine or Spravato (esketamine) nasal spray. Over five years, researchers will track how satisfied patients are with their treatment, how well it works, and…

This study aims to enroll 50,000 adults aged 45 and older in France to test for a gene called APOE, which is linked to Alzheimer's risk. Participants provide a saliva sample at home and complete online questionnaires. The goal is to build a large registry of genetic and health da…

This study looks at 48 teenagers with autism who were checked for psychotic symptoms 10 years ago. Researchers want to see how their mental health and daily functioning are now. They will compare those who had early signs of psychosis with those who did not, using interviews and …

Researchers are enrolling thousands of French college students to track how symptoms of anxiety, depression, ADHD, sleep problems, and other factors interact over time. Instead of counting how common these issues are, the study uses a network approach to see how symptoms influenc…

This study follows 600 people with neurodegenerative diseases such as Parkinson's, Alzheimer's, and related conditions over 1 to 10 years. Researchers collect data from routine clinical exams, brain imaging, movement analysis, and blood tests. They use statistical tools and artif…