Psychiatric disorder

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

Researchers are testing whether two dose combinations of metyrapone and oxazepam can help adults with cocaine addiction. The study enrolls 45 people aged 18 to 50 who want treatment and have cocaine in their system. Participants take the drugs or a placebo twice daily for six wee…

This study tests a structured, 8-week smoking cessation program delivered via weekly video group sessions. It enrolls adults addicted to nicotine who want to quit. Researchers track whether participants stay smoke-free six months after the program ends, and how their anxiety and …

This study tested whether daily nicotine patches could improve memory and daily function in 348 people with mild cognitive impairment (MCI). Participants wore either a nicotine patch (up to 21 mg) or a placebo patch for two years. The goal was to see if nicotine, known to affect …

This study tested a program that combines community-based fetal ultrasound with care navigation to help pregnant women with substance use disorder engage in prenatal care and substance use treatment. The program used motivational interviewing and strength-based education to suppo…

Researchers are testing a Spanish version of CANreduce, a web-based self-help program that uses cognitive behavioral therapy and motivational interviewing to help people reduce their cannabis use. The trial compares three groups: one gets the program plus psychological support, o…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This phase 2 trial tests whether glycerol phenylbutyrate (GPB) can slow corticobasal syndrome (CBS), a rare and fast-progressing brain disease. 32 adults with CBS will receive either GPB or a placebo for 26 weeks. The main goal is to see if GPB lowers levels of a nerve damage mar…

Researchers are studying a once-weekly tablet form of brexpiprazole, an antipsychotic drug, in adults with schizophrenia. The trial follows about 247 participants for 52 weeks to see how well they tolerate the medicine and whether it remains safe over the long term. Everyone in t…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

Researchers are testing whether hydralazine, a drug already approved for high blood pressure, can slow cognitive decline in people with early Alzheimer's disease. The trial will give 228 participants either hydralazine or a placebo for one year, alongside their usual Alzheimer's …

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This trial tests whether regular checkups after release from jail can help people with opioid use disorder stay in treatment. Researchers will compare standard re-entry care with two versions of a Recovery Management Checkups program, one with monthly meetings for three months an…

This trial tests whether combining an online form of Acceptance and Commitment Therapy with a noninvasive brain stimulation technique can improve sleep quality in adolescents with depression and sleep problems. About 160 teens aged 11 to 19 are randomly assigned to receive the co…

This study follows adults in the United States who were prescribed zuranolone for postpartum depression (PPD) after giving birth. Researchers will track symptom changes using a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) at several time points, i…

This study tests whether starting alcohol use disorder treatment while still in the hospital helps people stay in treatment and drink less after they go home. 450 adults with moderate to severe alcohol problems will receive either a brief counseling session alone, or that session…

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This trial tests whether adding minocycline or celecoxib to a standard antidepressant helps people with treatment-resistant depression. Treatment-resistant depression means symptoms have not improved enough with previous antidepressant treatment. About 78 adults aged 18 to 65 wil…

This Phase 2 trial tests three commonly used drugs—lorazepam, IVIG, and tofacitinib—in 66 people aged 8 to 30 with Down Syndrome Regression Disorder (DSRD). DSRD causes sudden severe symptoms like loss of speech, movement, and daily living skills. The study aims to see if these d…

This phase 2 trial tests whether a single dose of insulin given through the nose can change how the brain produces energy and improve thinking in people with psychotic disorders like schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis. Researchers will com…

Researchers are testing an experimental drug called MK-2214, given by IV infusion, in adults with mild cognitive impairment or mild-to-moderate Alzheimer's disease. The trial aims to see whether the drug is safe and tolerable, and whether it reaches meaningful levels in the brain…

This study tests a non-invasive brain stimulation technique called targeted temporal interference stimulation (tTIS) aimed at the caudate nucleus. The goal is to reduce drug cravings and improve decision-making in 60 adults with methamphetamine use disorder. Participants will rec…

This trial tests whether children with autism improve balance and coordination more when they exercise in a group or on their own. Researchers will randomly assign 16 children aged 3 to 12 to either individual or group exercise sessions, held three times a week for six weeks. The…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This study tests a smartphone app called Re-Connect that locks access to fun apps like social media and games. To unlock them, you must pass a breath test showing you haven't smoked recently. Researchers want to see if this reward system is easy to use, acceptable, and helps peop…

This trial tests whether continuous smartphone monitoring can detect early warning signs of depression or mania in people with bipolar disorder. Participants use an app that tracks activity and location, and some receive personalized alerts from their doctor when the app detects …

This trial compares three painkillers, hydromorphone, fentanyl, and butorphanol, given intravenously to ICU patients who are not on mechanical ventilation. The goal is to find the best dose of hydromorphone that achieves effective pain control while monitoring side effects like l…

This trial tests a 10-week multimodal pelvic floor rehabilitation program in children aged 5 to 18 with different types of urinary incontinence, including daytime wetting, bedwetting, or both. The program combines education, bladder and bowel training, manual techniques, and exer…

This trial tests whether tailored SMS text messages can improve treatment attendance among justice-involved youth aged 13-18 who are referred to community-based substance use or dual diagnosis treatment. Participants receive either appointment reminders plus motivational messages…

This phase 3 trial compares two steroid schedules for severe alcohol-associated hepatitis, a serious liver condition with high death rates. One group takes prednisolone for 7 days followed by a placebo for 7 days, while the other takes prednisolone for the full 14 days. Researche…

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers wil…

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This trial tests a digital program designed to help people quit tobacco. Over 2,200 participants will use the program or receive usual care. The main goal is to see if the program helps people stop using their primary tobacco product for at least 30 days.

This trial tests whether combining cognitive behavioral therapy with social skills training helps young people with early-onset psychosis improve their symptoms and daily functioning. Participants receive either this combined therapy or a control program of psychoeducation and he…

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder wi…

This trial tests whether psilocybin, the active ingredient in magic mushrooms, given alongside psychological therapy, can help adults with treatment-resistant depression. Participants receive either psilocybin or a placebo in a single dosing session, combined with therapy. The st…

This trial tests whether a peer-led support program, where trained patients guide group sessions, can reduce depressive symptoms in adults with major depression. Researchers in Mallorca will compare this approach to an online mental health app. About 70 participants from primary …

This trial tests two online programs designed to improve thinking skills in people with schizophrenia. One program focuses on cognitive remediation, helping participants build learning strategies and confidence. The other, metacognitive training, targets how people interpret info…

This trial tests whether a specialized two-year early intervention service, called OPUS YOUNG, can improve daily and social functioning in adolescents aged 12-17 who have experienced a first episode of psychosis. Participants are randomly assigned to either OPUS YOUNG or standard…

This trial explores whether it is possible to run a larger study of mirtazapine, an antidepressant, in people who have both major depression and inflammatory bowel disease (IBD). About 76 adults with IBD and depression will be randomly assigned to take either mirtazapine or a pla…

This trial tests whether letting smokers adjust their own nicotine patch dose—based on their smoking history and withdrawal symptoms—helps them stay smoke-free longer than the standard fixed-dose patch. Adult smokers who smoke at least 10 cigarettes a day and are motivated to qui…

This study tests whether adding DIR/Floortime—a child-led, relationship-based therapy—to standard care helps children aged 4-12 with mild-to-moderate autism improve emotional, social, communication, and daily living skills. Half the children receive the 10-week Floortime program …

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This trial tests an 8-week online coaching program that teaches parents of preschool autistic children how to use everyday interactions to boost their child's social communication. Families are randomly assigned to either the coaching program or a waitlist, and the study measures…

This trial tests a Family Mental Health Navigator (FMHN) program for publicly insured youth aged 6-17 who are already receiving services at a San Francisco hospital. The program pairs families with a navigator who uses mobile health tools to help them get referrals and start trea…

This trial tests whether a digital clinic, delivered through a smartphone app, can improve health outcomes for people with alcohol-associated liver disease (ALD) and alcohol use disorder (AUD). Participants' doctors are randomly assigned to refer them to this digital platform in …

This trial tests four family-oriented counseling programs designed to support children and adolescents (ages 3-18) who have a parent with a mental illness or addiction. The programs range from brief therapy for children showing signs of distress to preventive sessions for those w…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial uses brain scans to see whether 8 weeks of mindfulness-based group therapy changes how the brain processes reward, craving, and self-control in people with heroin addiction. About 157 adults on medication for opioid use disorder will be randomly assigned to mindfulness…

This study tests a program called Compassionate Mind Training for Teachers (CMT-T) to see if it can reduce depression, anxiety, and self-criticism in elementary school teachers. Forty teachers from public schools in Aracaju, Brazil, will take part in group sessions that include m…

This study tests whether a virtual reality program, based on the transtheoretical model of behavior change, can help university students quit smoking. Participants will use VR goggles to practice coping skills in realistic scenarios. The goal is to see if this training boosts the…

This study compares two treatments for depression in children aged 7 to 13: a family-focused therapy that works with both the child and parents, versus individual therapy for the child alone. The family approach aims to improve parent-child interactions, communication, and coping…

This study tests a smoking cessation program designed for adults with serious mental illness. Participants receive a combination of videogame-based physical activity, smoking cessation counseling, and the medication bupropion. The goal is to see if this approach is feasible and a…

This study tests a new virtual reality (VR) software that delivers behavioral activation therapy for people with depression. Behavioral activation helps people re-engage in positive activities to improve mood. Participants use hand-tracking to interact with the VR environment, co…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

Researchers are checking whether a short 3-question depression survey can identify moderate-to-severe depressive symptoms in older adults having surgery as accurately as the standard 9-question version. The study analyzes existing records from more than 10,000 patients aged 65 an…

This study is testing whether a set of memory and thinking tests, usually done in person, can be given remotely over a video call. Researchers will compare results from in-person and remote versions to see if they match. If it works, it could make dementia assessments easier for …

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

Older adults who have major reconstructive spine surgery often develop postoperative delirium, a sudden state of confusion that can lead to longer hospital stays and lasting cognitive problems. Poor pain control raises that risk, and opioids used for pain bring their own side eff…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

Researchers are testing whether adjusting anesthesia depth with a bispectral index (BIS) brain monitor lowers the chance that children wake up confused and agitated after tonsil or adenoid removal. The trial includes 125 children aged 2 to 12 who are generally healthy and go home…

Researchers at Yale University are testing whether adding cognitive behavioral therapy (CBT) after esketamine treatment helps prevent relapse in people with major depression and suicidal thoughts. All participants receive esketamine, then half are randomly assigned to also get co…

This early-stage trial tests a vaccine called AV-1959R, designed to prevent Alzheimer's disease by targeting a protein linked to the condition. Sixteen healthy adults aged 40-60 will receive three shots of the vaccine or a placebo over 14 weeks. Researchers will monitor for side …

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

Researchers at Stanford University are testing whether the Diabetes Body Project, a six-session group program, can reduce eating disorder symptoms and improve blood sugar control in young women with type 1 diabetes. The study enrolls 55 female-identifying participants aged 15 to …

Heavy drinkers who need a breathing machine in intensive care often become agitated, which can lead to pulling out tubes, falling, or harming themselves or staff. This Phase 3 trial tests whether baclofen, a drug that calms the nervous system, can prevent these dangerous events b…

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

People leaving acute psychiatric care in Alberta often wait months for a follow-up appointment, which raises the risk of relapse and a return to hospital. This trial tests a low-cost program that sends daily supportive text messages based on cognitive behavioral therapy and pairs…

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

About 25% of people who have knee replacement surgery develop persistent pain that can last for months. This trial tests whether taking a CBD-dominant oil before and after surgery can reduce that risk. Researchers will randomly assign about 40 adults to receive either CBD oil or …

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

Researchers are testing whether a four-week group program can help people who inject drugs and are in methadone treatment reduce their risk of HIV. The program teaches skills like cleaning needles and using condoms, and it is compared with a support group that does not focus on t…

Researchers are testing WorkWell, a mobile program designed to prevent prescription opioid misuse among construction workers and nurses. The app includes lessons on opioid risks, pain management alternatives, and how to talk with doctors. Participants answer questions about their…

This trial tests whether solanezumab, an antibody that targets amyloid plaques in the brain, can slow the progression of memory problems in people who have no symptoms but show early signs of Alzheimer's-related brain changes. Participants are older adults with normal thinking an…

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training pr…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tests whether a nurse-led program combining lifestyle education and cognitive play-based training can reduce dementia risk among older adults living in residential care. About 134 residents from seven care homes in Cairo, Egypt, will receive either the intervention or …

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This trial tests a 12-week group program designed to help adults aged 65 and older address modifiable risk factors for dementia, such as high blood pressure and cognitive decline. Participants meet weekly for an hour to learn about brain health and practice evidence-based lifesty…

Researchers at the University of Tulsa are testing a five-session psychological treatment called Exposure, Relaxation, and Rescripting Therapy for adults who have bipolar disorder and chronic trauma nightmares. The therapy asks participants to revisit and rewrite their nightmares…

Researchers at Meiho University are studying whether applying an oral moisturizing gel changes the mix of bacteria in the mouths of older adults living in long-term care. The trial enrolls people aged 65 and older who have lived in a care facility for at least six months, includi…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This study compares two support programs for family and friends caring for Veterans with dementia after a hospital stay. One program, Hospital GamePlan4Care, offers a handbook, online training, and phone coaching tailored to the caregiver. The other provides general education and…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

Researchers at Karolinska Institutet are testing a parent training program for parents of children aged 8 to 16 who show angry, defiant, or aggressive behavior. The program teaches cognitive behavioral therapy skills and adds virtual reality role-plays so parents can practice res…

Researchers at Karolinska Institutet are testing a program called YourSkills for children aged 10 to 16 who have elevated anger or disruptive behaviors. The program combines cognitive behavioral therapy with virtual reality role-plays to practice social skills. Children attend te…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

Researchers are testing whether giving children a popit toy or a stress ball during inhaled medication can reduce anxiety, fear, and distress. The trial includes children aged 4 to 6 who come to a pediatric emergency unit with a respiratory condition needing nebulizer or inhaler …

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

Researchers at the University of Tulsa are studying Exposure, Relaxation, and Rescripting Therapy (ERRT), a brief treatment for frequent trauma-related nightmares. The trial enrolls about 90 adults who have experienced trauma and have roughly one nightmare per week. Participants …

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

Researchers are testing a stepped mental health program for adolescents in Pakistani public schools. The program starts with teacher-led support for emotional distress. Students who do not improve move to a CBT-based guided self-help app. The study checks whether this approach is…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

Researchers are testing whether a horticultural therapy program can reduce anxiety and improve quality of life in older adults. The trial enrolls 56 volunteers who take part in gardening activities. Participants complete standard questionnaires about anxiety and well-being before…

Researchers are testing an accelerated form of brain stimulation called iTBS for depression. A single participant with major depressive disorder receives 50 iTBS sessions over 5 days while researchers monitor blood flow in the brain using fNIRS. The study measures changes in oxyg…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

Tonsillectomy causes significant pain in children. Researchers are testing whether injecting ropivacaine, a local anesthetic, around the tonsils during surgery reduces postoperative pain. The trial enrolls 60 children aged 3 to 6 who are having their tonsils removed. Doctors comp…

Electromyography (EMG) and nerve conduction studies (NCS) check how nerves and muscles work, and many patients find them painful or stressful. Researchers are testing whether letting adults choose and listen to their own music during these tests lowers anxiety and pain compared w…

Researchers at a smoking cessation clinic in Turkey tested whether adding WhatsApp messages to routine care helps people stop smoking. Adults who smoked at least one cigarette a day and used WhatsApp most days joined the study. Everyone received standard clinic support, and half …

Researchers at Hanoi Medical University are studying whether methadone clinics can effectively screen, treat, and keep people with methamphetamine use disorder in care. The trial enrolls 60 adults who test positive for meth but not opioids. Participants receive counseling and inc…

Researchers are testing a four-week acceptance and commitment therapy program for parents of children with complex medical conditions. The trial enrolls 24 parents who attend two-hour weekly sessions covering stress, values, mindfulness, and goal-setting. The study measures chang…

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) could help reduce cravings and improve symptoms in people with methamphetamine use disorder. Twenty-two adults in Indonesia who had not yet received treatment were given TBS …

Researchers at Oregon State University are testing whether a brief, Spanish-language group program can reduce anxiety in Latino/a adults. The program teaches neuroscience-informed cognitive behavioral therapy over three weekly 90-minute sessions and asks participants to track the…

Researchers are testing whether giving mothers with ADHD a stimulant medication along with behavioral parent training works better than parent training alone for reducing ADHD-related problems in their young children. The study enrolls mothers aged 21 and older who meet criteria …

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

Many people who move to a new country face depression, anxiety, stress, and trouble adjusting. This pilot study tests whether EMDR, a psychotherapy that uses guided eye movements to process distressing memories, can help when adapted for migration-related experiences. First-gener…

Researchers are testing whether a home-based program led by community health workers can reduce depression in older adults living in a low-resource district of Lima, Peru. The program, called VIDACTIVA, combines problem-solving exercises and physical activation over eight home se…

Researchers are studying whether adding a Chinese herbal capsule called Shuganjieyu to the antidepressant fluoxetine helps ease depression symptoms more than fluoxetine alone. The trial enrolls 160 adults with depression, ages 18 to 65, who score at least 18 on a standard depress…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

Intravitreal injections deliver medicine directly into the eye and are usually quick, but many patients feel anxious before and during the procedure. Researchers are testing whether playing classical music during the injection lowers anxiety and pain compared with no music. The t…

This study tested whether playing interactive digital games in a group could improve mood, behavior, and thinking in 24 older adults with early to moderate dementia. Participants played games like Mahjong on a touch-sensitive table twice a week for 20 weeks. Researchers measured …

Researchers are testing whether a soft silicone band placed over the frenulum, the sensitive underside of the penis head, can help men with lifelong premature ejaculation delay ejaculation. The pilot trial assigns 32 men aged 18 to 35 by chance to use either the band or a priloca…

This study tests whether a type of brain stimulation called cTBS can improve thinking and memory in people with schizophrenia. Forty participants will receive targeted stimulation to a brain network linked to daydreaming and self-focus. The goal is to see if this changes brain ac…

This study will test whether watching a liquid-gel or sand hourglass during blood collection can reduce pain, fear, and anxiety in children aged 5 to 10. About 120 children will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-d…

Researchers are studying whether TENS, a device that sends mild electrical pulses through the skin, can lower pain and reduce the need for painkillers after total hip replacement. The trial enrolls 60 adults who have had hip replacement surgery and do not have a pacemaker, heart …

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

Researchers are testing whether a five-module internet-based treatment program with therapist support works as well as the same treatment given face-to-face in specialized addiction care. The trial enrolls adults in Stockholm County who drink harmfully or show signs of alcohol de…

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study looked at whether structured play activities could reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in play sessions during chemo. Anxiety levels were measured before and after play. The goal is to s…

Researchers in Chile are testing whether pediatricians trained to detect and respond to social withdrawal can help late and moderately late preterm infants engage more with their parents. The study enrolls 110 preterm infants born between 32 and 36 weeks and their Spanish-speakin…

This study tests whether taking a probiotic supplement for four weeks can reduce alcohol cravings and improve thinking, mood, and gut health in people with alcohol use disorder. 38 participants are randomly assigned to receive either the probiotic or a placebo, and neither they n…

Researchers are testing whether the experimental drug LY2140023 (pomaglumetad methionil) reduces schizophrenia symptoms better than a placebo. The trial enrolls adults diagnosed with schizophrenia who stay in a hospital or clinic during the four-week study. Participants take the …

Researchers are testing whether an experimental drug, LY2140023, eases schizophrenia symptoms better than placebo in people who are acutely ill. The trial also compares it to risperidone, an approved antipsychotic. About 1,100 patients with schizophrenia join this phase 2 study. …

Researchers in Pakistan are comparing two psychological treatments, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), for people with post-traumatic stress disorder (PTSD) and major depression. The trial enrolls 100 adults aged 18 to 60 …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

Researchers test whether an 8-session mindfulness-based stress reduction program can lower anxiety and work-related burnout and improve job satisfaction among midwives. Midwives at a Turkish hospital join either the program or a control group. The program runs online twice a week…

This study tested whether a virtual reality experience where people see an avatar of their future self could help those in early recovery from opioid use disorder reduce drug use and stay abstinent. 104 participants were split into a VR group and a control group. Researchers meas…

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are testing whether a combination of water-based exercise and cognitive training can improve memory in veterans with amnestic mild cognitive impairment, a condition that often precedes dementia. Participants first complete six months of pool exercise three times a wee…

Researchers are testing whether combining a mild brain stimulation technique called tDCS with virtual reality can reduce anxious rumination in healthy people who tend to ruminate. The study enrolls 20 adults who score high on a rumination scale but do not have a psychiatric or an…

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

Researchers are testing whether memantine, a drug already used for Alzheimer's disease, can ease symptoms or slow decline in people with frontotemporal dementia. The trial enrolls adults aged 45 to 75 with mild to moderate FTD and compares memantine against a placebo over one yea…

Researchers are testing whether virtual reality glasses that show nature scenes with nature sounds can reduce pain and anxiety in women after a cesarean section. The trial enrolls 80 women who had spinal anesthesia and a healthy pregnancy, assigning half to use the VR glasses for…

This trial compares two ultrasound-guided nerve blocks—erector spinae plane block and paravertebral block—for pain relief after minimally invasive chest surgery (VATS). The goal is to see which method better preserves lung function, as measured by breathing tests, and reduces the…

This study tested whether adding a magnetic chair (extracorporeal magnetic innervation) to standard pelvic floor exercises helps men with premature ejaculation more than exercises alone. Forty-one men aged 25-45 took part over 8 weeks. Researchers measured pelvic floor muscle mov…

This study tests a smartphone app that sends personalized messages to help people quit smoking. The messages are triggered by real-time data like location and stress levels, offering coping strategies when urges strike. Seven participants will use the app for 45 days to see if it…

Researchers at Atlas University are comparing three daily breathing practices, mindfulness breathing, box breathing, and Nadi Shodhana pranayama, in 48 healthy adults aged 18 to 40. Participants practice one technique at home for six weeks after learning it in person. The trial m…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

Researchers are testing MDMA-assisted therapy in military veterans who have both alcohol use disorder and post-traumatic stress disorder. The treatment combines two monthly therapy sessions with the drug MDMA, along with preparation and follow-up counseling. The study measures ch…

Researchers are comparing two 9-week group classes for veterans who have a history of mild traumatic brain injury and post-traumatic stress disorder. One class teaches mindfulness, meditation, and yoga; the other teaches how the brain works and recovers after injury. The study me…

York University researchers are testing two ways to train teachers to help children with dyslexia who have not improved with standard classroom reading instruction. One program adds morphology, which teaches shared word meanings like sign, design, and signal. The other adds set-f…

This study will test whether watching a short educational video or having a standard talk with a doctor is better at reducing anxiety and stress in women scheduled for a planned cesarean delivery. 140 women will be randomly assigned to one of the two groups. Their anxiety levels …

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

Researchers at Tanta University are testing whether fractional CO2 laser can reduce skin amyloid deposits and itching in people with primary cutaneous amyloidosis. The trial enrolls 22 adults with confirmed disease who have not used other treatments for at least six months. Parti…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can help returning veterans who drink heavily. The trial enrolls veterans deployed after September 11, 2001, who have insomnia and at least one heavy drinking episode in the past month. Participants…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

Researchers at the University of Guadalajara are testing whether a short acceptance and commitment therapy (ACT) program can reduce anxiety in medical students. The program runs four in-person group sessions that teach students to accept difficult thoughts and feelings, step back…

This completed trial tested a virtual program for people with Alzheimer's or related dementias and their caregivers. Nearly 1,000 participants received monthly video or phone visits from nurses or social workers over a year. The program focused on managing symptoms, reducing care…

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

Researchers are testing a smartphone app called Pai.ACT that uses acceptance and commitment therapy to help parents of children with special needs manage stress and improve well-being. The study enrolls 60 Cantonese-speaking parents in Hong Kong who care for children aged 2 to 8 …

This trial tests whether acupressure, a traditional therapy that presses on specific body points, can reduce pain and anxiety in women who have just had a cesarean delivery. Sixty postpartum women will receive either acupressure or a sham version, along with standard medical care…

Researchers are testing a full-spectrum medicinal cannabis extract with very low THC to see if it can reduce the severity of autism spectrum disorder in young people aged 8 to 17. The study compares the extract to a control and then allows some participants to receive it openly. …

Researchers at Saveetha University studied a structured play-based program called the B.A.S.I.C.S. framework for children with autism spectrum disorder. The program combines balance, social, thinking, and self-reliance activities into 45-minute sessions three times a week for six…

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

Researchers test whether adding cognitive training to a 10-week exercise program helps children with developmental coordination disorder improve balance, motor skills, and fitness more than exercise alone. Twenty children aged 7 to 11 join the study and are randomly assigned to e…

This study tested whether a special type of heated yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 people were randomly assigned to either take yoga classes twice a week or join a waitlist. The main goals were to see if people would stick with the …

This study tests a group cognitive-behavioral therapy (CBT) program designed to help young adults who struggle with uncertainty. The program includes techniques like cognitive restructuring and exposure to uncertain situations, and it considers how a person's social environment a…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in adults with severe obsessive-compulsive disorder that has not improved with at least two antidepressants. The study compares ac…

Researchers at the University of Utah are testing a new non-invasive brain stimulation method for people with moderate-to-severe depression. The study uses a device called the Diadem prototype to deliver personalized low-intensity focused ultrasound to specific brain areas. Parti…

Researchers at MIT are testing whether a smartwatch that vibrates in time with your heartbeat can improve interoceptive awareness, the ability to sense what is happening inside your body. The study enrolls 29 people with high alexithymia scores, a trait linked to difficulty ident…

This study tests whether virtual cognitive behavioral therapy (CBT) can help reduce binge eating and bulimia symptoms in veterans and other underrepresented groups. About 144 adults with binge eating disorder or bulimia will receive therapist-led or self-help CBT via telehealth. …

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164 in girls and young women with Rett syndrome, a rare genetic disorder that affects movement, speech, and behavior. The study includes 14 participants aged 5 to 20 who take the extract daily for 16 wee…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

Researchers are testing an AI-integrated proactive thought control program for young adults with social anxiety disorder. The program uses two computer tasks: one where participants type the first word that comes to mind after seeing a social threat word, and another where they c…

Researchers are testing whether transcranial direct current stimulation (tDCS) can reduce symptoms in people with severe obsessive-compulsive disorder that has not improved with standard medications. The study enrolls 20 adults aged 18 to 70 who have chronic OCD and have tried at…

This study tests a smartphone app called CT-155 designed to help people with schizophrenia manage negative symptoms like low motivation and reduced pleasure. About 262 adults with schizophrenia will use the app for 16 weeks, with an optional extension. Researchers will track symp…

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

This early-stage study tests whether diclofenac, an FDA-approved painkiller, can reduce alcohol cravings in people with alcohol use disorder. Researchers believe diclofenac may work by shifting brain chemistry away from harmful effects of alcohol. The study involves 24 adults who…

This study tests whether Snoezelen multisensory therapy — a calming, personalized experience using lights, sounds, textures, and scents — can reduce agitation, depression, and anxiety in older adults with dementia. Sixty participants with mild to moderate dementia will receive ei…

This study looked at whether two specific diets—the ketogenic diet and the Therapeutic Lifestyles Changes diet—could improve thinking and memory in people with Alzheimer's disease. Researchers measured changes in cognitive test scores over three months in 84 adults aged 50 to 90 …

This trial tests a telephone-based coaching program called MOTIVATE for older veterans who live with chronic musculoskeletal pain and depression. Participants receive eight individual phone sessions with a health coach over up to five months, focusing on managing pain and mood. R…

This pilot study tests whether a single session of narrative therapy, a type of talk therapy, can help reduce depression and anxiety in people living with HIV. Researchers will enroll 64 adults from a primary care HIV clinic to see if the therapy is acceptable, feasible, and bene…

This trial tests whether a daily oral oil made from a full-spectrum cannabis plant extract with very low THC (FEN164) can safely help children with autism. The study will include 18 children aged 8 to 17 with moderate to severe autism (Level 2 or 3). Over 20 weeks, researchers wi…

This trial tests whether teaching mothers how to perform aspiration care for their children in the intensive care unit can lower their anxiety and hopelessness. Researchers will compare two teaching methods: a video and a picture booklet. The study includes mothers whose children…

Researchers at the University of Reading are testing an online guided-writing program for people who care for a loved one with Parkinson's disease. The program asks caregivers to complete four writing exercises that encourage them to respond to their own struggles with the same k…

This study tests a phone-based sleep therapy for people who have insomnia and drink alcohol in ways that could harm their health. The therapy adapts standard insomnia treatment to also address alcohol-related thoughts and behaviors. Researchers will first refine the approach with…

This trial tests whether a quilling exercise, a paper craft activity, can reduce fear and anxiety in children aged 9-12 who are about to undergo cardiac catheterization and angiography. Half an hour before the procedure, children in the intervention group will spend 15-20 minutes…

This trial tests whether letting children play video games or paint a mask during nebulizer treatment reduces their anxiety and improves how well they cooperate. The study includes children aged 7 to 12 who are receiving their first nebulizer treatment in the hospital. Researcher…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

This study tested an experimental drug called neflamapimod in 159 people with dementia with Lewy bodies (DLB). The goal was to see if it could improve memory, problem-solving, and attention compared to a placebo. Participants took the drug or a dummy pill for a set period, and re…

This pilot study tests whether a 10-week group program called Cog-Fun Aging helps older adults who worry about their memory. Participants learn about memory changes and practice strategies to manage daily challenges. Researchers compare those who take the program with those who d…

Researchers are testing whether chewing mint-flavored sugar-free gum during childbirth can reduce pain and anxiety in first-time mothers. The trial includes 106 pregnant women at term with no complications, who will chew the gum for at least 20 minutes at different stages of labo…

Researchers are testing whether psilocybin, the active compound in magic mushrooms, can safely help people with Parkinson's disease who also struggle with depression or anxiety. In this pilot study, 12 participants receive two oral doses of psilocybin with psychological support. …

This study is testing whether two devices used together can help new mothers with both depression and urinary incontinence. One device uses magnetic pulses to stimulate brain areas linked to mood, while the other strengthens pelvic floor muscles with electromagnetic energy. Sixty…

This study tests whether a text-message based chatbot support program can reduce symptoms of postpartum depression in people of color who recently gave birth. About 156 participants will either get the chatbot or usual care. The goal is to see if the chatbot lowers depression sco…

This study tested a new cognitive behavioral skills program (CBI) delivered in the metaverse for people with depression and anxiety. 306 participants were split into three groups: one using virtual reality, one using a flat-screen device, and a waitlist group. The program taught …

This trial tests whether a digital cognitive behavioral therapy (CBT) app called Daylight can reduce anxiety and improve health behaviors in adults who have had a heart event, such as a heart attack or stroke, and also experience significant anxiety. Participants will either use …

This study tests whether an oral oil containing THC and CBD can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the active drug or a placebo for 12 weeks. The main goal is to see if agitation scores improve af…

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

Researchers are testing whether a series of multisensory stimulation sessions can reduce depressive symptoms in adults with moderate-to-severe depression. Fifteen participants receive nine 20-minute sessions combining auditory, thermal, and pressure stimuli, calibrated to about 6…

This trial tests two ultrasound-guided nerve blocks for pain relief after thoracotomy, a surgery that opens the chest. One block targets the paravertebral space, while the other targets a point between the transverse process and the pleura. Researchers will compare how much morph…

This study tests whether giving a small amount of the sedative midazolam during anesthesia can lower the risk of delirium (sudden confusion) and anxiety in older adults after surgery. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to r…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

Many children with autism are picky eaters, often refusing fruits, vegetables, and proteins, which can lead to poor nutrition and obesity. This trial tests whether nutritional counseling focused on the Mediterranean diet can help these children become less selective and adopt hea…

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

Researchers at Brigham and Women's Hospital are testing whether automated motivational messages or coach support can improve engagement with SilverCloud, a digital mental health intervention for depression and anxiety. The trial enrolls adults with clinically significant symptoms…

This study tests whether using a virtual reality headset during labor can help reduce pain and anxiety and make the childbirth experience more satisfying. About 92 women in Taiwan will be randomly assigned to either use VR with calming nature scenes and music or receive standard …

This pilot study tested a 6-session virtual program called MASC that teaches mindfulness, self-compassion, and behavior management skills to caregivers of people with Alzheimer's or related dementias. 82 caregivers participated to see if the program is feasible and acceptable. Th…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This small study tests whether empagliflozin (Jardiance), a diabetes medication, can reduce symptoms of major depression. The drug helps the body produce ketones, which may provide an alternative energy source for the brain. Sixteen adults with moderate to severe depression will …

This trial tests whether aromatherapy with rose oil or a massage using that oil can reduce pain, anxiety, and discomfort in women after a cesarean delivery. About 90 first-time mothers will be randomly assigned to receive one of these treatments or a placebo. The goal is to see i…

This study tests whether a 4-week breathing muscle training program can improve lung function, reduce shortness of breath, and lessen cravings in people with substance use disorder. Thirty-four adults receiving inpatient treatment will either do breathing exercises with a device …

This study tests whether a 6-week group class on nonviolent communication (NVC) can improve mental well-being in parents of primary-school children. About 172 parents with mild to severe anxiety or depression symptoms will be randomly assigned to take the class right away or wait…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a new drug called ropanicant in 41 adults with moderate to severe major depressive disorder. The main goal was to check safety and side effects, while also measuring how well it improved depression symptoms using a standard rating scale. The trial was open-label…

Researchers at UCLA are testing whether a savoring intervention, which teaches people to focus on and amplify positive experiences, can improve mood and reduce inflammation in young adults with low positive affect. The study involves 20 participants aged 18 to 25 who will complet…

This trial tests whether watching short family videos or virtual reality nature scenes can reduce anxiety, agitation, and pain in adults staying in intensive care. Researchers will randomly assign 72 participants to one of three groups: family videos, family videos plus VR nature…

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests whether a common probiotic (Lactobacillus rhamnosus GG) can reduce stomach issues like constipation and diarrhea in children with autism spectrum disorder. About 50 children aged 4 to 12 with both autism and ongoing stomach problems will receive the probiotic or …

This study tested a new therapy called Processing of Positive Memories Technique (PPMT) for people with PTSD. Unlike standard treatments that focus on trauma, PPMT helps patients recall and describe positive memories. 70 adults with PTSD were randomly assigned to either PPMT or s…

This trial tests a web-based parent training program, called Parenting Wisely for Residential Treatment, for parents of adolescents aged 11 to 17 in psychiatric residential treatment. The program includes online modules and facilitated parent groups to prepare families for the te…

This trial tests a year-long caregiver training program called MISC-CBO. The program uses video feedback to help community-based organization caseworkers improve their interactions with orphaned and vulnerable children. Researchers will compare children whose caseworkers receive …

This trial tests whether virtual reality-based breathing yoga can reduce pain and anxiety in adults before chest tube removal after cardiac surgery. Participants are randomly assigned to either watch breathing yoga videos through VR glasses for 15-20 minutes before the procedure,…

This early-stage trial tested a drug called MW151 in 27 adults with brain tumors who were receiving whole-brain radiation. The drug aims to reduce brain inflammation and prevent memory and thinking problems that often follow radiation. The study focused on safety, but also looked…

This trial tests whether a six-week program of mandala coloring—two 20-30 minute sessions per week—can improve psychological resilience among midwives working in hospital delivery rooms. These professionals face high stress from heavy workloads, shift work, and traumatic events, …

Researchers are testing whether a virtual-reality program called RC2S+ can be used remotely to help people with schizophrenia improve social cognition, such as recognizing emotions and understanding others' thoughts. The study enrolls 15 adults with schizophrenia or related psych…

Researchers are testing whether daily sessions with a bright light lamp can ease depressive episodes in people with bipolar II disorder. The trial compares a bright 10,000 lux lamp against a dim placebo lamp, with each session lasting 30 minutes. Participants are adults whose dep…

This trial tests whether acupressure applied to the Yintang point—a spot on the forehead—can reduce pain, anxiety, and improve satisfaction during childbirth. About 104 first-time mothers in active labor will receive either Yintang acupressure or a light touch at a non-therapeuti…

This trial tests whether a smartphone app can help people with obesity take a more active role in their care around bariatric (weight-loss) surgery. The app helps users track diet and exercise, report problems, and organize medical documents, with a nurse available to connect the…

This trial tests whether a structured, adapted physical activity program can improve emotion regulation in adults with depressive disorders who have recently been discharged from psychiatric hospitalization. Participants are randomly assigned to either a standard exercise program…

This trial explores whether an internet-based cognitive behavioral therapy (CBT) program, combined with COPD education, can improve mental health, disease knowledge, and quality of life in adults with chronic obstructive pulmonary disease (COPD). Participants complete the 8-10 we…

This study tests whether playing movement-based digital games can improve motor skills in children aged 6-10 with mild or moderate autism. Half the participants will play these games twice a week for 10 weeks, while the other half continues their usual education and rehabilitatio…

This study tests whether making music in a group can help people with schizophrenia who hear voices. Participants will be randomly assigned to one of four activities: creating and performing their own song, singing karaoke, listening to popular music, or curating playlists. The g…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This trial tests whether a group-based psychological treatment for insomnia, adapted for people with depression, anxiety, or PTSD, can improve sleep and reduce psychiatric symptoms. Participants receive either the adjusted CBT-i program or usual care. The study measures changes i…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This trial tests a new psychoeducation program that teaches military veterans with PTSD how sensory processing affects their stress, emotions, and daily life. Participants learn strategies to better regulate overwhelming situations, improve sleep, and engage socially. The study a…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This trial is testing a program called TEAMSS, designed to help fifth graders with elevated anxiety transition more smoothly to middle school. The program includes reading materials, a school tour, group sessions, parent meetings, and teacher consultations. The goal is to see if …

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This trial tests whether a structured, nurse-led empowerment program can boost mothers' knowledge and caregiving practices for children with nocturnal enuresis (bedwetting). Around 200 mothers of children aged 6-12 will either receive the program in small group sessions or contin…

This study explores whether a single-session sleep training program can improve sleep and reduce symptoms of borderline personality disorder (BPD) in teenagers. Teens aged 13-18 with BPD symptoms will receive a brief intervention based on the TSC-Youth protocol, which teaches hea…

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study tests whether weekly live harp music sessions can reduce behavioral symptoms like agitation and anxiety in nursing home residents with moderate-to-severe dementia. Participants in memory care units will listen to a harp therapist play during the late afternoon, a time …

This trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood shortly after a single dose. Around 53 generally healthy adults will take either one of the supplements or a placebo, then complete a series of computer and paper…

This study tests a mobile app-based training designed to help people with social anxiety disorder interpret ambiguous social situations in a more positive, less threatening way. Adults aged 18-60 with moderate to severe social anxiety will use the app over several sessions, and r…

This study tests whether giving family caregivers of people with Alzheimer's or related dementias a tailored list of local resources – addressing needs like food, housing, and support services – can boost their confidence in caregiving. About 360 caregivers in specific Chicago zi…

This trial tests whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can reduce auditory hallucinations in people with schizophrenia who haven't found relief from antipsychotic medications. Participants receive either real tDCS or a…

This trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…

This trial tests whether a smartphone app called MindBoba, which uses problem-solving therapy techniques, can help Chinese Americans reduce stress and anxiety. Participants will be randomly assigned to use MindBoba, a standard cognitive-behavioral therapy app, or receive no app. …

This trial tests whether daily omega-3 fish oil supplements can improve sleep, mood, and behavior in children who have sleep problems and symptoms of ADHD, autism, or both. The study takes a symptom-focused approach, aiming to identify which specific difficulties—like emotional u…

This study follows 140 people with obstructive defecation syndrome (ODS) — a condition that causes straining and difficulty passing stool — who are scheduled for surgery. Researchers will measure depression and anxiety using standard questionnaires before and after the procedure,…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This 12-week trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood in healthy adults. Participants take one of the supplements or a placebo daily and complete four one-hour sessions of cognitive and mood tests. The goal i…

This trial tests whether an internet-based self-help program called Couple HOPES can reduce PTSD symptoms and improve relationship satisfaction in couples where one partner is a military member, veteran, first responder, or healthcare worker with COVID-19-related PTSD. Participan…

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This trial tests whether an eight-session cognitive-behavioral psychoeducation program can reduce internalized stigma in adults with bipolar disorder who are in remission. Participants are randomly assigned to the program or usual care, and their stigma levels are measured before…

This trial tests whether shared virtual reality (VR) experiences can improve quality of life, mood, and family closeness for older adults with mild cognitive impairment or dementia who live in senior communities, and for their adult children who live far away. Participants will t…

This trial tests a new couple-based therapy called Sage for people with borderline personality disorder who struggle with self-injury or suicidal thoughts. The therapy, delivered remotely over 12 sessions, aims to reduce these behaviors by addressing both emotional distress and r…

This trial tests whether a structured, therapist-led dance program can improve cognitive-motor skills, balance, self-esteem, and sensory processing in children aged 6 to 12 with ADHD. Over five weeks, participants attend ten dance sessions designed to combine rhythm and movement …

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The…

This trial tests whether using an immersive virtual reality headset during the first postoperative orthopedic dressing change can reduce anxiety and pain in children and adolescents aged 6 to 18. Participants are randomly assigned to either wear the VR headset during the procedur…

This trial tests a 9-session mindfulness and compassion program, called Cuida2, in 5th and 6th graders. Students are randomly assigned to either the program or a relaxation-based control group. Researchers measure changes in emotional and behavioral problems, academic performance…

This trial tests whether coloring pre-drawn mandala patterns for at least 30 minutes each day can lower anxiety and depression in adults awaiting open-heart surgery. About 69 first-time heart surgery patients will be randomly assigned to either the coloring activity or usual care…

This trial tests whether a gentle electrical stimulation of the vagus nerve through the ear (tVNS) can help athletes recover more quickly after intense training. About 121 professional athletes in sports like swimming, athletics, and gymnastics will use the device daily for 60 mi…

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The…

This study tests whether watching an animated educational video before laparoscopic tubal ligation reduces anxiety and pain more than standard verbal counseling. Eighty women are split into two groups: one receives routine verbal information, the other watches a video. Researcher…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This trial compares two ways to manage pain during hip replacement surgery: an ultrasound-guided nerve block (PENG block) versus injecting anesthetic directly into the joint. The study includes 60 adults scheduled for anterior hip replacement under general anesthesia. The main go…

This trial tests whether a newer nerve block called PENG block provides better pain relief than the standard intra-articular injection for people undergoing hip replacement surgery. Both methods use the anesthetic lidocaine. The study will measure how much morphine patients need …

This study tests whether using a stress ball or watching a short aquarium video with music can reduce fear, anxiety, and pain in children aged 6 to 12 who need an enema for constipation or bloating in the emergency department. Children are randomly assigned to one of the two dist…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests a specially adapted form of cognitive behavioral therapy for insomnia (CBT-i) in people with bipolar disorder who have sleep problems. The therapy includes sleep scheduling, light exposure, and relaxation techniques. Researchers want to see if it improves sleep q…

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this ap…

This study tests two digital sleep interventions designed to help teenagers aged 12-14 improve their sleep regularity and mental health. Participants wear a Garmin device and use a smartphone app that provides personalized feedback on their sleep patterns. The goal is to see if t…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

Researchers at the American University of Beirut are studying whether the rate at which an e-cigarette emits nicotine, called nicotine flux, predicts how much nicotine reaches the body and how users feel. About 142 adult dual users of e-cigarettes and tobacco will use devices wit…

This study looks at whether falls and mobility problems can signal very early, preclinical Alzheimer's disease in older adults who are still cognitively normal. Researchers will follow 355 volunteers aged 65 and older, some with and some without biological signs of Alzheimer's, t…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study looks at how the labels and marketing claims on cannabis products affect what people think about the product's risks and effects. About 2,000 adults in states where recreational cannabis is legal will answer online survey questions after viewing a cannabis advertisemen…

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

Researchers at Hacettepe University are studying people who had surgery for a massive rotator cuff tear. They want to see how the brain's signals to shoulder muscles, shoulder function, and psychological resilience relate to each other. Participants complete shoulder and mood que…

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This study explores the connection between anxiety and frailty in people aged 65 and older who are about to have hip replacement surgery. Researchers will measure anxiety and frailty using standard questionnaires before the operation. The goal is to understand how these factors r…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

This study tests a training program called DECIDE for MOM, designed to help healthcare providers better support pregnant and postpartum individuals with mental health concerns. The training teaches skills like shared decision-making and understanding patients' perspectives. Resea…

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study tests whether offering a $25 gift card encourages older adults from diverse backgrounds to join an Alzheimer's prevention registry. Researchers will recruit 400 people aged 50+ at community events, comparing the gift card to a non-cash gift. The goal is to see if small…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

Researchers at Nantes University Hospital are studying central coherence, the brain's ability to pull complex information into a coherent whole, in women with restrictive anorexia nervosa. The study compares patients in the active phase of the illness with healthy volunteers. All…

Researchers at Nantes University Hospital are comparing how people with different behavioral addictions think, feel, and process social situations. The study includes people with gambling disorder, sexual addiction, and eating disorders with bulimia episodes, along with healthy v…

Researchers at the University of California, San Francisco are studying how the brain processes rewards in people with early-onset schizophrenia, major depressive disorder, post-traumatic stress disorder, or gambling disorder, compared with healthy volunteers. Participants comple…

Researchers are studying whether immune and inflammatory markers in the blood relate to mood, fatigue, and thinking symptoms in people with major depression. The trial follows 30 adults starting SSRI antidepressants and compares them with 20 healthy volunteers. Participants give …

This study tests whether a training program for parents of children who have had a febrile convulsion (a seizure caused by fever) can lower parental anxiety and increase their knowledge about the condition. About 66 parents of children aged 6 months to 5 years will be randomly as…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

This study is a small survey of 10 adults exploring how nutrition, mental health, and faith-based practices relate to recovery from trauma or PTSD. Researchers want to understand what helps people overcome life challenges after stressful events. The results will be used to design…

Researchers at Jacobs University Bremen are running a three-phase study to understand how environmentally friendly behaviors relate to eco-anxiety, well-being, and loneliness. About 1,684 adults complete surveys about their food choices, consumption habits, and feelings of social…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This study tested a brief, computer-based personalized feedback program for adults with chronic pain who drink heavily and take prescription opioids. The program was designed to educate participants about the risks of mixing alcohol and opioids and to motivate them to reduce drin…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study looked at 128 physiotherapy students to see if taking an academic literacy class helped with their reading, writing, and thinking skills. Researchers compared students who took the class to those who did not using surveys. The goal was to understand if such education b…

Delirium is a common and serious problem for critically ill patients in intensive care units. Researchers at the Medical University of Graz are measuring light and noise levels in three ICUs to see whether these environmental factors are associated with the development of deliriu…

This study tested whether a 6-session psychoeducation program could improve autism knowledge, sibling relationships, well-being, and resilience in 88 adult siblings of people with autism. Participants were all neurotypical adults living in Greece. The program was designed to prov…

This study looks at whether certain immune system markers (IL-33, sST2, and CRP) are different in people with panic disorder compared to healthy individuals. Researchers will measure these markers in blood samples from 80 participants who have never taken medication for panic dis…

This study will measure levels of two proteins, LRFN5 and OLFM4, in the blood of 120 people—some with schizoaffective disorder and some healthy. Researchers want to see if these proteins are linked to symptoms, overall function, and inflammation. The goal is to better understand …

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tools lik…

This study tested whether a remote, telehealth approach can work to study how cigarette filter ventilation (the tiny holes in the filter) affects smoking behavior and exposure to harmful chemicals. 64 adult smokers participated from home, using their own devices for video visits …

This study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …

This trial tests whether two mental training methods, computer-based multiple object tracking and mental imagery, can improve tennis performance, thinking skills, anxiety, and body responses in university students taking a tennis course. Participants either practiced tracking mov…

Researchers want to know whether people with depression spend more time looking at their own reflection after recalling a personal failure. The study uses an eye tracker to measure where participants look on a reflective black screen before and after a directed autobiographical r…

Researchers are studying how a full-spectrum medicinal cannabis plant extract with very low THC, called NTI164, moves through the body of healthy adult volunteers. The trial measures how much of the drug reaches the bloodstream and how much leaves the body in urine over up to 28 …

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…

This trial tests whether a single session of transcranial magnetic stimulation (TMS) can alter brain activity related to reward processing in people with major depressive disorder. Researchers will compare active TMS to a sham (inactive) version, measuring brain signals during a …

This observational study examines how the brain processes rewards in people with major depressive disorder compared to those without. Using MRI and EEG, researchers measure brain responses during reward anticipation and feedback. The goal is to identify distinct neural patterns, …

This completed study looked at how 53 young adults (ages 21-34) who regularly vape perceive and react to e-cigarettes containing a new substance called metatine (6-methyl nicotine). Researchers measured how the body processes metatine, puffing behavior, sensory experiences, and a…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study tests whether removing price promotions (like discounts and bulk deals) from online pizza delivery menus changes what people order and eat. About 600 adults in three UK cities will order a real pizza for their household, with or without promotions. Researchers will tra…

This study looks at how stress changes the way opioid painkillers work in people with chronic back pain. Researchers will give participants oxycodone, a pain blocker, or a placebo in a lab setting to measure pain relief and drug liking. The goal is to understand why some people m…

This study looks at how different front-of-pack nutrition labels—warning labels versus traffic light labels—affect food choices and negative emotions in people with eating disorders. Around 246 UK adults with a current or past eating disorder will make hypothetical food choices o…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study tests whether telling Taiwanese university students their ALDH2 gene type, which affects alcohol intolerance, changes their drinking habits and attitudes. Participants receive their genotype results along with standard health education about alcohol risks. Researchers …

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This study looks at how autistic people who also have anorexia nervosa differ in brain structure and behavior from autistic people without anorexia. Researchers want to understand if 'masking' (acting non-autistic to fit in) is linked to eating disorder symptoms and brain changes…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

This study follows 100 adults who drink alcohol at least weekly and have some interest in cutting back. Researchers want to see how alcohol use, suicidal thoughts, and decision-making are linked. Participants get access to a self-guided online cognitive behavioral therapy program…

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…

This study surveys over 3,700 medical students and interns across the Middle East to find out how many have gastroesophageal reflux disease (GERD). It also looks at how eating habits, stress, anxiety, and depression relate to GERD and how the condition affects their quality of li…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

Researchers are testing whether a non-invasive brain stimulation technique called high-definition transcranial alternating current stimulation (HD-tACS) can change brain wave activity in people with schizophrenia who hear voices. The study compares patients with auditory hallucin…

This study looked at how adults who smoke cigarettes daily or only some days might react if certain tobacco products were no longer available. Researchers created a pretend online store where participants could shop for cigarettes and other nicotine products under different rules…

This study tests whether a simple team debriefing tool, called an After-Action Review, can help child welfare teams better connect children and families to mental health services. Researchers will work with 320 participants, including caseworkers and family members, to see if the…

This study tests whether an AI tool that uses electronic medical records can help predict and reduce delirium (sudden confusion) in older adults after major surgery. About 60 people aged 65 and older will take part. The goal is to see if giving doctors a delirium risk alert can l…

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This trial tests whether xenon gas can help reveal how the brain loses and regains consciousness. Healthy volunteers aged 20 to 40 will breathe xenon at concentrations up to 60% for two hours. Researchers will measure the brain concentration of xenon at the moment consciousness i…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

This study tested whether a tool inside a patient portal could help people with mild memory problems discuss and document their future healthcare wishes. Researchers enrolled 300 older adults with cognitive impairment who had a patient portal account. The goal was to see if peopl…

This completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …

This study tested whether regular support calls can help veterans who are not ready to quit smoking to eventually stop. Over 500 veterans received either four calls a year (enhanced care) or one call a year (standard care). The goal was to see if more calls led to more quit attem…

This study tests whether brain scans and decision-making tasks can predict how well people with anxiety and depression respond to different types of talk therapy. Participants will be randomly assigned to one of three therapies: behavioral activation, exposure-based therapy, or s…

This study looks at women who have had bariatric (weight-loss) surgery and later given birth. It aims to understand if these women face higher rates of depression or anxiety after childbirth, and how their weight and nutrition change during this time. By tracking these factors, r…

This study investigates how emotional stress impacts sleep and learning in children aged 7 to 12 with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD). Researchers will use a social stress task to trigger emotional responses, then monitor sleep pa…

This study follows children with specific reading disorders (like dyslexia) who previously took part in a training program using the Poppins Clinical app, which combines musical, cognitive, and written language exercises. The goal is to see if the benefits of that training on rea…

This study asks whether a single 30-minute session of moderate exercise can raise natural brain chemicals called endocannabinoids and improve thinking, stress, and mood in children and teens aged 9 to 17. Participants are randomly assigned to brisk walking or jogging on a treadmi…

This study follows people who have a 50% chance of inheriting a gene for spinocerebellar ataxia, a group of progressive brain disorders that affect movement and coordination. The goal is to identify the earliest clinical signs and biological markers that appear before the disease…

This study uses brain scans to compare how a single dose of two ADHD medications—guanfacine (a non-stimulant) and lisdexamfetamine (a stimulant)—affect brain function in children and teens with ADHD, relative to a placebo. Participants perform tasks of attention, working memory, …

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This study investigates how three weeks of cannabis abstinence influences brain responses to threat, reward, and cannabis cues in women with cannabis use disorder. Participants are randomly assigned to either continue using cannabis as usual or abstain for three weeks, with lab v…

This study looks at how often people who visit a community psychiatrist have had suicidal thoughts in the two weeks before their appointment. Researchers will ask about 262 adults to fill out questionnaires measuring suicidal risk, psychological pain, and self-esteem. The goal is…

This study looks at what makes some women naturally lean without dieting or eating disorders. Researchers will compare eating habits, physical activity, body composition, and appetite responses in three groups: constitutionally lean women, normal-weight women, and women with anor…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This study explores the experiences of people diagnosed with a psychiatric disorder who have used psychedelic substances on their own to relieve symptoms. Researchers will conduct in-depth interviews with 20 participants to understand their motivations, methods, and perceived eff…

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This observational study looks at whether the types of bacteria living in the gut, along with diet and lifestyle, are linked to a person's risk of catching SARS-CoV-2. It follows over 900 children, their family members, and teachers in Spain for 17 months. Researchers collect sto…

This study looks at how common dissociative tendencies are in adults with obesity who are seeking medical or surgical help for the first time. Participants fill out questionnaires that measure dissociation, eating behaviors, and other related factors. The goal is to better unders…

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…