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Could cannabis help fight diabetes? a study investigates

NCT ID NCT04114903

Knowledge-focused Sponsor: University of Colorado, Boulder Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use and after four weeks of regular use. The goal is to understand if cannabis might play a role in metabolic health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cannabis flower with varying levels of THC and CBD
What this could lead to
If cannabis compounds reduce inflammation and improve insulin sensitivity, this could point toward new approaches for managing type 2 diabetes and obesity.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may vary by individual, and cannabis use carries its own health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

233 people

The number who actually took part.

Started

Nov 2019

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Community Sample

Ages

21 to 40 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Able to provide informed consent * Cannabis users in Study A must have smoked or vaped cannabis at least once since January 1st 2014 with no negative effects but NOT used in the past three months * Cannabis users in Study B must have been a regular (at least weekly) user for at least a year * Non-users in Study B cannot have used any cannabis in the previous year * Weight stable (\<5 pound fluctuation in the past six months) * Planning to remain in the Boulder-Denver area for the next month * Fasting blood glucose greater than or equal to 55 mg/dl and less than or equal to 126 mg/dl * Cannabis users in Study A must endorse knowledge of the procedure(s) for smoking or vaping cannabis Exclusion Criteria: * Known auto-immune disease * Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs * Daily tobacco (cigarette, E-cigs, smokeless) user, given the impact of tobacco smoking on insulin function * Blood alcohol level greater than 0 at screening * Current use of medications for glucose lowering, immunosuppression, or anti-inflammation * Acute illness * Current use of psychotropic medications * Current diagnosis of diabetes * Heavy drinking as defined by an Alcohol Use Disorders Test (AUDIT) * Females can not be pregnant or trying to become pregnant * Females can not be nursing mothers * Have donated blood in the 8 weeks before the study or intend to donate blood in the 8 weeks after the study.

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Conditions

The condition(s) this trial relates to.

cannabis dependence diabetes mellitus Insulin Resistance Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis use Insulin sensitivity Obesity Type 2 diabetes

Contacts and locations

Locations

  • Center for Innovation and Creativity

    Boulder, Colorado, 80301, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.