OBESITY

This study looks at whether time-restricted eating (eating all meals within 8 hours) helps people with obesity keep weight off after losing it. About 212 participants will follow a calorie-restricted diet to lose 8-10% of their weight, then be split into two groups: one eats with…

This study aims to find the best weight-loss medication for people with bipolar disorder by matching drugs to specific obesity types (like 'hungry brain' or 'hungry gut'). About 100 adults aged 18-65 with bipolar or schizoaffective disorder and obesity will receive one of three F…

This study tests whether metformin, a diabetes medication, can help adults with intellectual disability who have gained weight from antipsychotic drugs. About 100 participants will receive either metformin or a placebo for several months. The goal is to see if metformin leads to …

This study looks at whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. About 45 participants will use an app or a standard program for 6 months, weighing themselves dail…

This study tests a new weekly injection, KAI-9531, to see if it helps people with obesity lose more weight than the existing drug semaglutide or a placebo. About 1,200 adults with a BMI of 35 or higher who have tried to lose weight before will take part. The main goal is to measu…

This study tests a once-weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The goal is to see if the drug can improve breathing during sleep and help with weight loss. Participants will be fo…

This study tests a remote behavioral program for people who have regained at least 5% of their weight after bariatric surgery. 200 participants will be randomly assigned to either the program or a control group that receives standard dietary advice. The goal is to see if the prog…

This study tests whether adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning improves gum health in people with both obesity and gum disease. Twenty-four participants will receive either standard cleaning alone or cleaning plus light ther…

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. Twenty participants will follow an intensive nutrition program for several weeks. Researchers will measure weight los…

This study is testing whether a probiotic supplement can help adults with obesity lose weight and reduce food addiction. Researchers will look at changes in gut bacteria and metabolism. The study involves 100 adults aged 18-50 with a BMI between 25 and 40. Participants will take …

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a breathing machine. The goal is to see if the drug helps them lose weight and reduce breathing pauses during sleep …

This study tests several experimental treatments to help adults with obesity or overweight lose weight and keep it off. About 1,481 participants will try different medicines or a placebo. The goal is to find safe and effective options for long-term weight management.

This study tests whether a simple saliva test can predict how well people with obesity will respond to the weight-loss drug semaglutide. Researchers will compare weight loss in people with a specific saliva biomarker versus those without it. The goal is to make obesity treatment …

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or have obesity and type 2 diabetes. About 630 adults will receive either the active drug or a placebo for several weeks. The main goal is to see if the drug safely helps reduce body we…

This study tests a new once-weekly injection, NNC0487-0111, in 300 adults who are overweight or have obesity and also have moderate-to-severe obstructive sleep apnea treated with a breathing machine. Participants are randomly assigned to receive either the study drug or a placebo…

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and improve blood sugar control over 6 months. About 30 adults will either use the app or follow a standard program, weighing themselves daily and checking blood sugar bef…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare tumor cell activity from …

This study compares two weight-loss surgeries for people with severe obesity: the newer omega gastric bypass with a 150 cm loop and the standard Roux-en-Y gastric bypass. About 368 adults aged 18-65 with a BMI of 40 or higher (or 35-40 with related health issues) will take part. …

This study tests whether a structured lifestyle program can help Malaysian adults with early type 2 diabetes achieve remission—meaning blood sugar returns to normal without medication. About 92 participants will either follow an intensive diet and exercise plan or receive usual c…

This study tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver scarring in people with fatty liver disease and obesity. Thirty adults with liver fibrosis will take either nicotinamide or a placebo daily for one year. Researchers will measure changes in liv…

This study tests a new weekly injection called HDM1005 against the existing drug tirzepatide for weight loss in 372 adults with obesity (BMI 28-40) who do not have diabetes. Participants receive either HDM1005 or tirzepatide for 52 weeks, plus diet and exercise counseling. The ma…

This study tests if bariatric (weight-loss) surgery is more effective than standard medical treatment at making nonalcoholic steatohepatitis (NASH) disappear without worsening liver scarring. It involves 100 obese adults with advanced liver fibrosis. Participants are randomly ass…

This study tests whether a mobile health program can help young adults (ages 18-39) who have survived cancer and are now overweight or obese lose weight. Participants will either get a full smartphone-based weight management program or just digital tools and support. The goal is …

This study tests a new, less invasive procedure called PSAM that cuts some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight. It is for adults aged 18-70 with a BMI over 35 who are eligible for weight loss proced…

This study tests a program called MiWeigh that helps people with obesity and weight-related health problems like diabetes or high blood pressure lose weight. About 500 adults will either join the program or receive standard weight-loss information. Researchers want to see if the …

This study tests a once-daily oral medication called orforglipron in 125 adolescents (ages 12-17) who have obesity or are overweight with related health issues. Participants take either the drug or a placebo for about 18 months. The main goal is to see how much body mass index (B…

This study looks at whether changing gut bacteria with antibiotics can help people keep weight off after losing at least 10% of their body weight. About 200 adults with obesity (BMI 28-35) will take either antibiotics or a placebo after weight loss. Researchers will track weight,…

This study tests a new weight loss program that starts with simple steps and adds more support only if needed, aiming to save money while helping people lose weight. About 492 adults with obesity will be assigned to this new program, a standard program, or a self-guided group. Th…

This study looks at whether robot-assisted weight-loss surgery is worth its higher cost compared to standard laparoscopic surgery. About 482 adults with obesity will be randomly assigned to one of the two surgical methods. Researchers will track complications, quality of life, an…

This study looks at whether eating all your food within a specific 9-hour window each day (time-restricted eating) can improve blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Researchers will compare three different eating windows to see if…

This study looks at whether eating according to the Dietary Guidelines for Americans (DGA) helps heart health more when people also lose weight. About 70 adults with overweight or obesity will follow either a DGA-style diet or a typical American diet, with some restricting calori…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain muscle mass and strength while taking GLP-1 medications like Ozempic or Mounjaro. About 100 adults who recently started or plan to start …

This early-phase study tests whether daily consumption of milk polar lipids (a natural milk fat component) can improve cholesterol levels, reduce inflammation, and positively affect gut bacteria in adults with high cholesterol and abdominal obesity. About 130 participants will ta…

This study tests a new medicine called MET097, given as a weekly shot, to help adults who are overweight or have obesity and type 2 diabetes lose weight. About 1,000 people will take part; two-thirds get the real medicine and one-third get a placebo. The study lasts about 21 mont…

This study looks at whether resistance exercise and/or extra protein can help people with obesity keep their muscle mass and physical function while losing weight with drugs like semaglutide and tirzepatide. About 232 adults will be randomly assigned to one of four groups: contro…

This study aims to help overweight or obese taxi and ride-share drivers lose weight. About 1,785 drivers will receive a combination of counseling, text messages, phone support, and self-monitoring tools. The goal is to find the most effective and affordable way to help this hard-…

This study tests an experimental drug called ARO-ALK7 in adults with obesity, some of whom also have type 2 diabetes. The goal is to check if the drug is safe and how it affects weight. Participants will receive either the drug or a placebo, and some will also take an existing we…

This study tests a weekly injection called tirzepatide to help adults with obesity lose weight and prevent type 2 diabetes. About 3000 participants without diabetes will receive either tirzepatide or standard care for up to 5 years. The goal is to see if the drug leads to meaning…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who do not use a breathing machine (CPAP). The goal is to see if the drug can reduce the number of breathing pauses during sleep and help with weight loss. Participants will receive either…

This study tests whether giving an intravenous iron supplement before weight-loss surgery can prevent anemia and improve quality of life in obese patients with low iron levels. About 200 participants will receive either the iron infusion or a placebo before their surgery. The goa…

This early-phase study at Vanderbilt University is testing whether a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a plac…

This study tests a drug called efsubaglutide alfa to help people who remain obese six months after weight-loss surgery. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they lose and if the dr…

This study tests an experimental drug called MKP10241 in 68 adults who are obese, with or without type 2 diabetes. The main goals are to check how food affects the drug, how it moves through the body, and whether it is safe. Participants will take different doses of the drug or a…

This study aims to find the best telehealth weight loss program for adults aged 65-85 who have obesity and at least two other chronic health conditions. Researchers will test different treatment combinations to see which helps participants lose the most weight over 52 weeks. The …

This study looks at whether limiting food intake to a 9-hour period each day can improve how the body uses insulin and manages blood sugar in people with obesity and prediabetes. Researchers will measure changes in insulin sensitivity, daily glucose control, and fat and muscle bi…

This study tests whether a virtual weight management program, including a weight-loss drug, can help people with obesity and advanced kidney disease lose enough weight to become eligible for a kidney transplant. About 60 adults will either join the program or continue their usual…

This study looks at whether a weight loss procedure called Endoscopic Sleeve Gastroplasty (ESG) is safe and effective for people with ulcerative colitis who are obese and need or have had colon removal surgery. About 12 participants will be followed to see how much weight they lo…

This study looks at 150 adults with obesity who stopped taking GLP-1 weight-loss drugs (like Wegovy or Mounjaro) because of side effects or not losing enough weight. It compares a procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size, to lifestyle chan…

This study tests two new drugs, CagriSema and cagrilintide, to help children and adolescents with overweight or obesity lose weight. About 460 participants will receive either the study drugs, a standard drug (semaglutide), or a placebo for up to 4 years and 10 months. The goal i…

This study tests whether replacing some animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to see if …

This study tests a new weekly injection called eloralintide to see if it helps adults with obesity or overweight lose more weight when added to their current weekly weight-loss medication. About 900 participants will receive either eloralintide or a placebo for around 80 weeks. T…

This study tests whether inviting up to two friends, family members, or co-workers to join a weight loss program helps Black or Hispanic adults with obesity lose more weight. About 264 participants will be randomly assigned to a lifestyle program either alone or with their social…

This study tests a weight loss program for 522 low-income adults with obesity in Louisiana. Participants will receive health coaching, digital self-monitoring tools, and group support to lose weight and improve health. The goal is to see if the program helps people lose weight an…

This study is testing an investigational drug called angiotensin-(1-7) to see if it can improve cardiovascular health in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery function during a short infusion of the drug compared …

This study looks at how three weight-loss medications—CagriSema, semaglutide, and cagrilintide—affect muscle health in 100 adults aged 50-70 with obesity and slightly high blood sugar. Participants will receive one of the drugs or a placebo for up to 15 months. The goal is to mea…

This study is testing a new single-port robot to help with weight loss surgery in 50 overweight or obese adults. The goal is to see if the robot makes the surgery safer and more effective. Participants will have their weight loss, blood pressure, blood sugar, and any complication…

This study tests whether eating protein and fiber bars three times a day as part of a low-calorie diet helps people with overweight or obesity lose weight and improve heart, joint, and metabolic health. About 144 adults aged 18-65 with a BMI between 27 and 40 will be assigned to …

This study is testing different ways to increase the dose of a medication called retatrutide to help people with obesity or overweight lose weight. About 600 participants who do not have diabetes will take the drug for around 113 weeks. The main goal is to see how much weight the…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study tests whether a new medicine, UBT251, is safe and helps people with overweight or obesity lose weight. About 333 adults will receive either UBT251 or a placebo (dummy pill) by chance. The main goals are to check for side effects and measure weight change over time.

This study tests a telehealth program for cancer survivors to help them quit smoking, lose weight, and be more active. About 1500 adults who have had cancer (except skin cancer) and have at least one risk behavior will join. Some will get 12 coaching sessions by phone or video, w…

This study looks at whether a type of diabetes medication (GLP-1 receptor agonists) can help people with chronic kidney disease by improving how their fat tissue works. Researchers will measure changes in fat around the kidneys and heart, as well as kidney function, in 250 adults…

This study explores whether a culturally tailored sleep program can help African American adults who sleep 6 hours or less and have overweight or obesity. The goal is to increase sleep and physical activity to reduce obesity-related health risks. The research has two phases: firs…

This study tests whether a simple, home-based breathing exercise program can improve brain function and reduce inflammation in adults with obesity. Researchers will measure blood flow to the brain and immune system changes in 30 participants before and after 8 weeks of training. …

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 72 patients and 24 doctors will take part. The goal is to see if the tool is easy to use and…

This study looks at whether adding a procedure called omentopexy (stitching part of the stomach lining to the abdominal wall) during sleeve gastrectomy can prevent new heartburn. About 526 adults with obesity will be randomly assigned to get sleeve surgery alone or with omentopex…

This study tracks the safety and effectiveness of the Orbera365 intragastric balloon, a device placed in the stomach to help with weight loss. About 200 obese adults in Europe will be followed during the time the balloon is in place (up to 12 months) and for 30 days after removal…

This study tests a program called FEAST Perinatal Support Program for pregnant Latino individuals. The program offers nutrition education, cooking skills, social support, and grocery gift cards to help participants eat healthier. The goal is to see if the program is practical and…

This study looks at whether doing aerobic exercise before eating (fasted) is better for heart health and weight loss than exercising after a meal. Over 16 weeks, 40 adults with overweight or obesity will be assigned to either fasted or fed exercise. Researchers will measure chang…

This study tests if doing many short, one-minute exercise sessions throughout the day (called 'exercise snacks') can improve fitness and health in adults with obesity. Researchers will enroll 80 inactive adults aged 35-64 with a BMI of 30-45. The goal is to see if this approach i…

This early-stage study tests a new drug called LY4167586 in 84 adults who are overweight or have obesity but are otherwise healthy. The main goal is to check the drug's safety and how the body processes a single dose. Participants will be monitored for about 7 months, and the stu…

This study compares the experimental drug CagriSema (cagrilintide and semaglutide) to a calorie-restricted diet in 80 adults with obesity. It measures how each approach changes the body's energy use, including sleeping metabolic rate. The trial lasts about 1.5 years, and all part…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study looks at whether an online weight management program for child care teachers can lead to healthier eating and more physical activity for the 2-5-year-old children in their care. About 84 child care centers and over 900 participants (directors, teachers, and children) w…

This study tests a once-weekly injection called tirzepatide in adults who are obese or overweight with related health issues like high blood pressure. About 2,500 participants will receive one of three doses or a placebo, along with diet and exercise advice. The main goal is to s…

This study tests whether a dietary supplement made from omega-3s (called SPM) can reduce blood vessel inflammation and improve artery function in 60 adults with obesity and high blood pressure. Participants will take the supplement or a placebo for 12 weeks. The goal is to see if…

This study looks at whether adding extra protein to your diet can protect your muscles while you lose weight with GLP-1 medications like Ozempic. About 130 adults with obesity (BMI over 30) will take the drug and either follow standard care or get protein-focused meal advice. The…

This study tests whether a 6-month program combining exercise training, problem-solving skills, and support from community health workers can improve fitness and health in 210 adults with type 2 diabetes, obesity, and early signs of heart trouble. Participants have low income and…

This study looks at whether a special clinic focused on heart health and weight can help obese adults with heart disease lose weight and improve their health. About 60 participants will be followed for 12 months to measure weight loss, body mass index, and belly fat. The goal is …

This study tests a modified version of sleeve gastrectomy (a common weight-loss surgery) to see if it can reduce acid reflux, a frequent side effect. About 44 adults with obesity and GERD will be randomly assigned to the standard or modified surgery. The main goal is to measure c…

This study tests a new weekly injection called KAI-9531 to help people with obesity lose weight. About 250 adults with a BMI of 35 or higher who have tried and failed to lose weight through diet and exercise will receive either the drug or a placebo for 48 weeks. The main goal is…

This study looks at whether a probiotic called Lactobacillus paracasei LC-19 can help overweight or obese adults lose weight and improve their metabolism. Over 12 weeks, participants will follow a reduced-calorie diet and exercise plan, and also take either the probiotic, a weigh…

This study tests an experimental drug called ALN-2232, alone or together with an approved weight-loss medication (tirzepatide), in adults with obesity. The goal is to see if the combination is safe and helps people lose more weight. About 156 participants with a BMI between 30 an…

This study tests a new drug called brenipatide in healthy adults who are overweight or have obesity. Participants receive different doses as injections under the skin to see how much weight they lose and if the drug is safe. The study lasts about 42 weeks and involves 150 people.

This study looks at the best way to maintain weight loss after initial success with a weight-loss drug called mazdutide. It will test whether a year of intensive lifestyle changes, a lower dose of the drug, or both together can help people with obesity keep the weight off. The st…

This study tests whether mobile health technology, like smartphone apps and activity trackers, can help overweight or obese African American women in low-resource areas increase their physical activity. About 325 women aged 21-75 from specific neighborhoods near Washington, DC wi…

This early-stage study tests a new drug called DA-1726 in 139 people with obesity but otherwise healthy. The main goal is to check if the drug is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor side effects, drug levels…

This study tests whether a new medication, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have both heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a pl…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The goal is to check the drug's safety, how the body processes it, and its potential to help with weight and blood sugar control. About 564 part…

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by standard inhalers. About 84 participants will be randomly assigned to receive either the balloon pl…

This study tests whether a type of counseling called acceptance and commitment therapy (ACT) can help people who have had weight-loss surgery stay physically active and avoid regaining weight. About 164 adults who had surgery 6 to 20 months ago will either receive ACT or standard…

This study tests a new medicine called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The goal is to see if the drug is safe and helps with weight loss, either alone or with another weight-loss drug. Participants receive injections and are closely m…

This study looks at people who had a sleeve gastrectomy but didn't lose enough weight or regained it. It compares two follow-up surgeries: a newer, simpler one called SADI-S and a standard one called DS. The goal is to see if SADI-S works just as well for weight loss but with few…

This study is testing a program that combines medication (Naltrexone + Bupropion) with counseling to help people lose weight and quit smoking before they have bariatric surgery. The goal is to see if this approach is practical and acceptable for patients. About 20 adults who smok…

This study tests whether a low dose of the drug semaglutide can help obese adults lose weight and improve heart health. Sixty Pakistani adults without diabetes will receive weekly injections and lifestyle advice for 24 weeks. The main goal is to measure how much weight they lose.

This early-stage study tests an experimental injection called SHR-2906 in healthy volunteers and people with obesity. The main goal is to check safety and how the body processes the drug. Around 124 participants will receive either the drug or a placebo to gather initial data.

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or usual care to see if it helps with weight loss and blood sugar control. The goal is to understand if this d…

This study tests whether tirzepatide, a weight-loss medication, can reduce the burden of atrial fibrillation (an irregular heart rhythm) in 100 adults with obesity. Participants will receive either tirzepatide or a placebo for 12 months. The goal is to see if significant weight l…

This study checks if two versions of the drug survodutide work the same way in the body. It involves 80 healthy adults who are overweight or have obesity. Participants will receive both formulations at different times to compare how the drug is absorbed and processed.

This study tests a new weekly injection called KAI-9531 to help people with obesity or overweight lose weight. It includes 1,800 adults who do not have diabetes but have weight-related health problems like high blood pressure or sleep apnea. Participants receive either the drug o…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study compares two ways to help people with overweight or obesity lose weight: avoiding tempting situations (AVOID) or practicing self-control when faced with cravings (RESIST). About 500 adults will be followed for 12 months to see which approach works better for weight los…

This study tests whether a daily ketone ester drink can reduce liver fat and improve blood sugar control in 40 adolescents and young adults (ages 18–25) with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). Participants are randomly assigned to drink …

This study tests two minimally invasive procedures that reduce stomach size to help with weight loss. It involves 184 adults aged 21–65 with obesity (BMI 30–50) who have not lost weight through diet or exercise alone. Participants will receive either the new EndoZip system or the…

This early-stage trial tests whether attapulgite, a natural clay, is safe and helps reduce weight in 40 adults with obesity or overweight with type 2 diabetes. Participants take attapulgite and are monitored for changes in BMI, waist size, and body fat. The goal is to see if this…

This study looks at whether a stepped-care digital health program can help adults with obesity maintain at least 5% weight loss for a year. Participants first lose weight through group counseling and meal replacements, then are randomly assigned to usual care, self-monitoring wit…

This study looks at whether whole or nonfat milk is better for body fat, heart health, and diet in 200 children aged 9-12 who have a higher BMI. Participants drink either whole or nonfat milk for one year while researchers measure changes in fat mass, lean mass, and other health …

This study tests whether simple home-based strategies and wearable devices can help reduce the negative health impact of evening screen time. Researchers will enroll 30 adults who spend at least 3 hours per day on recreational screens and have risk factors for heart disease, diab…

This study tests whether an intensive weight loss program—including meal replacements, counseling, and weight-loss medication—works better than standard care for adults with severe obesity. About 600 participants aged 18 to 60 with a high BMI and related health issues like diabet…

This study is testing a smartphone app with phone coaching to help teens and young adults who are overweight after a stem cell transplant. The goal is to see if the app can help them lose weight and improve their health. The study will include 20 people aged 13 to 30 who are at l…

This study tests a new drug, maridebart cafraglutide, in people with heart failure and obesity. The goal is to see if it reduces heart failure events like hospitalizations and urgent visits, and improves symptoms. About 5,056 adults with a BMI of 30 or higher will take the drug o…

This study tests a new weekly injection called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for 75 weeks. Researchers will measure changes in body weight, fat, waist size, and b…

This study tests whether a drug called ACM-001.1 can help prevent muscle loss in obese people taking the weight-loss medication semaglutide. About 120 adults with a BMI of 30 or higher will receive either ACM-001.1 or a placebo alongside semaglutide, and later continue ACM-001.1 …

This study tests a new once-weekly injection called NNC0487-0111 for weight loss in adults with obesity. About 600 participants will receive either the drug or a placebo for 68 weeks. The main goal is to see how much body weight they lose and if the treatment is safe.

This study tests a new drug called BGM0504 against an existing weight-loss medication, tirzepatide, in adults with obesity. About 90 participants who do not have diabetes will take one of the two drugs for 26 weeks. The main goal is to see how much weight they lose and whether th…

This early-stage study tests a new drug called MBX 4291 in 124 adults with obesity (BMI 30 to under 50). The main goal is to see if the drug is safe and how well people tolerate it. Participants receive either the drug or a placebo as an injection under the skin. The study is cur…

This study looks at whether losing weight and exercising can improve walking ability and emotional well-being in veterans who are overweight and have had a stroke. About 130 participants will be assigned to a diet program, a diet-plus-exercise program, or a waitlist. The goal is …

This study tests an experimental drug called CS060380 in adults with both fatty liver disease (MASH) and obesity. About 120 participants will receive either the drug or a placebo, plus a weight-loss medication, for 36 weeks. The goal is to see if the drug reduces liver fat and bo…

This early-stage study is testing a new drug called HM17321 to see if it is safe and how the body processes it. About 90 healthy and obese adults will receive either the drug or a placebo. The main goal is to check for side effects, not to treat obesity yet.

This early-stage study tests a new drug called HRS-5817, given as an injection, to see if it is safe and how the body processes it. The study involves 92 healthy adults, some with obesity and some without. Researchers will monitor side effects and measure drug levels in the blood…

This study tests a new once-weekly injection called eloralintide for weight loss in adults with obesity or overweight who do not have type 2 diabetes. About 1,980 participants will receive either the drug or a placebo for up to 75 weeks, with some continuing for 2 more years. The…

This study tests whether adding weight-loss medications (topiramate, phentermine, or both) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained a…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study looks at whether semaglutide, a drug already used for weight loss, can help people with HIV who are obese lose more weight than just diet and exercise. About 80 adults with well-controlled HIV will take semaglutide or follow standard lifestyle advice for 28 weeks. Rese…

This study looks at whether a daily capsule made from fermented fruits and vegetables (Rutazyme® lemon fermented product) can help improve metabolic health in adults with obesity. Forty adults aged 18 to 65 with a BMI of 27 or higher will take either the active capsule or a place…

This study tests a new weekly injection called retatrutide (LY3437943) to help people with obesity or overweight who also have weight-related health problems like high blood pressure or heart disease. About 300 adults will receive either the drug or a placebo, along with diet and…

This study looks at whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older Veterans who have obesity and signs of muscle loss (sarcopenia). About 50 Veterans aged 55 and older will take part. The goal is…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30 or higher) lose weight and improve their fertility. About 98 men aged 22-40, whose partners are also in the study, will follow the program while undergoing assisted…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. The goal is to see if it helps control blood sugar and reduce weight.

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat better and control blood pressure. The goal is to see if th…

This study tests whether empagliflozin, a diabetes medication, can improve artery stiffness in 50 veterans with obesity but without diabetes. Participants will take either the drug or a placebo for 12 weeks, and researchers will measure changes in arterial health. The goal is to …

This study tests the safety and effectiveness of new medicines to help children and teens with obesity or overweight manage their weight long-term. It includes 125 participants aged 12 to 17 who have already tried lifestyle changes like diet and exercise without enough success. T…

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural nighttime drop in blood pressure in people with obesity. Obese individuals often have high nighttime blood pressure, which raises their risk for heart problems. Res…

This study tests whether adding a low dose of levothyroxine (a thyroid hormone medication) to a healthy diet and exercise program helps people with obesity lose more weight and keep it off. About 286 adults aged 25-60 with mild to moderate obesity and slightly high thyroid-stimul…

This study compares two different programs designed to reduce heart disease risk factors in Black women after pregnancy. Researchers will track changes in blood pressure and body weight at 6 weeks and 12 months after delivery. The goal is to find the best way to support heart hea…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) can help adults with obesity lose mostly fat instead of muscle and bone. About 63 participants will receive one of three treatments for 52 weeks, plus lifestyle advice. The …

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study tests a weight loss program for adult survivors of childhood acute lymphoblastic leukemia (ALL) who are overweight or have obesity. Participants receive a weekly injection of tirzepatide plus remote, supervised resistance exercise three times a week for 28 weeks. The g…

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach helps Veterans lose more weight and reduce PTSD symptoms better than standard care. About 182 Veterans will take part…

This study tests a new drug, maridebart cafraglutide, in 250 adults with obstructive sleep apnea who are overweight or obese and already use a breathing machine (PAP therapy). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 …

This study looks at whether combining bariatric surgery with GLP-1 weight-loss drugs works better than surgery alone for severe obesity. About 200 adults aged 18-60 with a BMI of 35 or higher will take part. The goal is to see if the combo leads to greater weight loss and better …

This study looks at whether adding protein supplements to a weight-loss plan (diet and the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part, with some getting just diet, some diet plus…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults to see if the drug helps control disease risk. The goal is…

This early-stage study tests a new drug called ABBV-295 in 48 adults with obesity. The main goals are to check safety, how the drug moves through the body, and any weight changes. Participants receive multiple injections of the drug or a placebo over several weeks.

This study compares two approaches for people with severe obesity: a non-surgical program using meal replacements, behavioral support, and weight-loss medication versus bariatric surgery. Researchers will track 500 adults aged 18-60 to see which method better improves health and …

This study tests whether taking glutamine, a natural amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo powder. The goal is to s…

This study tests a practical program that uses motivational interviewing—a supportive counseling style—to help children ages 2 to 8 with overweight or obesity lower their body mass index (BMI). About 6,600 children from Kaiser Permanente clinics will take part over two years. The…

This study looks at whether adding whole-body vibration sessions to a standard 3-week weight-loss program helps obese teenage boys burn more energy while resting. About 28 boys aged 13-18 will either get the vibration training plus the program or just the program alone. Researche…

This study tests an experimental daily pill called KAI-7535 to see if it helps people with obesity or overweight lose more weight than a placebo. The trial includes 320 adults who also have at least one weight-related health problem like high blood pressure or sleep apnea. Partic…

This study tests a once-weekly medicine called tirzepatide in 300 teens with obesity and at least two weight-related health issues like high blood pressure or prediabetes. Participants receive the drug or a placebo along with healthy eating and exercise advice for about 76 weeks.…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants receive either the drug or a placeb…

This study tests whether two approved drugs, mirabegron and tadalafil, can improve how the body handles sugar in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drugs can reverse prediabetes a…

This study tests whether a diet rich in plant-based protein can help adults aged 55 and older with obesity lose weight while preserving muscle. Two hundred participants will follow a calorie-restricted diet for six months, with either mostly plant or mostly animal protein. Resear…

This study looks at whether adding different exercise programs to a Mediterranean diet can lower inflammation better than diet alone in adults aged 18-65 with obesity and non-alcoholic fatty liver disease (NAFLD). About 90 participants will be assigned to diet only, diet plus one…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. Sixty adults aged 21-65 with a BMI of 25 or higher and signs of insulin resistance will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. Re…

This study tests whether a time-efficient breathing muscle training can lower blood pressure in adults with obesity. About 44 participants with a BMI between 30 and 40 will do the training at home and have their blood pressure measured in the lab and at home. The goal is to see i…

This study tests a new medicine called NNC0487-0111, given as a weekly shot, to see if it helps people with obesity lose weight safely. About 1,150 adults will receive either the active drug or a placebo (dummy shot) for several months. The main goal is to measure how much body w…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests an experimental drug called HDM1005 to help obese adults who do not have diabetes lose weight. About 240 people will receive either the drug or a placebo injection. The main goal is to see how much weight they lose after 22 weeks, and whether the drug is safe.

This study looks at the best amount of a green fluorescent dye (indocyanine green) to use during repeat weight loss surgery. The dye helps doctors see blood flow in real time. About 108 people with obesity will get different doses to find the smallest amount that works well. The …

This study tests whether eating a Mediterranean diet during pregnancy can help prevent allergies in babies. Researchers will enroll 276 healthy pregnant women who are at risk of having a child with allergies. The goal is to see if this diet reduces the chance of allergic diseases…

This study tests a web and mobile program called Healthy Together ("Juntos") for Hispanic teens aged 12-15 and their parents. The goal is to prevent unhealthy weight gain and improve physical activity and diet. About 750 families will use the program to see if it helps teens stay…

This study looks at whether taking a daily iron supplement (60 mg) after sleeve gastrectomy surgery can prevent iron deficiency anemia better than taking only a standard multivitamin. About 66 adults having the surgery will be split into two groups based on their hospital unit an…

This study looks at whether adjusting meal timing can reduce health risks for night-shift nurses and nursing assistants who are overweight. Participants will either track their diet, follow a 10-hour daytime eating window, or add a low-glycemic snack during night shifts. The goal…

This study tests a program called Healthy Family Foundations for military couples expecting their first baby. The program includes 10 online group classes (5 before birth and 5 after) to help parents support each other with healthy eating, activity, and parenting. Researchers wan…

This study tests a 6-month virtual dietary education program (PEDALL) to prevent overweight and obesity in children and teens (ages 5-21) with acute lymphoblastic leukemia (ALL) during maintenance chemotherapy. The program is offered in English and Spanish and includes 376 partic…

This study is testing a family-centered program to help Hispanic families lose weight and prevent obesity. Parents and their children ages 8-12 will work together to build healthy habits. The goal is to find the best way to support families using text messages and other tools.

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study looks at whether using a sit-stand desk can help prevent type 2 diabetes in people who are overweight and sit a lot at work. About 198 adults with prediabetes or other risk factors will be randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to a con…

This study tests whether using a special lung-monitoring device (EIT) to set the ventilator during surgery can reduce lung complications like pneumonia or respiratory failure in people having laparoscopic gastric sleeve surgery. About 118 obese adults will be randomly assigned to…

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults will receive either real or fake TDCS sessions over 4 weeks, combined with a reduced-calorie diet. The goal is to see if stimula…

This study tests whether the Mayo Clinic Diet helps adults with obesity lose at least 5% of their body weight compared to standard care. Researchers will follow 250 participants for up to 52 weeks to see if the diet is practical and sustainable. The goal is to improve weight, bod…

This early-stage study tests whether a once-weekly injection called NNC0487-0111 can lower how much people with obesity eat and how hungry they feel. About 120 adults aged 18-64 will receive either the drug or a placebo for several months. The goal is to see if the treatment safe…

This study tests a once-weekly injection called retatrutide to see if it can relieve chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The main goals are t…

This study tests whether a simple breathing muscle training program can help obese breast cancer survivors exercise longer and with less difficulty. About 78 participants who finished breast cancer treatment will do breathing exercises for 8 weeks. The goal is to see if this impr…

This early-stage study tests an experimental drug called AZD1043 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will recei…

This study tests whether a once-weekly injection of semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive either semaglutide or a placebo, and researchers will track changes in body weight, body fa…

This study looks at whether minocycline, an antibiotic that also fights inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if the approach is practical and acceptable for 35 participants. The goal i…

This study is testing a program that helps people with obesity who are waiting for a kidney transplant. The program includes education on weight loss and tools to support healthy eating and lifestyle changes. About 30 adults will take part to see if the program improves their qua…

This study compares early pain after two types of weight-loss surgery: robotic sleeve gastrectomy and laparoscopic sleeve gastrectomy. About 91 people who qualify for sleeve gastrectomy will be randomly assigned to one of the two procedures. The main goal is to see if robotic sur…

This study looks at whether lifestyle changes can help lower eye pressure in people who have both glaucoma and obstructive sleep apnea. Researchers will track 40 participants and measure changes in eye pressure, sleep quality, and body measurements. The goal is to see if simple d…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for it. The app uses proven strategies to improve self-control and eating habits. About 50 teens will use the app for 16 weeks and give feedback on how helpf…

This early-stage study tests a new nasal spray form of semaglutide (WL1006) in 60 overweight or obese adults. The main goal is to check safety and how the drug moves through the body, not weight loss itself. Participants receive a single dose and are monitored closely.

This study tests a weight loss program using a smartphone app and a coach for teens and young adults who are overweight after a stem cell transplant. The goal is to help them lose weight and build healthy eating habits. About 20 people will join, and researchers will track change…

This study tests whether a special ultrasound-guided nerve block (M-TAPA) can reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy, a common weight-loss surgery. About 60 adults having this surgery will either receive the block or standard care. T…

This study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or have obesity and also suffer from knee osteoarthritis. The goal is to see if the drug helps with weight loss and reduces knee pain compared to a placebo. Participants are randomly ass…

This early-stage study tests the safety of a new drug called RT-114 in 60 healthy volunteers. Some will get a single dose as a pill or injection, others will get multiple doses or a placebo. The goal is to see if the drug is safe and how the body processes it, before testing it i…

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can improve the quality of embryos in overweight or obese women. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive semaglutide…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study is testing an experimental medicine called cagrilintide to see if it can reduce how much people eat and their appetite. About 120 adults with overweight or obesity will receive either the drug or a placebo for around 30 weeks. The main goal is to measure changes in tot…

This study tests whether tradipitant can reduce nausea and vomiting caused by GLP-1 weight-loss medications. About 280 healthy overweight or obese adults will receive either tradipitant or a placebo. The goal is to help people stay on their weight-loss treatment without unpleasan…

This study tests whether a gentle brain stimulation technique called tDCS can boost the effects of cognitive training to help veterans with obesity control impulsive eating and lose weight. About 124 veterans will receive either real or fake tDCS during training sessions. The goa…

This study compares an intensive lifestyle program to standard weight loss advice in 32 women aged 18-25 with a BMI of 25-50. The goal is to see if the intensive program leads to greater reductions in weight, waist size, and body fat, and also improves markers of inflammation ove…

This study is testing whether adding social well-being workshops to standard obesity care can reduce the negative effects of weight stigma. About 210 adults with obesity will either join these workshops plus exercise classes for 12 months or receive usual care. Researchers will m…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and weight loss, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks and be monitored for side …

This early-stage study tests an experimental injection called LY3971297 in healthy volunteers and people with obesity and high blood pressure. The main goal is to check for side effects and see how the drug moves through the body. About 225 participants will be involved, with stu…

This study tests a once-weekly injection called NNC0487-0111 in 400 adults with overweight or obesity and knee osteoarthritis. Half get the drug, half get a placebo. Researchers will measure weight loss and changes in knee pain and function over time. The goal is to see if the dr…

This study tests a new home-based program that uses a virtual reality treadmill to help children aged 6 to 17 with conditions like cerebral palsy, neuromuscular diseases, or obesity improve their walking. The program involves at least three 30-minute sessions per week combining w…

This study looks at whether lifestyle changes can improve dry eyes in obese women with polycystic ovary syndrome (PCOS). Researchers will measure eye dryness using tests and questionnaires. The goal is to see if simple lifestyle adjustments can ease both conditions.

This study tests whether applying special elastic tape (kinesio tape) to the chest can improve lung function, breathing muscle strength, and sleep quality in people who are overweight or obese. Researchers will measure breathing tests and sleep quality in 36 adults before and aft…

This early-stage study tests a new medicine called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in different parts of the study …

This study compares two types of nerve blocks for shoulder surgery in adults with obesity. The goal is to see if a phrenic-sparing block reduces early breathing problems like shortness of breath or need for oxygen, compared to the standard block. Participants will take a simple b…

This early-stage study tests whether a new medicine, NNC6989-0001, is safe for healthy people who are overweight or have obesity. About 96 participants will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through t…

This study looks at whether a special vacuum dressing (negative pressure wound therapy) helps heal the belly incision better than standard bandages in obese women having breast reconstruction surgery. About 80 participants will be randomly assigned to one of two dressing types. T…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This study looks at whether taking N-acetylcysteine (NAC), an antioxidant supplement, can improve the effects of high-intensity interval training in adults with overweight or obesity. Researchers will measure changes in body composition, fitness, and markers of inflammation and o…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can reduce the number and severity of hot flashes in women after menopause who also have obesity. Researchers will also check if the drug affects biological aging markers. About 40 women aged 46-60…

This study tests whether avoiding opioids during and after obesity surgery can improve recovery and reduce side effects. About 220 adults having laparoscopic obesity surgery will be randomly assigned to opioid-free care (with or without personalized support) or standard opioid-ba…

This study aims to learn how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide for eight days to temporarily stop insulin production. Researchers will measure their fasting blood suga…

This study aims to understand how obesity and diabetes influence gene activity in tissues that process sugar and fat. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn how body weight and blood sugar levels change ge…

This study looks at how the brain and body react to different nutrients (sugar, fat, protein) in people with obesity compared to healthy-weight individuals. Sixty participants will drink a liquid meal and have brain scans and blood tests to measure changes. The goal is to underst…

This study looks at how problems with thinking skills (called executive dysfunction) affect physical performance and overall well-being in 100 adults with obesity. Participants will be split into two groups based on a thinking test, and researchers will measure things like walkin…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study looks at how changing the amount of protein, fat, carbs, and total calories in your diet affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 9 separate 24-hour p…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect blood, tissue, and perform imaging tests like MRI and CT scans. The goal is to improve diagnosis and understanding of these conditions. P…

This study aims to understand why people who work night shifts are more likely to become overweight or obese. Researchers will compare 1000 shift workers and day workers across five European countries by analyzing their diet, sleep, and biological samples like blood and saliva. T…

This study aims to see if a specially designed education module helps people with spinal cord injury learn about their increased risk for heart disease, obesity, and related health problems. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure chang…

This study looks at whether certain fats made from diet are linked to breast cancer and obesity. Researchers will measure these fats in 60 postmenopausal women, some with breast cancer and some without. No treatment is given; the goal is to understand connections between body fat…

This study looks at how bariatric surgery affects two key body chemicals—cortisol and bile acids—in obese women. Researchers will measure these substances before and after surgery in 30 non-menopausal women with a BMI between 35 and 50. The goal is to understand why the surgery l…

This study looks at how blocking certain nerve signals for two weeks changes the way the body produces sugar in people with obesity and high blood pressure. Researchers will compare three treatments: a placebo, a blood pressure drug (amlodipine), and a nerve-blocking drug (moxoni…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study looks at how what children eat affects their growth and development in remote farming areas of Swat, Pakistan. Researchers will follow 832 children from birth to age 5, measuring their height, weight, head size, and skills like talking and moving. The goal is to unders…

This study follows up to 150 people with MEHMO syndrome or related disorders to track how the disease progresses over time. Researchers will collect medical history, imaging, and lab samples to identify biological markers. The goal is to better understand these conditions and dev…

This study looks at whether a short nutrition and exercise program before cancer treatment is practical and helpful for American Indian patients. About 30 adults with any cancer type will eat walnuts and increase their walking for at least 3 weeks before starting treatment. Resea…

This study is observing 650 adults to understand how obesity and aging interact. Researchers will measure blood markers and body fat to see if obesity makes people age faster biologically. The goal is to lay groundwork for future treatments or lifestyle changes that could slow ag…

This study looks at how having excess body fat in midlife (ages 40-60) might increase the risk of Alzheimer's disease. Researchers will compare brain scans and blood tests from 240 cognitively healthy adults to see if those with obesity show more brain inflammation or Alzheimer's…

This study looks at whether bariatric surgery can slow or reverse biological aging in people with obesity. Researchers will track 300 adults before and after surgery, measuring changes in biological age, fat cell health, gut bacteria, and daily body rhythms. The goal is to unders…

This study looks at whether breathing limitations make it harder for people with heart failure and obesity to exercise. Researchers will measure how much oxygen breathing takes and test if breathing a special gas mixture (helium-oxygen) helps with shortness of breath and exercise…

This study looks at how high-intensity interval training (HIIT) changes brain activity and appetite in people who regained weight after bariatric surgery. Researchers will use brain scans and questionnaires to understand the connection between exercise, brain function, and weight…

This study follows up on people who already received the experimental obesity drug INV-347 in an earlier study. Participants will not receive any new treatment. The goal is to track any side effects and measure how long the drug stays in the body. About 91 adults aged 18 and olde…

This study looks at how eating and sleeping at mismatched times—like shift workers or people with jet lag—affects body weight. Researchers will measure energy use, body composition, and brain responses in 42 adults. The goal is to understand how meal and sleep timing, independent…

This study looks at how newer weight loss medications (like semaglutide) compare to gastric bypass surgery in people with severe obesity. Researchers want to see how each treatment affects muscle mass, metabolism, and side effects like nausea or fatigue. About 60 adults who are p…

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to temporarily change brain activity in healthy adults. Researchers want to understand how a part of the brain called the cerebellum helps control feelings of fullness and food choices. 1…

This study looks at whether adding beans to your daily diet can improve bowel and metabolic health. Overweight adults aged 30-80 who are scheduled for a colonoscopy will drink a bean smoothie for two weeks. Researchers will measure changes in gut bacteria, blood markers, and colo…

This study aims to discover new biological factors that lead to type 2 diabetes in people with severe obesity. Researchers will collect tissue samples during planned weight-loss surgery from 270 adults with different metabolic states—some with diabetes, some with insulin resistan…

This study looks at whether starting with a low-carbohydrate diet and then switching to a low-fat diet leads to more body fat loss than the opposite order. Over 8 weeks, 42 overweight adults will eat only delivered meals and track their weight, activity, and blood sugar at home. …

This study looks at how time restricted eating (eating only during a 6-hour window each day) affects metabolism and the immune system in healthy women aged 18-50. Researchers will compare women with a healthy weight to those with obesity. Participants will stay in the clinic for …

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns, and collect genetic samples. About 2,000 healthy adu…

This study looks at whether taking a daily supplement called SPM Active® for 12 weeks can increase certain omega-3 fatty acid derivatives in the blood and improve feelings of burnout, life satisfaction, and sleep quality in adults with obesity. About 33 people aged 45-60 with a B…

This study is creating a biobank—a collection of DNA samples and health information—from 500 adults. Researchers will use this resource to study genetic links to heart disease, high blood pressure, diabetes, and obesity. The goal is to provide a valuable tool for future medical d…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels, inflammation, and dietary intake over two years in 70 South African women. The goal is to understand why obes…

This study is for teens and young adults aged 12 to 24 who are planning to have weight loss surgery (sleeve gastrectomy). Researchers want to understand how the body changes after surgery and why some people lose more weight than others. They will also test if adding a medication…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. About 3600 adults who speak English or Spanish can join if they have obesity, are behind on colon or cervical cancer screening…

This study looks at how fat tissue and gut bacteria may influence memory and thinking in people with obesity. Researchers will analyze tissue, blood, and gut samples from 100 adults scheduled for surgery. The goal is to find new ways to diagnose and treat brain problems linked to…

This study looks at 100 adults with severe obesity to see if the type of weight-loss surgery—sleeve gastrectomy or gastric bypass—changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is to…

This study looks at 8,000 obese young adults in eastern China to find out how genes and body traits are linked to obesity and metabolic syndrome. Participants must have a BMI of 30 or higher and be willing to give a blood sample. The goal is to learn more about what causes obesit…

This study looks at bone health in teens aged 12-21 with obesity who take GLP-1 weight-loss drugs compared to those using only lifestyle changes. Over 24 months, participants will have check-ups, lab tests, and bone scans. The goal is to see if these drugs affect bone strength, h…

This study looks at why insulin fails to properly control fat breakdown in people with upper body obesity. Researchers will test whether the diabetes drug pioglitazone can improve how fat cells respond to insulin. The study involves 64 adults, both non-obese and obese, and aims t…

This study looks at how tiny particles called extracellular vesicles (EVs) affect blood vessel function in people with type 2 diabetes. Researchers want to understand if exercise can change how these particles influence blood flow and metabolism. The study involves 60 adults aged…

This study aims to understand how type 2 diabetes and obesity in young people (ages 12-25) affect heart and blood vessel health over time. Researchers will follow 930 participants for up to 25 years, using yearly checkups, scans, and stress tests. No treatments or drugs are being…

This study looks at how different types of anesthesia affect stress during weight-loss surgery. About 70 people having sleeve gastrectomy or gastric bypass will get opioid-free anesthesia, some with a gas called desflurane and some without. Researchers will measure stress hormone…

This study aims to find the best dose of acyclovir for people with obesity by measuring how the body processes the drug. Twenty healthy volunteers with different body sizes will take a single dose and provide blood and urine samples. The goal is to use lean body mass to predict d…

This study looks at how a park-based afterschool program called Fit2Play affects children's physical fitness and mental health. Researchers will analyze data from about 5,000 kids to see changes in weight, blood pressure, fitness tests, and feelings of anxiety or depression. The …

This study aims to understand how people eat after weight-loss surgery by using a special device called a drinkometer. Researchers will measure tiny details of drinking behavior in 420 adults, including those who had surgery and those who did not. They also want to see if sex and…

This study looks at whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cylindrical cuff on the upper arm in pregnant women. The goal is to improve diagnosis and management of high blood pressure during pregnancy, especia…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood of healthy adults aged 35 to 65. These particles help cells talk to each other and may affect heart and brain health. Researchers will compare blood samples …

This study looks at how a pattern of sleeping only a few hours on weekdays and longer on weekends (yo-yo sleep) affects weight, blood sugar, and heart health. Researchers will compare this to getting enough sleep every night in 72 adults aged 18-49. The goal is to understand if y…

This early-stage study looks at how a new weight-loss medication, maridebart cafraglutide, changes the way oral contraceptives are processed in the body. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth co…

This early-stage study tests an experimental oral drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check the drug's safety and how it interacts with two common statins (pitavastatin and rosuvastatin). Participants will receive multiple doses o…

This study will check how many adults with obesity also have sarcopenia (loss of muscle mass and strength). Researchers will study 300 people at a specialized obesity center, looking at factors like age, diet, and activity. The goal is to understand how common this problem is and…

This study works with churches in Washington D.C. to understand heart health in the Black community. About 200 adults will get a health exam, including blood pressure, cholesterol, and blood sugar tests. They will also wear an activity monitor for a month. The results will help d…

This study looks at why people from lower-income backgrounds often have less success in weight loss programs. Researchers will track daily experiences and decision-making patterns in 230 adults with obesity. The goal is to understand how stress and thinking habits affect weight l…

This study looks at how 12 weeks of endurance exercise changes the quality of fat tissue and how the body responds to insulin in men and women with obesity. Researchers will take small fat samples from the belly before and after the exercise program to see if new fat cells form. …

This study is testing a new care program for people with obesity. The program, called the Chronic Disease Unit, offers personalized support and education to help patients feel more confident in managing their health. Researchers will measure changes in self-confidence and whether…

This study looks at how a low-carbohydrate diet and a supplement called nicotinamide riboside (NR) change the way the body uses fat for energy. Researchers will measure things like how many calories participants burn while sleeping and how much fat they burn. The study involves 1…

This study looks at how GLP-1 medications change fat tissue in 40 people with obesity who are about to have weight-loss surgery. Researchers want to see if these drugs raise oxytocin levels in fat and how they affect fat scarring. The goal is to better understand how GLP-1s work …

This study looks at two different training programs for doctors and health workers in community health centers that serve people on Medicaid. The goal is to see which training helps patients lose more weight and get better access to obesity care. About 6,200 patients and their pr…

This study aims to understand why fat tissue in the belly area doesn't respond normally to signals that 'turn on' fat cells in people with obesity. Researchers will measure how fat is released from different parts of the body in 24 adults with and without excess weight. The goal …

This study looks at how growth hormone affects beta-cells, which make insulin and control blood sugar, in people with a family history of type 2 diabetes. Researchers will compare two groups of 30 obese adults—those with and without a family history of diabetes—to understand why …

This study explores how a natural heart hormone, called natriuretic peptide, influences metabolism and exercise in people with different genetic makeups. Researchers will measure hormone levels and energy use in 200 adults after a sugary drink and exercise. The goal is to underst…

This study is looking at whether overweight girls start puberty earlier than girls of normal weight. Researchers will use breast ultrasound and other tests to tell the difference between breast tissue and fatty tissue. The study will enroll 150 healthy girls ages 8-14 who have so…

This study looks at how eating different types of food (like high-carb vs. high-protein) affects what you want to eat later. Researchers want to see if this 'food memory' is different for people with normal weight, overweight, or obesity. 45 adults aged 18-45 will take part.

This early-stage study tests a new medicine, BI 456906, in 30 adults with obesity. It uses special scans to see how the drug attaches to receptors in the liver and pancreas that control appetite and weight. Participants receive either BI 456906 or the approved weight-loss drug se…

This study aims to find out why some people lose more weight than others after a minimally invasive stomach-reducing procedure called endoscopic sleeve gastroplasty. Researchers will track 205 adults with obesity (BMI 30-35 with complications, or BMI over 35) for 12 months after …

This study looks at how the body fights to keep its weight stable. Researchers will have 12 people—some with low body weight and some with obesity—fast for 2 days and then eat freely for 2 days while staying in special metabolic chambers. The goal is to measure how much the body …

This study looks at fat tissue from older adults to see how cells change with age and obesity. Researchers will take small fat samples and use advanced techniques to map different cell types. Some older participants will also try lifestyle changes or a drug that targets aging cel…

This study explores whether tiny particles released from fat cells can serve as early warning signs for blood vessel damage in people with obesity. Researchers will compare these particles in normal-weight and obese adults, then see if weight loss reduces the particles and improv…

This study looks at how GLP-1 weight loss medications change muscle and bone in people with obesity. About 50 adults will take the drug and either follow a diet and exercise program or just standard advice. Researchers will measure muscle mass, bone health, and related blood mark…

This study looks at whether a ketogenic diet can increase the number of calories your body burns each day and help control appetite after you've lost weight. Researchers will enroll 20 adults with obesity who are otherwise healthy. Participants will follow a keto diet, and their …

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans, physical tests, and blood draws. The goal is to understand how the drug affects muscle health, especially in people at ri…

This study looks at how beta-cells (which make insulin) respond to growth hormone in women who had gestational diabetes. Researchers want to understand why some women develop high blood sugar during pregnancy. The study involves 30 women and uses tests to measure insulin producti…

This study looks at how a substance called lactate helps control blood flow to the brain, especially in people with obesity. Researchers will compare 24 healthy adults with and without obesity, and test whether short-term exercise training can improve lactate levels and brain blo…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study is following 2,800 pregnant women and their children in Weifang, China, to learn how things like diet, lifestyle, and environment before and during pregnancy affect the health of both mother and child. Researchers will track health issues like diabetes, high blood pres…

This study compares two ways of using a breathing machine during weight-loss surgery in 40 adults with obesity. The goal is to see which method keeps oxygen levels higher and puts less pressure on the lungs. Results may help doctors choose safer breathing settings for future surg…

This observational study explores how hormones in a mother's blood and breast milk relate to her baby's growth, body fat, and eating behavior. Researchers will compare mothers who had a normal weight before pregnancy with those who were overweight or obese. The study involves 130…

This study looks at why blood flow in muscles is poor in people with obesity and how exercise might help. Researchers will measure harmful molecules and blood flow in 25 adults before and after an 8-week exercise program. The goal is to understand the body's inner workings, not t…

This study is testing a new, ultra-thin endoscope that goes through the nose without sedation, making it easier and cheaper to examine the upper digestive tract in people with obesity. Researchers want to see if patients and doctors find it acceptable and comfortable. If successf…

This study looks at how a new drug (NNC0662-0419) affects birth control pills and stomach emptying in 45 overweight women who cannot become pregnant. Participants will receive the study drug, a birth control pill, and a mild painkiller to measure drug levels in the blood. The goa…

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat sends out signals that make your muscles less responsive to insulin, and if weight loss can quiet those signals. About 70 adults with obesity will fo…

This study looks at two ways of giving a meal test to healthy adults to measure blood sugar changes. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's body size. The goal is to find out which method produces more consi…

This study looks at whether body composition (like weight and shape) is linked to how stiff or reactive a person's airways are. Researchers will use a device called an oscillometer to measure airway resistance in 100 adults already scheduled for a methacholine challenge test. The…

This study follows 1,000 adults aged 50 and older who take part in a park-based fitness program in Miami-Dade County. Researchers will measure changes in weight, blood pressure, arm and leg strength, and mobility over time. The goal is to see if community exercise programs can im…

This study looks at whether obesity raises heart disease risk in African American men and women. Researchers will measure body fat, blood fats, and how well insulin works in 2000 healthy non-diabetic adults. The goal is to understand why heart disease risk factors may differ betw…

This study is a registry that gathers information from medical records and patient visits about endoscopic bariatric therapies (EBTs), which are non-surgical procedures to help with weight loss. It includes adults who have had or plan to have an EBT within six months. The goal is…

This study tests a web and mobile program to help Hispanic women who survived breast, uterine, or ovarian cancer, along with their adult daughters, eat better and move more. About 60 pairs (survivor and daughter) will use the program for 8 weeks. The goal is to see if the program…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that could explain why some groups face higher risks for metabolic problems. No…

This study looks at brown fat, a special type of fat that burns energy and may help control metabolism. Researchers will collect small fat samples from 40 healthy adults during planned surgeries. The goal is to learn how brown and white fat differ, which could lead to new ways to…

This study looks at why adults who carry extra weight in their belly area process insulin differently than lean people. Researchers will measure how fat is released from different parts of the body in 48 overweight or obese volunteers. The goal is to better understand the link be…

This study looks at whether whole milk or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will follow 625 children ages 1-2 for one year, measuring changes in waist size and body mass index. Families will be randomly assigned to give their child only w…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study follows 1,500 children ages 8-17 over several years to understand how genes, sleep, mood, and thinking skills affect eating behavior and health. Participants wear a wrist monitor, answer smartphone questions, and have yearly check-ups including body measurements, blood…

This study looks at stomach tissue from 100 obese adults undergoing weight-loss surgery to understand how immune cells and blood vessels change. Researchers compare these samples to normal tissue to see if early signs of stomach cancer can be detected. The goal is to learn more a…

This study aims to find rare genetic changes that cause severe obesity starting in early childhood. Researchers will enroll 500 children and adults who had a very high BMI before age 6. Participants will provide a saliva or blood sample for genetic testing, answer health question…

This study follows up on 301 mothers and their 14-year-old children who were part of a earlier trial. The original trial tested if a low-calorie diet and exercise during pregnancy could improve health. Now researchers want to see if those lifestyle changes helped prevent obesity …

This study aims to find out why some people succeed at losing weight and keeping it off while others struggle. Researchers will look at factors like blood sugar, metabolism, genetics, and body composition in 3,200 volunteers. The goal is to move away from a one-size-fits-all appr…

This study is following 1,000 people who are having bariatric (weight-loss) surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the h…

This study looks at whether a single dose of apple cider vinegar can change levels of malondialdehyde, a marker of oxidative stress, in adults with obesity. Researchers will compare two groups: one that eats a standard meal with apple cider vinegar and one that eats the same meal…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. The goal is to measure changes in insulin sensitivity, fitness, and overall he…

This study follows 320 people who had omega gastric bypass surgery 8 to 12 years ago to compare long-term side effects of two different loop lengths. Researchers will track serious complications, nutritional problems, weight loss, and quality of life. The goal is to find out whic…

This study looks at whether eating oil rich in oleic acid (a healthy fat in olive and sunflower oil) changes how fat cells process cholesterol in women with obesity. About 40 women scheduled for weight-loss surgery will take either regular sunflower oil or an oleic-acid-rich vers…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study looks at how being obese changes your DNA and harms blood vessels. Researchers want to see if 12 weeks of aerobic exercise can reverse these changes. 80 adults scheduled for weight-loss surgery will take part. The goal is to understand the body's inner workings, not to…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study looks at why some ultra-processed foods (like those high in fat or sugar) make people want to eat more. Researchers will measure cravings, mood, and calorie intake in 50 adults with obesity after they eat different snack foods. The goal is to understand which ingredien…

This study looks at whether resistance training (like lifting weights) can improve how fat is broken down in obese postmenopausal women who have prediabetes. Researchers will measure fat metabolism before and after 12 weeks of training. The goal is to find a practical way to prev…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at how popular weight-loss drugs (GLP-1 receptor agonists) affect muscle mass and physical function in people with obesity, and whether adding exercise helps. Researchers will follow 40 participants for 2 years, measuring muscle, strength, and metabolism. They al…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at whether people with obesity who also have binge eating or food addiction experience taste differently than those without these behaviors. Researchers will measure sweet and salty taste thresholds in 300 participants. The goal is to understand why some people o…

This study looks at how the bacteria in your gut might talk to your brain, affecting your ability to control eating. Researchers will compare 116 adults with and without obesity using brain scans, memory tests, and gut bacteria analysis. The goal is to understand why some people …

This study looks at how long you need to fast and whether temporarily stopping GLP-1 medications (like liraglutide or semaglutide) affects how much food stays in your stomach. Researchers will study 75 adults with obesity who already take these drugs. The goal is to improve safet…

This study looks at tiny particles released from fat tissue, called extracellular vesicles, to understand how obesity leads to insulin resistance in muscles. Researchers will compare these particles in lean and obese people, and also check for differences between men and women. T…

This study looks at how people with obesity feel about their quality of life after a less invasive stomach procedure called endoscopic vertical gastroplasty (GVE). Researchers will interview 20 Italian adults who had the procedure at least six months ago. The goal is to understan…

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …

This study looks at how diet affects gum health in 200 adults with obesity but no other health problems. Researchers will calculate each person's dietary inflammatory index (DII) score and measure markers of inflammation in their gum fluid and blood. The goal is to see if a pro-i…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…