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Obesity linked to iron deficiency in young women – new study investigates why

NCT ID NCT07081152

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over time in 70 South African women. The goal is to understand why obesity raises the risk of iron deficiency, which can lead to anemia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Of African descent * BMI of 18.5 to 24.9 kg/m2 for participants living without OW/OB and BMI ≥ 28 kg/m2 for participants living with OW/OB * Having low to moderate inflammation-adjusted iron stores (ferritin ≤50 µg/L) * Absence of low-grade inflammation (CRP\<2 mg/l) for participants living without OW/OB and presence of low-grade inflammation CRP 2-20 mg/l) for participants living with OW/OB * Planning to reside in the study area for at least 2 years Exclusion Criteria: * Hemoglobin \< 11 g/dl * Treated or self-reported chronic or malabsorptive disorder * Current use of chronic anti-inflammatory medication, like corticosteroids or non-steroidal anti-inflammatory medication * Pregnancy or planning to become pregnant in the next 2 years * Lactation * Fear of needles or experiencing vaso-vagal episodes when exposed to blood * Difficulty drawing blood due to poor quality veins * Blood donation in the past 4 months or plans to donate blood during the study * On a weight-loss diet or program or planning to start the same during the study * Smoking * Unwillingness to stop taking iron and /or vitamin C-containing supplements during phase 1 of the study * Regular use of antacids, proton pump inhibitors or H2 blockers Additional inclusion criteria applicable to phase 2 of the study * Labelled with stable iron isotope (tracer) for a minimum of one year * Willingness not to start or stop contraceptive use during the 6 months * BMI ≥ 18.5 to 24.9 kg/m2 for participants living without OW/OB and BMI ≥ 28 kg/m2 for participants living with OW/OB Additional exclusion criteria applicable to phase 2 of the study \- Blood transfusion, intravenous iron infusion, blood donation or significant blood loss during the equilibration period

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Esté Vorster Research Facility

    RECRUITING

    Potchefstroom, North West, 2531, South Africa

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