Inflammatory disease

Chronic granulomatous disease (CGD) caused by p47phox deficiency is a rare, life-threatening genetic disorder that leaves people vulnerable to severe infections. Standard treatments include daily antibiotics and antifungal drugs, but they do not fix the underlying genetic defect.…

Researchers are testing whether a new oral polio vaccine called nOPV2, given at birth, helps infants block type 2 poliovirus in their intestines. The trial enrolls 740 healthy newborns who have received standard injected polio vaccines. Scientists will check stool samples for sig…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This Phase 3 trial tests whether efimosfermin alfa can improve liver fibrosis in adults with compensated cirrhosis caused by MASH (a fatty liver disease). Participants receive either the drug or a placebo via injection. The main goal is to see if liver scarring improves by at lea…

This study tests whether combining risankizumab with either trosunilimab or ABBV-701 can safely reduce inflammation and improve symptoms in adults with moderately to severely active Crohn's disease or ulcerative colitis. Participants are randomly assigned to one of the combinatio…

This study tests whether MK-8690, a drug given as a shot, can help people with moderate-to-severe ulcerative colitis achieve remission. About 100 adults who haven't responded well to other treatments will receive either MK-8690 or a placebo. The main goal is to see if more people…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This early study tests baricitinib, a drug already approved for other immune conditions, in 20 people with Job syndrome who also have lupus-like disease or eczema. Participants take the pill daily for 6 months. The main goal is to see if it is safe and tolerable, while also check…

This early-phase trial is testing an injection called GT719 in 10 adults with moderate to severe autoimmune diseases that haven't responded to other treatments. The main goal is to check safety and find the right dose. Researchers will also look for signs that the therapy might h…

This Phase 3 trial tests whether survodutide, a weekly injection, can improve liver outcomes in 1590 adults with NASH or MASH cirrhosis. Participants are randomly assigned to receive survodutide or a placebo, along with diet and exercise counseling. The study will track serious l…

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

Researchers are testing a topical filmogel device called URGO MICKAEL on mild to moderate toenail fungus. About 54 adults with one or two damaged big toenails apply the device daily for up to six months. The study measures whether fungal cultures from the treated nail turn negati…

This study tests a new medicine called BI 765423 in 71 adults with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. Participants receive either the drug or a placebo by infusion every four weeks for about 3 months. The main goal is …

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This Phase 2 trial tests whether adding belimumab to standard rituximab treatment helps more people with primary membranous nephropathy achieve remission. The study enrolls 58 adults with confirmed disease. Belimumab targets new immune cells, while rituximab depletes existing one…

This phase 2 trial tests an oral drug called ManNAc in 30 adults with primary focal segmental glomerulosclerosis (FSGS), a kidney disease that causes scarring and protein loss. Participants take ManNAc powder dissolved in water twice daily for 14 weeks. The study aims to see if t…

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

This study looks at whether an essential oil from Pelargonium graveolens (a type of geranium) can be used to treat deep cavities in children's baby teeth. The goal is to see if it works as well as current materials to relieve pain and prevent infection. Thirty children will recei…

This study tests a drug called zasocitinib in adults with nonsegmental vitiligo, an autoimmune condition that causes white patches on the skin. About 200 participants will take either the drug or a placebo for up to a year. The main goal is to see if the drug can improve skin col…

This study tests whether omega-3 fatty acid supplements from fish oil, combined with a healthy diet, can reduce disease activity in adults with dermatomyositis, a rare autoimmune disease causing muscle weakness and skin rashes. About 300 participants will take either fish oil cap…

Researchers at a Korean hospital are following 210 adults who receive a cementless total hip replacement using the collarless Actis femoral stem. The study focuses on Asian patients, who tend to be younger at surgery and more often need the operation because of lost blood supply …

This phase 3 study tests whether an experimental drug called efimosfermin alfa can prevent serious liver complications in adults with compensated cirrhosis due to MASH (metabolic dysfunction-associated steatohepatitis). Participants receive either the drug or a placebo as a shot …

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This study tests a new drug, povetacicept, against a standard treatment (calcineurin inhibitor) in 176 adults with primary membranous nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the new drug can put the disease into remission more safely a…

This trial tests an experimental drug called DDY391 in about 220 adults with moderate to severe psoriatic arthritis, a condition that causes joint pain, swelling, and skin patches. Researchers want to see whether DDY391 can reduce joint symptoms better than a placebo and at what …

This study tests a new medicine called empasiprubart against the standard treatment (IVIg) for people with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disease that causes weakness and numbness. About 218 adults who have used IVIg before will receive either t…

This study tests a one-time treatment called CABA-201, made from a patient's own immune cells, for people with active inflammatory muscle diseases like dermatomyositis. The therapy aims to reset the immune system by targeting and removing certain immune cells. Researchers will ch…

This phase 3 trial tests a drug called efimosfermin alfa in 1250 adults with MASH (a fatty liver disease) and moderate liver scarring. The main goal is to check safety and side effects. Participants will receive either the drug or a placebo, and researchers will monitor liver hea…

This phase 3 study tests the drug risankizumab in about 120 children aged 2 to 18 with moderate to severe ulcerative colitis. The trial has three parts: an initial 12-week IV treatment period, a 52-week maintenance phase where patients get one of two doses by injection, and a lon…

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. Th…

Researchers are testing an experimental drug called GenaKumab in children and teens with active systemic juvenile idiopathic arthritis, a condition that causes joint inflammation and recurring fevers. The trial enrolls about 290 participants aged 2 to under 18 who have had sympto…

This study tests whether tofacitinib, a drug already used for rheumatoid arthritis, is safe and helpful for people with Sjogren's disease. About 60 adults with mild-to-moderate Sjogren's will take the pill twice daily for 28 weeks. Researchers will track side effects and measure …

This study tests a drug called ublituximab for people with a rare autoimmune disease that causes severe muscle weakness. The goal is to see if adding this drug to standard treatment improves muscle strength and function more than standard treatment alone. About 30 adults with ear…

This trial tests whether fospropofol disodium, a newer form of propofol, can improve the surgical field quality during endoscopic sinus surgery compared to standard propofol anesthesia. The study includes adults aged 18-65 with chronic rhinosinusitis who are scheduled for sinus s…

This study tests a drug called efgartigimod, given as a shot under the skin, for adults with Graves' disease whose thyroid levels are still too high despite taking standard antithyroid drugs. About 230 people will take part, and some will get the drug while others get a placebo. …

This phase 3 trial tests survodutide, a weekly injection, in 1800 adults with MASH and moderate to advanced liver fibrosis. Participants receive either the drug or a placebo for up to 7 years, alongside diet and exercise advice. The goal is to see if survodutide can improve or re…

This trial tests whether a mobile app called OpenTele can help people with fatty liver disease (MASLD) follow lifestyle changes like diet and exercise, which are currently the only treatments. The app guides patients daily and gives healthcare professionals a dashboard to monitor…

This study tests whether combining mycophenolate mofetil (MMF) with prednisone can better treat liver inflammation caused by checkpoint inhibitor cancer drugs. The trial includes adults with moderate to severe immune-related hepatitis who need to pause their cancer therapy. The m…

This phase 3 trial tests whether the oral drug rentosertib (INS018_055) can slow lung function decline in adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. About 320 participants will receive either rentosertib or a placebo daily for 52 weeks. The main …

This study tests two doses of an experimental drug, zampilimab, against a placebo in 240 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal is to see if the drug can improve lung function over 24 weeks, with an …

This study tests an experimental drug called STL303 for people with IgA nephropathy, a kidney disease. About 15 adults will receive either STL303 or a placebo to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Possible side effects include na…

This early-phase trial tests a new type of cell therapy called BCMA-CD19-IL-15/IL15sushi compound CAR T cells in 20 people with severe lupus that hasn't improved with standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells…

This phase 3 trial tests whether empasiprubart, given by IV infusion, can help adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder that causes weakness and disability. The study will enroll 160 participants. For the first 6 months, some get the …

This trial tests whether the drug sebetralstat can prevent swelling attacks in people with hereditary angioedema (HAE) when taken before a medical procedure. Participants aged 12 and older with HAE type I or II will take sebetralstat just before their scheduled procedure. The mai…

This study tests an investigational drug called efgartigimod for adults with Graves' disease whose thyroid levels are still high despite taking standard antithyroid medications. About 230 participants will receive either the drug or a placebo as a shot under the skin. The goal is…

This study tests whether BHV-1300 can help adults with Graves' disease achieve normal thyroid function without antithyroid drugs. Participants receive either BHV-1300 or a placebo via injection. The main goal is to see if more people on BHV-1300 have normal thyroid hormone levels…

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

Researchers compare two versions of corneal crosslinking to treat corneal neovascularization, a condition where abnormal blood vessels grow into the clear front surface of the eye. Both versions use riboflavin eye drops followed by ultraviolet A light, but one shines the light fo…

This phase II trial tests whether a drug called BIO 300, made from a soy compound, can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease. About 25 participants will receive BIO 300 along wi…

This trial tests whether nicorandil, a drug currently used for heart conditions, can reduce disease activity and symptoms in people with rheumatoid arthritis. About 70 adults with moderate-to-severe RA will take either nicorandil or a placebo twice daily for three months, while c…

This study tests an experimental drug called VIB4920 in people with active lupus nephritis, a serious kidney complication of lupus. About 74 adults will receive either VIB4920 or a placebo, along with standard medications, to see if the drug helps improve kidney function. The goa…

This Phase 3 trial tests whether mezagitamab, an injectable drug, can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a condition where immune complexes damage the kidneys. About 347 participants will receive either mezagitamab or a placeb…

This study tests an experimental tablet, BI 764198, in adults and some teens with four types of kidney disease that cause protein in the urine. Participants take the drug or a placebo daily for 20 weeks while continuing their usual care. The main goal is to see if the drug lowers…

Researchers compare two magnification tools, dental loupes and a dental operating microscope, during non-surgical deep cleaning for stage 3 periodontitis. Thirty adults with the disease receive scaling and root planing on different areas of the mouth, one area cleaned with loupes…

This trial is testing whether adding a Lactobacillus probiotic or a trace element supplement to standard ulcerative colitis treatment can help keep the disease in remission. About 132 adults with mild to moderate ulcerative colitis will be randomly assigned to one of three groups…

Researchers are testing a new once-weekly injection called NNC0487-0111 in about 400 Japanese adults with overweight or obesity. Half the participants receive the drug and half receive a placebo, assigned by chance. The main goal is to measure how much body weight changes over th…

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

This study tests a new antibody drug called XmAb942 for moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. First, healthy volunteers will receive the drug to check safety. Then, about 270 people with ulcerative colitis will get either XmAb942 or a placeb…

Researchers are testing whether the drug daratumumab can treat kidney diseases caused by monoclonal gammopathy of renal significance (MGRS), a group of conditions where abnormal antibody proteins damage the kidneys. The trial enrolls 30 adults with biopsy-confirmed MGRS. Particip…

This study tests a drug called felzartamab in people with IgA nephropathy, a kidney disease where abnormal antibodies build up and damage the kidneys. The goal is to see if felzartamab can reduce protein in the urine, a sign of kidney damage. About 454 adults will receive either …

Researchers are testing efgartigimod, an intravenous drug that reduces certain antibodies, in adults with anti-NMDAR encephalitis, a rare autoimmune condition that causes psychiatric symptoms, seizures, and movement problems. The trial enrolls 20 participants who receive four wee…

This study tests whether giving tranexamic acid early after a traumatic brain injury can reduce harmful inflammation. Researchers will enroll 60 adults with mild or moderate head injuries. The goal is to see if this drug can help control the body's inflammatory response and impro…

This study tests whether combining two immune-suppressing drugs, rituximab and cyclosporine, can safely reduce protein leakage in the urine of people with membranous nephropathy, a kidney disease where the immune system attacks the kidneys. About 30 adults with persistent high pr…

Researchers are testing whether regularly checking a marker called Gd-IgA1 can help doctors adjust treatment for IgA nephropathy, a kidney disease. Adults with biopsy-confirmed IgA nephropathy or IgA vasculitis-associated nephritis receive Nefecon or telitacicept. Half have Gd-Ig…

This Phase 3 trial tests a drug called dazukibart in people with active dermatomyositis or polymyositis, rare diseases that cause muscle weakness and inflammation. About 318 adults will receive either the drug or a placebo by IV every 4 weeks for 48 weeks. The study aims to see i…

Researchers are testing fecal microbiota transplantation (FMT) for ulcerative colitis, a chronic inflammatory bowel disease. They will compare stool from healthy Han donors with stool from healthy Dai donors, a Yunnan ethnic group with distinct diets, to see if donor background a…

This study tests an investigational drug called duvakitug in people with moderate-to-severe ulcerative colitis who have already responded to treatment. The goal is to see if duvakitug can help maintain remission better than a placebo over 40 weeks, with an optional long-term exte…

This trial asks whether clear aligners are kinder to gum health than traditional braces during the first three months of orthodontic treatment. Thirty healthy adults with mild crowding will receive either braces or clear aligners, after all participants get a standard teeth clean…

This phase 2 trial tests whether galvokimig, an experimental biologic drug, can reduce the number of moderate-to-severe COPD flare-ups in people with chronic bronchitis. About 400 adults aged 40 to 80 with moderate-to-severe COPD will receive either galvokimig or a placebo as an …

This trial is testing an investigational drug called GIA632 in people with moderate-to-severe cutaneous lichen planus, a skin condition that causes itchy, purple bumps. The study aims to see if GIA632 can clear or nearly clear the skin rash and reduce itching compared to a placeb…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This early-stage trial tests a cream called ruxolitinib on people with hidradenitis suppurativa, a condition causing painful lumps under the skin. The study includes 24 adults and teens and focuses on safety and how much of the drug gets into the body. Participants apply the crea…

This early-stage trial tests an oral drug called QX-4533 in healthy volunteers and in people with moderate-to-severe atopic dermatitis, a common type of eczema. The main goal is to check the drug's safety and how the body processes it, while also looking for early signs that it m…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 i…

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

This study offers continued treatment with povorcitinib for up to 600 adults with hidradenitis suppurativa who completed a prior trial and saw benefit. The main goal is to track side effects over time, with a secondary focus on reducing skin abscesses, nodules, and tunnels. Parti…

This study tests a new oral medication, upadacitinib, in children aged 1 to 17 with active systemic juvenile idiopathic arthritis (sJIA), a rare and serious form of arthritis that can affect the whole body. About 90 participants will receive either upadacitinib or the standard in…

This study tests whether a supplement called palmitoylethanolamide (PEA) can help people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity, quality of life, and inflammation markers in 60 participants. The goal is to see if adding PEA …

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This phase 2 trial is testing a new treatment called FT819 for people with lupus nephritis, a serious kidney complication of lupus. FT819 is made from donor immune cells that are engineered to target and destroy faulty B cells. The study will enroll 53 participants and aims to se…

This early-stage trial is testing two experimental drugs, vonsetamig and odronextamab, in people with lupus nephritis that has not responded to standard treatments. The main goal is to check safety and side effects over the long term. Researchers will also see if the drugs can he…

This phase 3 trial tests whether adding trimodulin (a protein mixture from donated blood) to standard care can lower death rates in adults with severe community-acquired pneumonia who need a breathing machine. About 590 hospitalized patients will receive either trimodulin or a pl…

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain and skin plaques. Researchers will compare different doses of the drug to a placebo in 140 adults to see if it improves symptoms like joint tenderness an…

This study tests a cream called delgocitinib for lichen sclerosus, a skin condition that causes itching, pain, and scarring in the genital area. About 652 adults with mild to severe disease will apply the cream twice daily for up to 52 weeks. Researchers will check if the cream i…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

Researchers compare two intracanal medicaments, calcium hydroxide and a calcium silicate-based paste, in 56 adults with acute apical abscesses in single-rooted teeth. They place each medicament inside the cleaned root canal for 7 to 10 days. Bacterial samples are taken before and…

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This study tests a cream called ruxolitinib in 180 children with nonsegmental vitiligo, a condition that causes white patches on the skin. The goal is to see if the cream can safely bring back color, especially on the face. Participants will apply the cream daily for several mont…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This phase 2 trial tests whether an inhaled form of nintedanib (MNKD-201) is safe and effective for people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring. About 210 adults with IPF will receive either a low or high dose of the inhaled drug or a plac…

This study tests an experimental drug called rezpegaldesleukin (NKTR-358) for people aged 12 and older with moderate-to-severe atopic dermatitis, a type of eczema. Participants receive either the drug or a placebo as a shot under the skin. The goal is to see if the drug can clear…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This study compares two ways of dosing the drug mycophenolate mofetil (MMF) for children with lupus nephritis, a kidney disease caused by lupus. One method uses a standard dose based on body size, while the other adjusts the dose based on drug levels in the blood. The goal is to …

This study will test whether a diet rich in protein and fiber can reduce harmful gas-producing bacteria in the gut of people with ulcerative colitis. Forty adults with mild to moderate disease will eat specially prepared frozen meals for two separate week-long periods. Researcher…

This study compares two treatments after surgery for stage III-IVA head and neck cancer: radiation alone versus radiation plus the chemotherapy drug cisplatin. The goal is to see which approach better prevents the cancer from returning, especially in patients with certain TP53 ge…

This phase 3 study tests the long-term safety and effectiveness of remibrutinib, an oral drug, in 710 adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful abscesses. Participants have already completed a prior remibrutinib study. …

This study tests two different doses of an intravenous immune globulin (IGIV 10%) as maintenance therapy for adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder causing weakness and numbness. About 161 participants will receive either a higher o…

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is t…

Researchers are testing whether a higher daily dose of the antiviral drug entecavir suppresses hepatitis B virus better than the standard lower dose in adults whose livers are already scarred and failing. The trial enrolls 48 people with hepatitis B and decompensated cirrhosis. P…

This study tests a new handheld device called CLiKX that helps doctors place ear tubes in children and adults with chronic ear infections or fluid buildup. The device uses sensors and controlled force to make the procedure more precise. Researchers will check if the tube is place…

Researchers are studying how well benralizumab works in adults with eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease that inflames blood vessels and can affect the lungs, nerves, and sinuses. The study follows about 100 patients at European referral centers wh…

This study tests a new drug called sonelokimab for adults with active psoriatic arthritis who have not improved with or cannot take standard TNF-blocker medications. About 600 participants will receive either sonelokimab, a placebo, or an existing drug (risankizumab) for comparis…

This study tests whether adding injectable platelet-rich fibrin (i-PRF) to a standard bone graft helps fill in bone defects caused by advanced gum disease. Sixteen adults with stage III periodontitis will receive either the combo treatment or the graft alone during surgery. Resea…

This study tests a new medicine called galvokimig in 160 adults with moderate-to-severe atopic dermatitis (eczema). The goal is to see if different doses can reduce skin redness, itching, and rash better than a placebo. Participants will receive injections and be monitored for 16…

Researchers are testing whether an intravenous dose of the enzyme dornase alfa can reduce the body's inflammatory response after an acute ischemic stroke. The trial enrolls 36 adults who arrive at the hospital within 12 hours of symptom onset and have moderate to severe stroke sy…

This study tests whether transplanting vaginal fluid from healthy donors can restore a healthy bacterial balance in women with recurrent bacterial vaginosis (BV). Participants receive either the transplant or a placebo after antibiotic treatment. The goal is to see if the transpl…

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This study tests a drug called surovatamig in 43 adults with primary membranous nephropathy, a kidney disease caused by antibodies attacking the kidneys. The drug is given as a shot under the skin. Researchers want to see if it is safe and can reduce protein in the urine, which i…

This trial tests an experimental oral drug called resmetirom in children aged 6 to 17 with metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. The study aims to evaluate the drug's safety, how the body processes it, and its effects on the liver. Participan…

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This Phase 2b study tests whether the drug IMVT-1402 can help adults with CIDP, a nerve disorder causing weakness and numbness. About 162 participants will receive either the drug or a placebo weekly for up to 52 weeks. The main goal is to see if the drug keeps the disease from w…

This study tests whether switching from the current drug bulevirtide to a new drug called brelovitug can better control chronic hepatitis Delta. About 120 adults who have been on bulevirtide for at least 6 months will take brelovitug for 24 weeks. The main goal is to see if the v…

This study tests whether injecting the antibiotic moxifloxacin directly into the cornea can help treat bacterial eye infections that don't improve with standard antibiotic drops. About 60 adults with stubborn corneal infections will receive either the injection plus drops or drop…

This phase 3 trial is testing an experimental drug called ADX-324 in 90 adults with hereditary angioedema (HAE) types 1 or 2. HAE causes sudden, painful swelling in the body. ADX-324 uses a technology called siRNA to lower levels of a protein involved in triggering these attacks.…

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to rec…

This study is testing whether Botox injections can reduce inflammation in people with hidradenitis suppurativa (HS), a chronic skin condition that causes painful lumps. Researchers believe that blocking certain nerve signals may calm the immune response. The study will enroll 20 …

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goals are to check safety and see if it can impr…

This trial tests whether walking on uneven nature trails in minimalist shoes can strengthen the small muscles of the foot and reduce pain in people with plantar fasciitis. Researchers will compare this nature-walking routine to a standard approach in healthy adults and those with…

This study tests a new treatment called AZD0120 for people with severe lupus that hasn't improved with standard therapies. AZD0120 is a type of CAR T cell therapy that targets two proteins (CD19 and BCMA) on immune cells to calm the overactive immune system. The trial will enroll…

This study tests whether the drug CardiolRx can prevent another episode of pericarditis (inflammation around the heart) in people who have had repeated attacks. About 110 adults who have been stable on an IL-1 blocker for at least a year will stop that medication and receive eith…

This Phase 3 trial tests whether adding the experimental drug Rina-S to standard care (bevacizumab or monitoring) can help keep platinum-sensitive ovarian cancer from returning after chemotherapy. About 528 participants will receive either Rina-S alone, Rina-S plus bevacizumab, b…

This study tests a new drug called remibrutinib (a tablet) against a placebo in 44 adults with chronic hives (either spontaneous or triggered by things like pressure or cold). The goal is to see if it reduces symptoms like itching and burning, and how it works in the body. Partic…

This study tests the long-term safety and effectiveness of an oral drug called zasocitinib (TAK-279) in adults with active psoriatic arthritis, a condition causing joint pain and skin patches. About 1,182 participants who completed a one-year parent study will take either a lower…

This phase 2 trial tests whether ursodeoxycholic acid (UDCA), a drug already used for other liver conditions, can treat cholestatic hepatitis—a liver inflammation caused by immunotherapy—better than standard steroids. About 94 adults with cancer (excluding liver cancer) who devel…

This study tests two experimental drugs, ECC4703 and ECC0509, alone or together, in 160 adults with MASH (a type of fatty liver disease). The goal is to see if they can safely reduce liver fat over 12 weeks. Participants will be randomly assigned to receive the drugs or a placebo…

This phase 3 trial is testing an experimental daily capsule called TQH3906 in adults with moderate to severe plaque psoriasis. The drug works by blocking a key immune pathway involved in skin inflammation. Researchers are comparing TQH3906 against a placebo and an approved treatm…

This study tests a new gene therapy, PS-002, for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The therapy aims to control the disease in people who are at high risk of getting worse despite current treatments. Participants receive a single dose a…

This trial tests whether adding radiofrequency ablation to standard chemotherapy and bile duct stenting helps patients with inoperable bile duct cancer. Radiofrequency ablation uses a catheter to deliver heat that destroys tumor tissue blocking the bile duct. Researchers compare …

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. It is an extension study, meaning participants must have already taken tulisokibart in a previous study. The main goal is to see ho…

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

This study tests a drug called secukinumab in Chinese adults with moderate to severe hidradenitis suppurativa, a painful skin condition that causes boils and tunnels under the skin. The goal is to see if the drug reduces skin lesions and prevents flare-ups over 16 weeks. About 36…

This study tests an experimental drug called GIA632 in 210 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The goal is to see if the drug can safely restore skin color and to find the best dose for future studies. Participants will receive e…

This early-stage trial evaluates an investigational oral drug called ONO-6414 in healthy adults and in people with active ulcerative colitis. The main goals are to assess the drug's safety, tolerability, and how the body processes it. The study includes single and multiple doses,…

This study looks at how well the medication pegcetacoplan works and how safe it is for people with two rare kidney conditions: C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). Researchers will follow about 150 patients who are…

This study tests a new medicine called MH002, which contains live bacteria meant to restore gut health in people with mild-to-moderate ulcerative colitis. About 204 adults whose current treatment isn't working well enough will receive either a low dose, high dose, or placebo caps…

This study tests a new medicine called MAS825 for people with Still's disease, a rare inflammatory condition causing fever, rash, and joint pain. About 20 children and adults with active disease will receive the drug to see if it safely controls symptoms. The goal is to improve d…

This study follows 700 adults with moderate-to-severe plaque psoriasis who are already prescribed risankizumab by their doctor. Researchers will track changes in quality of life, including skin symptoms and daily impacts, over up to 2.5 years. The goal is to see how well the drug…

This 2-year extension study looks at lupus nephritis patients who finished a previous trial of ianalumab. Some patients who responded well will stop treatment to see if their kidney disease stays under control. Others who did not respond or were already on open-label ianalumab wi…

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This Phase 3 trial tests whether the experimental drug zasocitinib (TAK-279) can reduce joint swelling and pain in people with active psoriatic arthritis. About 600 adults will receive either the drug or a placebo for up to 60 weeks. The main goal is to see if more people on the …

This study is testing a drug called secukinumab, given as an IV infusion, in 20 children aged 2 to 17 with juvenile psoriatic arthritis. The main goals are to see how the drug moves through the body and to check its safety over up to 6 years. This is an early-stage trial, so it f…

This early study tests a new treatment called azercabtagene zapreleucel (azer-cel) for people with B-cell mediated autoimmune disorders like multiple sclerosis and neuromyelitis optica. The treatment uses a patient's own immune cells that are modified in a lab to target and destr…

This phase 3 trial tests whether zasocitinib, an oral medication, can safely and effectively treat moderate-to-severe plaque psoriasis in children and teens aged 4 to 17. The study involves 110 participants and lasts up to 4 years. In the first part, some receive the drug and oth…

This study tests an experimental drug called iptacopan in 31 children aged 2 to under 18 with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug reduces protein in the urine, a sign of kidney damage, and to check its safety and how t…

This study tests an experimental drug called VTX2735 in 50 adults with recurrent pericarditis, a condition where the heart's lining becomes inflamed and painful. The goal is to see if the drug is safe and can reduce pain and inflammation. Participants receive different doses over…

This study tests an oral drug called LY4268989 (MORF-057) in adults with moderate-to-severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo for up to 108 weeks. The goal is to see if the drug can safely help control the disease and improve s…

This study tests an experimental drug called LY4005130 in 60 adults with non-segmental vitiligo, a condition that causes white patches on the skin. Participants receive either the drug or a placebo by IV every few weeks for 24 weeks. The goal is to see if the drug can reduce the …

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this comb…

This phase 3 trial tests an experimental drug called SHR-1819 in about 200 teenagers aged 12 to 17 with moderate-to-severe atopic dermatitis (eczema). Participants receive either the drug or a placebo injection. The study measures how well the drug clears skin rashes and reduces …

This study tests whether a cream containing ruxolitinib (Opzelura) combined with corticosteroid injections or pills can improve facial vitiligo. It includes people aged 12 and older with active, non-segmental vitiligo affecting the face. Participants use the cream twice daily and…

This phase 3 trial tests efruxifermin, a weekly injection, in 2,150 adults with liver scarring (cirrhosis) caused by NASH/MASH, a type of fatty liver disease. Half get the drug, half get a placebo. The goal is to see if efruxifermin can prevent serious liver events like liver fai…

This early-stage trial will test the safety and tolerability of a new drug, cevostamab, in 46 people with systemic lupus erythematosus, some of whom also have active lupus nephritis. The drug is given intravenously, and researchers will monitor side effects and how the drug moves…

This study tests an experimental drug called rezpegaldesleukin (NKTR-358) for people aged 12 and older with moderate-to-severe atopic dermatitis, a type of eczema. Participants receive either the drug or a placebo as a shot under the skin. The goal is to see if the drug can clear…

This early-stage trial tests an investigational drug called MWN105, given as a weekly injection for 8 weeks, in Chinese adults who are overweight or obese but do not have diabetes. The study aims to see if the drug is safe and tolerable, and how it moves through the body. Partici…

This study is for people with moderate-to-severe eczema who have already completed a previous APG777 trial. It aims to see if APG777 is safe and works well over a longer period. Participants will receive injections of the drug every 12 or 24 weeks and be monitored for side effect…

This study tests a new medicine called afimkibart in children aged 2 to 17 with moderate to severe ulcerative colitis, a disease that causes inflammation and sores in the colon. The goal is to see if the drug can safely help children feel better and achieve remission (no symptoms…

This phase 2 study is testing two new drugs — mirikizumab (given by IV or injection) and LY4395089 (a pill) — in 60 adults with moderately to severely active ulcerative colitis or Crohn's disease. The goal is to see if these treatments are safe and can help control the disease. T…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This study tests whether adding a new oral drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab plus a placebo fo…

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This study tests whether abrocitinib, a liquid medicine, can improve moderate-to-severe eczema in children aged 6 to 12. About 150 kids will be randomly assigned to receive either the drug or a placebo for 16 weeks. The goal is to see if the medicine clears the skin and reduces i…

This study tests whether injecting a substance made from donated amniotic membrane into the bladder can reduce pain and urgency in women with interstitial cystitis (painful bladder syndrome). One hundred women who have not gotten better with other treatments will receive either t…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study looks at the long-term safety and effectiveness of the drug afimkibart for people with atopic dermatitis (eczema) who have already taken it in earlier studies. About 120 adults will be followed to see how well the drug controls their eczema over time and what side effe…

This trial asks whether adding a Mediterranean diet or a low-histamine diet to standard care can reduce disease activity and improve quality of life in teens aged 12-18 with chronic spontaneous urticaria (CSU), a condition causing persistent hives. Participants are randomly assig…

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. …

This study looks at the best time to give hepatitis C medication to people without HCV who receive a kidney from an HCV-positive donor. One group starts the drug just before transplant and takes it for only 2 weeks; the other starts after transplant and takes it for 12 weeks. The…

This phase 2 trial tests a new combination of an anti-PD-1 antibody (a type of immunotherapy) plus standard antiviral drugs in 120 adults with chronic hepatitis B. The goal is to achieve a functional cure, where the virus is no longer active and patients can stop medication. The …

This phase 2 trial tests a combination of an anti-PD-1 antibody, interferon, and standard antiviral drugs in 120 adults with chronic hepatitis B. The goal is to boost the immune system to clear the virus and achieve a functional cure, where the virus stays under control without l…

This 24-month study tests the long-term safety and effectiveness of abrocitinib, a liquid oral medication, in children aged 2 and older with moderate-to-severe atopic dermatitis (eczema). About 500 participants will receive the drug, with or without topical creams. The goal is to…

This study is for people with hereditary angioedema (HAE) who have already completed a previous trial of the drug ADX-324. ADX-324 is an RNA-based medicine designed to lower a protein involved in swelling attacks. The goal is to see if long-term use is safe and can reduce the num…

This phase 2 trial tests whether felzartamab, an antibody that targets immune cells producing harmful antibodies, can restore normal thyroid function in people with Graves' disease. Participants will receive either felzartamab or a placebo alongside their usual anti-thyroid drugs…

This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …

This study is testing the long-term safety and effectiveness of a drug called ORKA-001 for people with moderate-to-severe plaque psoriasis. It is an open-label extension, meaning everyone gets the drug, and it includes 240 adults who already completed a previous trial with ORKA-0…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This phase 2 trial tests an experimental drug called YB-101 in people with Graves' disease, an autoimmune condition that causes an overactive thyroid. The study will see if YB-101 can help normalize thyroid hormone levels and allow patients to stop taking anti-thyroid medications…

This study tests whether a weekly under-the-skin antibody treatment (XEMBIFY) provides similar blood levels as a standard IV infusion (Gamunex-C) given every 3 weeks in people with CIDP, a chronic nerve disorder. About 40 adults who are stable on IVIG will first receive Gamunex-C…

This study tests whether adding a Mediterranean diet (rich in olive oil, nuts, fish, and limited red meat) improves psoriasis symptoms in 36 adults who are about to start biologic therapy (Anti-IL-17 or Anti-IL-23 drugs). Participants are randomly assigned to either follow the di…

This study tests whether an investigational drug called tilrekimig, given as injections alongside medicated creams or ointments, can improve moderate-to-severe eczema (atopic dermatitis) in people aged 12 and older. Participants will be randomly assigned to receive either tilreki…

This trial tests whether a radiofrequency device can reduce inflammatory acne lesions as effectively as a standard topical gel. About 60 adults with mild-to-moderate facial acne will be randomly assigned to receive either three radiofrequency sessions or daily application of a co…

This study tests a new drug, pegozafermin, in 1,350 adults with MASH (a type of fatty liver disease) and moderate liver scarring (stage F2 or F3). The goal is to see if the drug can improve scarring or resolve liver inflammation without making the disease worse over 52 weeks. Par…

This Phase 2 study tests a new drug called ADX-038, alone or with another drug (telitacicept), in 30 Chinese adults with kidney diseases caused by an overactive complement system (IgA nephropathy, C3G, or IC-MPGN). The goal is to see if the treatment is safe and can help control …

This study tests if obinutuzumab can help teens and children with lupus nephritis, a serious kidney complication of lupus. About 40 participants aged 5 to 17 will receive either the drug or a placebo. The goal is to see if the drug improves kidney function and reduces protein in …

This trial tests whether photodynamic therapy (PDT) can clear toenail fungus. People with a confirmed fungal nail infection will have a special gel applied to the affected nail, then exposed to red light. The study will check if the nail looks healthy and if the fungus is gone at…

This early study tests whether taking capsules containing donor fecal bacteria can change the gut and skin bacteria of people with hidradenitis suppurativa (HS), a painful skin condition. Sixteen adults with HS will receive either the bacteria capsules or a placebo for three week…

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This early-stage trial tests UX016, a drug designed to help people with GNE myopathy, a rare genetic muscle-weakening disease. Researchers will give the drug or a placebo to 24 adults to see if it is safe and improves muscle strength. The study is not yet recruiting.

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This Phase 3 study tests an experimental drug called pegozafermin in 762 adults with liver scarring (cirrhosis) caused by MASH, a fatty liver disease. Participants receive weekly injections of the drug or a placebo for about two years. The goal is to see if the drug can improve l…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This trial tests whether people with rheumatoid arthritis who have stable disease can stop taking methotrexate or leflunomide while continuing their TNF inhibitor, restarting the drug if needed. Researchers compare this approach to staying on the combination therapy. They track d…

This study tests an experimental drug called SAR445399 in 144 adults with moderate to severe hidradenitis suppurativa (HS), a painful skin condition that causes abscesses and tunnels under the skin. Participants will receive one of two doses of the drug or a placebo for 32 weeks.…

This study tests a new drug, LYT-100, against an existing one (pirfenidone) for idiopathic pulmonary fibrosis, a lung disease that gets worse over time. About 1,100 adults will take either drug three times daily for up to a year, and researchers will measure how well their lungs …

This Phase 3 study tests whether the drug apremilast (Otezla) can safely reduce joint inflammation and pain in children aged 5 to 17 with active juvenile psoriatic arthritis. About 60 participants will receive either apremilast or a placebo pill for 16 weeks. The main goal is to …

This study tests an experimental drug called ABBV-142 in people with idiopathic pulmonary fibrosis (IPF), a rare lung disease that causes scarring and breathing problems. About 165 adults will receive either ABBV-142 or a placebo for 52 weeks to see if the drug is safe and can he…

Researchers are testing whether taking ashwagandha, a plant extract used in traditional medicine, for 12 weeks alongside regular weight training can improve muscle strength, reduce stress hormones, and support sleep and thinking in healthy men aged 25 to 40. Participants will tak…

This study tests a daily pill called deucravacitinib in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. About 366 participants will receive either the drug or a placebo. The main goals are to see if the drug improves skin clearance by at least 75% and reduces ov…

This Phase 2 study is testing a new drug called ADX-038 in 45 adults with complement-mediated kidney diseases, such as IgA nephropathy and C3G. The drug is an siRNA that targets the complement system, which is overactive in these conditions. Researchers are checking if it is safe…

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This Phase 3 trial tests whether the drug claseprubart (DNTH103) can prevent relapses in adults with CIDP, a nerve disorder that causes weakness and disability. About 256 participants will receive either the drug or a placebo. The main goal is to see how long it takes for symptom…

This study tests whether adding TAVNEOS to standard treatment helps control ear, nose, and throat symptoms in people with granulomatosis with polyangiitis (GPA). About 30 adults with active ENT disease will receive either TAVNEOS or a placebo for 52 weeks. The goal is to see if m…

This study looks at whether adding a bone marrow injection to standard knee surgery can improve pain and function for people with cartilage or meniscus injuries. Fifty adults aged 18 to 64 will be randomly assigned to get either the bone marrow injection or a placebo saltwater in…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This study tests a drug called donidalorsen in 20 children aged 2 to 12 with hereditary angioedema (HAE), a condition that causes sudden, painful swelling. The goal is to see if the drug is safe and how it works in young bodies. Researchers will monitor side effects and measure h…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether a probiotic supplement containing Lactobacillus crispatus can reduce the number of times bacterial vaginosis (BV) comes back in women who have had it repeatedly. About 156 women aged 18-45 will take either the probiotic or a placebo daily for 12 weeks aft…

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can pr…

Researchers compare selective imaging guided by clinical scores to routine imaging in adults with suspected appendicitis. Participants are assigned to one of three groups: selective imaging based on the Adult Appendicitis Score, selective observation plus selective imaging, or ro…

This study tests whether a simple esophageal string test (EST) can diagnose eosinophilic esophagitis (EoE) in people who have trouble swallowing. Participants swallow a capsule with a nylon string that collects fluid from the esophagus, which is then analyzed. The results will be…

This study compares a rapid test that identifies pneumonia-causing bacteria in about one hour to standard lab methods that take 2-4 days. Researchers want to see if the faster test helps doctors choose the right antibiotics sooner for 150 hospitalized patients with pneumonia. The…

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build …

Researchers at Johns Hopkins University are studying whether neuromuscular ultrasound and MRI can serve as reliable markers of swallowing muscle problems in people with inclusion body myositis (IBM). The study compares imaging and clinical findings in 30 participants, including p…

People with lupus can develop kidney inflammation called lupus nephritis, which is easier to treat when caught early. This study enrolls adults with lupus who are at higher risk for kidney problems and assigns them by chance to either standard care alone or standard care plus wee…

Researchers are studying whether a blood test called HepQuant DuO can measure liver function over time in people with alcohol-related liver disease. Participants drink a natural compound called cholate, then give two blood samples at 20 and 60 minutes. The study follows about 40 …

Nonalcoholic fatty liver disease affects many people with obesity or type 2 diabetes, and its more serious form, nonalcoholic steatohepatitis, can lead to cirrhosis and liver failure. Doctors currently rely on liver biopsy to judge how severe the disease is, but that test is inva…

Researchers at Sohag University Hospital want to know how many women with acne also have polyendocrine metabolic ovarian syndrome, a hormonal and metabolic condition. The study enrolls 90 women aged 15 to 49 who have been diagnosed with acne. Doctors will check each participant f…

Researchers test whether giving people education materials and free access to screening helps them get checked for colorectal cancer and hepatitis C. The trial enrolls adults ages 45 to 75 who receive care at community health centers and are not up to date on these screenings. Pa…

This study looks at two different lab tests (live-cell and fixed-cell) to see which one is better at diagnosing MOGAD, a rare autoimmune disease that affects the brain and nerves. Researchers will test 240 adults who are suspected of having MOGAD, along with people who have other…

Researchers are studying whether a digital management platform can help diagnose liver cancer at an earlier stage in people with chronic liver disease. The study enrolls adults aged 18 to 75 with conditions such as chronic hepatitis B. The platform tracks patients and guides stan…

Uveitis is an inflammation inside the eye that can cause permanent vision loss in children, often without symptoms. This study compares a high-resolution, non-contact eye scan called AS-OCT with the standard slit-lamp eye exam in 300 children aged 2 to 16 who attend a pediatric u…

IgA nephropathy is a kidney disease where immune proteins build up in the kidney's filtering units. Researchers in China are collecting samples from 600 people aged 16 and older, including those with biopsy-confirmed IgA nephropathy, to study the bacteria living in their mouths, …

This study tests a new blood test (Malabsorption Blood Test, or MBT) to find mild-to-moderate pancreatic insufficiency in people with chronic or recurrent acute pancreatitis. A small group of participants who respond to pancreatic enzyme replacement therapy (PERT) will then be ra…

This study will test whether a new urine-based test can accurately diagnose pneumococcal pneumonia in children under 5 in Malawi. Researchers will use 350 stored urine samples from healthy kids and those with pneumonia, comparing results to standard lab methods. If it works, this…

Researchers at 32 medical centers in Europe, the USA, and South Africa are testing two new questionnaires designed to measure how severe chronic rhinosinusitis feels and how well it is controlled. About 1,000 patients with chronic rhinosinusitis, with or without nasal polyps, fil…

This Canadian study tests whether adding two questions about morning stiffness and lower back pain to a standard screening tool (PEST) can help dermatologists identify psoriatic arthritis earlier in people with moderate-to-severe plaque psoriasis. About 502 adults who are candida…

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

Researchers are testing whether a radioactive tracer called 18F-DPA714 can help PET/CT scans spot inflammation in the brain. The study includes adults with conditions linked to brain inflammation, such as stroke and neurodegenerative diseases. Each participant receives one inject…

This study tests a new liquid biopsy that measures TB DNA in fluid from around the lungs to diagnose tuberculous pleuritis, a common form of TB. Current methods often require invasive tissue biopsies or have low accuracy. The trial will enroll 350 adults with new-onset pleural ef…

Researchers are testing whether giving the antibiotic zinacef during labor lowers infections for women with meconium-stained amniotic fluid at term and for their newborns. The trial enrolls 182 women with a single full-term pregnancy and meconium in the fluid. Half receive zinace…

When a tooth is removed, the jawbone underneath can shrink, which may make it harder to place a dental implant later. This trial tests two methods to limit that bone loss: one uses a bone graft plus a membrane made from the patient's own blood (platelet-rich fibrin), and the othe…

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

Researchers are testing whether a mouthwash made from copaiba oil, combined with low-level laser therapy, can prevent oral mucositis in people undergoing autologous hematopoietic stem cell transplantation. Oral mucositis is a common and painful side effect of the high-dose chemot…

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

Researchers are testing whether tributyrin, a dietary supplement, can prevent radiation-induced rectal injury in people receiving chemoradiotherapy for locally advanced rectal cancer. About 23 participants will take tributyrin three times daily alongside standard treatment. The s…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This study tests whether a nasal spray called OPN-375 can reduce symptoms of chronic sinusitis (like stuffy nose, discharge, and facial pain) in adolescents aged 12 to 17. About 84 teens will receive either the spray or a placebo twice daily for 12 weeks. The main goal is to see …

This study looks at whether a natural compound from licorice root, called glycyrrhetinic acid, can help calm irritated skin and repair the skin barrier. Researchers will apply a mild irritant to the skin of 30 healthy adults, then treat the area with a cream containing the compou…

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests a device that uses focused sound waves to block pain signals in the knee, offering a needle-free option for people with chronic osteoarthritis pain. Ten adults with moderate to severe knee pain will receive a one-hour treatment and be followed for six months. The…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

Researchers test whether the location used to pull out the appendix (near the belly button versus the lower left abdomen) and numbing medicine injected into the small incisions change pain after laparoscopic appendectomy. Adults with acute appendicitis having emergency surgery jo…

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

This study tests a new, ultrasound-guided acupotomy technique to improve symptoms in people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. About 60 adults with active disease will receive the treatment to see if it reduces pain and improves …

This study tests a new medication called ARS-2 for people with chronic spontaneous urticaria (long-term hives). It aims to see if ARS-2 can quickly reduce itching and hives during flare-ups. The trial involves 42 adults who will receive either ARS-2 or a placebo during separate f…

Researchers are testing a new balloon device called SmartWave that uses shock waves to break up calcium in severely narrowed mitral valves. The study enrolls 10 adults with symptomatic mitral stenosis caused by mitral annular calcification or severely calcified rheumatic heart di…

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

This study tests a 6-week physiotherapy program designed to improve pain, function, and joint awareness in adults with knee osteoarthritis. The program uses sensory modulation and graded weight-bearing exercises, and the trial compares outcomes between male and female participant…

This study is testing a gel called OSTENIL TENDON to see if it safely reduces pain and improves movement in people with tendon problems. Researchers will enroll 84 adults with one of four types of tendinopathy. The main goal is to measure pain changes three months after treatment…

Researchers are studying the Exactech Vantage Mobile-Bearing Total Ankle System, an implant used to replace a damaged ankle joint. The study enrolls 400 adults with ankle arthritis or related joint failure who are scheduled for total ankle replacement. Participants receive the im…

Researchers are studying the Exactech Vantage Total Ankle System, an implant used to replace a damaged ankle joint in people with arthritis or a failed previous replacement. The study enrolls 370 adults who are candidates for total ankle replacement and follows them for up to 10 …

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

Researchers are testing a 1550nm non-ablative fractional laser on adults with skin concerns such as acne scars, wrinkles, and dark spots. The trial enrolls about 200 people aged 18 to 70. Participants receive laser treatment, then answer questionnaires about their experience. Der…

This study tests whether an extended-release form of nalbuphine, a pain medication, can safely reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. About 306 adults with IPF and a cough lasting at least 8 weeks will receive either t…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

Researchers are comparing two schedules of electroacupuncture for adults with chronic plantar fasciitis, a common cause of heel pain. Participants receive either one session per week or three sessions per week for four weeks. The trial measures whether at least half of participan…

Researchers are testing whether giving the steroid dexamethasone during total knee replacement helps with pain, nausea, and recovery, and whether it matters if the drug goes into a vein or is injected around the knee joint. The trial enrolls 159 adults with knee osteoarthritis ha…

This study compares three different root canal sealers—AH Plus, ProRoot Bio Sealer, and BC Sealer ion+—to see which one leads to the least pain after treatment. About 135 adults with irreversible pulpitis in a lower molar will be randomly assigned to one of the three sealers. Pat…

Achilles tendinopathy is a painful condition of the tendon at the back of the ankle. Researchers are testing whether injecting a collagen-based medical device around the tendon, combined with a physiotherapy program of eccentric strengthening exercises, improves pain and function…

This study tests a disposable silicone device that clips onto eyeglasses to trap moisture around the eyes. Thirty-five adults with mild to moderate dry eye will wear it for two hours. Researchers will measure tear film stability, tear volume, and symptom changes before and after …

This study tests three different numbing medicine combinations for pain after total knee replacement. 90 adults having knee surgery will get one of three options: a long-acting numbing drug, or a standard numbing drug plus one of two additives. The goal is to see which approach r…

Researchers are testing whether adding gait re-education on an R-Force anti-gravity treadmill to standard physiotherapy helps adults with knee osteoarthritis. The trial enrolls 80 people aged 40 to 70 who have radiologically confirmed knee arthritis and ongoing knee pain. Partici…

This early-stage trial is testing a new injectable drug called ARQ-234 in healthy volunteers and people with moderate to severe eczema. The main goals are to check safety and how the body processes the drug, while also looking for early signs that it might improve eczema symptoms…

Researchers are studying whether skipping opioids during functional endoscopic sinus surgery leads to better recovery. The trial follows 104 adults with chronic sinusitis who receive anesthesia with dexmedetomidine and other non-opioid pain relievers instead of standard opioid dr…

This study compares two surgical treatments for rhizarthrosis, a type of arthritis at the base of the thumb. One group gets a new prosthesis (HORUS implant), the other gets the standard trapezectomy. Researchers will measure hand function and pain in 50 patients over the short te…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This study tests whether cross training—exercising the healthy arm—can improve pain, function, and mobility in people with frozen shoulder, without directly working the painful shoulder. About 38 adults aged 18-65 with unilateral frozen shoulder will be randomly assigned to stand…

This study looks at whether lowering salt in your diet can make eczema less severe. Forty adults with eczema will eat a low-salt diet for 24 weeks. For 5 weeks they'll take salt pills, and for another 5 weeks they'll take placebo pills, to see the real effect of sodium. Researche…

Researchers at the University of Alberta are comparing two virtual physical therapy programs with usual care for rural adults who have hip or knee osteoarthritis and are not waiting for joint replacement surgery. Participants first continue their usual arthritis care for 12 weeks…

Researchers are testing whether an augmented reality guidance system helps surgeons make more accurate bone cuts and align knee implants during total knee replacement. The study enrolls about 50 adults with advanced osteoarthritis who are scheduled for a primary knee replacement …

This study compares a new emollient balm made from seawater (Relipid+) to a leading balm (Lipikar) for mild to moderate eczema in people aged 6 months to 70 years. The goal is to see if the new balm works just as well at reducing symptoms and improving skin health. Researchers wi…

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This early-stage trial tested an experimental oral drug called BGB-16673 in 34 adults with chronic spontaneous urticaria (CSU), a condition causing persistent hives and itching. The study was double-blind and placebo-controlled, meaning neither patients nor doctors knew who got t…

Researchers at Minia University are testing whether the shape of a single-file rotary dental instrument affects how much debris gets pushed out of the root tip during a root canal, and whether that changes how much pain patients feel afterward. Thirty teeth with irreversible pulp…

Researchers are testing an experimental ointment called IN-115314 in adults with mild to moderate atopic dermatitis, a common form of eczema. The trial compares two strengths of the ointment, 1% and 3%, against a placebo ointment. Participants apply the treatment twice daily for …

This study will follow 86 adults with knee osteoarthritis to see if injections of sugar-water (dextrose) or local anesthetic around the knee nerves provide better pain relief and function. Participants will be assessed for six months after their routine injection. The goal is to …

This phase 3 trial tests whether a lozenge called BupiZenge, which contains the long-acting painkiller bupivacaine, can relieve mouth pain from radiation therapy better than the standard lidocaine rinse. About 150 adults with head and neck cancer will be randomly assigned to one …

This study tests whether giving a steroid (dexamethasone) during shoulder replacement surgery can improve recovery. Researchers will measure pain, nausea, shoulder movement, and how long patients stay in the hospital. The study involves 74 adults with shoulder arthritis who are h…

Adults with inflammatory bowel disease often face psychological distress, especially during transitions like a new diagnosis, a flare, or surgery. Researchers are testing IBD Strong Peer, a program where trained peer mentors provide emotional support through up to 10 virtual call…

This study tests an experimental antihistamine called rupatifen fumarate for people with seasonal allergic rhinitis (hay fever). About 550 adults aged 18 to 65 with at least a 2-year history of seasonal allergies will take either the new drug, an existing antihistamine, or a plac…

This early-stage study tests a single dose of an experimental drug called GTX-B001 in healthy people and those with chronic inducible urticaria—a condition where cold or scratching causes painful hives. The main goal is to check safety and how the body handles the drug. About 72 …

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This study tests a 'fast-track' recovery plan for children aged 2 to 17 who had surgery for a burst appendix. The goal is to see if they can go home sooner without raising the risk of problems like infection or needing another surgery. About 772 children will take part, and their…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This trial tests whether regular use of a digital mindfulness meditation app can help adolescents aged 12-17 with moderate to severe atopic dermatitis (eczema) improve disease control and quality of life. Participants will use the app for 10-15 minutes, 3-4 times a week, while a …

This Phase 2 study tests an experimental ointment called GX-03 in adults with moderate-to-severe eczema. About 110 to 200 participants will apply either the active ointment or a placebo for 8 weeks. Researchers will measure improvements in skin rash, itch, and patient-reported sy…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This trial compares two injection sites for steroid shots in people with moderate-to-severe knee osteoarthritis. Participants get the injection on either the inside or outside of the knee, then report pain and function over 12 weeks. The goal is to see if one spot provides better…

This trial tests whether Daydrop Triple Action eye drops can relieve symptoms of allergic conjunctivitis, such as itching, redness, and tearing. The drops contain ectoine, hyaluronic acid, and carboxymethylcellulose, which are meant to hydrate and protect the eye surface. About 4…

This trial tests whether remote tai chi, taught through web-based sessions twice a week for 12 weeks, can reduce knee pain in adults aged 50 and older with knee osteoarthritis. Researchers compare adding remote tai chi to routine care against routine care alone, measuring pain, p…

This study tests an experimental daily tablet (PF-08049820) for adults with moderate to severe eczema (atopic dermatitis). About 165 participants will take either the study drug or a placebo for 12 weeks. Researchers will check skin improvement, itching, and safety through clinic…

This phase 2 trial is testing whether daily doses of THC, CBD, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 participants will take one of the study drugs or a placebo for 16 weeks, with regular pain assessments, blood tests, and brain…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This trial tests two common injections for pain in the shoulder, elbow, wrist, or hand caused by arthritis or tendon problems. One injection is triamcinolone, a corticosteroid that reduces inflammation. The other is ketorolac, a non-steroidal anti-inflammatory drug (NSAID). Parti…

This study tests whether hyaluronic acid injections into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also measure changes in inflammation-related substances in blood and joint fluid. 50 adults aged 45-75 with moderate knee os…

This study tests whether an injection called stapokibart can reduce nasal allergy symptoms like runny nose, congestion, sneezing, and itching in adolescents aged 12 to 17 with seasonal allergic rhinitis (hay fever). Participants receive either stapokibart or a placebo alongside t…

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

This study tests if a steroid mouthwash can prevent or reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 100 adults with advanced breast or lung cancer will use the mouthwash and be monitored for 12 weeks. The goal is to see if this simple step…

This study tests two different nerve block methods to control pain in people with multiple broken ribs. The goal is to see which technique provides better pain relief, helps patients breathe deeper, and shortens hospital stays. Thirty-six adults with at least two rib fractures wi…

This study tests a new imaging method using a special dye (FAPI) to detect bowel scarring in people with Crohn's disease. Scarring affects up to half of patients and often leads to surgery, but current tests can't spot it early. The study will involve 30 adults starting biologic …

Lateral epicondylitis, often called tennis elbow, causes pain and tenderness on the outside of the elbow and can linger despite treatment. Researchers are comparing 128 people with chronic lateral epicondylitis to healthy controls to see whether those with elbow pain have lower p…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

Researchers are running an observational registry to study whether vonoprazan, an oral drug for heartburn and acid reflux, is safe to take during pregnancy. The study follows women aged 15 to 50 who took vonoprazan while pregnant and compares their outcomes with women who did not…

This early-phase study is testing whether afimkibart, an experimental drug for ulcerative colitis, changes how the body processes common medications like caffeine, warfarin, and omeprazole. About 25 people with moderate to severe active ulcerative colitis will receive afimkibart …

This study looks at how much of the drug bimekizumab passes into breast milk. Researchers will collect milk samples from 20 breastfeeding mothers with conditions like psoriasis or arthritis over several weeks. The goal is to understand potential exposure for nursing infants, not …

Researchers are studying whether an ischemic stroke in the middle cerebral artery territory triggers inflammation and scarring in the heart muscle. The trial enrolls 44 adults with acute stroke and 24 people with stroke-like symptoms but no brain infarct as a comparison group. Pa…

Researchers are studying whether cigarette smoking is linked to levels of two proteins, MFN1 and NLRP3, in the fluid between the teeth and gums. The study includes 88 adults aged 25 to 65, split into four groups: nonsmokers and smokers with healthy gums, and nonsmokers and smoker…

Researchers are observing how often children hospitalized with non-severe pneumonia receive antibiotics and how doctors decide whether a child needs them. The study follows 200 children admitted to two German hospitals, recording treatment choices, medical complications, and pare…

This study is for people with pancreatic cysts or other pancreas issues. Researchers will collect blood, tissue, and scan data from over 1,100 participants to create a large database. The goal is to develop noninvasive tools that predict which cysts may become cancerous, helping …

This study follows 150 adults with eosinophilic esophagitis (EoE) who are starting dupilumab as part of their normal care. Researchers will collect information on medical history, symptoms, and quality of life over two years to see how well the treatment works in real-world setti…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

The Pulmonary Fibrosis Foundation runs an online registry where people with pulmonary fibrosis or interstitial lung disease, their caregivers, and their family members can share information about their health and experiences. Participants enroll themselves and answer questions ov…

Researchers at a dental institute in India are studying whether levels of two inflammation markers, IL-1beta and IL-6, in the tooth's pulp can predict how well a full pulpotomy works. The procedure removes the inflamed crown portion of the pulp, caps it with a mineral-based mater…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical data, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better understan…

This study aims to develop a blood test that measures B regulatory cells, which may indicate whether allergen immunotherapy (allergy shots) is successfully reducing allergic reactions. Researchers will study 80 adults with pollen or venom allergies who are starting routine allerg…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study aims to understand how the immune system and skin healing are connected in people with primary immunodeficiency, psoriasis, or eczema, as well as in healthy volunteers. Researchers will collect skin biopsies, blood samples, and optional skin swabs to analyze microbes a…

This study aims to understand what causes primary sclerosing cholangitis (PSC), a rare chronic liver disease. About 143 adults with PSC will provide blood, saliva, urine, stool, and tissue samples, plus undergo imaging and procedures like colonoscopy and liver biopsy. No treatmen…

This study looks at thumb osteoarthritis, a common cause of pain and weakness at the base of the thumb. Researchers will assess 93 people using a broad approach that includes physical, psychological, and social factors. They will also test whether artificial intelligence can pred…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study tests how a single injection of HRS-4729 behaves in people with mild, moderate, or severe kidney impairment compared with healthy people. Researchers measure drug levels in the blood over time to see if kidney function affects how the body processes the drug. The trial…

This study looks at the tiny organisms living on our skin—like bacteria and fungi—and how they might differ in people with eczema (atopic dermatitis). Researchers will collect skin samples from healthy volunteers and patients aged 2 to 40 with moderate to severe eczema, as well a…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study is for people with certain autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn more about what causes these diseases and how they affect the body over time. Participants will have medical tests a…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study aims to learn more about how lupus (SLE) develops and changes over time by observing patients and their relatives. Up to 2000 people aged 3 and older with known or suspected lupus, along with their family members, will provide medical history, blood and urine samples, …

This study examines how common eczema treatments, including antibiotics and bleach baths, change the types and amounts of bacteria on the skin. Researchers will compare people with eczema to healthy volunteers. The goal is to understand the skin microbiome better, not to test a n…

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 children and adults with myositis, along with healthy volunteers, to track changes in the immune system and other health problems over…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This study collects blood stem cells and immune cells from healthy volunteers and patients with primary immune deficiencies or blood disorders. The cells are used in the lab to develop new gene and cell therapies. Up to 850 adults aged 18-70 will participate. The goal is to advan…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

Researchers in China are building a registry of people diagnosed with lupus nephritis, a kidney complication of lupus. The study plans to enroll 5,000 patients from participating hospitals and follow them with yearly check-ins. By collecting baseline and follow-up information, th…

Researchers in China are enrolling people with biopsy-confirmed primary IgA nephropathy into a long-term registry. Participants are followed once a year, with baseline and follow-up details recorded in a database. The study tracks deaths from any cause and heart-related deaths, p…

This study is testing a handheld device called Nevisense Go to see if it can predict eczema (atopic dermatitis) flares before they become visible or cause symptoms. About 450 people aged 12 to 89 with a history of eczema flares will use the device at home for 90 days. The goal is…

Researchers at Shanghai Pulmonary Hospital are studying how much breathing force people with idiopathic or progressive pulmonary fibrosis can generate through inhaler devices of different resistances. Sixty participants will use a handheld tool called the In-Check DIAL G16, which…

This study is creating a European registry for people with idiopathic granulomatous mastitis (IGM), a rare inflammatory breast condition that causes pain, redness, and abscesses. Researchers will collect information from 1,000 participants to better understand symptoms, treatment…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 patients through biopsy or surgery to assess quali…

Researchers at Biruni University are studying whether baseline blood levels of three hormones (DHEAS, FSH, and LH) are linked to how well adult women with moderate to severe acne respond to the drug isotretinoin. The trial enrolls 64 women aged 18 and older who are starting syste…

This study tests whether a chatbot called 'Pneumonia Care Helper' can improve the knowledge, attitudes, and caregiving skills of people caring for elderly pneumonia patients. 150 caregivers will either use the chatbot with educational videos for 5 days or receive standard paper i…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

OPERA is a large observational database that collects health records from people treated for chronic conditions such as HIV, liver disease, inflammatory bowel disease, heart disease, rheumatic disease, and neurodegenerative disease. Researchers use the records to study how these …

This study is creating a large collection of microbiome samples—like stool, saliva, and skin swabs—from 600 people of all ages, including healthy volunteers and those with various illnesses. The goal is to build a resource for future research on how the microbiome affects health …

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study follows 80 adults in Canada with moderate-to-severe psoriasis who are starting the drug tildrakizumab. Researchers want to see how the treatment affects quality of life and skin clearing over one year, especially in people with darker skin tones (Fitzpatrick type III a…

This study compares two types of visual cues during treadmill walking in 36 athletes who had ACL reconstruction. One cue is a steady beat (isochronous), the other has natural fluctuations (fractal). The goal is to see which better restores natural walking patterns and brain activ…

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

This study looks at how gum surgery changes inflammation markers in the blood. Researchers will take blood samples from 30 adults before, during, and after dental procedures. The goal is to see if surgical stress causes a different inflammatory response compared to non-surgical c…

Immune checkpoint inhibitors help the body's immune system fight cancer, but in some patients they trigger dangerous heart inflammation and other cardiovascular problems. Researchers are combing through the World Health Organization's global drug safety database, two French natio…

This study looks at how common chemicals in personal care products, processed foods, and synthetic materials affect skin, gut, and airway health. One hundred twenty healthy adults will stay in a controlled hospital room for two 7-day periods—one with filtered air and pure product…

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before an…

This study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition causing fevers and organ damage. Researchers will follow 300 participants for up to 3 years, collecting blood samples and medical data to identify…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

Many people with Graves' disease keep feeling mentally drained even after treatment brings their thyroid hormones back to normal. Researchers suspect the immune system may be attacking the brain in a way that standard thyroid tests miss. The study follows 430 people newly diagnos…

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in brea…

This early-stage study tests a new drug called ECC4703, being developed for a serious fatty liver condition (MASH). Researchers want to see how taking the drug with or without food changes the amount that gets into the blood. 72 healthy adults will receive a single dose of the dr…

This study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study looks at whether changing how much salt you eat can affect skin sodium levels and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either sodium tablets or a placebo for several weeks. The goal is to see if this approach is practic…

Researchers are studying whether the mix of bacteria in the gut relates to complications of gallstone disease, such as pancreatitis and acute cholecystitis. Adults with confirmed gallstones at East Kent hospitals provide stool samples at several points, including before and after…

Researchers are tracking how lebrikizumab, a treatment for atopic dermatitis, changes the community of fungi, bacteria, and Staphylococcus on the skin. The study enrolls 60 adults with eczema who are starting lebrikizumab. Skin swabs taken before treatment and at weeks 4 and 16 w…

Researchers at IRCCS San Raffaele are creating a registry of images and videos from endoscopic ultrasound procedures performed to investigate pancreatic diseases. The study will gather data from about 12,000 patients with conditions like pancreatitis, pancreatic cancer, and neuro…

This pilot study will test if parents can learn to use a digital otoscope (ear camera) at home to check for ear infections in their young children. About 40 children aged 1-4 who have had ear infections before will take part. Parents in the study group will get training and a dev…

This study is gathering health information from 2,000 adults with primary sclerosing cholangitis (PSC) to build a real-world data comparator group. The goal is to help design and run future drug trials more efficiently by providing a control group from real patient experiences. P…

Researchers are creating a biobank of biological samples and clinical data from 2000 adults with various pancreatic conditions, including pancreatitis and pancreatic cancer. The goal is to investigate how genetic predisposition and environmental exposures interact to trigger thes…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This early-stage study tests an experimental drug called HEC169584 in 96 healthy adults aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it, not to treat any disease. Results will help guide future studies for non-alcoholic steatohepatitis (…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This pilot study tests whether a tool called ClassIntra, used to grade unexpected events during surgery, can be applied to children having their appendix removed. Researchers will record the operations of 80 children aged 5 to 17 and have two independent surgeons review the video…

This study aims to find new blood-based markers that can predict or diagnose infected pancreatic necrosis (IPN) in people with severe pancreatitis. About 20% of acute pancreatitis cases develop tissue death (necrosis), and when that tissue gets infected, the risk of death rises t…

This study is observing 223 people with active lupus (including kidney inflammation) who haven't gotten better with steroids and at least two immunosuppressants. Researchers want to see how well today's standard treatments work for these tough cases. The goal is to measure how ma…

This study collects and stores medical information from people treated for orthopaedic conditions like osteoarthritis, scoliosis, and cerebral palsy. Researchers at the University of Florida will gather data during routine clinical care to create a resource for future research. T…

Researchers at University Hospital Bonn are following 300 adults who undergo knee or hip replacement surgery to understand how their recovery unfolds. The study measures quality of life, hand grip strength, and bone density before and after the procedure. The goal is to identify …

This observational study looks at whether oral health and the bacteria in saliva are linked to disease activity in children with juvenile idiopathic arthritis (JIA). Researchers will compare children with active disease to those in remission, examining their teeth, gums, oral hyg…

This study follows children aged 0 to 14 with suspected non-IgE food allergies, which cause digestive symptoms like reflux, colic, or constipation rather than immediate allergic reactions. Researchers will track symptoms, triggers, and growth over time, and analyze blood samples …