Could your soap and food be making you sick? new study investigates
NCT ID NCT07271381
First seen Jun 24, 2026 · Last updated Sep 11, 2026 · Updated 4 times
Summary
This study looks at how common chemicals in personal care products, processed foods, and synthetic materials affect skin, gut, and airway health. One hundred twenty healthy adults will stay in a controlled hospital room for two 7-day periods—one with filtered air and pure products, and one with everyday exposures. Researchers will measure changes in skin, gut, and lung function to understand links to allergic and inflammatory conditions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Environmental exposures (chemicals in personal care products, processed foods, synthetic materials)
- What this could lead to
- If successful, this could help identify which everyday chemicals trigger allergic or inflammatory responses, guiding future prevention strategies.
- What could go wrong
- This is an early-stage observational study with only 120 healthy volunteers. Results may not apply to people with existing conditions, and the controlled setting may not reflect real-world exposure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2026
- Expected to finish
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Jan 2031
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: To participate in this study, an individual must meet all of the following criteria: 1. Ability to provide informed consent. 2. Age 18-80 years. 3. Agreement to adhere to lifestyle considerations. 4. Ability to exclusively adhere to UPD and MPD during inpatient stay. 5. Ability to speak English. 6. Willing to allow storage of samples and data for future research. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Diagnosis of atopic (physician-diagnosed asthma, AD, food allergy, chronic hives), autoimmune, metabolic, or chronic infectious or inflammatory diseases. 2. Current or history of neoplastic disease within 5 years. 3. Use of medication(s) that may affect skin, GI, and/or airway symptoms and may have an effect on skin microbiome, GI microbiome (topical or oral antibiotic use may require 3-6 month delay in enrollment for gut microbiome repopulation, see #8), and/or serum cytokines (other than oral birth control, which is not exclusionary and is allowed during participation provided there is consistence use for 3-6 months prior to enrollment). 4. Current receipt of chemotherapy. 5. HIV, hepatitis B, or hepatitis C infection. 6. Receipt of any vaccine within 1 month prior to enrollment. 7. Receipt of oral antibiotics within 3-6 months prior to enrollment. 8. Use of topical, oral, or parental corticosteroids within 1 month prior to enrollment. 9. Participation in another treatment or intervention study within 3 months prior to enrollment. 10. Currently pregnant or lactating. 11. Currently smoking or vaping. 12. Any other condition or intercurrent illness deemed by the investigators to be of potential risk to the participant or validity of study results.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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