National Institute Of Allergy And Infectious Diseases (niaid)

This study is testing whether starting powerful HIV medicines within 48 hours of birth can lead to long-term remission, meaning the virus stays undetectable even after stopping treatment. It will enroll over 1,100 infants born to mothers with HIV. The goal is to see if this very …

This study is testing a new gene therapy for a single patient with a rare and serious inherited immune disorder called CD40L-HyperIgM syndrome. Doctors will use a precise gene-editing tool to fix the patient's own blood stem cells and immune cells, then infuse them back after a m…

This study is testing the safety of two new experimental vaccines designed to prevent infection with Epstein-Barr virus (EBV), which causes mononucleosis ('mono') and is linked to certain cancers. Researchers are enrolling 750 healthy adults aged 18-29, both those who have never …

This study is testing how well the Shingrix shingles vaccine works and how safe it is for people living with HIV. Researchers will compare the immune response in people with HIV to that of healthy volunteers. Participants will receive two vaccine shots over two months and be foll…

This study aims to develop a vaccine that prevents malaria infection during pregnancy, which poses serious risks to both mothers and babies. Researchers are testing potential vaccine candidates using laboratory tests with malaria parasites collected from pregnant women in Mali. T…

This early-stage study is testing the safety and immune response of a new COVID-19 booster vaccine called Boost-2867. It will be given to 140 healthy adults who have already been vaccinated, either as a shot in the arm or as a nasal spray. Researchers want to find the safest and …

This early-stage study is testing whether three new experimental HIV vaccines are safe for people. Healthy volunteers will receive two nasal spray vaccines followed by a booster shot, while researchers monitor for side effects and check if the vaccine viruses can spread to househ…

This is an early-stage study to check the safety and immune response of a new type of flu vaccine. The vaccine targets a stable part of the flu virus that doesn't change much, which could lead to protection against many different flu strains. Researchers are testing it with and w…

This is a very early study to test the safety and immune response of a new two-part HIV vaccine regimen in healthy adults. The study involves giving a 'prime' shot followed by 'boost' shots to try to train the immune system to fight HIV. Researchers will closely monitor 42 partic…

This early-stage study is testing a new experimental flu vaccine called FluMos-v2. Researchers want to see if it's safe and how well it triggers an immune response in healthy adults, both by itself and when mixed with an experimental immune-boosting ingredient (ALFQ adjuvant). Th…

This study is testing the safety and immune response of a new HIV vaccine candidate called VRIPRO. It will enroll 40 healthy adults, aged 18-60, who previously participated in a specific earlier HIV vaccine trial (HVTN 706). Participants will receive three injections over 24 week…

This study is testing if a stem cell transplant can better control multiple sclerosis (MS) than the strongest available drugs in people whose MS stays active despite treatment. The transplant involves wiping out a person's faulty immune system with chemotherapy and then rebuildin…

This study is testing a drug called emapalumab in people with APECED, a rare autoimmune disease that attacks the small intestine. The goal is to see if the drug can reduce gut inflammation and improve symptoms like diarrhea and pain. Participants will receive the drug through an …

This study is testing a new drug combination given before a stem cell transplant to improve the procedure's success for people with Chronic Granulomatous Disease (CGD). CGD is a serious immune disorder that causes frequent infections. The trial aims to help the donor stem cells t…

This early-stage study is testing whether a medication called daratumumab, already used for some cancers, is safe for people with antiphospholipid syndrome (APS), a disorder that causes dangerous blood clots. Up to 22 adults with APS will receive the drug through an IV to see wha…

This study is testing whether a spray containing a harmless skin bacteria (Roseomonas mucosa) mixed with ground cardamom seeds can help control eczema symptoms. 120 participants aged 2 and older with eczema will spray the solution on their skin 2-3 times a week for 14 weeks, then…

This study aims to evaluate and treat people with parasitic infections like malaria or intestinal worms using standard medical approaches. Participants (age 3+) with known or suspected infections will receive examinations, tests, and individualized treatment plans. The goal is to…

This early-stage study is testing a new procedure for adults with Chronic Granulomatous Disease (CGD), a rare genetic disorder that weakens the immune system. Researchers collect a patient's white blood cells, use messenger RNA (mRNA) to temporarily correct the genetic flaw in a …

This study is testing if adding two lab-made antibodies to standard HIV medication, when started very early after infection, can help the body control the virus on its own. The goal is to see if people can safely take a break from their daily pills without the virus quickly rebou…

This study has two main parts. First, it will follow 800 new kidney transplant patients to see if a new blood test can predict who is at higher risk for organ rejection. Second, for 300 of the most stable patients, it will test if switching from the standard anti-rejection drug t…

This study is testing a multi-part strategy to help the immune system control HIV without daily antiviral pills. It combines a vaccine, an immune-stimulating drug, and two lab-made antibodies. The goal is to see if this approach can keep HIV levels low when participants temporari…

This study is testing whether a drug called belimumab is safe for people with idiopathic CD4 lymphopenia (ICL), a rare condition where the body has too few infection-fighting white blood cells. Twenty adults with ICL will receive belimumab through an IV over six months and be clo…

This study is testing whether Mozobil, a drug already used for other conditions, can safely improve low white blood cell counts in adults with WHIMS syndrome. WHIMS is a rare genetic disorder where the immune system doesn't work properly, leading to frequent infections, warts, an…

This study is testing a two-part treatment for adults with moderate-to-severe Crohn's disease that isn't controlled by standard medicines. First, researchers want to see if a drug called vorinostat is safe and can reduce gut inflammation and symptoms. If it works, participants ma…

This study is testing whether adding an investigational drug called ublituximab to standard medications helps people with a rare autoimmune muscle disease. It will enroll 30 adults who were recently diagnosed and still have active muscle weakness. The main goal is to see if the c…

This study is testing new combinations of tuberculosis drugs to see if they work better and are safer than the current standard treatment. It will enroll 315 adults with drug-susceptible lung TB to compare experimental regimens against the usual four-drug therapy. The main goal i…

This study is testing a new gene-editing treatment for adults with a rare, inherited immune disorder called X-linked chronic granulomatous disease (X-CGD). Doctors will collect a patient's own blood stem cells, use a precise gene-editing tool called 'base editing' to try to fix t…

This study is testing whether adding an approved drug called dupilumab helps people with hypereosinophilic syndrome (HES) who still have symptoms like breathing problems or skin issues despite taking other biologic medications. The goal is to see if the combination better control…

This early-stage study is testing a new cell therapy for people who have been waiting over a year for a kidney transplant and have immune systems that would reject almost any donor kidney. Researchers will collect a patient's own immune cells, modify them in a lab to target antib…

This early-stage study aims to find a safe and effective dose of a new oral drug called letermovir for newborn infants with symptomatic congenital cytomegalovirus (CMV). The study will enroll 12 infants to see how their bodies process the drug and to check for any side effects. I…

This study is testing whether people with early-stage relapsing multiple sclerosis can safely stop taking the drug ocrelizumab after two years and remain in remission. All 123 participants will receive the drug for two years, then some will switch to placebo infusions while other…

This study is for people with giant cell arteritis (GCA) whose disease is under control after at least a year of treatment. It aims to see if they can safely stop or reduce their current medication (tocilizumab) without the disease coming back. About 78 participants will be rando…

This trial is testing a new gene therapy for patients aged 2 to 50 with X-linked Severe Combined Immunodeficiency (XSCID), a severe genetic immune disorder. The treatment aims to correct the faulty gene in a patient's own blood stem cells and infuse them back after mild chemother…

This study is testing if baricitinib, a drug used for other immune conditions, is safe for people with Job syndrome who also have lupus-like disease or a severe skin rash (atopic dermatitis). It will enroll about 20 participants aged 12 and older. The main goal is to check for si…

This study is testing if a drug called belatacept can safely replace part of the standard anti-rejection medication regimen for heart transplant patients. The goal is to protect the new heart from rejection while reducing the kidney damage often caused by long-term use of the sta…

This study is testing if adding a new drug called lenacapavir to standard HIV medication can reduce the hidden, inactive virus that persists in the body. It will involve 50 adults whose HIV is already well-controlled with long-term therapy. Researchers will compare the size of th…

This early-stage study is testing whether a combination of two drugs (everolimus and epoetin) can help stable liver transplant recipients safely reduce and potentially stop their lifelong anti-rejection medications. The goal is to help patients achieve 'operational tolerance' whe…

This study is testing if the drug ruxolitinib can help regrow hair in people with a rare immune system disorder called APECED who have severe hair loss (alopecia areata). About 70 participants, aged 12 to 65, will take the drug as a pill twice a day for 8 months. Researchers will…

This early-stage study is testing a new drug called NT-I7 (efineptakin alfa) to see if it is safe and can increase the number of a key type of immune cell (CD4 T cells) in people with idiopathic CD4 lymphopenia (ICL). ICL is a rare condition where people have very low levels of t…

This study is testing if adding a drug called tocilizumab to standard anti-rejection medications can better protect transplanted lungs. It will involve 350 recent lung transplant recipients, who will receive either tocilizumab or a placebo for about 20 weeks. The main goal is to …

This study is testing if a new, shorter treatment plan works better for a severe brain infection called tuberculous meningitis (TBM). It will compare a 6-month regimen using higher doses of key drugs against the current standard 9-month treatment. The main goal is to see if the n…

This study aims to find better ways to control multiple sclerosis (MS) progression by testing if personalized drug combinations work better than single drugs. Researchers will measure inflammation markers in spinal fluid to match 250 adults with progressive MS to one of four drug…

This study is testing if a combination of two immune-suppressing drugs works better than one to control primary membranous nephropathy, a serious autoimmune disease that damages the kidneys. It will enroll 58 adults to see if adding belimumab to rituximab leads to a more lasting …

This study aims to find a better way to prevent rejection in young people who receive a kidney transplant. It will compare the safety and effectiveness of two different combinations of anti-rejection drugs. The goal is to see which regimen better protects the new kidney's functio…

This study is testing a new topical gel containing a specific strain of bacteria (Staphylococcus hominis A9) to see if it is safe and can help control eczema. It will enroll about 86 adults and adolescents with eczema who have a common 'bad' bacteria (Staphylococcus aureus) on th…

This study is testing an experimental pill called soquelitinib for people with ALPS-FAS, a rare genetic disorder where the immune system stores too many white blood cells, causing enlarged organs and low blood counts. Researchers want to see if taking this pill twice daily for ab…

This study is testing if an experimental drug called VIB4920 can help control kidney damage in people with active lupus nephritis. About 74 participants will receive either VIB4920 or a placebo (inactive substance) through an IV, along with standard medications, to see if it impr…

This study is testing whether injecting a medication called Berinert directly into a donated kidney during transplant surgery can help the kidney work better in the first year after transplant. Researchers will compare Berinert to a placebo in 180 adults receiving high-risk decea…

This study is testing whether a fecal microbiota transplant (FMT) can reduce colon inflammation in people with chronic granulomatous disease (CGD)-associated colitis. CGD weakens the immune system and often causes painful gut inflammation. Researchers will give 20 participants a …

This study is testing whether adding the drug belumosudil to standard care can prevent chronic lung rejection in high-risk transplant patients. Researchers will enroll 234 lung transplant recipients who show early signs of inflammation or rejection on a recent biopsy. Participant…

This study is testing a new, simpler way to diagnose eosinophilic esophagitis (EoE), a condition that causes painful swallowing. Researchers want to see if a swallowable string that collects fluid from the throat is as accurate as the current standard test, which requires a more …

This study is testing a new, simpler way to detect H. pylori, a common stomach bacteria that can cause ulcers and other problems. Participants with a known infection will swallow a capsule on a string to collect stomach fluid, which is then tested. Researchers will compare this n…

This study is testing a new radioactive dye used during PET/CT scans to find and track clumps of protein called amyloidosis. Amyloidosis is a rare side effect that can happen in people with a genetic immune disease (CAPS) who take the drug anakinra. Researchers want to see if thi…

This study is testing whether a vaccine given before liver transplant surgery can prevent or reduce Cytomegalovirus (CMV) infection afterward. CMV is a common virus that can cause serious illness in transplant patients. Researchers will give two vaccine doses to 416 CMV-negative …

This study is testing three different antibody injections to see if they can safely prevent HIV infection in people who are not living with HIV. Researchers will give the antibodies to 200 healthy adults and monitor them for 18 months to check for side effects and measure how lon…

This study is testing if a single injection of an antibody called L9LS can safely prevent malaria infection. It will involve 290 adults, primarily women of childbearing age in Mali, who will receive either the antibody or a placebo. Researchers will monitor participants for six m…

This study is testing the safety of two lab-made antibodies, given as shots to newborns who were exposed to HIV during birth. The goal is to see if these antibodies are safe for infants and to measure how long they stay in the body. Researchers will give the antibodies to 48 heal…

This study aims to compare the safety and effectiveness of two different medications, pramipexole and escitalopram, for treating major depression in people living with HIV. The trial will also look at whether these treatments help with mild memory and thinking problems that somet…

This study is collecting biological samples like saliva, blood, urine, and tissue from volunteers to help scientists better understand blood disorders like sickle cell disease, thalassemia, and malaria. Researchers need samples from both people with these conditions and healthy i…

This study aims to better understand how HIV hides and replicates in the body's lymph nodes and bone marrow, compared to what is seen in the blood. Researchers will collect blood and lymph node tissue samples from 400 people living with HIV and some without HIV for comparison. Th…

This study aims to find the best way to measure kidney function in critically ill patients with serious bacterial infections. Researchers will compare a new blood test (Cystatin C) to the standard method to see which one more accurately predicts how the body processes two common …

This study aims to learn more about nontuberculous mycobacterial (NTM) infections by observing people who have them. Researchers will collect detailed health information, perform tests, and study genetics to understand why some people get these recurrent infections and how the di…

This study is not a treatment trial but a screening program to find healthy adults who might qualify for future malaria research. Researchers want to build a pool of volunteers for upcoming studies testing malaria vaccines, drugs, or prevention methods. Participants undergo healt…

This study follows people with neurocysticercosis (a brain infection caused by pork tapeworm larvae) during and after their standard medical treatment. Researchers will track 500 patients over time to understand how the disease progresses, what factors lead to better or worse out…

This study aims to collect biological samples from healthy volunteers to help researchers develop and improve laboratory tests used in medical research. Participants ages 3-80 will provide blood, saliva, stool, and skin/mucus swabs during visits over several years. The samples wi…

This study collects blood, urine, and other samples from healthy volunteers to help researchers understand eosinophilia, a condition involving high white blood cell counts. Researchers will compare samples from healthy people with those from patients who have this condition. The …

This study aims to better understand how HIV infection works by collecting blood samples from people with and without HIV. Researchers will analyze these samples in the lab to learn how the virus interacts with the immune system and causes disease. The goal is to gather knowledge…

This study collects blood, urine, and other samples from volunteers to support medical research. The samples help scientists study diseases like HIV and hepatitis, understand how the immune system works, and develop new vaccines and treatments. Volunteers aged 3 and older can par…

This study aims to better understand tuberculosis (TB) by observing people who have it. Researchers will collect blood and other samples from 150 participants, both children and adults, who have either active or latent TB. The goal is to learn how the disease progresses and how t…

This is the first study in humans to test a new oral medication called VNT-101, which is being developed to treat influenza (flu). Researchers will give the drug to about 78 healthy adults to see how safe it is and how the body processes it at different single and multiple doses.…

This study aims to understand why vaccine protection weakens over time by tracking immune system responses. Researchers will follow 1200 healthy adults who are getting either their first COVID-19 vaccine or a booster shot. Participants will give blood samples up to eight times ov…

This study aims to better understand why some people have inherited problems with their immune system that lead to frequent or unusual infections. Researchers will observe patients and their family members over time, collecting samples like blood and saliva to learn about the gen…

This study aims to understand how two common HIV medications affect the body's energy use and metabolism, which may explain why some people taking these drugs gain weight. Researchers will compare the effects of dolutegravir (an integrase inhibitor) and tenofovir alafenamide in 1…

This study aims to discover why some people develop severe, recurring, and treatment-resistant warts and lesions from HPV, while others do not. Researchers will follow 850 participants, including people with these severe conditions and their healthy family members, for up to 10 y…

This study aims to understand a rare condition called Idiopathic CD4+ Lymphocytopenia (ICL), where people have very low levels of a key infection-fighting white blood cell for unknown reasons. Researchers will observe up to 950 participants, including patients with ICL and their …

This study aims to understand why some people develop severe, long-lasting forms of Valley Fever, a fungal lung infection. Researchers will examine the immune systems and genetics of 400 participants who have had the disease for over 6 months or where it has spread beyond the lun…

This study aims to learn more about rare, lifelong conditions where the body's immune system causes harmful inflammation, leading to fevers, rashes, and organ damage. Researchers will observe up to 3,200 people with these diseases, their healthy relatives, and volunteers over man…

This study is observing people who previously participated in type 1 diabetes treatment trials. Researchers will follow them for up to five years to see how long their bodies continue to produce insulin naturally and how their immune systems change over time. The goal is to gathe…

This study aims to understand why some people get severe, recurring, or unusual fungal infections, often due to problems with their immune system. Researchers will collect medical information and samples (like blood, saliva, and tissue) from people with these infections, their fa…

This study aims to understand what causes the body to produce too many mast cells in people with mastocytosis. Participants, including patients and some unaffected relatives, will provide blood and bone marrow samples during a single visit. Researchers will analyze these samples …

This study aims to understand why a small group of people with HIV, called 'long-term nonprogressors,' can naturally control the virus for years without medication. Researchers will collect blood samples from 400 people with HIV—including these rare controllers, typical progresso…

This study aims to learn how the body's immune system is connected to skin health and healing. Researchers will collect small skin samples and blood from adults with conditions like eczema, psoriasis, or immune deficiencies, as well as from healthy volunteers. The goal is to gath…

This is an observational study aiming to understand why food allergies develop and how they progress over time. Researchers will follow up to 1,800 participants, including people with food allergies, their relatives, and healthy volunteers, for many years. The study involves coll…

This study aims to discover the genetic and biochemical causes of inherited immune disorders that affect how the body balances white blood cells. Researchers will screen up to 5,000 patients and their family members over 20 years by reviewing medical records and analyzing blood a…

This study aims to understand how harmful bacteria manage to survive and cause disease by evading our body's white blood cells, which normally destroy them. Researchers will collect blood samples from healthy volunteers to study these interactions in a lab. The goal is to gather …

This study aims to learn more about GATA2 deficiency, a genetic disorder that can cause a wide range of health problems from immune issues to cancer. Researchers will follow 600 participants, including people with the gene mutation and their relatives, for up to 15 years to track…

This study aims to learn more about how anthrax affects the body and how people's immune systems respond to it over time. Researchers will observe and collect samples from people who have been infected with anthrax, people who were exposed but not sick, and healthy people who rec…

This study monitors adults with HIV in the Washington, D.C. area to understand long-term health outcomes and how the immune system responds to standard treatments. Participants visit every few months for check-ups and blood tests that support ongoing research and train new infect…

This study aims to better understand primary immunodeficiency disorders (PIDs), which are diseases that weaken the immune system. Researchers will follow up to 2,500 people with a PID, their healthy relatives, and unrelated healthy volunteers for up to 10 years. The main goal is …

This study aims to gather detailed information about pregnancy and malaria in a community in Mali. Researchers will follow up to 9,500 women of childbearing age and their babies for several years to track health outcomes. The data collected will help plan future clinical trials t…

This study aims to learn how the body's immune system responds to vaccines and infections by collecting samples from healthy volunteers. Researchers will analyze blood, saliva, urine, and sometimes tissue samples from up to 500 adults over about a year. The goal is to gather know…

This study aims to discover the specific genes that cause certain inherited immune disorders and understand how they affect health and family risk. It involves patients and their family members who have or are suspected of having these genetic conditions. Participants provide blo…

This study aims to collect samples from people with respiratory virus infections like the flu or COVID-19. Researchers will store these samples in a repository to be used in future research. The goal is to learn more about how these viruses work and how our bodies fight them, whi…

This study aims to understand how malaria develops in people and how it spreads from humans to mosquitoes. Healthy volunteers will be intentionally infected with a malaria parasite via an injection of donated blood, then closely monitored as they develop symptoms. Researchers wil…

This study aims to understand why some tuberculosis patients unexpectedly get worse after starting treatment, a problem called a paradoxical reaction. Researchers will observe 140 adults being treated for TB, with and without these reactions, using scans and blood tests over 6-18…

This study aims to create a safe and reliable model for testing future flu medicines and vaccines. Healthy adult volunteers are intentionally given a specific strain of the flu virus to find the dose that reliably causes mild illness. Researchers will closely monitor participants…

This study aims to learn more about leishmaniasis, a parasitic disease, by observing how people's bodies respond to the infection and to standard treatments. Researchers will enroll people aged 3 to 100 who have or are suspected of having the disease. The main goal is to gather d…

This study aims to understand why and how a specific type of white blood cell, called an eosinophil, becomes active in the body. Researchers will observe people with high levels of these cells, which can occur due to allergies, asthma, or parasitic worm infections. The goal is to…

This study aims to learn how the body's immune system causes inflammation in the gut of people with Crohn's disease and ulcerative colitis. Researchers will observe up to 1,000 patients and collect blood and tissue samples to understand the disease better. The study does not test…

This study aims to better understand primary immunodeficiency disorders (PIDs) by collecting and analyzing biological samples from patients and their relatives. Researchers will perform genetic and immune system tests on these samples to identify the causes of these conditions. T…

This study aims to understand a rare, inherited condition called familial hypereosinophilia, where high levels of a specific white blood cell can damage organs over time. Researchers will follow about 50 family members, both with and without the condition, for many years with ann…

This study aims to understand why some otherwise healthy people get extremely sick from common viruses like herpes, flu, or chickenpox. Researchers will examine 600 participants who have had severe, long-lasting, or hard-to-treat viral infections, along with some of their family …

This study aims to observe and understand how rare immune system disorders progress over time. It will enroll up to 3,500 people, including patients with conditions like Severe Combined Immunodeficiency (SCID), their family members, and healthy volunteers. Researchers will collec…

This study aims to understand how the human immune system responds to infections caused by parasitic worms (filariasis). Researchers will observe 500 participants, aged 3 to 100, who have or are suspected of having these infections. Participants will receive standard medical care…

This study aims to screen healthy adults to create a pool of volunteers for future research on infectious diseases like influenza (flu) and Zika virus. Researchers will collect health information and samples from up to 5,000 participants to quickly identify eligible people for up…

This study aims to understand how disorders of the immune system can cause problems with the brain and nervous system. Researchers will follow 350 participants, including people with immune conditions and healthy volunteers, for 5 years with annual checkups and sample collections…

This study aims to build a large collection of samples and health data from people with allergies, asthma, eczema, and sinus disorders. Researchers will collect blood, nasal swabs, skin swabs, and other samples from up to 10,000 participants aged 3 to 100 over 1-3 years. The goal…

This study aims to learn more about diseases caused by bioterrorism agents (like anthrax) or new, emerging infections (like Ebola or SARS). Researchers will observe and monitor people who have been exposed to or infected by these dangerous germs. The goal is to better understand …

This study aims to understand how the immune system works and ages in people with Down syndrome over 15 years. It will follow 700 participants, including those who had their thymus gland removed during heart surgery as infants and those who did not. By collecting health data and …

This study aims to understand how our genes contribute to immune system problems like allergies, primary immunodeficiencies, and autoimmune diseases. Researchers will analyze the DNA of up to 20,000 participants, looking for genetic differences that might explain these conditions…

This study aims to learn more about Hyper IgE Syndrome, a rare immune disorder that causes severe eczema and frequent infections. Researchers will observe 300 patients and 300 of their relatives over time to understand how the disease develops, identify its genetic causes, and im…

This study aims to understand how the body's immune system responds and changes over time after receiving the seasonal flu vaccine and/or a COVID-19 vaccine. Researchers will follow about 150 adult NIH staff members for roughly a year, collecting monthly blood and nasal samples. …

This study aims to learn more about rare immune system disorders like Common Variable Immunodeficiency (CVID). Researchers will observe 500 patients and some of their family members over time, collecting blood and other samples. The goal is to understand how these diseases progre…

This study screens healthy adults to see if they qualify for future vaccine and antibody research trials at the National Institutes of Health. Participants undergo health checks and provide blood samples, but don't receive any experimental treatments in this screening. The goal i…

This study aims to understand why some people continue to experience symptoms long after they have finished antibiotic treatment for Lyme disease. Researchers will enroll 700 participants, including those with ongoing symptoms, people who recovered fully, and healthy volunteers. …

This study aims to understand how viruses like COVID-19 and herpes change and spread by collecting samples from people. Researchers are enrolling 1,000 participants, including both healthy individuals and those with weakened immune systems, to provide samples like blood and swabs…

This study aims to discover and understand new genetic disorders that cause the immune system to malfunction. Researchers will evaluate up to 500 adults and children with unexplained immune problems, as well as their family members, by reviewing medical records and collecting sam…

This study aims to understand how the immune system responds in people with HIV, especially when treatment is started early. Researchers will collect white blood cells from up to 750 HIV-positive adults who are not yet on medication, using a special blood filtering process. The g…

This study aims to understand why some pregnant women and young children in Mali get severe malaria while others don't. Researchers will follow thousands of mothers and children over several years, collecting health and blood sample data. The goal is to gather knowledge that can …

This study aims to understand why some people with HIV and low immune cell counts develop new or worsening symptoms soon after starting their HIV medications, a condition called IRIS. Researchers will use PET scans, blood tests, and lymph node biopsies to study 300 adults, includ…

This study aims to understand why some otherwise healthy adults develop serious fungal infections called cryptococcosis, which typically affects people with weakened immune systems. Researchers will enroll 800 participants, including patients with the infection, their relatives, …

This study aims to understand a rare disorder where the immune system attacks the body, causing swollen glands and other problems. Researchers will observe patients and their family members over many years to learn how the disease develops, runs in families, and progresses. The m…

This is a long-term screening study to better understand why some people get frequent or severe infections. Researchers will evaluate up to 2000 participants, including people with these infection problems and their healthy blood relatives, over 25 years. The goal is to identify …

This study aims to understand a rare condition called Idiopathic CD4 Lymphocytopenia (ICL), where people have very low levels of a key immune cell. Researchers will collect special cells from the blood of 40 participants, including patients with ICL and healthy volunteers. These …

This study collects blood and bone marrow cells from healthy volunteers and patients with certain immune or blood disorders. The collected cells are used in laboratory research to develop new gene therapies and cell-based treatments. The goal is to create future treatments that c…

This study aims to see if data from smartwatches and smartphones can detect early, subtle signs of respiratory virus infections like flu and coronavirus. Researchers will monitor 1,000 healthy adults who are already participating in separate virus exposure studies, tracking their…

This study aims to understand how staph bacteria cause serious infections, particularly in the spine, which can lead to paralysis. Researchers will use tonsil tissue that would normally be thrown away after routine tonsil removal surgeries. By studying how the bacteria interact w…

This study is collecting body samples like stool, saliva, and blood from 600 people to build a library for future research. The goal is to help scientists understand how the trillions of microbes living in and on our bodies affect our health and contribute to diseases. Participan…

This study aims to learn why some adults develop a severe, life-threatening immune system disorder called secondary hemophagocytic lymphohistiocytosis (sHLH). Researchers will observe 300 adults already diagnosed with sHLH over time, collecting blood samples and health informatio…

This study aims to find the genetic causes of a rare and serious illness called Chronic Active Epstein-Barr Virus (CAEBV), which mostly affects children and young adults. Researchers will analyze blood and tissue samples from patients with CAEBV and their family members to look f…

This study aims to understand how HIV behaves in different body tissues, not just the blood. Researchers will collect small tissue samples from the tonsils, lymph nodes, intestines, and lungs of HIV-positive patients, patients with a rare immune condition (ICL), and healthy volun…

This study aims to discover what germs are causing fevers in Cambodia, especially diseases spread by insects like mosquitoes and ticks. Researchers will enroll up to 6,500 people, from infants to adults, who have a fever or are close contacts of someone with a specific infection.…

This study aims to learn how the body's immune system interacts with the brain and spinal cord in diseases like multiple sclerosis. Researchers will compare detailed tests, including brain scans and blood samples, from healthy volunteers and people with symptoms of immune-related…

This study aims to understand why people have such different reactions to COVID-19, from no symptoms to severe illness. Researchers will collect and analyze blood and other samples from up to 5,000 people, including those who are infected, those who were exposed but didn't get si…

This long-running National Institutes of Health (NIH) study aims to better understand infectious and inflammatory diseases by evaluating patients with these conditions. It enrolls people aged 3 and older who have symptoms or a suspected exposure. The main goal is to gather medica…

This study aims to understand why some people and their families are more prone to serious fungal infections, often due to rare immune system problems. Researchers will collect blood and other samples from patients, their relatives, and healthy volunteers to compare and look for …

This study collects blood samples from healthy volunteers and people with HIV to support laboratory research on infectious diseases and immune function. Participants undergo a special blood collection procedure called apheresis, which allows researchers to obtain larger quantitie…

This study aims to understand why some people, especially children, develop PFAPA syndrome—a condition causing recurring fevers, sore throats, and mouth sores—and other tonsil disorders. Researchers will collect blood, saliva, and other samples from 1500 participants to look for …

This study aims to observe and learn more about Lyme disease by following 500 patients over time. Participants will receive standard medical evaluations and treatments, not experimental therapies. Researchers will collect health data and optional blood samples to study how the in…