Scientists hunt for hidden immunity to animal viruses in cambodia
NCT ID NCT06680843
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how the immune system of healthy adults in Cambodia reacts to viruses that can spread from animals to people. Researchers will collect blood samples from 400 people who have close contact with animals, such as those working in wet markets or living near bat caves. The goal is to measure antibodies and immune cells that fight these viruses, which may help understand how to prevent future outbreaks.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 400 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Healthy adults aged 18 to 65 years who handle suspected infected animals or their excreta, or living within 5 km of animal reservoirs, in Cambodia (n=160 to 320).
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Capacity to provide informed consent. 2. Adult aged 18-65 years. 3. Have interaction with suspected infected animals within the last 2 years, including (but not limited to) the following risk factors: 1. Hunting, slaughtering, or consuming suspected infected animals; 2. Fruit collection, date palm sap harvesting, or tree pruning within agricultural plantations containing bat roosts; 3. Bat guano farming; 4. Ancillary work in live animal markets or wild animal habitats identified as likely containing infected animals (e.g., provision of cleaning, transportation, or tourism services); 5. Living within 5 km of identified animal markets or wild animal habitats identified as likely containing infected animals. 4. Willing to allow biological samples and data to be stored for future research. Exclusion Criteria: 1. Pregnancy (based on self-reporting). 2. Any underlying, chronic, or current medical condition that, in the opinion of the investigator, would interfere with participation in the study (e.g., inability or great difficulty in drawing blood, known anemia). 3. Self-reported symptoms suggestive of acute infection (acute myalgias, arthralgias, headache, retro-orbital pain, dyspnea, rash) within 7 days prior to enrollment. 4. Signs suggestive of acute infection (fever, defined as internal temperature \>38°C; hypoxemia, defined as peripheral oxygen saturation of \<90%; hypotension, defined as systolic blood pressure \<90 mm Hg or diastolic blood pressure \<50 mm Hg) present at screening. 5. Self-reported diagnosis of immune deficiency, including HIV infection, chronic corticosteroid use (≥10 mg prednisone dose or its equivalent for a continuous period of ≥30 days within the last 1 year), ongoing or prior (within the last 10 years) receipt of chemotherapy or immunotherapy, or current hematological malignancy. 6. Receipt of blood products, including immunoglobulin products, within 120 days of study enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
5 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Communicable Disease Control Department
RECRUITINGBattambang, Cambodia
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Communicable Disease Control Department
RECRUITINGKampong Thom, Cambodia
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Communicable Disease Control Department
RECRUITINGKampot, Cambodia
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Communicable Disease Control Department
RECRUITINGStung Treng, Cambodia
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Communicable Disease Control Department
RECRUITINGTakeo, Cambodia