National Institute Of Allergy And Infectious Diseases (niaid)

This study is testing whether giving a single dose of an antibody called L9LS can improve how well the body responds to a new malaria vaccine, R21/Matrix-M. It will involve 24 healthy adults and 333 healthy infants in Mali. Researchers want to see if the timing of the antibody sh…

This is a first-in-human, early-stage trial to test the safety and immune response of two new experimental HIV vaccines. The vaccines, called DV201P-RNA and DV202B1-RNA, use mRNA technology (similar to some COVID-19 vaccines) to train the immune system to fight HIV. The study wil…

This study is testing an experimental flu vaccine called BPL-1357 to see if it is safe and can protect people from getting sick with the flu. Healthy adults aged 18-55 will receive the vaccine either as a shot in the arm, a spray in the nose, or a placebo. Later, some participant…

This large study aims to determine if a common steroid medication (prednisolone) helps hospitalized adults with severe breathing infections and low oxygen levels. Researchers will compare giving the steroid for 7 days against not giving it, tracking whether it reduces deaths, sho…

This study is testing whether alendronate, a medication typically used for bone health, can reduce the hidden reservoirs of HIV that persist in people on standard antiretroviral therapy. Thirty people with well-controlled HIV will be randomly assigned to receive either alendronat…

This study aims to understand how hepatitis C medication works in pregnant women and whether it's safe for both mothers and babies. Researchers will give the drug combination glecaprevir/pibrentasvir to 30 pregnant women with hepatitis C, some of whom also have HIV. They'll measu…

This study is testing if a drug called tezepelumab, given as an injection, can improve the effectiveness of peanut oral immunotherapy (OIT). OIT is a treatment where people eat tiny, increasing amounts of peanut protein to build tolerance. The goal is to see if this combination h…

This early safety study is testing whether two lab-made antibodies can help control HIV when people temporarily stop their regular antiviral medication. It will involve 40 adults living with HIV who started treatment very soon after infection. Researchers want to see if the antib…

This study is testing whether adding two new drugs, carfilzomib and belatacept, to the standard anti-rejection medications can better control a specific type of kidney transplant rejection. It will involve about 25 kidney transplant patients whose bodies are making harmful antibo…

This early-stage study is testing whether the cancer medication dasatinib can reduce the hidden HIV that persists in the body even during effective treatment. Fourteen adults with well-controlled HIV on long-term therapy will take either dasatinib or a placebo pill for 12 weeks. …

This study aims to find the safest and most effective dose of a 28-day medicine combination to prevent tuberculosis (TB) in children under 13 years old. It will include up to 144 children, both with and without HIV, who are at risk of getting TB. Researchers will closely monitor …

This early-stage study is testing the safety of three lab-made antibodies designed to prevent HIV infection. Researchers will give these antibodies, alone and in combination, to 83 healthy adults without HIV to check for side effects and see how the body processes them. The goal …

This study aims to understand how cat allergy shots (immunotherapy) work by comparing people who have been on the shots for over a year with those who have never had them. Researchers will give a small cat allergen skin test and then take samples from nearby lymph nodes and blood…

This study aims to identify blood markers that can predict whether children with suspected peanut allergy will react during a supervised feeding test. Researchers will enroll 500 children aged 1-17 years who may have peanut allergy. Participants will undergo a carefully monitored…

This study aims to understand how everyday exposures to chemicals in food, air, and personal care products affect our health. Healthy volunteers will spend two separate weeks in a hospital, living in either a 'pure' environment with filtered air and natural products or a 'common'…