National Institute Of Allergy And Infectious Diseases (niaid)

This study tests whether tuberculosis (TB) treatment can be tailored to each person's risk of a poor outcome. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment course, while higher-risk partic…

This study tests a new type of COVID-19 booster vaccine given as a nasal spray. The vaccine uses a weakened live virus to train the immune system, potentially offering stronger protection in the nose and throat where the virus enters. Researchers are enrolling 80 healthy adults a…

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

Researchers are testing an experimental tuberculosis vaccine called VIR-1778 in healthy adults who do not have HIV. The vaccine uses a weakened form of human cytomegalovirus to deliver seven TB proteins to the immune system. The trial aims to see if VIR-1778 is safe and whether i…

This phase 1 trial tests a higher dose of the experimental HIV vaccine VIR-1388 in about 12 adults aged 18 to 55 who already carry cytomegalovirus (CMV). The vaccine uses a weakened CMV virus to deliver HIV proteins, aiming to trigger a strong immune response. Participants receiv…

This early-stage trial is testing whether experimental HIV vaccines can safely teach the immune system to recognize and fight the virus. Healthy adults without HIV will receive a protein nanoparticle vaccine, followed by a booster—either another protein nanoparticle or an mRNA va…

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This early-stage study tests whether two lab-made antibodies can help people with HIV control the virus after stopping their regular antiretroviral therapy. The 40 participants all started HIV treatment very early after infection. Researchers will monitor safety and see if the an…

This study tests whether giving a 7-day course of corticosteroids (like prednisolone) to hospitalized adults with severe respiratory infections and low oxygen levels can reduce deaths and the need for breathing machines. About 3,000 participants will be randomly assigned to recei…

This study tests a 28-day daily combination of two drugs, rifapentine and isoniazid, to prevent tuberculosis (TB) in children under 13. About 144 children, some with HIV and some without, will join to find the right dose and check for side effects. The goal is to see if this shor…

This study collects cell samples from the inside of healthy volunteers' noses to create a biobank for future research on respiratory viruses. The goal is to better understand how these viruses infect the nose, travel to the lungs, and spread between people. Healthy adults aged 18…