National Institute Of Allergy And Infectious Diseases (niaid)

This early-stage study tests two new mRNA vaccines designed to help people with HIV produce antibodies against the virus. About 42 adults with well-controlled HIV will receive the vaccines and then temporarily pause their regular HIV medication under close monitoring. The main go…

This early-stage study tests whether two lab-made antibodies can safely help people with HIV keep the virus under control after stopping their daily antiretroviral therapy. The study involves 40 adults who started HIV treatment very early after infection. Participants will receiv…

This study tests whether tuberculosis (TB) treatment can be personalized based on a person's risk of poor outcomes. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment, while higher-risk partici…

This study tests whether alendronate, a drug used for bone health, can reduce the amount of hidden HIV in people who are already on standard HIV treatment. About 30 participants will be randomly assigned to receive either alendronate or a placebo, and neither they nor their docto…

This study tests whether adding the drug tezepelumab to peanut oral immunotherapy (OIT) helps people with peanut allergy safely eat more peanut without symptoms. About 62 people aged 12 to 55 with severe peanut allergy will receive either tezepelumab or a placebo along with OIT f…

This early-stage study tests whether dasatinib, a drug used for cancer, can lower the amount of hidden HIV in the body (the HIV reservoir). Fourteen adults with well-controlled HIV on standard therapy will take either dasatinib or a placebo daily for 12 weeks. The goal is to see …

This study looks at whether giving a common steroid (prednisolone) for 7 days can help hospitalized adults with severe lung infections and low oxygen levels. About 3,000 participants will be randomly assigned to receive the steroid or standard care without it. The goal is to see …

This study looks at whether children who had a liver transplant before age 7 can safely reduce their anti-rejection medication by half. One hundred children will slowly lower their medicine over 18 months while doctors check their liver health with blood tests and biopsies. The g…

This study is testing a 28-day daily treatment (rifapentine plus isoniazid) to prevent tuberculosis (TB) in children under 13 years old, including those with HIV. About 144 children will take part, split into two groups based on HIV status. The goal is to find the best dose and e…

This study looks for signs in the body, called biomarkers, that might show if a child will have a reaction to peanut during a feeding test. It will include 500 children aged 1 to 17 who are thought to have a peanut allergy. The goal is to find better ways to predict allergic reac…