National Institute Of Allergy And Infectious Diseases (niaid)

This study tests a high-dose stem cell transplant for people with chronic granulomatous disease (CGD), a condition that weakens the immune system. The goal is to replace faulty stem cells with healthy donor cells to cure the disease. To prevent the donor cells from attacking the …

This study tests a new approach to bone marrow transplant for people with chronic granulomatous disease (CGD) who don't have a perfectly matched donor. The goal is to see if using a partially matched relative as a donor, along with special drugs and radiation, can safely cure the…

This early-stage study tests an experimental HIV vaccine in 35 people living with HIV. The goal is to see if the vaccine can safely train the immune system to produce special antibodies that might help control the virus. Participants will temporarily pause their regular HIV medic…

This early-stage study tests a new type of COVID-19 booster vaccine called PepGNP-COVID19 in 60 healthy adults aged 18-64. Unlike current vaccines that focus on antibodies, this one uses tiny gold particles to train the body's T cells to recognize and fight the virus, potentially…

This early-stage study tests a new mRNA-based flu vaccine in 50 healthy adults aged 18 to 49. Participants receive two shots, 28 days apart, at different dose levels. The main goal is to check safety and how well the vaccine triggers an immune response, compared to a standard flu…

This study tests whether giving infants an investigational antibody (L9LS) before a malaria vaccine (R21/Matrix-M) is safe and helps the vaccine work better. About 180 healthy infants in Mali, aged 1 to 12 months, will receive either the antibody or a placebo, followed by the vac…

This early-stage study tests three experimental mRNA vaccines designed to teach the body to fight HIV. About 108 healthy, HIV-negative adults aged 18-55 will receive the vaccines to check for safety and whether they produce protective antibodies. The goal is to see if these vacci…

This early-stage study tests a new malaria vaccine made from genetically weakened parasites. The goal is to see if it is safe and can train the immune system to fight malaria without causing the disease. About 22 healthy adults who have never had malaria will receive the vaccine …

This early-stage trial tests two experimental mRNA vaccines designed to train the immune system to make powerful antibodies that could block HIV. The study involves 53 healthy adults without HIV to check if the vaccines are safe and trigger the desired immune responses. The goal …

This early-stage study tests two experimental HIV vaccines for the first time in people. The goal is to see if they are safe and how well the immune system responds. Forty-five healthy adults without HIV, aged 18 to 55, will receive the vaccines and be followed for about 16 month…

This study tests whether the 9-valent HPV vaccine (Gardasil 9) can help people with idiopathic CD4 T cell lymphocytopenia (ICL), a rare condition that weakens the immune system and makes HPV infections more severe. About 54 adults with ICL and healthy volunteers will receive thre…

This early-stage study tests whether two experimental HIV vaccines are safe and can trigger a strong immune response in healthy adults without HIV. The vaccines are designed to train the body to make special antibodies that can fight many types of HIV. The study involves 52 parti…

This early-stage study tests whether two experimental HIV vaccines (UVAX-1107 and UVAX-1197) are safe and can trigger an immune response in healthy adults without HIV. Twenty-five volunteers will receive injections and be monitored for about a year. The goal is to see if the vacc…

This early-stage study tests an experimental vaccine called HydroVax-001B WNV in 30 healthy adults aged 18 to 49. The vaccine uses an inactivated (killed) form of the West Nile virus to train the immune system without causing disease. Participants receive either the vaccine or a …

This study tests whether an experimental malaria vaccine (PfSPZ) is safe for pregnant women. About 400 healthy pregnant women in Mali will receive either the vaccine or a placebo. Researchers will monitor the mothers and their babies for side effects and birth outcomes for up to …

This early-stage study tests a new HIV vaccine in 36 healthy adults without HIV. The vaccine uses a two-step approach: first, a nanoparticle that displays HIV-like proteins, followed by an mRNA boost to strengthen the immune response. The goal is to see if this combination is saf…

This early-stage study tests a new mRNA vaccine designed to protect against bird flu (H5N1). About 80 healthy adults aged 18-49 will receive two doses of the vaccine. Researchers will closely monitor safety and measure the body's immune response over about 6 months.

This study tests a new gene therapy for X-linked severe combined immunodeficiency (XSCID), a rare immune disorder. Researchers take a patient's own stem cells, fix the faulty gene, and return the cells to the body. The goal is to restore immune function. The trial includes 18 peo…

This study tests whether two drugs, carfilzomib and belatacept, can lower immune sensitivity in highly sensitized kidney transplant candidates. These patients often wait over 5 years for a compatible donor. The goal is to make more donors acceptable and speed up transplantation. …

This early-phase study tests whether specially trained immune cells (called Tregs) can help liver transplant recipients safely reduce or stop their anti-rejection drugs. Nine participants receive the cell therapy and are monitored for side effects and whether they can maintain a …

This study aimed to test a stem cell transplant approach for people aged 3 to 40 with severe combined immune deficiency (SCID). Participants would receive low-dose chemotherapy with or without radiation before the transplant to help their bodies accept donor cells. The trial was …

This study tests whether adding dupilumab to standard asthma care can prevent asthma attacks in 240 children and teens (ages 6-17) living in urban areas who have frequent asthma attacks. Participants receive either dupilumab or a placebo for 12 months, and researchers count how m…

This study tests a new gene therapy for people with a rare genetic disorder called chronic granulomatous disease (CGD), which makes them prone to severe infections. The treatment involves taking the patient's own stem cells, adding a missing gene in the lab, and returning them to…

This study looked at three treatments for early HIV infection: zidovudine (AZT) alone, interferon alone, or both together. The goal was to see which best lowered the amount of virus in the blood, protected the immune system, and delayed serious infections. 180 adults with early H…

This study tests whether a combination of two drugs, dasatinib and quercetin (D+Q), can safely improve physical abilities in people aged 50 and older with HIV who are frail or prefrail. Participants take D+Q or a placebo in short cycles over 12 weeks, then are monitored for anoth…

This study tests whether imatinib (Gleevec) can safely reduce high levels of eosinophils (a type of white blood cell) in people with hypereosinophilic syndrome (HES). About 70 participants with the myeloid form of HES or those who did not respond to steroids will take imatinib da…

This study tests a gene therapy for people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder that leads to severe infections. The treatment takes a patient's own stem cells, adds a working copy of the faulty gene, and returns them to the body after mild …

This study tests whether two drugs, daratumumab and belatacept, can lower immune sensitivity in kidney transplant candidates who are highly sensitized, meaning their bodies reject most donor kidneys. Nineteen participants with very high antibody levels receive the drugs to see if…

This study tests a new vaccine designed to help the immune system fight HIV in people who are already on successful HIV medication. About 30 adults with well-controlled HIV will receive either the vaccine or a placebo. The goal is to see if the vaccine is safe and can create new …

This study tested whether a long-acting injectable HIV medication works better than daily oral pills for people who have had trouble sticking to their treatment. 456 participants with HIV and a history of poor adherence were enrolled. The goal was to see if the injectable option …

This early-stage study tests whether two experimental antibodies (3BNC117-LS and 10-1074-LS) are safe and can reduce the hidden HIV reservoirs that persist even when standard antiretroviral therapy (ART) keeps the virus undetectable. About 105 adults with HIV who are stable on AR…

This study looks at whether giving C-section babies a dose of their mother's vaginal bacteria can lower their risk of developing allergies and asthma. Researchers believe that babies born by C-section miss out on beneficial bacteria that help train the immune system. The study in…

This study tested whether a long-acting injectable drug (cabotegravir) is safe and effective for preventing HIV in women, compared to taking a daily oral pill (TDF/FTC). Over 3,200 HIV-uninfected women aged 18-45 participated. The goal was to see if the shot could offer a more co…

This early-stage study tests a new booster vaccine, STX-S, in 60 healthy adults who have already had their primary COVID-19 shots and at least one booster. The goal is to check if different doses are safe and how well they boost the body's immune defenses against the virus. Parti…

This study tests a new way to prevent HIV using a rectal gel (tenofovir douche) instead of taking pills. About 150 men will try both methods for 8 weeks each to see which is safer, easier to use, and more acceptable. The goal is to offer more choices for on-demand HIV prevention.

This study tests whether the meningitis vaccine Bexsero can prevent gonorrhea, a common sexually transmitted infection. About 2,600 adults aged 18-50 at high risk will receive either the vaccine or a placebo. Researchers will track how many get gonorrhea over 16 months to see if …

This study is tracking how often people of all ages get malaria in two villages in Liberia. Researchers will also collect mosquitoes from homes each month. The goal is to gather information that could help make a future malaria vaccine more effective in Liberia. About 396 healthy…

This study looks for a common genetic change called alpha thalassemia trait in healthy volunteers of African ancestry aged 18-39. Participants provide a one-time saliva sample by mail or in person. The goal is to learn how these gene deletions affect blood vessels, which could he…

This study re-infects healthy adults who previously had a mild bird flu (H10N7) with the same virus. The goal is to understand how the body fights off repeat infections, which can help design better flu vaccines. Participants stay in the hospital for at least 9 days and provide s…

This study collects small skin samples from up to 200 people with immune system disorders and healthy volunteers. Researchers will use these samples to grow skin cells in the lab, which may help develop new gene therapies for immune diseases in the future. Participants must be en…

This study gives approved researchers access to blood samples and data collected from people who took part in earlier HIV studies. The goal is to learn more about HIV and help develop vaccines. All samples are coded to protect privacy, and researchers cannot contact participants …

This study looks at why some HIV-negative people get infections that usually only affect those with weak immune systems. Researchers will test if these patients have special antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiwan will be followed for tw…

This study follows about 583 adults who recovered from COVID-19 or were in close contact with someone who had it. Over 3 years, researchers will check for lasting health problems, mental health changes, and whether the body builds immunity that prevents reinfection. Participants …

This study looks at whether the amount of HIV in the blood of people on long-term antiretroviral therapy stays the same or changes over time. It also checks if the virus develops new genetic mutations while being suppressed. About 70 adults with HIV who have very low virus levels…

This study looks at how having certain gut worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India to measure infections and immune markers. The goal is to understand how thes…

This study enrolls 50 people with HIV who previously received either a combination of two anti-HIV antibodies (bNAbs) or a placebo in an earlier study. Participants will temporarily stop their HIV medications so researchers can measure how quickly the virus returns and how high i…

This study follows 2,500 children from before birth up to age 3 (or 6) to learn what causes food allergies and eczema. Researchers collect samples and health information to find early warning signs and biological pathways. The goal is to better understand and predict these condit…

This study was designed to see if giving a monoclonal antibody (L9LS) before the R21/Matrix-M malaria vaccine changes how well the vaccine works. It planned to enroll healthy adults and infants in Mali. However, the study was withdrawn before any participants were enrolled, so no…

This study follows 200 people who have recently had the flu to see how their immune system changes over two years. Researchers will take blood and nasal samples every three months to measure antibodies. The goal is to understand long-term immunity and help design more effective f…

This study aims to observe and follow people with inflammatory disorders, such as those caused by infections or immune system problems. Up to 500 participants aged 2 to 80 will receive standard medical care and tests. The main goal is to learn more about these conditions and iden…

This study aimed to see if the BCG vaccine could protect healthy adults from tuberculosis (TB) by measuring how the body fights the bacteria. It planned to enroll 64 people aged 18-45, giving some the vaccine and later a controlled exposure. However, the study was withdrawn befor…

This study aims to find out why some people have severe allergic reactions (anaphylaxis) without a clear cause. Researchers will look for genetic or molecular differences in immune cells (mast cells) from 115 participants aged 13 to 75. The study involves medical tests, blood wor…