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Liberia malaria study aims to guide future vaccine use

NCT ID NCT04704674

Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tracks how often people of all ages in two Liberian villages get malaria, and how many mosquitoes carry the parasite. Researchers will test blood samples monthly and collect mosquitoes from homes. The goal is to gather data that could help decide the best way to use a malaria vaccine in Liberia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could provide crucial data on malaria patterns in Liberia, helping to plan effective vaccine campaigns and reduce disease spread.
What could go wrong
This is an observational study, not a treatment trial. It won't directly cure or prevent malaria, and results may not apply to other regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

396 people

The number who actually took part.

Started

Sep 2021

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

An estimated total of 400 volunteers from Fleh-la and Marshansue and surrounding villages will be enrolled. Participants above the age of six months will be approached to participate in the study; and will be followed for up to 3 years.

Ages

6 months and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Subject Inclusion Criteria: * 6 months of age and above * Known resident of Fleh-la and Marshansue or the surrounding villages and planning to remain for duration of study * Willingness to allow stored laboratory specimens to be used for future research * Acceptance and signature of the written informed consent and the assent for children aged 12-17 years who are not otherwise emancipated Household Inclusion Criteria: To be eligible for participation, households must meet the following criteria: * Household with at least 3 residents eligible for participation. * Household with at least one compound member who is below 18 years of age whose parents or caretakers are willing to provide informed consent for the child to participate. * Household members willing to accommodate mosquito sampling in their compound, both indoors and outdoors. Exclusion Criteria: Subject Exclusion Criteria: * Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol. * Other condition that, in the opinion of the investigator, would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol.

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Conditions

The condition(s) this trial relates to.

Infections malaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malaria

Contacts and locations

Locations

  • National Public Health Institute of Liberia (NPHIL)

    Fleh-la, Liberia

More trials for these conditions

Other studies related to the condition(s) this trial covers.