MALARIA

This study aims to develop a vaccine that prevents malaria infection during pregnancy, which poses serious risks to both mothers and babies. Researchers are testing potential vaccine candidates using laboratory tests with malaria parasites collected from pregnant women in Mali. T…

This study is testing whether giving children a lower dose of an existing malaria vaccine, or giving it on a different schedule, is safe and still helps their bodies build protection. It involves 238 healthy children, aged 5 months to 5 years, who live in an area where malaria is…

This study aims to evaluate and treat people with parasitic infections like malaria or intestinal worms using standard medical approaches. Participants (age 3+) with known or suspected infections will receive examinations, tests, and individualized treatment plans. The goal is to…

This study is testing a focused strategy to control a type of malaria in Peru. It will involve over 7,500 people across many villages. Researchers will compare giving preventive anti-malaria drugs to people living near recent cases against the current standard of care, which incl…

This study aims to find the safest and most effective malaria treatments for children, especially those also living with HIV. Researchers in Uganda will follow 380 children for two years, comparing two common malaria drugs and checking how they interact with HIV medication. The g…

This study is testing if a single injection of an antibody called L9LS can safely prevent malaria infection. It will involve 290 adults, primarily women of childbearing age in Mali, who will receive either the antibody or a placebo. Researchers will monitor participants for six m…

This study aims to understand how dozens of different infectious diseases spread in Cambodian communities. Researchers will survey 10,000 residents and test for 57 different germs, including viruses, bacteria, and parasites. The goal is to gather information to help public health…

This study is collecting biological samples like saliva, blood, urine, and tissue from volunteers to help scientists better understand blood disorders like sickle cell disease, thalassemia, and malaria. Researchers need samples from both people with these conditions and healthy i…

This study is not a treatment trial but a screening program to find healthy adults who might qualify for future malaria research. Researchers want to build a pool of volunteers for upcoming studies testing malaria vaccines, drugs, or prevention methods. Participants undergo healt…

This study aims to learn if the R21 malaria vaccine, given to prevent malaria, might also reduce the risk of a dangerous bacterial infection called invasive non-typhoidal Salmonella (iNTS) in young children. Researchers will observe up to 10,000 children under age 5 in the Democr…

This study aims to gather detailed information about pregnancy and malaria in a community in Mali. Researchers will follow up to 9,500 women of childbearing age and their babies for several years to track health outcomes. The data collected will help plan future clinical trials t…

This is the first study to test a new oral drug called E1018 in people. Researchers will give single, increasing doses to 32 healthy adults to check for safety and see how the body absorbs and eliminates the drug. The goal is to gather initial data to see if the drug is safe enou…

This study aims to understand how malaria develops in people and how it spreads from humans to mosquitoes. Healthy volunteers will be intentionally infected with a malaria parasite via an injection of donated blood, then closely monitored as they develop symptoms. Researchers wil…

This study aims to understand why some pregnant women and young children in Mali get severe malaria while others don't. Researchers will follow thousands of mothers and children over several years, collecting health and blood sample data. The goal is to gather knowledge that can …