MALARIA

This study is testing a malaria vaccine (RTS,S/AS01E) in 238 healthy children aged 5 months to 5 years living in an area where malaria is common. Researchers want to see if giving a lower dose or changing the vaccination schedule is still safe and helps the body build immunity. T…

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines in the lab using blood samples from pregnant women aged 15-25 in Mali. The goal is to find a vaccine that blocks malaria parasites from attaching to the placenta.

This study aims to evaluate, treat, and monitor people with known or suspected parasitic infections like malaria or intestinal worms. It involves up to 800 participants aged 3 and older. The study uses standard medical treatments, not experimental drugs, and includes regular chec…

This study tests a lab-made antibody called L9LS to see if it can safely prevent malaria in women who could become pregnant. About 290 adults in Mali will receive either the antibody or a placebo and be monitored for side effects and infections. The goal is to find a new way to p…

This study tests whether giving antimalarial drugs to everyone living near a recent malaria case can stop the disease from spreading. Over 7,500 people in villages in Peru will take part. Half will get the extra drugs, and the other half will receive standard care like bed nets a…

This study looks at whether the malaria vaccine (R21/Matrix-M) can also lower the risk of invasive non-typhoidal Salmonella (iNTS) disease in children under 5. Researchers will compare vaccinated and unvaccinated children who come to health centers with fever in the Democratic Re…

This study follows 380 children in Uganda for 2 years to see how malaria and HIV treatments affect each other. Half the children have HIV and half do not. Researchers will measure changes in body weight, drug levels, and malaria recurrence to improve treatment guidelines.

This study is observing up to 15,000 pregnant women and children in Mali to understand why some get malaria and others don't. Researchers will collect blood samples and health data over several years. The goal is to find factors that protect against or increase the risk of malari…

This study aims to learn how malaria develops in people, how the immune system reacts, and how the parasite spreads from humans to mosquitoes. Healthy adults aged 18 to 54 will be infected with a malaria parasite through donated blood and closely monitored. They will also have mo…

This early-stage study tests a single dose of an experimental oral drug called E1018 in 32 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body absorbs and removes it. No treatment or prevention benefit is expected for participants. The res…

This study collects biological samples like blood, saliva, urine, and fat tissue from people with blood disorders (such as sickle cell disease and thalassemia) and healthy volunteers. The goal is to learn more about these conditions and improve future treatments. Participants age…

This study will test 10,000 people in Cambodia for antibodies against 57 different infectious diseases, including dengue, flu, and malaria. The goal is to learn how these diseases spread in communities and which ones are most common. This information will help health officials de…

This study screens healthy adults aged 18 to 50 to see if they can join future malaria research trials. The goal is to find safe and effective malaria vaccines, drugs, or prevention methods. Participants will have medical history, physical exam, and blood/urine tests. No treatmen…

This study will follow about 9,500 women in Kalifabougou, Mali, to track pregnancy outcomes and malaria infections. Researchers will collect data through home visits and at a local health center. The goal is to better understand how malaria affects pregnancy and to improve care f…