Malaria

This study tested an experimental RNA-based vaccine called BNT165e to see if it can prevent malaria. 163 healthy adults who had never had malaria received either the vaccine or a placebo. Researchers measured safety, immune responses, and whether the vaccine protected against a c…

This early-stage trial tests a new malaria vaccine called PfSPZ-LARC2 in up to 22 healthy adults who have never had malaria. The vaccine uses live but genetically weakened malaria parasites that stop developing late in the liver, aiming to trigger a stronger immune response than …

This trial tests an experimental malaria vaccine called RH5.2-VLP, given with an adjuvant (Matrix-M) to boost the immune response. Healthy adults aged 18–45 receive three doses, and some volunteers are later exposed to malaria parasites in a controlled setting to see if the vacci…

This study tested two experimental malaria vaccines in 345 healthy Indonesian soldiers deployed to a malaria-endemic region. One vaccine uses weakened malaria parasites, and the other uses live parasites with a preventive drug. The goal was to see if either vaccine could safely p…

This study tested the R21/Matrix-M malaria vaccine in 594 children aged 5 to 36 months in Mali. Researchers checked if the vaccine is safe and triggers an immune response, both when given alone and alongside routine childhood vaccines like measles and yellow fever. The goal is to…

This study tested the RTS,S/AS01E malaria vaccine in nearly 78,000 young children in Sub-Saharan Africa. Researchers checked the vaccine's safety and how well it prevents malaria. The goal was to see if the vaccine can be safely used in routine immunization programs to protect ch…

This early-stage trial tested a vaccine called PRIMVAC, designed to prevent malaria during pregnancy. Researchers gave three different doses to 68 healthy adults in France and Burkina Faso to check safety and immune response. The vaccine targets a protein that helps malaria paras…

This study tested a new vaccine designed to stop the malaria parasite from spreading from people to mosquitoes. 105 healthy adults received three doses of the vaccine over several months. The main goal was to check if the vaccine is safe and triggers an immune response. Participa…

This early-stage trial tested an experimental RNA vaccine called BNT165b1 in 60 healthy adults to see if it is safe and triggers an immune response against malaria. The vaccine uses messenger RNA to teach the body to recognize a key malaria protein. The study was completed and fo…

This early-stage trial tested a lab-made antibody called MAM01 in 63 healthy adults who had never had malaria. The goal was to see if it is safe and can prevent malaria infection when people are deliberately exposed to the parasite. The study is complete, but results are not yet …

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, some living with HIV and some without. The goal was to see if the vaccine is safe and produces an immune response in these children. The trial has been c…

This study looked at whether finding and treating low-density malaria infections (infections with very few parasites) in children can improve their health and well-being over time. 600 children in Tanzania, aged 6 months to 10 years, took part. The goal was to see if this approac…

This study tested a new approach to fight malaria: giving malaria medicine to everyone in a community, even if they feel fine. The goal was to remove the malaria parasite from the whole community, making it harder for mosquitoes to spread the disease. Over 3,300 people took part,…

This study tested giving a single dose of the drug tafenoquine to everyone in three villages in Myanmar to see if it could safely stop the spread of P. vivax malaria. Over 1,200 people took part, and researchers tracked side effects and malaria cases for six months. The goal was …

This study tested a single injection of an antibody called L9LS in healthy Kenyan children aged 5 months to 10 years. The goal was to see if it safely protects against malaria infection caused by the Plasmodium falciparum parasite. The trial involved 912 children and was complete…

Malaria in pregnancy can hide in the placenta and harm both mother and baby, yet it often goes undetected. This study enrolls about 1,200 pregnant women in Africa to see whether malaria rapid diagnostic tests, blood smears, and PCR on maternal blood can accurately detect or predi…

Researchers in Senegal are testing a new way to care for children under 15 who come to primary health clinics with fever or diarrhea. The strategy combines rapid tests for malaria, dengue, and strep A with a digital tool that suggests treatment based on symptoms and test results.…

This trial tests whether giving infants a preventive dose of the antimalarial drug sulfadoxine-pyrimethamine during routine health visits can lower their risk of malaria and anemia. Researchers will follow about 2,100 children in Cameroon, comparing those in areas receiving this …

This trial tests whether giving infants in Côte d'Ivoire a preventive dose of an antimalarial drug at routine health visits can lower their risk of malaria and anemia. Researchers will compare outcomes for infants in areas receiving this intervention against those receiving stand…

This study tests the safety of an experimental medicine called L9LS in infants aged 1 to 12 months in Mali. It also looks at how L9LS affects the immune response to a malaria vaccine called R21/Matrix-M. The goal is to find a better way to prevent malaria in young children.

This study tested whether a single dose of an antibody called L9LS can safely prevent malaria in women of childbearing age in Mali. 279 healthy women and men received either the antibody or a placebo and were monitored for 24 weeks. The goal was to see if the antibody could block…

This study tested whether specially built houses (Star Homes) could reduce malaria, respiratory infections, and diarrhea in children under 13 in rural Tanzania. Over 1,100 children lived either in a Star Home or a traditional mud house. The Star Homes have screened windows, solar…

This large study tested giving infants up to 6 doses of a malaria preventive medicine alongside their regular vaccinations during the first two years of life. Over 94,000 children in Mozambique, Sierra Leone, and Togo took part. The goal was to see if this approach could reduce m…

This study tested two kinds of long-lasting insecticide-treated bed nets across Uganda to see which better prevents malaria. Over 215,000 people took part, and researchers tracked malaria cases reported at health clinics. The goal is to find the most effective net for nationwide …

This large phase 3 trial tested whether combining two malaria drugs (SP and DP) works better than either alone to prevent malaria and improve birth outcomes in pregnant women. Over 2,700 HIV-negative women in Uganda received monthly doses of SP, DP, or both. The study tracked com…

This study looked at how often people of all ages in Sabou, Burkina Faso, get malaria. Researchers checked 608 healthy volunteers monthly for a year, taking blood samples and asking about symptoms. They also collected mosquitoes from homes and did feeding experiments to understan…

This completed study looked at how common malaria and worm infections are in pregnant women (18 and older) and children (6-12 months old) in two counties of Liberia. Researchers tested blood samples from over 1,200 participants to measure infection rates. The goal was to gather i…

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. Researchers exposed 147 healthy adults in Thailand to lab-grown mosquitoes that can carry malaria or dengue. The goal was to find markers in the blood that show how much expo…

This study tested a new experimental drug called MMV367 in 12 healthy adults. Participants were intentionally infected with a controlled, low-level malaria infection to see how well the drug works and how safe it is. The goal was to measure how the body processes the drug and how…

This study surveyed 222 healthcare workers in Sudan to find out what they know and how they feel about the malaria vaccine. Researchers asked about awareness of the vaccine, its safety, and whether workers would recommend it. The results will help design programs to increase vacc…

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…