MALARIA

This study tested the safety and immune response of a new vaccine designed to protect pregnant women from placental malaria. It involved 68 healthy adult women from France and Burkina Faso who received three doses of the experimental vaccine. The main goal was to check for side e…

This study tested the safety and immune response of a new malaria vaccine called R21/Matrix-M in nearly 600 young children in Mali. Researchers compared different ways of preparing and scheduling the vaccine, and checked if it was safe to give alongside other standard childhood s…

This study tested the safety and immune response of a new malaria vaccine in young African children, most of whom were living with HIV. Researchers gave 122 children aged 5-36 months a series of three vaccine shots plus a booster. The main goal was to see if the vaccine was safe …

This was a first-in-human study to test the safety and immune response of a new RNA-based malaria vaccine called BNT165b1. The trial enrolled 60 healthy adults to receive one of three dose levels or a placebo. The main goal was to find a safe and tolerable dose for future develop…

This study tested whether finding and treating very low-level malaria infections in children leads to better long-term health, growth, and development. It involved 600 children in Tanzania, comparing standard care to two methods using more sensitive tests to detect these hidden i…

This study tested a strategy to control recurring malaria outbreaks in three high-risk villages in Myanmar. Researchers gave a single-dose malaria treatment (tafenoquine) to nearly all willing villagers to see if it was safe and could quickly reduce infections. The goal was to fi…

This early-stage study tested a new oral drug, MMV367, for malaria. Researchers deliberately infected 12 healthy adult volunteers with malaria parasites to see how the drug is processed by the body and how well it kills the parasites. The main goal was to understand the relations…

This study tested a community-wide approach to prevent malaria. Researchers gave anti-malaria medicine to everyone in participating households, including people who felt fine, to see if this would reduce the overall spread of the parasite. They focused on protecting children unde…

This study tested a malaria prevention program for infants and young children in three African countries. It gave up to six doses of a preventive malaria medicine during routine childhood vaccination visits in the first two years of life. The goal was to see if this was a practic…

This study tested a new vaccine designed to stop the spread of malaria by mosquitoes, not to protect the person getting the shot. Researchers gave the vaccine to 105 healthy adults who had never had malaria to check if it was safe and if it triggered an immune response. Volunteer…

This large study tested whether combining two malaria prevention drugs works better than using either drug alone to protect pregnant women and their babies. Researchers enrolled 2,757 HIV-negative pregnant women in Uganda and randomly assigned them to receive different monthly pr…

This study tested a one-time injection of an experimental antibody called L9LS to see if it could safely protect children from getting malaria. Over 900 healthy children in Kenya, where malaria is common, received either the antibody or a placebo shot. Researchers monitored the c…

This large study monitored the safety and real-world performance of the RTS,S malaria vaccine after it was introduced into routine childhood immunization programs in sub-Saharan Africa. Researchers followed over 77,000 young children, comparing health outcomes between those who r…

This large study in Uganda compared two different types of insecticide-treated bed nets to see which one was better at preventing malaria. Over 200,000 people across 20 districts received either a newer net type or a standard one during a national distribution campaign. Researche…

This study aimed to understand how the human immune system responds to mosquito bites. Researchers exposed 147 healthy volunteers in Thailand to controlled mosquito bites from species that can carry malaria or dengue. By measuring antibody levels in blood samples, they looked for…

This study surveyed 222 Sudanese healthcare workers to understand their knowledge and attitudes about the malaria vaccine. Researchers examined what healthcare workers know about the vaccine's safety, effectiveness, and recommendations, and how willing they are to recommend it. T…

This study aimed to measure how common malaria and worm infections were in pregnant women and young children in two counties of Liberia. Researchers enrolled over 1,200 participants seeking routine care at local health centers. They collected small blood samples to test for infec…

This study aimed to understand if having type 2 diabetes changes a person's risk of getting malaria and other parasitic worm infections. Researchers in Cameroon followed 406 adults, some with diabetes and some without, for one year. They tested blood and stool samples regularly t…