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Scientists study mosquito saliva to predict malaria and dengue risk

NCT ID NCT04478370

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. Researchers exposed 147 healthy adults in Thailand to lab-grown mosquitoes that can carry malaria or dengue. The goal was to find markers in the blood that show how much exposure a person has had to these mosquitoes, which could help predict disease outbreaks and test mosquito control methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

147 people

The number who actually took part.

Started

Jan 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy male or female participant judged by a responsible physician with no abnormality identified on a medical evaluation; * Thai, Burmese or Karen ethnicity; * Aged ≥ 18 to \<60 years old; * Living in Mae Sot city for the last 12 months; * Willing to participate in the activity and able to give informed consent for participating in the study; * Able to tolerate direct mosquito exposure. Exclusion Criteria: * History of travel in a malaria endemic are (rural village) in the last 12 months, or plan to do so during the study; * Medication or condition deemed to interfere with the outcome measure by a responsible physician; * Moderate and severe anemia (haemoglobin concentration less than 110 g/L of blood); * Hypersensitivity or anaphylaxis to mosquito bites; * Pregnant women

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Conditions

The condition(s) this trial relates to.

dengue disease malaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dengue Malaria

Contacts and locations

Locations

  • Shoklo Malaria Research unit (SMRU)

    Mae Sot, Changwat Tak, 63110, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.