National Institute Of Allergy And Infectious Diseases (niaid)

This study tests whether adding special drugs (IL-6 and IFN-gamma blockers) to the standard stem cell transplant process can help cure chronic granulomatous disease (CGD), a condition that makes people prone to severe infections. About 50 people aged 4 to 65 with CGD will receive…

This study is testing a hepatitis C medication (glecaprevir/pibrentasvir) in 30 pregnant women who have hepatitis C, with or without HIV. The goal is to see if the drug is safe and works well during pregnancy, potentially curing the mother and preventing the baby from getting the…

This early-stage study tests an experimental flu vaccine called FluMos-v2, with or without an added booster (ALFQ), in 45 healthy adults aged 18-50. Participants receive two shots, four months apart, and are monitored for safety and immune response over 15 months. The goal is to …

This study compares a high-dose flu vaccine to the standard-dose vaccine in children aged 3-17 who have received a kidney, heart, or liver transplant within the past 2 years. The goal is to see if the high-dose vaccine provides better protection against the flu without causing mo…

This study looks at how well the Shingrix vaccine works and how safe it is for people with HIV, compared to healthy volunteers. About 225 adults will get two shots of the vaccine and be followed for a year. The goal is to see if the vaccine boosts immunity against shingles in peo…

This early-stage study tests whether a two-part HIV vaccine is safe and can trigger the immune system to produce special antibodies that may fight HIV. About 42 healthy adults without HIV will receive the vaccine and be monitored for side effects and immune responses over a year.…

This early-stage study tests a new HIV vaccine booster called VRIPRO in 40 healthy adults aged 18 to 60 who previously received an HIV vaccine in the HVTN 706 trial. Participants will get three shots over 24 weeks. The main goals are to check for side effects and measure the immu…

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot into the muscle (with or without an adjuvant) or as a nasal spray. The main goals are to check safet…

This early-stage study tests a new flu vaccine designed to target the stable stem part of the flu virus, aiming for broader protection. Healthy adults aged 18-50 who have had a flu shot since 2020 will receive two doses, with or without an adjuvant to boost the immune response. T…

This early-stage trial tests a new booster vaccine called OCU500 for COVID-19. Unlike a shot, this vaccine is given as a nasal spray or inhaled mist. The study involves 80 healthy adults aged 18-64 who have already had their primary COVID-19 vaccines and at least one booster. The…

This study tests an experimental flu vaccine called BPL-1357 in 129 healthy adults aged 18 to 55. The vaccine is given as a shot or nasal spray, and participants are later exposed to flu virus in a controlled setting to see if the vaccine prevents illness. The goal is to find a v…

This study tests a vaccine against cytomegalovirus (CMV) given to people before they receive a liver transplant. The goal is to see if the vaccine reduces the amount of antiviral medicine needed after transplant. About 416 participants who are CMV-negative and waiting for a liver…

This early-stage study tests two experimental mRNA vaccines designed to train the immune system to make powerful antibodies against HIV. About 40 healthy adults without HIV will receive the vaccines to check for safety and measure immune responses. The goal is to see if this appr…

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines in the lab using blood samples from pregnant women aged 15-25 in Mali. The goal is to find a vaccine that blocks malaria parasites from attaching to the placenta.

This study tests the safety of two experimental vaccines designed to prevent Epstein-Barr virus (EBV) infection, which causes mono and is linked to certain cancers and autoimmune diseases. Healthy adults aged 18 to 29, whether or not they have had EBV before, will receive three d…

This study tests whether three new HIV vaccines are safe for healthy adults aged 18 to 49. Two vaccines are given as nasal sprays and one as a booster shot. Researchers will also check if the vaccines help the body fight HIV and if the viruses used in the vaccines can spread to o…

This study aims to evaluate, treat, and monitor people with known or suspected parasitic infections like malaria or intestinal worms. It involves up to 800 participants aged 3 and older. The study uses standard medical treatments, not experimental drugs, and includes regular chec…

This study tests whether baricitinib, a drug already approved for other immune conditions, is safe for people with Job syndrome who also have lupus-like disease or eczema. About 20 people aged 12 and older will take the pill daily for 6 months. Researchers will monitor side effec…

This study looks at 800 adult first-time kidney transplant recipients to see if a blood test can predict who is at higher risk for rejection. Six months after transplant, 300 eligible participants will be randomly assigned to switch from the standard drug tacrolimus to abatacept …

This study tests whether adding tocilizumab to standard anti-rejection drugs can prevent chronic lung allograft dysfunction (CLAD), the main cause of lung transplant failure. 350 lung transplant recipients will receive either tocilizumab or a placebo over 20 weeks, alongside thei…

This study tests whether transplanting healthy donor stool into the gut can reduce colon inflammation in people with chronic granulomatous disease (CGD) who have colitis not helped by standard treatments. About 20 participants aged 10-60 will receive the transplant during a colon…

This early-stage study tests an oral medication called letermovir in 12 infants born with symptomatic congenital CMV, a viral infection that can cause hearing loss and developmental problems. The main goal is to measure how the drug is processed in the body and check for side eff…

This study looks at whether liver transplant recipients can safely stop one anti-rejection medicine (tacrolimus) and use only everolimus to protect their kidneys. About 340 adults who received their first liver transplant will take part. The goal is to see if this approach keeps …

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of early rejection or inflammation. About 234 participants will receive either belumosudil or a placebo for 52 weeks, alongs…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden viral reservoirs that prevent a cure. About 50 adults with well-controlled HIV will either continue their usual therapy or receive lenacapavir injections plus pills. Researchers w…

This study tests a cream made with a harmless bacteria (Staphylococcus hominis A9) to see if it can safely control eczema in adults and teens. Participants apply the cream for 14 weeks, starting with a short course of steroid cream. The goal is to see if the bacteria cream can de…

This study tests a drug called ublituximab for people with a rare autoimmune muscle disease (IMNM) that causes weakness. The trial will compare the drug to a placebo in 30 adults with early-stage disease. The goal is to see if adding ublituximab to standard therapy improves muscl…

This early-stage study tests two drugs, carfilzomib and belatacept, in 25 kidney transplant recipients whose bodies are attacking the new organ. The goal is to see if the combination is safe and can reduce harmful antibodies or improve kidney function over a year. Participants wi…

This study tests whether a drug called belatacept can safely replace the standard anti-rejection drug tacrolimus over time in heart transplant patients. The goal is to prevent organ rejection while reducing kidney damage often caused by tacrolimus. About 66 adults receiving their…

This study tests whether giving very early, intensive anti-HIV drugs, with or without an added antibody, can help infants living with HIV achieve remission — meaning the virus stays undetectable even after stopping treatment. Researchers will enroll over 1,100 mothers and their b…

This study tests whether adding dupilumab to standard treatment can help adults with hypereosinophilic syndrome (HES) who still have symptoms. HES causes too many eosinophils, damaging organs. About 30 participants will receive dupilumab injections for up to 48 weeks. The goal is…

This early-stage study tests whether an experimental oral drug called VNT-101 is safe in healthy adults aged 18 to 59. About 78 participants will receive either the drug or a placebo, with some taking a single dose and others taking multiple doses over several days. The goal is t…

This early-stage study tests whether giving patients with chronic granulomatous disease (CGD) their own white blood cells, corrected with mRNA, can temporarily help them fight infections. Up to 25 men aged 18-75 with a specific gene mutation will receive the treatment and be moni…

This study tests whether Mozobil, a drug already used in stem cell transplants, can safely and effectively raise white blood cell counts in people with WHIMS, a rare genetic condition that causes frequent infections. About 20 adults aged 18 to 75 with WHIMS and a history of sever…

This study tests new combinations of medicines for adults with lung tuberculosis (TB) to see if they work faster and have fewer side effects than the current standard treatment. About 315 participants will receive either a new drug mix or the usual treatment for 8 weeks, then con…

This study tests an experimental drug called VIB4920 for people with active lupus nephritis, a serious kidney complication of lupus. About 74 adults will receive either VIB4920 or a placebo, along with standard medications (mycophenolate mofetil and prednisone). The main goal is …

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra). About 78 adults who have been on high-dose tocilizumab for at least a year and off steroids for 3 months will either stop the drug…

This study is testing whether the drug vorinostat is safe and can help control symptoms in people with moderate-to-severe Crohn's disease that hasn't responded to standard treatments. Participants who respond well may then receive maintenance therapy with another drug, ustekinuma…

This study tests whether adding belimumab to rituximab works better than rituximab alone for people with membranous nephropathy, a kidney disease that causes protein leakage. About 58 adults will receive either the combo or rituximab alone, and researchers will check if their kid…

This study tests whether a special HIV vaccine, combined with an immune-boosting drug and two powerful antibodies, can help people with HIV control the virus on their own after stopping daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment soon afte…

This study tests a drug called soquelitinib in 15 people aged 16 and older with autoimmune lymphoproliferative syndrome (ALPS), a rare condition where the body stores too many immune cells, causing enlarged spleen and lymph nodes. The drug is taken as a tablet twice daily for one…

This study tests whether giving powerful HIV-fighting antibodies along with standard antiretroviral therapy (ART) during very early HIV infection can help control the virus without needing daily pills. 48 adults with acute HIV will receive either the antibodies or a placebo, plus…

This early-stage study tests whether lab-made antibodies that target HIV are safe and how the body processes them. About 83 healthy adults without HIV will receive one or three antibodies by vein or under the skin. The goal is to find the right dose and check for side effects, no…

This study looks at whether people with early relapsing multiple sclerosis (MS) can stop taking the drug ocrelizumab after two years and still stay relapse-free. About 123 participants will receive ocrelizumab for two years, then be randomly assigned to either continue the drug o…

This study compares a stem cell transplant (AHSCT) with the best standard treatments for people whose relapsing multiple sclerosis (MS) is not controlled by usual therapies. About 156 adults aged 18 to 55 will be randomly assigned to one of the two approaches and followed for 6 y…

This early-stage trial tests a new gene-editing technique (base editing) to repair a specific genetic mutation in people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder. Up to 10 adults will have their own blood stem cells collected, edited in a lab, a…

This study tests whether a 6-month combination of high-dose antibiotics works as well as the standard 9-month treatment for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take either the shorter experimental regimen or the usual car…

This study in Botswana tests whether a combination of three lab-made antibodies can keep HIV under control in children who started treatment early. About 41 kids aged 2 to 12 will receive the antibodies while pausing their regular HIV pills. The goal is to see if the antibodies a…

This early-phase trial tests whether daratumumab is safe for people with antiphospholipid syndrome (APS), a condition that raises the risk of blood clots and pregnancy complications. Up to 22 adults will receive one of three doses of the drug to find the highest safe dose. The st…

This study is testing a long-acting injectable HIV medication (cabotegravir and rilpivirine) in children aged 2 to 12 who already have their HIV under control with daily pills. The goal is to see if switching to monthly or every-other-month shots is safe, tolerable, and works as …

This study tests a drug called emapalumab for people with APECED, a rare disease where the immune system attacks the body, causing severe gut inflammation (enteritis). Ten participants aged 2 to 75 will receive 7 doses of the drug through an IV over 6 months. The goal is to see i…

This early-stage study tests whether belimumab is safe for people with idiopathic CD4 lymphopenia (ICL), a rare condition where the body has too few CD4 immune cells, raising infection risk. About 20 adults aged 18-70 with ICL and autoantibodies will receive 8 doses of belimumab …

This study tests if a single injection of Berinert into a donor kidney before transplant can improve kidney function one year later. It involves 180 adults on dialysis waiting for a deceased-donor kidney transplant. Half receive the drug, half receive a placebo, and neither the p…

This study involves 200 children aged 13-20 who are receiving a kidney transplant. Researchers are comparing a new combination of immunosuppressive drugs (belatacept and sirolimus) with the standard combination (tacrolimus and MMF) to see which better prevents the body from attac…

This study tests whether the drug ruxolitinib can help hair regrow in people with APECED, a rare immune disorder, who also have severe alopecia areata (hair loss). About 70 participants aged 12 to 75 will take ruxolitinib pills twice daily for 8 months. Researchers will measure h…

This study tests whether two drugs, everolimus and epoetin, can help liver transplant recipients safely stop taking their standard anti-rejection medication (tacrolimus). The goal is to achieve 'operational tolerance,' where the body accepts the new liver without needing lifelong…

This study is testing whether giving two powerful antibodies (PGT121.414.LS and VRC07-523LS) to newborns exposed to HIV is safe and how long they stay in the body. About 48 infants will receive one or two doses soon after birth. The goal is to help control HIV, not cure it, and t…

This study tests a gene therapy for people aged 2 to 50 with X-linked severe combined immunodeficiency (SCID-X1), a condition that leaves the body unable to fight infections. Participants receive a mild chemotherapy drug to prepare their bone marrow, followed by an infusion of th…

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This study tests a one-time gene therapy for a rare immune disease called CD40L-HyperIgM syndrome, which causes severe infections and autoimmune problems. One male participant will receive his own stem cells and T cells that have been corrected in the lab using a precise editing …

This study tests a new drug called NT-I7 in people with idiopathic CD4 lymphopenia (ICL), a rare condition where the body lacks key immune cells called CD4 T cells. The goal is to see if NT-I7 can safely increase these cells and help prevent severe infections. About 60 adults age…

This study compares a new, less invasive test called the esophageal string test (EST) to standard methods for diagnosing H. pylori, a stomach bacteria that can cause ulcers and cancer. About 25 adults with persistent H. pylori infection will swallow a capsule with a string that c…

This study looks at 200 people aged 3-21 with eczema and high allergy antibody levels to improve how doctors test for milk and peanut allergies. Participants will eat small amounts of the suspected food under medical supervision to see if they truly react. The goal is to find bet…

This study checks if a simple, low-cost string test can diagnose eosinophilic esophagitis (EoE), a condition that causes trouble swallowing. Currently, diagnosis requires a camera tube down the throat (endoscopy). The string test involves swallowing a capsule with a string that c…

This study aims to see if a special dye used during PET/CT scans can find protein clumps (amyloidosis) in internal organs without needing a tissue biopsy. It involves 30 adults with CAPS who developed amyloidosis from the drug anakinra. Participants will have scans every 6 months…

This study tests a lab-made antibody called L9LS to see if it can safely prevent malaria in women who could become pregnant. About 290 adults in Mali will receive either the antibody or a placebo and be monitored for side effects and infections. The goal is to find a new way to p…

This study tests whether a combination of three lab-made antibodies, given through an IV, is safe and can help prevent HIV in healthy adults. Researchers will enroll 200 participants without HIV and follow them for 18 months. The goal is to see if these antibodies can neutralize …

This study compares two medications, pramipexole and escitalopram, to see which works better for treating major depression in people with HIV. About 186 participants will take one of the drugs for several weeks, and researchers will track mood changes and side effects. The goal i…

This study tests whether a spray made from ground cardamom and a harmless skin bacteria (Roseomonas mucosa) can improve eczema symptoms. About 120 people aged 2 and older with eczema will use the spray at home 2-3 times a week for 14 weeks. The goal is to see if it reduces rash a…

This study screens healthy adults aged 18 to 50 to see if they can join future malaria research trials. The goal is to find safe and effective malaria vaccines, drugs, or prevention methods. Participants will have medical history, physical exam, and blood/urine tests. No treatmen…

This study is for people with immune system problems that cause frequent infections or inflammation, including rare inherited conditions like CGD and XSCID. Researchers will collect medical history, blood, and other samples from up to 3,500 participants (patients, their family me…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or CMV. Researchers want to find out if problems in the immune system or genes are to blame. Up to 600 participants and their relatives will provide blood…

This long-term study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants, including patients, their relatives, and healthy volunteers, ove…

This study aims to learn more about what causes food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will follow up to 1,800 people (ages 2-99) and their relatives for up to 12 years, collecting blood, skin, and genetic samples. The goal is …

This study looks at healthy adults who get a rare fungal infection called cryptococcosis. Researchers want to learn why some healthy people get this infection and how their bodies react. Up to 800 adults over 18 with confirmed cryptococcosis can join. No new treatments are tested…

This study looks at whether signs of inflammation in spinal fluid can help predict which multiple sclerosis (MS) drugs a person will respond to. About 250 adults with progressive MS will take one or two study drugs for up to 18 months. Researchers will track changes in biomarkers…

This study aims to collect mast cells from people with mastocytosis to understand what makes these cells grow and survive. Up to 600 participants aged 2 to 80 will provide blood and bone marrow samples during a single 8-hour visit. No treatment is given; the goal is to learn more…

This study collects nose, blood, and saliva samples from 20,000 people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The goal is to learn more about these viruses and how the body fights them. Samples will be stored for future research, including…

This study is observing up to 15,000 pregnant women and children in Mali to understand why some get malaria and others don't. Researchers will collect blood samples and health data over several years. The goal is to find factors that protect against or increase the risk of malari…

This study looks at how immune system problems can affect the brain and nerves. Researchers will study 350 people with immune diseases, plus their healthy relatives and volunteers, over 5 years. They will collect blood, spinal fluid, and other samples to better understand these c…

This study aims to find the right dose of a specific flu virus that safely causes mild flu symptoms in healthy adults aged 18 to 55. About 90 volunteers will receive either the virus or a sham (placebo) and be closely monitored. The goal is to create a reliable human infection mo…

This study enrolls 16 cat-allergic adults to compare immune cells in lymph nodes between those receiving allergy shots and those not. Participants get a cat allergen skin test, then lymph node samples are taken at 3 days and 3 weeks. The goal is to see how many usable cells can b…

This study looks at how the immune system works in people with HIV who start treatment early. Researchers will collect white blood cells through a process called leukapheresis before and during therapy. The goal is to learn more about immune function, not to provide a new treatme…

This study aims to find the genetic and biochemical causes of inherited immune diseases that disrupt the balance of lymphocytes, a type of white blood cell. People with conditions like enlarged lymph nodes, autoimmune disease, or immune deficiencies, along with their relatives, c…

This study aims to discover what germs are causing fevers in Cambodia, especially those spread by insects like mosquitoes. Researchers will use advanced DNA testing on blood and nasal samples from 6,500 people with fever. The goal is to better understand and diagnose these diseas…

This study aims to learn how malaria develops in people, how the immune system reacts, and how the parasite spreads from humans to mosquitoes. Healthy adults aged 18 to 54 will be infected with a malaria parasite through donated blood and closely monitored. They will also have mo…

This study aims to understand why the protection from COVID-19 vaccines decreases over time. Healthy adults aged 18 and older who are scheduled to receive a new vaccine or booster will give blood samples and health updates over one year. The goal is to learn how the immune system…

This study follows people aged 3 to 100 with known or suspected leishmaniasis to learn how the infection behaves and how treatments work. Researchers will collect blood and tissue samples, and monitor patients during and after treatment. The goal is to improve diagnostic tests an…

This study aims to learn how the immune system responds to COVID-19 during and after infection, and why some people get very sick while others have no symptoms. Researchers will collect blood and stool samples from up to 5,000 people of all ages, including those with confirmed or…

This study collects blood, urine, skin swabs, and other samples from healthy volunteers aged 18 and older. The samples are used by NIAID's Vaccine Research Center to study diseases like HIV and hepatitis, and to develop new vaccines. Participants may donate once or multiple times…

This study follows 600 adults with known or suspected HIV in the Washington, D.C., area to better understand the infection and related conditions. Participants visit the clinic every 3-4 months for check-ups and blood tests. The study does not offer experimental treatments but he…

This study follows people who previously took part in type 1 diabetes treatment trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could help…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Researchers will observe up to 1,000 participants aged 0 to 75, using blood tests, tissue samples, and standard medical care. No experimental tre…

This study is collecting tonsil tissue and nasal swabs from 500 people having their tonsils removed to learn how Staphylococcus aureus bacteria cause infections in the body. Researchers will use the tissue to create lab models and study immune responses. The goal is to find bette…

This study looks at how people's immune systems react to infections from parasitic worms (filariae) and their treatment. Researchers will evaluate up to 500 participants aged 3 to 100 who have or may have these infections. The goal is to learn why some people get sick and others …

This study collects blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. The samples help researchers develop and improve laboratory tests. Participants are not treated for any condition; they simply donate samples over up to 5 years.

This study aims to find the causes of immune system problems that make people prone to infections. Up to 2,000 participants (patients with frequent infections and their healthy blood relatives, aged over 1 month) will undergo medical history, physical exams, blood tests, genetic …

This study screens healthy adults aged 18 to 65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a 3-5 hour checkup including blood tests, heart test, and chest X-ray. No treatment is given; the goal is to build a pool of eligib…

This study screens healthy adults aged 18 to 60 to see if they can join future vaccine and antibody trials at the NIH. Volunteers give blood and urine samples and have a physical exam. No experimental products are given in this screening study. The goal is to build a pool of elig…

This study looks at people with Common Variable Immunodeficiency (CVID) and similar immune system problems to learn why they get sick more often and develop other health issues. Researchers will track up to 500 patients over time using blood tests, scans, and check-ups. The goal …

This study follows people with Hyper IgE Syndrome (HIES), a rare immune disorder that causes severe eczema, lung infections, and other health problems. Researchers will track up to 600 participants and their relatives over time to learn how genetic changes cause the disease and h…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth ulcers in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal …

This study aims to understand why some people are more prone to fungal infections, especially those with immune system problems. Researchers will collect blood, saliva, and tissue samples from up to 850 participants, including affected individuals, their family members, and healt…

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track things like temperature, heart rate, coughing, and voice changes. The goal is to see if these devices can detect …

This study looks at why some people in Mali develop allergic diseases like asthma or eczema. Researchers will collect samples and health information from 288 people with and without allergies. They will compare germs on the skin and in the gut, as well as environmental factors li…

This study is looking at the DNA of up to 20,000 people to find genetic differences linked to immune system problems like allergies, autoimmunity, and primary immunodeficiency. Participants are already part of other NIH studies, and some of their relatives may also join. Research…

This study collects biological samples like blood, saliva, urine, and fat tissue from people with blood disorders (such as sickle cell disease and thalassemia) and healthy volunteers. The goal is to learn more about these conditions and improve future treatments. Participants age…

This study follows 500 people with neurocysticercosis, a brain infection caused by pork tapeworm larvae, to see how they do over the long term after standard treatment. Participants receive anti-parasite drugs and anti-inflammatories based on current guidelines. Researchers colle…

This study looks at how common chemicals in air, food, and personal care products affect our skin, gut, and lungs. Healthy adults aged 18 to 80 will stay in a hospital room for two separate 7-day periods—one in a 'pure' room with filtered air and simple products, and another with…

This study collects blood stem cells and immune cells from healthy volunteers and patients with immune or blood disorders. The cells are used in the lab to develop new gene and cell therapies. Up to 850 adults aged 18-70 will participate. The goal is to advance treatments, not to…

This study aims to learn how the immune system responds to vaccines and natural infections by collecting blood, urine, saliva, and tissue samples from healthy adults aged 18 and older. Participants may also undergo procedures like bronchoscopy or imaging scans. The goal is to bet…

This study aims to understand why some people develop severe or widespread Valley Fever, a fungal lung infection. Researchers will study the immune systems and genetics of 400 participants aged 2 and older with this condition. The goal is to identify immune defects and track dise…

This study looks at how the immune system of healthy adults in Cambodia reacts to viruses that can spread from animals to humans. Researchers will collect blood samples from 400 people aged 18 to 65 who have close contact with animals or live near animal habitats. The goal is to …

This study collects white blood cells and plasma from 400 adults with HIV, including a rare group called long-term non-progressors who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand why some people's immune system…

This study aims to find genetic mutations that cause chronic active Epstein-Barr virus (CAEBV), a rare and serious disease affecting mostly children and young adults. Researchers will analyze blood and tissue samples from up to 50 patients and 150 relatives, plus anonymous donor …

This study looks at how the immune system responds to flu and COVID-19 vaccines over a full year. About 150 NIH staff members who plan to get these vaccines will provide monthly blood and nasal samples. No vaccines are given as part of the study; it only observes natural immune c…

This study follows people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where the body has too few CD4+ immune cells, raising the risk of serious infections. Researchers aim to learn how the disease progresses, what causes it, and how it affects the body over time.…

This study looks at how anthrax affects the body and how the immune system responds to it. Researchers will follow people who have been infected with or exposed to anthrax, as well as healthy people who received the anthrax vaccine. The goal is to learn more about the disease and…

This study looks at people with certain immune system disorders and their relatives to find new genes that may cause these conditions. Researchers will collect blood, saliva, and tissue samples, and may follow participants over several years. No new treatments are being tested; t…

This study aims to see if a newer kidney function test (Cystatin C) can help doctors give the right dose of two common antibiotics (meropenem and cefepime) to critically ill ICU patients with drug-resistant infections. About 200 adults will participate, and researchers will compa…

This study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other infections. Researchers will study up to 1,000 people with NTM, Job syndrome, or cystic fibrosis to understand the genetics, symptoms, and best treatments. Part…

This study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition that causes fevers and can be life-threatening. Researchers will follow 300 adults with sHLH for up to a year, collecting blood samples and medica…

This study aims to understand how eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic worm infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are offere…

This study looks at where HIV hides in the body by comparing virus levels in blood, lymph nodes, and bone marrow. Researchers want to understand how HIV damages the immune system and why it's so hard to eliminate. The study involves up to 400 adults with and without HIV, who will…

This study will follow about 9,500 women in Kalifabougou, Mali, to track pregnancy outcomes and malaria infections. Researchers will collect data through home visits and at a local health center. The goal is to better understand how malaria affects pregnancy and to improve care f…

This study aims to understand why some people develop severe, recurring HPV-related warts or lesions that do not respond to standard treatments. Researchers will collect medical history, blood, tissue, and other samples from 850 participants aged 3 and older, including healthy re…

This study looks at why some people with tuberculosis (TB) feel worse after starting treatment, a condition called a paradoxical reaction. Researchers will follow 140 adults on TB therapy, with or without these reactions, using blood tests, urine samples, and PET/CT scans over 6 …

This study aims to understand how the human body, especially the skin, reacts to tick bites. Researchers will place clean, lab-grown ticks on the skin of healthy volunteers who have never been bitten before. By studying skin samples and immune responses over several months, they …

This study looks at a rare condition called idiopathic CD4 lymphocytopenia (ICL), where people have very low levels of important immune cells. Researchers will give a drug combination to both ICL patients and healthy volunteers to collect their blood stem cells. These cells will …

This study tracks up to 600 people with GATA2 deficiency, a genetic condition that can affect the immune system and other body systems. Researchers want to learn why some people have mild symptoms while others face serious issues like infections or cancer. Participants will have …

This study aims to learn more about tuberculosis (TB) by collecting blood and other samples from people with active or latent TB. Researchers want to better understand how the disease works and how it affects the body. Participants will provide samples and may receive treatment f…

This study looks at why some people with HIV develop new or worse symptoms soon after starting HIV medications, a condition called IRIS. Researchers will use PET scans, blood tests, and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to le…

This study aims to collect blood, nasal fluid, skin cells, urine, and other samples from 10,000 people aged 3 to 100 with allergic or sinus diseases like asthma, eczema, and food allergies. Participants will have clinic visits over 1 to 3 years and complete questionnaires. The go…

This study follows up to 1,200 people with Autoimmune Lymphoproliferative Syndrome (ALPS) and their relatives to learn how the disease works, how it is inherited, and how it changes over time. Participants will have yearly check-ups and tests at the NIH. The goal is to better und…

This study aims to understand why some HIV drugs cause weight gain. Healthy volunteers aged 18 to 55 will take one of four HIV medications for 4 weeks. Researchers will measure changes in blood, fat tissue, and metabolism to find early signs of weight gain.

This study is creating a large collection of samples—like stool, saliva, blood, and skin cells—from up to 600 people of all ages, both healthy and with various conditions. Researchers will use these samples to learn how the tiny organisms living in and on our bodies (the microbio…

This study follows about 50 family members who have a genetic condition causing high levels of a certain white blood cell, which can damage organs. Researchers will track their health over many years with yearly check-ups and tests to learn how the disease progresses and find bet…

This study looks for genes that cause immune disorders like severe infections, allergies, or autoimmune diseases. Researchers will collect blood, cheek swabs, or skin samples from 5,000 patients and their family members. The goal is to understand these conditions better and help …

This study aims to collect blood, saliva, urine, stool, or other samples from up to 3000 people with primary immunodeficiency (PID) or their relatives. Researchers will analyze the samples to find genetic and immune system abnormalities that cause PIDs. No treatment is given; the…

This study collects blood, urine, stool, and other samples from up to 150 healthy volunteers aged 18 to 85. Researchers will use these samples to compare with those from patients who have too many eosinophils (a type of white blood cell) in their body. The goal is to better under…

This study aims to understand how certain immune cells (phagocytes) interact with bacteria to cause or prevent disease. Researchers will collect blood from 200 healthy adults to study these interactions in the lab. The goal is to learn more about how bacteria evade the immune sys…

This study enrolls people with known or suspected infections or inflammatory conditions to help doctors learn and improve diagnosis. It is not a treatment trial but a way to gather information and train medical staff. Participants will receive standard medical care and may be ref…

This study looks at people who get frequent or unusual infections, along with their family members, to find the genetic and biochemical causes of immune system problems. Researchers will collect blood, saliva, urine, and other samples to better understand these defects and develo…

This study collects blood plasma and white blood cells from healthy volunteers, HIV patients, and their relatives using a procedure called apheresis. The samples are used for laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH s…

This study aims to collect samples and health information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to learn how viruses behave differently in healthy individuals versus those with weakened immune sy…

This study is for people with certain autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn more about what causes these diseases, how they affect the body over time, and how to better manage them in the futu…

This study follows 700 people with Down syndrome (and some healthy relatives) for up to 15 years to understand how their immune system changes over time. Researchers will check for infections, autoimmune problems, and cancers, and see if having part of the thymus removed during h…

This study aims to improve how doctors evaluate and treat people exposed to dangerous germs like anthrax or new flu strains. It will enroll up to 200 people, including patients and healthcare workers, to collect data and provide standard or experimental care. The goal is to learn…

This study aims to understand how the immune system and skin healing are connected. Researchers will study people with primary immune deficiency, eczema, or psoriasis, as well as healthy volunteers. Participants will provide blood and skin samples to help identify differences in …

This study aims to learn more about inflammatory diseases of the brain and spinal cord, such as multiple sclerosis (MS), which may be caused by the immune system attacking the body. Researchers will compare tests from 2,400 people—both healthy volunteers and those with symptoms o…

This study is for people with active Lyme disease. Its main goal is to learn more about the infection by following patients over time. Participants will receive standard medical tests and FDA-approved treatments. The study does not test any new drugs or procedures.

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood and other biological samples from up to 2,419 adults, both with and without HIV. Researchers will compare these samples to better understand the virus and related immune de…

This study looks at people who still feel sick after being treated for Lyme disease. Researchers want to find out if the Lyme bacteria are still alive in the body and causing these ongoing symptoms. Up to 700 participants, including those with chronic Lyme, recovered patients, an…

This study looks at the genetic causes of primary immunodeficiency disorders (PIDs), which weaken the immune system. Researchers will compare people with PIDs, their healthy relatives, and healthy volunteers to find genetic differences. Up to 2,500 participants aged 0-90 will pro…