TB mystery: why do some patients worsen on treatment?

NCT ID NCT04052022

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 24 times

Summary

This study looks at why some people with tuberculosis (TB) feel worse after starting treatment, a condition called a paradoxical reaction. Researchers will follow 140 adults on TB therapy, with or without these reactions, using blood tests, urine samples, and PET/CT scans over 6 to 18 months. The goal is to understand the body's immune response and find clues that predict or explain these reactions.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Mexican Emerging Infectious Diseases Clinical Research Network (LaRed)
RECRUITING

Alcaldia Tlalpan, 14050, Mexico

Contact Phone: •••-•••-•••• Email: •••••@•••••
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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TUBERCULOSIS