National Institute Of Allergy And Infectious Diseases (niaid)

This study tested whether taking doxycycline for 3 days works as well as the usual 7-day treatment for curing chlamydia. About 664 men and women with chlamydia took part, receiving either a 3-day or 7-day course of the antibiotic. The goal was to see if the shorter treatment is j…

This study tested a vaccine called Triplex in 94 adults who have both HIV and cytomegalovirus (CMV). The goal was to see if the vaccine is safe and helps the immune system fight CMV better. Participants received two shots of either the vaccine or a placebo, and researchers monito…

This study tested a new vaccine designed to stop the malaria parasite from spreading from mosquitoes to people. It involved 105 healthy adults aged 18 to 50 who received three shots over a few months. The main goal was to check safety and how the immune system responded, not to t…

This early-stage study tested a new yellow fever vaccine (MVA-BN-YF) in 92 healthy adults aged 18-45. The goal was to check if the vaccine is safe and triggers a strong immune response, with some groups receiving an extra ingredient (adjuvant) to boost effectiveness. Results will…

This study tested whether giving smaller doses of the MVA-BN monkeypox vaccine under the skin (instead of the usual larger dose under the fat) still triggers a strong immune response. About 229 healthy adults aged 18 to 50 received either the standard shot or one of two reduced d…

This study tested whether an experimental HIV vaccine could prevent infection in over 5,400 sexually active adults in South Africa. Participants received either the vaccine or a placebo and were followed for up to 36 months. Unfortunately, the vaccine did not provide enough prote…

This early-stage study tested a new HIV vaccine in 51 healthy adults. The goal was to see if the vaccine is safe and if it triggers an immune response. Researchers tried different combinations of vaccine and adjuvants (ingredients that boost the immune system) to find the best ap…

This early-stage trial tested a new COVID-19 vaccine given as a nasal spray. The vaccine uses a weakened virus to teach the body to fight SARS-CoV-2. 27 healthy adults aged 18 to 50 took part. The main goals were to check safety and see if the vaccine triggers an immune response.

This study tested updated COVID-19 vaccines designed to protect against new and emerging variants. About 1,270 adults who were already fully vaccinated received one or two doses of these variant-specific vaccines. The goal was to see how well the vaccines boosted the immune syste…

This early-stage study tested a single-dose mRNA flu vaccine in 50 healthy adults aged 18 to 49. The goal was to check safety and see how well the vaccine triggers an immune response compared to a standard flu shot. Participants received one of three doses (10, 25, or 50 mcg) or …

This study tested the MVA-BN mpox vaccine in about 315 healthy teens aged 12-17 and compared their immune response to about 211 adults. The goal was to see if the vaccine works as well in teens as it does in adults. Researchers also closely monitored safety, including any side ef…

This early-stage trial tested a new vaccine (CJCV2) designed to prevent Campylobacter infection, a common cause of food poisoning. About 60 healthy adults received three different doses of the vaccine, with or without an immune-boosting ingredient called ALFQ. The main goal was t…

This early-stage trial tested a new HIV vaccine in 24 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a liposome (a tiny fat bubble) to deliver a piece of the HIV virus. The study found no major safety concerns and measured the body's antibod…

This early-stage study tested two experimental RSV vaccines given as nose drops to 60 children. Some children already had RSV antibodies (ages 1-5), while others did not (ages 6 months-2 years). The main goal was to check safety and whether the vaccine triggered an immune respons…

This study tested a new vaccine called HSV529 to see if it is safe for people. The vaccine is designed to prevent genital herpes caused by the herpes simplex virus type 2 (HSV-2). A total of 69 healthy adults aged 18 to 40, some with and some without HSV infection, received eithe…

This study tested a new vaccine designed to prevent Epstein-Barr virus (EBV) infection, which causes mononucleosis and is linked to certain cancers and autoimmune diseases. Twenty-five healthy adults aged 18 to 25 who had never been infected with EBV received either the vaccine o…

This study tested an experimental HIV vaccine in 127 healthy, HIV-negative adults to see if it was safe and could trigger an immune response. Participants received different combinations of the vaccine with adjuvants (ingredients that boost the immune system). The main goal was t…

This early-stage study tested an experimental mRNA vaccine (mRNA-1215) for Nipah virus, a serious disease with no approved treatments. Forty healthy adults received two doses of the vaccine and were monitored for safety and immune response over about a year. The vaccine cannot ca…

This early-stage study tested whether two experimental HIV vaccines (EnvSeq-1 and CH505 M5 gp120) are safe and can trigger an immune response. A total of 117 healthy, HIV-negative adults received the vaccines along with an adjuvant to boost immunity. The main goal was to check fo…

This study tested a single dose of a live-attenuated RSV vaccine given as nose drops to 88 children aged 4 months to 5 years. The goal was to check safety and whether the vaccine triggers an immune response. Participants included children who had and had not been infected with RS…

This early-stage study tested a new type of HIV vaccine in 46 healthy adults without HIV. The vaccine uses synthetic DNA to train the immune system, with some participants also receiving a protein boost. The main goal was to check safety and see if the vaccine triggers a strong i…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could make them work better. About 240 healthy adults aged 18 to 45 received either a regular flu shot or one with an adjuvant. Researchers checked for side…

This early-stage trial tested a new HIV vaccine called INO-6160 in 20 healthy adults without HIV. The vaccine uses synthetic DNA to teach the body to recognize HIV and includes an immune booster (Interleukin-12). Some participants also received a booster shot with a different HIV…

This early-stage study tested whether giving a booster shot of an H5N1 flu vaccine to people who had previously received other experimental flu vaccines could create broader, longer-lasting protection. Thirty-two healthy adults took part to see if this 'prime-boost' approach safe…

This study checked how safe the MVA-BN (Jynneos) vaccine is for adults at high risk of monkeypox. About 500 staff and study workers in the Democratic Republic of the Congo received two vaccine doses. Researchers tracked any side effects or serious health problems for up to 28 day…

This early-stage trial tested a new COVID-19 booster vaccine given as a nasal spray. The goal was to see if it is safe and how well it boosts the immune system. The study involved 60 healthy adults who had already received the standard COVID-19 shots. Researchers monitored side e…

This study tested an experimental smallpox vaccine called IMVAMUNE in 226 healthy adults who had never received a smallpox vaccine. Participants received either the vaccine or a placebo, and researchers monitored side effects and immune responses for up to 425 days. The goal was …

This study tested an experimental HIV vaccine in 132 healthy adults to see if it is safe and triggers an immune response. Participants received different combinations of the vaccine with or without adjuvants (substances that boost the immune response). The main goals were to chec…

This study tested two experimental nasal spray vaccines designed to protect children against human metapneumovirus (HMPV) and parainfluenza virus type 3 (HPIV3), both of which can cause serious breathing problems. Twenty-four children aged 2 to 5 who already had antibodies to HPI…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current shots that target only one or two. Participants received two doses four months ap…

This study tested an experimental vaccine (CssBA+dmLT) to prevent moderate-to-severe diarrhea caused by ETEC bacteria, a common cause of travelers' diarrhea. 72 healthy adults received either the vaccine or a placebo, then were intentionally exposed to the bacteria in a controlle…

This early-stage study tested a new oral vaccine (dmLT) to see if it is safe for people. The vaccine aims to protect against a type of E. coli that causes diarrhea, often called traveler's diarrhea. About 36 healthy adults aged 18-45 received one of four vaccine doses and were mo…

This study tested a new HIV vaccine called VIR-1388 in 93 healthy adults who did not have HIV. The goal was to see if the vaccine is safe and whether it triggers an immune response. Participants were randomly assigned to receive either the vaccine or a placebo, and researchers mo…

This early-stage trial tested a new HIV vaccine candidate in 57 healthy adults without HIV. The vaccine uses a protein designed to train the immune system to recognize HIV. The main goals were to check safety and see if the vaccine triggers a specific immune response. Results wil…

This study tested the safety of the drug tofacitinib in 10 adults with chronic granulomatous disease (CGD) who had ongoing inflammation in the gut, skin, or lungs. Participants took tofacitinib pills for 3 months and were monitored for side effects and infections. The goal was to…

This study tested a drug called AMG 714 in 60 adults with vitiligo, a condition that causes white patches on the skin. The goal was to see if the drug could reduce facial patches by at least 35% after 24 weeks. Participants received either the drug or a placebo, and all were aske…

This study looked at 48 kidney and liver transplant recipients who had a weak antibody response after their initial COVID-19 vaccines. Researchers gave them an extra vaccine dose, and for some, they temporarily reduced the patients' immune-suppressing medications to see if that w…

This study tested whether taking a double dose of the HIV drug dolutegravir (50 mg twice daily) along with the tuberculosis drug rifapentine is safe and maintains HIV viral suppression. Thirty adults with both HIV and tuberculosis participated. The goal was to see if the higher d…

This study tested whether adding tocilizumab to standard anti-rejection medicines helps heart transplant recipients have better outcomes one year after surgery. Researchers looked at whether the drug reduced rejection, harmful antibodies, and heart function problems. The trial in…

This early-stage study tested a lab-made antibody called VRC01 in 24 adults with very recent HIV infection. The goal was to see if the antibody is safe and can lower the amount of virus in the blood, either alone or with standard HIV medicines. While the antibody was generally sa…

This study tested whether certain drugs could safely help hospitalized COVID-19 patients who have severe breathing problems. About 473 participants received either a study drug (like aviptadil or remdesivir) plus standard care, or a placebo plus standard care. The goal was to see…

This study tested whether the drug aviptadil helps hospitalized COVID-19 patients with severe breathing problems recover better than standard care alone. About 471 adults took part, receiving either aviptadil plus usual care or a placebo plus usual care. The main goal was to see …

This early-phase study tested a drug called brentuximab vedotin, originally used for lymphoma, in 17 people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The main goal was to see if the drug is safe and tolerable. Researchers believe the drug may calm …

This study looked at how safe and tolerable the HIV drug dolutegravir is for newborns whose mothers have HIV. Researchers gave the medicine to 48 infants during their first month of life and monitored them for 16 weeks. The goal was to find a safe dose that works well alongside s…

This study tested whether a simple finger-prick blood test done at home, with reminders from a mobile device, helps bone marrow transplant patients stay on schedule with weekly CMV monitoring. CMV is a common virus that can cause serious illness in people with weakened immune sys…

This study aims to understand why some people with HIV still have high virus levels despite taking combination antiretroviral therapy (ART). Researchers will monitor 26 participants during hospital stays and follow-ups to see if directly observed medication and tailored support c…

This early-stage study tested a new approach to help kidney transplant recipients stop their daily anti-rejection drugs. Eight adults received donor stem cells along with a special drug combination, with the goal of safely weaning them off all immunosuppression. The main focus wa…

This early-phase study tested rituximab, a drug used for rheumatoid arthritis, in 7 adults with rare diseases where the immune system attacks the body's own proteins. The goal was to see if the drug is safe and can help control these hard-to-treat conditions. Participants receive…

This study looked at how safe and effective the drug bedaquiline is for children and teens with a hard-to-treat form of tuberculosis (TB) that is resistant to the antibiotic rifampin. Fifty-four participants, some also living with HIV, received bedaquiline along with their person…

This study tested whether the drug remdesivir helps hospitalized COVID-19 patients with severe breathing failure recover better than standard care alone. 87 adults were randomly assigned to receive either remdesivir or a placebo, plus usual treatments. The main goal was to see ho…

This study tested a single dose of a mixture of viruses (bacteriophages) given intravenously to adults with cystic fibrosis who have a chronic lung infection with Pseudomonas aeruginosa bacteria. The goal was to see if the treatment is safe and can reduce the amount of bacteria i…

This study tested two different doses of the drug linezolid, combined with three other medicines, to treat drug-resistant tuberculosis (TB). The goal was to see if a lower dose could work just as well but with fewer side effects. 138 adults with drug-resistant TB took part, and r…

This study tested an experimental oral drug called selgantolimod in 29 adults who have both chronic hepatitis B and HIV and have been on stable antiviral therapy for at least 5 years. The goal was to see if the drug is safe and can reduce hepatitis B surface antigen (HBsAg) level…

This study tested two long-acting injectable HIV medications (cabotegravir and rilpivirine) in 168 children and teens whose HIV was already under control. The goal was to find the right doses and see if the shots were safe and acceptable. Participants received oral pills first, t…

This study looked at whether a special liquid diet (elemental diet) could improve gut symptoms in people with chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD). Three participants aged 8-65 stayed in the hospital for up to 2 weeks and followed the diet for …

This large study tested whether the statin drug pitavastatin could lower the risk of heart attacks, strokes, and other serious heart problems in people with HIV. Over 7,700 adults with HIV who were already on standard HIV treatment took either pitavastatin or a placebo pill. The …

This completed study tested whether the drug tecovirimat is safe and helps people with mpox heal faster. 328 adults and children with confirmed mpox and active lesions took part. The main goal was to see how quickly their skin lesions scabbed and healed compared to those who rece…

This study tested whether the drug tecovirimat is safe and effective for treating monkeypox (mpox) in adults and children. About 600 participants received either tecovirimat or a placebo, along with standard care, for 14 days. The main goal was to see how quickly skin lesions hea…

This study tested whether giving two lab-made antibodies (VRC01LS and 10-1074) could keep HIV suppressed in 30 children in Botswana who started HIV treatment very early. The children stopped their regular HIV pills and received antibody infusions instead. The goal was to see if t…

This study tested whether a simple saltwater mouth rinse can detect pneumocystis, a lung infection that can be life-threatening for people with weak immune systems (like those with HIV, cancer, or organ transplants). Current diagnosis requires coughing up sputum or a lung scope, …

This study looked at two new ways to prevent RSV, a serious lung infection in babies. Researchers compared giving a vaccine to pregnant women, giving a long-acting antibody shot to infants, or using both. The goal was to see how well each approach protects babies during their fir…

This study tested a new way to prevent dengue fever and similar viruses. Researchers released mosquitoes infected with Wolbachia bacteria into certain neighborhoods in Brazil. These "good" mosquitoes are less able to spread viruses. Over 5,700 children aged 6-11 took part, and th…

This early-stage study tested a new lab-made antibody called CAP256J3LS in 24 healthy adults to see if it is safe. The antibody is designed to stop HIV from infecting cells. Participants received either one or three doses by injection or IV, and were monitored for side effects an…

This large study tested whether an injectable drug called cabotegravir, given every 2 months, could prevent HIV better than taking a daily pill. It involved over 4,500 HIV-negative men and transgender women who have sex with men and are at high risk for HIV. The goal was to see i…

This study tested a vaginal ring that slowly releases the HIV drug tenofovir over 90 days. 49 women participated to see how safe the ring is and how much drug gets into the body. The goal is to find a convenient way for women to protect themselves from HIV.

This study looked at whether a single dose of the dengue vaccine TV003 or a past Zika infection could protect people from getting infected with Zika virus again. 27 healthy adults who either received the vaccine or had prior Zika infection were deliberately exposed to Zika virus.…

This study tested a single injection of a lab-made antibody called L9LS in healthy Kenyan children aged 5 months to 10 years. The goal was to see if it is safe and can protect against malaria caused by the Plasmodium falciparum parasite. Over 900 children took part, and researche…

This study tested whether a grass pollen tablet (SLIT) combined with the drug dupilumab could help adults with moderate to severe seasonal allergies tolerate grass pollen better. About 199 participants received the combination or a placebo for two years. The goal was to see if th…

This study tested a drug called JBT-101 (lenabasum) in 109 adults with lupus who had active joint pain. The goal was to see if it could reduce pain better than a placebo over 84 days. Participants took the drug by mouth and reported their daily pain levels. The study is complete,…

This study tested whether omalizumab, an allergy medication, helps people with peanut and other food allergies eat those foods without severe reactions. Over 470 children and adults received either omalizumab or a placebo, then took a food challenge. The goal was to see if omaliz…

This study collected tissue samples from tonsils, lymph nodes, intestines, and lungs of people with HIV and healthy volunteers. The goal was to measure the amount of virus and immune cells in these tissues. It helps researchers understand how HIV behaves in the body, but did not …

This study tracked how often people of all ages in Sabou, Burkina Faso get malaria over one year. Researchers collected monthly blood samples and mosquito data from 608 healthy volunteers aged 6 months to 65 years. The goal was to measure infection rates by age group, which will …

This study looked at liver damage in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Researchers used liver biopsies, ultrasound, and CT scans to check for fibrosis and other liver problems. The goal was to better understand how HIV medications affect…

This study looked at how HIV and tuberculosis medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to understand dosing needs during pregnancy and after childbirth. Over 1,500 women participated…

This study looked at the genes in the skin of 433 people with eczema (atopic dermatitis) to find patterns that explain why some have mild symptoms and others have severe symptoms. Researchers collected skin samples and tracked how these patterns changed with standard treatments l…

This study followed 1,377 people living with HIV in Liberia over three years to understand how the disease affects them. Researchers collected blood and urine samples, performed physical exams, and asked about health and behaviors. The goal was to gather information to improve HI…

This study tested different doses of the oral herpes medicine valacyclovir in 17 newborns whose mothers had genital herpes. The goal was to find a dose that gives similar drug levels in the blood as the standard IV treatment. The results help doctors know how to safely give this …

This study looked at how a single dose of the drug pretomanid works in 32 children with rifampicin-resistant tuberculosis (TB), some of whom also had HIV. Researchers measured drug levels in the blood and checked for side effects. The goal was to gather information to help design…

This study looked at how the tuberculosis drug pretomanid is handled by the body in people with different levels of kidney function. Twelve adults with kidney impairment and healthy volunteers took a single dose to compare drug levels and safety. The goal is to find the right dos…

This study looked at whether measles infection can cause 'immune amnesia'—temporarily wiping out a child's existing immunity to other diseases. Researchers followed 264 children aged 1 to 15 in Africa, comparing those with and without measles. They measured antibody levels and re…

This study explored how malnutrition, diabetes, and worm infections influence the body's response to latent tuberculosis (LTBI) in a South Indian population. Researchers enrolled 626 people aged 14 to 65, with or without LTBI, and measured these risk factors along with immune bio…

This study tested a new tablet form of the experimental COVID-19 drug ALG-097558 in 51 healthy adults. Researchers checked how the drug interacts with other medications and whether food changes how it works. The goal is to gather safety and dosing information, not to treat the di…

This study looked at 200 adults with HIV in Liberia to compare two ways of checking for hidden tuberculosis (TB) infection: a skin test and a blood test. The goal was to see which test works better in this group. Participants had both tests and results were compared. This researc…

This study looked at how the virus that causes COVID-19 affects lymphocytes, a type of white blood cell that fights infection. Researchers studied 240 adults who had or recently recovered from COVID-19. They collected blood samples and medical records to learn more about the immu…

This study looked at how children's immune systems respond to the flu vaccine. Researchers collected nasal swabs and finger-prick blood samples from 65 kids aged 2-17 before and after they got their regular flu shot. The goal was to understand both the body-wide and nose-specific…

This study looked at how well different COVID-19 vaccines work in adults from 7 countries. About 5,400 people joined within a day of getting their vaccine. Researchers measured antibody levels to see how strong and long-lasting the immune response was.

This study looked at HIV that stays hidden in the body even when the virus is under control. Researchers measured this 'latent reservoir' in 90 Ugandan adults with HIV. The goal was to learn more about the reservoir and compare it to what is seen in Western countries, which may h…

This study tested a special method called xenodiagnosis to see if Lyme disease bacteria can survive after antibiotic treatment. Researchers placed disease-free ticks on the skin of 45 adults with different stages of Lyme disease, as well as healthy volunteers. The goal was to see…

This study measured how common malaria and worm infections are in pregnant women and young children in two counties of Liberia. Over 1,200 participants gave a small blood sample for testing. The goal was to gather information to help understand and fight these diseases.

This study followed 190 HIV-positive women starting antiretroviral therapy (ART) to see how often herpes viruses become active again. Researchers collected blood, urine, and vaginal samples over a year to track viral shedding and symptoms. The goal was to understand why some wome…

This study looked at blood markers of inflammation, clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. The goal was to better understand how these markers, especially D-dimer, relate to HIV and risks like heart disease and stroke. Participants …

This early-stage study tested a single dose of an experimental drug called SAR440894 in 42 healthy adults to see if it is safe. The drug is being developed to fight chikungunya virus infection, but this trial did not involve infected people. The main goal was to check for side ef…

This study looked at how the body processes IV artesunate in children with severe malaria. About 90 Ugandan children aged 6 months to 14 years received standard doses of the drug. Researchers measured changes in vital signs and lab values to better understand how the drug works a…

This study screened up to 1,000 people (ages 1–80) with severe allergic conditions, like anaphylaxis or high IgE, plus their relatives, to find genetic causes. Researchers collected blood samples and medical history but did not provide any treatment. The goal was to build a libra…

This study looked at how HIV and tuberculosis (TB) medications are processed in the body during pregnancy and after childbirth. Researchers measured drug levels in 205 women to see if standard doses provide enough protection for both mother and baby. The goal was to gather inform…

This study intentionally gave a mild cold-causing virus (RSV) to 32 healthy adults aged 18-50 in a hospital setting. The goal was to closely monitor how the body fights the infection and track symptoms, viral shedding, and immune responses. The information gathered will help desi…

This study followed nearly 1,000 people with severe allergic conditions like eczema and related genetic disorders to understand how these diseases develop and change over time. Participants, including children and adults, underwent tests such as allergy skin pricks, blood draws, …

This early-stage study tested the safety of a single dose of an experimental drug called EV68-228-N in 36 healthy adults aged 18 to 49. Participants received either the drug or a placebo by IV, and were monitored for side effects for up to 29 days. The goal was not to treat illne…

This study looked at how bismuth subsalicylate (the active ingredient in Pepto-Bismol) affects the bacteria living in the gut. 34 healthy adults took the medicine for 2 days, and researchers compared their stool samples before and after. The goal was to understand if this common …

This study followed 775 healthy children aged 2-9 in Cambodia for three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples each wet and dry season to check for infections and mosquito exposure. The goal was to gather information to help …

This study collected blood, saliva, stool, urine, and skin samples from 19 people aged 2 and older with known or suspected immune defects. The goal was to learn how different parts of the immune system work together, not to test a treatment. Participants were followed for up to 5…

This study looked at why some people get hives from physical triggers like cold, pressure, or exercise. Researchers tested 173 participants to confirm their triggers and collected blood and skin samples to study immune system activity and genetic factors. The goal was to better u…

This study looked back at medical records of 137 people with chronic granulomatous disease (CGD), a rare immune disorder. Researchers compared those who had a stem cell transplant with those who received standard care to see who lived longer and had fewer infections. The goal was…

This study looked at how two common antibiotics (amoxicillin and azithromycin) change the community of microbes living in healthy people, and whether those changes affect metabolism and the immune system. Over 100 healthy adults took antibiotics for a week or less, and researcher…