National Institute Of Allergy And Infectious Diseases (niaid)

This study tested the safety and immune response of two experimental HIV vaccine candidates in healthy adults who do not have HIV. The 127 participants received different versions of the vaccines, which were mixed with substances called adjuvants designed to boost the body's reac…

This study tested a vaccine designed to strengthen the immune system's response to cytomegalovirus (CMV) in adults who have both HIV and CMV. 90 participants, all with well-controlled HIV on stable medication, received either two doses of the experimental vaccine or a placebo. Th…

This early-stage study tested two new experimental vaccines designed to protect against Respiratory Syncytial Virus (RSV) in young children. The vaccines were given as nose drops to 60 children, including some who had never had RSV before. The main goals were to check if the vacc…

This early-stage study tested a new mRNA-based flu vaccine in healthy adults to see if it's safe and triggers a good immune response. Researchers gave 50 volunteers different doses of the experimental vaccine or a standard flu shot for comparison. The main goal was to check for s…

This study tested the safety and immune response of several experimental HIV vaccines in healthy adults who do not have HIV. The main goal was to see if the vaccine shots were safe and if they could trigger the body to produce antibodies that might fight the virus. Researchers en…

This early-stage study tested the safety and immune response of a new HIV vaccine approach in 46 healthy adults without HIV. Participants received synthetic DNA injections, some with an additional protein boost, to see if they could trigger specific immune responses against HIV. …

This early-stage study tested the safety and immune response of a new oral vaccine designed to protect against a type of E. coli bacteria that causes severe diarrhea, often called traveler's diarrhea. The study involved 36 healthy adults who received one of several doses of the e…

This early-stage study tested a new experimental HIV vaccine in 51 healthy, HIV-negative adults. The main goals were to check if the vaccine was safe and to see if it could stimulate the immune system to produce antibodies that might fight HIV. Researchers tested different doses …

This early-stage study tested a new type of COVID-19 vaccine given as a nasal spray. Researchers enrolled 27 healthy adults aged 18-50 to receive two doses of the experimental vaccine, 56 days apart. The main goals were to check if the vaccine was safe and whether it triggered an…

This early-stage study tested the safety and immune response of a new experimental HIV vaccine in healthy adults. Twenty participants received either the new DNA-based vaccine alone or in combination with another vaccine shot. The main goal was to see if the vaccines were safe an…

This early-stage study tested the safety and immune response of an experimental flu vaccine called FluMos-v2. The vaccine is designed to protect against six different flu strains, potentially offering broader coverage than current shots. Thirty healthy adults received two doses a…

This was an early safety study for a new vaccine designed to prevent infections from Campylobacter jejuni, a common cause of food poisoning. About 60 healthy adults received different doses of the vaccine, with or without an immune-boosting additive, to see if it was safe and if …

This was a small, early-stage study to check the safety and immune response of a new HIV vaccine in healthy adults. It involved 24 participants who received either the vaccine or a placebo. The main goal was to see if the vaccine was safe and if it triggered an immune response, n…

This study tested the safety and immune response of an experimental HIV vaccine called VIR-1388. The trial involved 93 healthy adults without HIV who received either the vaccine or a placebo. Researchers monitored participants for side effects and measured whether the vaccine tri…

This study tested updated COVID-19 booster shots designed to protect against new virus variants. It involved 1,270 adults who were already fully vaccinated and boosted. Researchers gave different variant-specific booster formulas to see which ones best strengthened the immune sys…

This early-stage study tested the safety and immune response of a new nasal spray COVID-19 booster vaccine called MPV/S-2P. It involved 60 healthy adults who had already received their primary mRNA COVID-19 vaccines and at least one booster shot. Researchers gave participants the…

This study tested whether adding special immune-boosting ingredients, called adjuvants, to two already-approved seasonal flu vaccines would improve their safety and effectiveness. It involved 241 healthy adults aged 18-45. Researchers compared the standard vaccines to versions mi…

This early-stage study explored a new vaccination strategy aimed at creating broader protection against multiple flu strains, potentially moving toward a 'universal' flu vaccine. Researchers tested an H5N1 flu shot in 32 healthy adults, comparing those who had received previous e…

This was a first-in-human safety study for a new experimental yellow fever vaccine. Researchers enrolled 92 healthy adults to test the vaccine's safety and the body's immune response to it. They compared the vaccine given with and without an extra ingredient (an adjuvant) designe…

This study tested a new smallpox vaccine called IMVAMUNE to see how safe it is and how well it triggers the body's immune defenses. It involved 226 healthy adults who had never received a smallpox vaccine before. Researchers compared different dosing schedules and tracked side ef…

This was the first study in people to test an experimental mRNA vaccine designed to prevent Nipah virus infection. The trial enrolled 40 healthy adults to check if the vaccine was safe and if it triggered an immune response. Participants received two shots a month apart, and rese…

This early-stage study tested whether a new experimental vaccine for herpes simplex virus type 2 (HSV-2), which causes genital herpes, is safe for people. The trial involved 69 healthy adults, some with and some without prior herpes infections, who received three injections of ei…

This study tested whether adding a drug called tocilizumab to standard anti-rejection medications could lead to better results for people who received a heart transplant. Researchers enrolled 385 participants to see if this combination reduced organ rejection, improved heart func…

This study tested long-acting injectable HIV medications in children and adolescents whose HIV was already well-controlled with daily pills. The goal was to find the right dose and see if getting shots every month or two was safe, tolerable, and kept the virus suppressed. Researc…

This study tested if taking a double dose of the HIV medication dolutegravir is safe and effective when used alongside a specific tuberculosis (TB) treatment. Researchers wanted to see if the higher dose would keep HIV levels low, as the TB drug can interfere with the HIV medicat…

This study aimed to find safe and effective doses of the drug bedaquiline for children and adolescents with a hard-to-treat form of tuberculosis (TB) that resists standard antibiotics. It involved 54 young participants, from infants to teens, who also received their standard TB t…

This early-stage study tested the safety and initial effects of an experimental antibody called VRC01 in adults recently diagnosed with HIV. Participants received either the antibody alone, the antibody plus standard antiretroviral therapy (ART), or a placebo plus ART. The main g…

This study tested whether an injection called omalizumab, alone or combined with gradually eating small amounts of problem foods (oral immunotherapy), could help people with multiple food allergies. It involved 471 children and adults allergic to peanut and at least two other foo…

This large, international study aimed to find safe and effective drug treatments for people hospitalized with COVID-19 who developed severe breathing failure. It tested several investigational drugs, including aviptadil and remdesivir, by adding them to the standard hospital care…

This study aimed to help people with HIV whose standard medication combinations were no longer controlling the virus. Researchers closely monitored 26 participants, checking if missed doses or drug resistance was the problem, and then designed new, personalized treatment plans. T…

This study tested an investigational drug called AMG 714 to see if it could help restore skin color (repigmentation) in adults with vitiligo. The trial involved 60 participants and compared the drug against a placebo over 24 weeks. Researchers also looked at whether adding light …

This study tested whether a special, nutrient-rich liquid diet could improve gut bacteria and ease bowel inflammation in people with two related conditions: chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD). Three participants, aged 8 to 65, followed the di…

This study tested whether a drug called rituximab could safely treat rare diseases where the immune system mistakenly attacks the body's own proteins. Seven adults with these conditions, who were not helped by standard treatments, received rituximab infusions over six months. The…

This study tested a method to help kidney and liver transplant patients get better protection from COVID-19. Researchers gave 48 transplant recipients a booster shot and randomly assigned half to also temporarily lower their anti-rejection medications. The goal was to see if this…

This study tested if making virus monitoring easier could help patients stick to their doctor's advice. Researchers wanted to see if sending reminders to a smartphone and letting patients collect a tiny blood sample at home would help them complete their weekly virus checks. The …

This early-phase trial tested the safety and initial effectiveness of a single-dose, intravenous therapy made from special viruses called bacteriophages. The goal was to see if these viruses could safely target and reduce levels of Pseudomonas aeruginosa, a harmful bacteria that …

This study tested whether a drug called tecovirimat helps people with monkeypox get better faster. Nearly 600 adults and children with confirmed monkeypox were randomly given either the real drug or a placebo pill, along with standard hospital care, for two weeks. Researchers tra…

This study tested whether a shorter, 3-day course of the antibiotic doxycycline works as well as the standard 7-day course for curing chlamydia infections. Over 600 men and women with confirmed chlamydia were randomly assigned to take either the 3-day or 7-day regimen. Researcher…

This small, early-stage study tested whether a combination of donor cells and specific immunosuppressive drugs could allow kidney transplant recipients to slowly reduce and potentially stop all anti-rejection medications without rejecting their new kidney. The goal was to see if …

This study tested whether the drug tecovirimat helps people with monkeypox recover faster. It involved 328 adults and children with confirmed monkeypox infection. The results showed the drug was safe but did not speed up skin lesion healing compared to standard medical care alone…

This study tested whether the drug Aviptadil could help hospitalized COVID-19 patients with severe lung failure. 471 participants received either Aviptadil plus standard hospital care or a placebo plus standard care. Researchers tracked patients for 90 days to see if the drug imp…

This study tested whether the drug remdesivir, added to standard hospital care, could help people hospitalized with severe COVID-19 and life-threatening breathing problems. About 87 very sick patients received either remdesivir or a placebo (dummy drug) along with standard care. …

This study aimed to see if a new lab method could use a simple saltwater mouth rinse to detect a serious fungal lung infection called Pneumocystis pneumonia. This infection is life-threatening for people with weakened immune systems, like those with HIV or cancer. Current diagnos…

This early-stage study tested a vaginal ring designed to be worn for 90 days to help prevent HIV infection. Researchers enrolled 49 healthy, HIV-negative women to check how much of the drug tenofovir entered their bodies and to monitor safety. Participants were randomly assigned …

This study aimed to find a safe and effective oral dose of the drug valacyclovir for newborns at risk of catching herpes from their mothers during birth. It involved 17 healthy, full-term infants whose mothers had a history of genital herpes. Researchers tested how the babies' bo…

This study tested a new vaccine designed to stop the spread of malaria by mosquitoes, not to protect the person getting the shot. Researchers gave the vaccine to 105 healthy adults who had never had malaria to check if it was safe and if it triggered an immune response. Volunteer…

This small, early-stage study aimed to see if a vaccine for dengue fever (called TV003) could also protect people from getting infected with the Zika virus. Researchers also tested whether people who had a past Zika infection were immune to getting it again. A total of 27 healthy…

This study tested whether releasing mosquitoes infected with a harmless bacteria called Wolbachia could reduce infections from dengue, Zika, and chikungunya viruses in Brazil. Over 5,700 children aged 6-11 participated over four years. Researchers compared areas where these speci…

This was an early-stage study to check the safety of a new antibody drug, SAR440894, in healthy people. The goal is to see if this antibody could eventually be used to prevent infection from the Chikungunya virus, which is spread by mosquitoes. Forty-two healthy adults received a…

This large study tested whether a long-acting injection given every two months (cabotegravir) works as well as or better than a daily oral pill (Truvada) to prevent HIV infection. It enrolled over 4,500 HIV-negative men and transgender women who have sex with men and are at high …

This large, international study aimed to see if a daily cholesterol-lowering pill (pitavastatin) could prevent heart attacks, strokes, and other major heart-related problems in adults living with HIV. Over 7,700 participants on stable HIV treatment, who had a low-to-moderate risk…

This study tested a one-time injection of an experimental antibody called L9LS to see if it could safely protect children from getting malaria. Over 900 healthy children in Kenya, where malaria is common, received either the antibody or a placebo shot. Researchers monitored the c…

This is an early safety study of a new drug called EV68-228-N, which is being developed to treat enterovirus infections. The study enrolled 36 healthy adult volunteers to test three different doses of the drug, given as a single infusion into a vein. The main goals are to see if …

This study looked at whether common HIV medications work correctly when taken at the same time as feminizing hormone therapy (estradiol). It involved 93 transgender women living with HIV who were already on stable HIV treatment. Participants received study-provided hormone therap…

This study aimed to understand why some people develop itchy hives (urticaria) in response to physical triggers like cold, heat, pressure, or sunlight. Researchers enrolled 173 participants, including people with these conditions and their family members, to collect blood and ski…

This study aimed to understand how a tuberculosis drug called pretomanid is processed by the body in people with different levels of kidney function. It involved 12 participants, some with healthy kidneys and some with mild to severe kidney impairment. Each person received a sing…

This study aimed to understand the genetic causes of severe allergic diseases like anaphylaxis, eczema, and asthma. Researchers screened 824 participants, including patients and their family members, by collecting blood samples for genetic and immune cell testing. No treatments w…

This study aimed to understand how the body processes HIV and tuberculosis medications during pregnancy and after birth. Researchers observed 205 pregnant and breastfeeding women who were already taking these medications for their health care. They measured drug levels in the mot…

This study aimed to gather detailed health information from over 1,300 people living with HIV in Liberia over three years. Participants attended regular clinic visits where researchers collected health data and samples. The goal was to better understand how HIV affects people in …

This study aimed to measure how common malaria and worm infections were in pregnant women and young children in two counties of Liberia. Researchers enrolled over 1,200 participants seeking routine care at local health centers. They collected small blood samples to test for infec…

This study aimed to understand how HIV medications might cause long-term liver damage and scarring. Researchers enrolled 127 HIV-positive adults who had been on stable HIV drug regimens for at least a year and had elevated liver enzymes for six months. They performed detailed tes…

This study aimed to understand how common health problems like malnutrition, diabetes, and worm infections might increase the risk of latent tuberculosis (TB) becoming active. Researchers in India enrolled 626 people with and without latent TB to measure how often these other con…

This study aims to understand how the COVID-19 virus causes a dangerous drop in lymphocytes, a type of white blood cell that fights infections. Researchers collected blood samples from 240 adults who either had active COVID-19 or had recently recovered. By analyzing these samples…

This study monitored the safety of the Jynneos monkeypox vaccine in 500 healthcare staff and researchers in the Democratic Republic of the Congo. Participants received two doses of the vaccine and were followed for 28 days after their last shot to track any side effects. The goal…

This study aimed to understand how bismuth subsalicylate (BSS), the active ingredient in medicines like Pepto-Bismol, affects the community of bacteria living in a healthy person's gut. Thirty-four healthy adults took BSS for two days, and researchers collected stool samples befo…

This study aimed to understand how children's immune systems respond to the seasonal flu vaccine. Researchers followed 65 children, ages 2-17, who received their flu shot from their regular doctor. Participants collected simple nasal swabs and fingerstick blood samples at home ov…

This study aimed to understand why herpes virus symptoms can suddenly start or get worse when women with HIV begin taking their HIV medication (ART). Researchers followed 190 women for one year after they started ART, collecting blood and other samples to track herpes virus activ…

This study aimed to understand how the standard treatment for severe malaria works in children's bodies. Researchers in Uganda gave 90 children the standard IV drug (artesunate) and then carefully measured drug levels and key health markers in their blood. The goal was to learn t…

This study aimed to understand how the human body responds to Respiratory Syncytial Virus (RSV), a common virus that can cause serious illness in children and the elderly. Researchers intentionally gave a small dose of RSV to 32 healthy adult volunteers and monitored them closely…

This international study tracked how people's immune systems responded to COVID-19 vaccines they received through their local vaccination programs. Researchers followed over 5,000 adults across 7 countries, measuring antibody levels and monitoring for breakthrough infections. The…

This study looked back at the medical records of 137 patients with Chronic Granulomatous Disease (CGD), a rare immune disorder. It compared the long-term survival and health of patients who received a stem cell transplant to those who received standard medical care. The goal was …

This study aimed to understand how common antibiotics affect the body's natural systems in healthy people. Researchers gave 108 healthy adults either amoxicillin, azithromycin, or no drug, and then measured changes in their gut bacteria, immune system, and metabolism. The goal wa…

This study aimed to find out if live Lyme disease bacteria can still be present in people after they finish antibiotic treatment, which might explain why some people have lasting symptoms. Researchers used a method called xenodiagnosis, where clean, lab-raised ticks were placed o…

This study collected blood, saliva, and other samples from people with unexplained immune system problems and their healthy relatives. Researchers aimed to better understand how different parts of the immune system work together in complex disorders that don't have clear genetic …

This study aimed to better understand certain markers in the blood related to inflammation and clotting in people with HIV. Researchers collected blood samples from 310 HIV-positive adults and healthy volunteers to see how these markers might be linked to risks like heart disease…

This study aimed to measure and understand the hidden, inactive HIV that persists in the body even when treatment is working well. Researchers followed 90 Ugandan adults with well-controlled HIV for up to 20 years, taking yearly blood samples. The goal was to see how much hidden …

This study aimed to understand how HIV and tuberculosis (TB) medications are processed by the body during pregnancy and after birth. Researchers followed over 1,500 pregnant and postpartum women who were already taking these medications for their care. By measuring drug levels in…

This study aimed to understand how mosquito bites lead to dengue and similar viral infections in children. Researchers followed 775 healthy children aged 2-9 in Cambodia for three years, checking their blood regularly during wet and dry seasons. The goal was to gather information…

This study aimed to understand how severe allergic diseases like eczema develop and progress over time. Researchers observed 945 participants, including people with conditions like severe eczema and their family members, to learn about the biology of these disorders. The study in…

This study aimed to understand the different genetic patterns, or 'endotypes,' in the skin of people with mild versus moderate-to-severe eczema (atopic dermatitis). Researchers collected skin samples from 433 participants, including people with eczema and those without, over mult…