National Institute Of Allergy And Infectious Diseases (niaid)

This early-stage study tested whether new HIV vaccines are safe and can trigger an immune response in healthy adults. Researchers gave different combinations of vaccines to 44 participants to see how well they were tolerated. The study was terminated early, so results are limited…

This early-stage study tested a new Ebola vaccine given as a nasal spray in 15 healthy adults. The goal was to check safety and whether the vaccine triggers an immune response. The study was terminated early, so results are limited.

This study tested two lupus medications—mycophenolate mofetil (MMF) alone or with voclosporin—in 12 adults with moderately severe lupus. The goal was to see if treatment response differs based on a person's immune system type. The trial was terminated early, so results are limite…

This study tested four different doses of a drug called siplizumab in 8 people aged 8 to 45 who were diagnosed with type 1 diabetes within the past 18 months. The goal was to find a safe dose that could help preserve the body's ability to make insulin by changing certain immune c…

This study tested a drug called elotuzumab combined with prednisone for people with active IgG4-related disease, a rare condition causing swelling and organ damage. The trial was stopped early after enrolling only 8 of the planned 75 participants. The main goal was to check safet…

This study tested whether the drug tecovirimat is safe and effective for treating mpox. Researchers compared it to a placebo in 719 people with confirmed or suspected mpox. The main goals were to see if the drug could speed up healing of skin lesions and reduce pain. The trial wa…

This study tested whether adding a 12-week course of VIB4920 to standard TNF-inhibitor therapy could improve disease control in people with rheumatoid arthritis who did not respond well to TNF-inhibitors alone. Only 2 participants were enrolled before the study was stopped. The g…

This study tested a device that sends mild electrical pulses through the skin to stimulate the vagus nerve, aiming to reduce pain and inflammation in children with juvenile idiopathic arthritis (JIA). The trial enrolled 18 participants aged 5-18 and compared active stimulation to…

This study looked at how feminizing hormone therapy (estrogen) interacts with HIV medications in transgender women living with HIV. Researchers wanted to see if the hormones affect drug levels in the blood. The study enrolled 93 adults and was stopped early, but the goal was to p…