Could a cancer drug calm scleroderma? early trial hints at hope
NCT ID NCT03222492
First seen May 06, 2026 · Last updated May 23, 2026 · Updated 2 times
Summary
This early-phase study tested a drug called brentuximab vedotin, originally used for lymphoma, in 17 people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The main goal was to see if the drug is safe and tolerable. Researchers believe the drug may calm overactive immune cells that drive the disease. This is a first step toward a possible new treatment for a condition with few options.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Duke University Medical Center: Division of Rheumatology and Immunology
Durham, North Carolina, 27710, United States
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Georgetown University Medical Center: Division of Rheumatology
Washington D.C., District of Columbia, 20057, United States
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Hospital for Special Surgery, New York: Division of Rheumatology
New York, New York, 10021, United States
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Medical University of South Carolina: Division of Rheumatology & Immunology
Charleston, South Carolina, 29425, United States
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UCLA Medical Center: Division of Rheumatology
Los Angeles, California, 90095, United States
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University of Michigan Health System: Department of Internal Medicine, Division of Rheumatology
Ann Arbor, Michigan, 48109, United States
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University of Pittsburgh Medical Center: Division of Rheumatology and Clinical
Pittsburgh, Pennsylvania, 15217, United States
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University of Texas Houston Medical School: Division of Rheumatology and Clinical Immunogenetics
Houston, Texas, 77030, United States
Conditions
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