SCLERODERMA

This study is testing a new treatment for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, myositis, or scleroderma) that have not responded to standard therapies. The treatment combines a natural killer cell therapy called AlloNK with the drug ri…

This study tests a new drug called tibulizumab for adults with systemic sclerosis, a rare disease that causes skin thickening and can affect internal organs. About 80 participants will receive either the drug or a placebo for 24 weeks, followed by an open-label period where every…

This early study tests an experimental injection called EVM18001 in 12 people with active, hard-to-treat lupus, myasthenia gravis, or scleroderma. The main goals are to check safety and find the right dose. Researchers will also look at how the drug works in the body and if it he…

This early-stage study tests a new treatment called HN2301 in 30 people with autoimmune diseases like lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also look at how well the therapy works and how the body r…

This early-stage study tests a new medicine, SAR448501/DR-0201, in adults with lupus or rheumatoid arthritis. The goal is to find safe and tolerable doses by checking side effects and how the drug works in the body. About 62 participants will receive multiple doses and be followe…

This study tests whether sildenafil, a drug that relaxes blood vessels, can improve walking distance and heart function in 30 people with scleroderma who have mildly high blood pressure in their lungs. Participants will receive either sildenafil or a placebo for up to 12 months. …

This study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy certain immune cells that drive th…

This study tests new medicines for people with scleroderma who have lung scarring (interstitial lung disease). About 400 adults will receive either an experimental drug or a placebo for 52 weeks. The main goal is to see if the drugs help maintain or improve lung function, measure…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves physical function, skin health, and overall well-being. Participants are randomly assigned to BETY or standard care, and outcomes are meas…

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study looks at whether leg muscle issues contribute to shortness of breath and exercise problems in people with interstitial lung disease (ILD). Researchers will compare leg muscle structure and function in 40 ILD patients, and test if muscle fatigue limits exercise. They wi…

This study follows 500 adults with systemic sclerosis (scleroderma) for up to 5 years. Researchers will track how the disease naturally progresses by monitoring key complications like lung and kidney problems. They will also collect blood and tissue samples to better understand t…

This study looks at skin cells called fibroblasts from people with scleroderma and compares them to cells from healthy volunteers. The goal is to find which genes are turned on or off in these cells, especially those linked to aging and inflammation. By understanding these differ…

This study is creating a large collection of blood samples and medical information from 3000 people with autoimmune diseases like lupus, scleroderma, and myositis. The goal is to help researchers find new markers and develop better treatments. Participants will not receive any ex…

This study is creating a registry and repository for people with scleroderma, a rare autoimmune disease. Researchers will collect medical information and samples from 300 participants to better understand the disease's features, genetics, and biology. The goal is to lay the groun…

This study looks at how scleroderma affects chewing and swallowing in both children and adults. Researchers will measure mouth opening, swallowing ability, and eating performance using simple tests and questionnaires. The goal is to better understand these problems and find the b…

This study looks at how scleroderma affects physical abilities and daily functioning in both children and adults. Researchers will measure walking, stair climbing, and other tasks to understand the challenges patients face. The goal is to find better ways to support disease manag…

This study is a registry that will enroll up to 1,000 pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will collect information to identify risk factors for poor pregnancy outcomes. The goal…

This study collects tissue and blood samples from 300 people with autoimmune diseases like ulcerative colitis, multiple sclerosis, and Crohn's disease. Researchers will identify which T-cells are active in inflamed tissues and find their targets. The goal is to discover new targe…