SCLERODERMA

This study is testing whether sildenafil (the active ingredient in Viagra) can help people with scleroderma who have mildly elevated blood pressure in their lungs. Researchers will give 30 participants either sildenafil or a placebo pill for 4-12 months to see if it improves how …

This early-stage study is testing a new mRNA-based therapy called HN2301 in people with autoimmune diseases including lupus, scleroderma, and rheumatoid arthritis. The main goal is to check if the treatment is safe and well-tolerated in 30 participants who have active disease des…

This study aims to test several new experimental drugs to see if they can slow the decline in lung function caused by scleroderma. It will involve 400 adults who have had scleroderma for 7 years or less and have developed lung scarring. Participants will receive either one of the…

This is an early-stage study testing a new cell therapy called EVM18001 for people with severe, hard-to-treat autoimmune diseases: lupus, scleroderma, and myasthenia gravis. The main goal is to check if the treatment is safe and to find the right dose. Researchers will also look …

This study is testing whether adding a new type of immune cell therapy (called AlloNK) to an existing drug (rituximab) can better control several autoimmune diseases that have come back after standard treatments. The trial will enroll 90 adults with rheumatoid arthritis, Sjögren'…

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This study is testing whether an investigational drug called tibulizumab can help control systemic sclerosis, a rare autoimmune disease that causes skin thickening and can damage internal organs like the lungs. For the first 24 weeks, some participants will receive the drug while…

This early-stage study is testing a single dose of an experimental cell therapy called CABA-201 for adults with active systemic sclerosis (scleroderma). The therapy, known as CAR T-cell therapy, is designed to target and remove a type of immune cell (B cells) thought to drive the…

This study is testing a special exercise program called BETY, designed to help manage the symptoms of scleroderma. It will involve 48 children and adults with the condition. The goal is to see if this program can improve physical function, skin health, and overall well-being.

This study aims to understand how systemic sclerosis (scleroderma), a rare and serious autoimmune disease, naturally changes over time. Researchers will follow 500 adult patients for five years, collecting health data and biological samples. The goal is to build a detailed pictur…

This study aims to understand how scleroderma affects the ability to chew and swallow in both children and adults. Researchers will measure chewing and swallowing performance using simple tests and questionnaires. The goal is to gather information to help improve future care and …

This registry aims to understand how autoimmune diseases like lupus and rheumatoid arthritis affect pregnancy. Researchers will follow 1,000 pregnant women with these conditions to identify factors linked to poor outcomes. The study collects information from regular doctor visits…

This study aims to understand the complete picture of how scleroderma affects people's lives. Researchers will observe 50 children and adults with the condition, measuring their physical performance, pain, mental health, and social participation. The goal is to gather detailed in…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases like rheumatoid arthritis and lupus. The goal is to help researchers better understand what causes these conditions and how they progress over time. …

This study aims to understand the causes of scleroderma by comparing skin cells from patients with the disease to cells from healthy volunteers. Researchers will analyze the genes in these cells to see how they differ. The goal is to learn more about what drives the disease, whic…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study aims to create a large collection of blood samples and health information from people with autoimmune diseases like lupus and scleroderma. Researchers will use these samples to look for new biological markers that could help diagnose diseases earlier, predict how they …

This study is creating a registry to collect health information and optional blood samples from adults with scleroderma. The goal is to better understand this complex disease, its causes, and how it progresses. This knowledge will help researchers develop future treatments for a …