SCLERODERMA

This early-phase study tested a drug called brentuximab vedotin, originally used for lymphoma, in 17 people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The main goal was to see if the drug is safe and tolerable. Researchers believe the drug may calm …

This study tested whether using a stem cell transplant early in the disease is better than starting with standard immunosuppressive drugs for people with a severe form of scleroderma. Sixty adults with early diffuse scleroderma were randomly assigned to either receive their own s…

This study tested whether adding a strong immune-suppressing drug (cyclophosphamide) to standard prednisone can stop lung function from getting worse in people with scleroderma-related lung scarring. Forty adults with worsening lung function took part. The goal was to see if more…

This study tested an online self-management program for people with scleroderma, a chronic autoimmune disease. The program includes educational videos and group video calls led by trained peers. It aims to help patients feel more confident managing their symptoms like pain, fatig…

This small early study tested a new way to help people with scleroderma who have trouble opening their mouth (microstomia). Doctors used a laser to deliver a natural enzyme called hyaluronidase into the skin around the mouth. The goal was to loosen tight tissue, making it easier …

This study tested whether gentle yoga and breathing exercises are practical and helpful for people with scleroderma. Thirty participants learned the exercises and practiced twice daily at home for 12 weeks. Researchers measured quality of life, stress, depression, and saliva mark…

This study looked at whether the way depression questions are arranged affects how people with scleroderma answer them. 851 adults with scleroderma were randomly assigned to take a standard depression questionnaire either in its usual order or with physical symptom questions plac…

This study tested whether MRI can detect lung disease in people with scleroderma, a condition that can cause scarring in the lungs. Researchers compared MRI images with standard CT scans in 25 adults. The goal was to see if MRI could be a safe, radiation-free way to screen for an…

This study looked at 43 people with scleroderma or unexplained pulmonary hypertension to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures to measure heart function and changes over 6 months. The goal was …

This study measured prolactin levels in 71 people with systemic sclerosis (scleroderma) to see if high levels are common. Researchers compared results with healthy volunteers matched by age and sex. The goal was to understand if prolactin plays a role in the disease, not to test …

This study tested whether a special MRI scan can measure lung scarring (fibrosis) in people with scleroderma. 24 adults with scleroderma had MRI scans while holding their breath at full inhale and full exhale. A computer program then analyzed how the lungs moved, looking for stif…