SCLERODERMA

This completed Phase 3 trial tested whether adding intravenous cyclophosphamide to standard prednisone treatment could better stabilize or improve lung function in people with scleroderma-related lung scarring. The study involved 40 adults whose lung function had recently worsene…

This study aimed to find the best initial treatment for people recently diagnosed with a severe, fast-moving form of scleroderma. It compared two approaches: an aggressive stem cell transplant right away versus starting with standard immunosuppressive drugs and saving the transpl…

This study tested whether a special type of MRI scan could be used to measure lung scarring (fibrosis) in people with scleroderma. Researchers wanted to see if this method, which doesn't use radiation, could be a better and more reproducible way to track the disease compared to c…

This study tested an online program designed to help people with scleroderma (systemic sclerosis) better manage their symptoms and daily life. The program included educational videos and group video sessions led by trained peers. Researchers compared the program to usual care to …

This small, completed pilot study explored whether gentle yoga and breathing exercises could help people with scleroderma manage their symptoms and improve their quality of life. Thirty participants learned the exercises and practiced them at home twice daily for 12 weeks while r…

This study aimed to understand if a hormone called prolactin is involved in systemic scleroderma, a disease that causes hardening of the skin and internal organs. Researchers measured prolactin levels in 71 adults with scleroderma and compared them to healthy people. The goal was…

This study investigated whether the order of questions in a standard depression survey affects how people with scleroderma (systemic sclerosis) report physical symptoms like fatigue and sleep problems. Researchers wanted to know if patients score these symptoms differently when t…

This research study aims to understand why people with scleroderma and pulmonary hypertension develop heart muscle weakness. Researchers will compare heart function and collect tissue samples from 43 participants during their standard medical procedures. The goal is to identify d…