Hidden TB risks: study links diet, diabetes, and parasites to latent infection

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* PARTICIPANT INCLUSION CRITERIA (Screening Phase) Individuals who meet the following criteria are eligible to participate in the screening phase: * Aged 14 to 65 years. * Willingness to provide blood, urine, and stool samples for examination. * Willingness to have samples and data stored. * Able to provide informed consent. PARTICIPANT EXCLUSION CRITERIA (Screening Phase) * Pulmonary symptoms suggestive of TB (cough \>2 weeks in duration and/or intermittent fever \>1 week in duration and/or hemoptysis). * Two IGRA tests with indeterminate results (mitogen values \<10 IU). PARTICIPANT INCLUSION CRITERIA (Study Phase) Individuals are eligible for the study phase if they meet the requirements for one of the study groups, as follows: 1. LTBI+ and severe to moderate malnutrition (BMI \<17 kg/m2); 2. LTBI+ and uncontrolled DM (HbA1c \>8%); 3. LTBI+ and helminth infection (positive stool qPCR and/or serology); 4. LTBI+ with more than one of the conditions defined in groups 1 3; 5. healthy LTBI+ controls who are negative for all of the above conditions; and 6. healthy LTBI-negative controls with none of the above conditions. PARTICIPANT EXCLUSION CRITERIA (Study Phase) * Pulmonary symptoms suggestive of TB (cough \>2 weeks in duration and/or intermittent fever \>1 week in duration and/or hemoptysis). * Pregnant or lactating women. * Previous treatment for LTBI. * Anemia with hemoglobin \<8 g/dl (evaluated at the screening phase visit). * For LTBI+ participants, clinically indicated chest X-ray positive for pulmonary TB. * For malnourished participants, clinically indicated abdominal ultrasound positive for abdominal TB. * Known documented cases of cancer, acquired immune deficiency syndrome, or other immunosuppressive illness. * History of any other illness or condition which, in the investigator s judgment, may substantially increase the risk associated with the participant s participation in the protocol, or compromise the scientific objectives.