Diabetes mellitus

Researchers at Sheba Medical Center are studying a tele-diabetes remote monitoring system for children and teens with type 1 diabetes. The system analyzes real-time glucose data from continuous monitors and sends automated WhatsApp alerts when it detects high or low patterns. The…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

Researchers compare empagliflozin and dapagliflozin, two similar diabetes drugs, to see which works better at preventing death, heart problems, and kidney damage in adults with type 2 diabetes, heart failure, or chronic kidney disease. The trial uses electronic health records to …

Researchers are testing a 12-week online program that teaches adults with type 2 diabetes and excess weight to follow a low-fat vegan diet. Participants meet weekly with a physician and a registered dietitian for education and support. The team measures body composition, blood su…

This phase 3 trial asks whether survodutide, an investigational weekly injection, can help adults with type 2 diabetes lower their blood sugar more than a placebo. Around 600 participants, who also follow diet and exercise or take standard diabetes medications (including insulin)…

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in adults aged 55+ who have both diabetes and mild cognitive impairment. About 309 participants will attend weekly group sessions and provide …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

Researchers are testing a new once-weekly injection called NNC0487-0111 in about 400 Japanese adults with overweight or obesity. Half the participants receive the drug and half receive a placebo, assigned by chance. The main goal is to measure how much body weight changes over th…

This trial is testing an experimental once-daily pill called ASC30 in adults who are overweight or have obesity and also have type 2 diabetes. The study aims to see if ASC30 can help with long-term weight loss and improve blood sugar control compared to a placebo. Participants wi…

This study tests a single dose of a new drug, ALN-4324, to see if it improves how the body uses insulin in people with type 2 diabetes. About 40 adults who are on a stable dose of metformin will take part. The main goal is to measure changes in insulin sensitivity using a glucose…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar c…

This study tests a new medication, CX11, for people with type 2 diabetes who need better blood sugar control despite taking metformin. About 240 adults will receive different doses of CX11 or a placebo for 24 weeks to see if it safely lowers blood sugar. The goal is to find the b…

This Phase 3 trial tests a new injection called UBT251 in 360 adults with type 2 diabetes who have not been able to control their blood sugar with diet and exercise alone. Participants will receive either a weekly shot of UBT251 (at different doses) or a placebo for several weeks…

This study tests two ways to help Chinese immigrants with type 2 diabetes control their blood sugar: watching educational videos, or videos plus a community health worker. 540 adults in NYC will join. The goal is to see if these tools lower HbA1c levels and boost confidence in ma…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This early-stage trial tests a single injection of UBT38006 in 43 healthy adult men to see if it is safe and how the body processes it. Participants receive either the drug, a placebo, or an active comparator (insulin degludec). The goal is to gather safety data and measure drug …

This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the duodenum (the first part of the small intestine). The goal is to improve blood sugar control and reduce fat buildup in the liver for people with type 2 diabetes and fatty l…

This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the first part of the small intestine (duodenum) in people recently diagnosed with type 2 diabetes. The goal is to see if this can help control blood sugar levels without needi…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This phase 3 study compares an experimental weekly injection called UBT251 to the approved drug semaglutide in adults with type 2 diabetes whose blood sugar is not well controlled by oral medications like metformin. The main goal is to see if UBT251 is at least as effective as se…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

Researchers are testing whether a daily probiotic supplement can improve blood sugar, blood pressure, and body composition in people over 65 who have prediabetes or type 2 diabetes and known heart disease. Participants take one probiotic capsule each morning for 60 days, while a …

This Phase 2 trial tests an experimental drug called LY3457263 in 240 adults with type 2 diabetes who still have high blood sugar despite taking stable doses of semaglutide or tirzepatide. Participants receive weekly injections of either the new drug or a placebo for about 9 mont…

This study tests a new medicine called UBT251, given as a weekly shot, in 300 adults with type 2 diabetes. Some participants will get UBT251, others will get a placebo or an existing drug (semaglutide). The goal is to see if UBT251 can safely lower blood sugar and help with weigh…

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the drug against a placebo and an approved medication, semaglutide, to see how well it controls blood sugar and promotes weight loss. The trial is currently recruiting…

This study looks at whether changing the types of carbohydrates people with type 1 diabetes eat can improve blood sugar control. Researchers will compare a diet with more whole grains and beans to one with mostly refined grains. 80 adults will be monitored to see if the diverse c…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

Researchers are testing whether adding fingolimod to standard diabetes care can improve blood sugar control in adults with type 2 diabetes. The trial enrolls 40 people aged 18 to 70 whose blood sugar is not fully controlled on no medication or one oral drug. Half receive fingolim…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This phase 3 trial is testing whether an experimental drug called AZD6234, given as a weekly injection, can help adults with obesity or overweight lose more weight when added to their current incretin-based therapy. The study includes about 500 participants who either have type 2…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This trial investigates an experimental drug called GUB-UCN2 for people with obesity and type 2 diabetes. The study includes healthy volunteers and those with the conditions, testing the drug alone or alongside standard care. The main goal is to check safety and how the drug beha…

This study tests whether montelukast, a medicine used for asthma, can help protect the kidneys and blood vessels in 50 teens and young adults (ages 14-24) with type 2 diabetes. The drug works by blocking harmful inflammatory chemicals linked to diabetes complications. Researchers…

This study compares two telehealth approaches—digital health coaching and remote patient monitoring—to see which works better for managing type 2 diabetes in people with physical disabilities and at least one other chronic condition. About 5,000 participants will be randomly assi…

Researchers are testing an experimental oral drug called MWN109 in adults with type 2 diabetes. The trial compares several doses of MWN109 against a placebo and against semaglutide tablets, a standard treatment, to see which works better at lowering blood sugar over 20 weeks. Abo…

This phase 3 study tests a new oral drug, elecoglipron, against the approved pill semaglutide in adults with type 2 diabetes who also have increased heart risk. The goal is to see which works better for lowering blood sugar and body weight over about a year. Participants take one…

This study tests whether the drug tirzepatide, given once weekly, helps adults with obesity (but without diabetes) lose weight and avoid developing type 2 diabetes. About 3,000 participants will receive either tirzepatide or standard care for up to 5 years. The goal is to see if …

This phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol level…

Researchers are testing whether low-dose interleukin-2 (IL-2) can help people recently diagnosed with type 1 diabetes preserve their own insulin production. The trial enrolls 24 people aged 16 to 45 who still make some insulin. Participants first receive a two-month course of cyc…

This study tests a once-weekly injection called CagriSema (a mix of cagrilintide and semaglutide) in 80 children and adolescents with type 2 diabetes. The goal is to see if it lowers blood sugar and body weight better than a placebo. The trial lasts about 15 months, with everyone…

This study compares two drugs, ATG and teplizumab, to see if they can delay or prevent type 1 diabetes in people who are at high risk. About 60 participants aged 4 to 35 will receive either two infusions of ATG or 14 daily infusions of teplizumab. Researchers will monitor them fo…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This study follows about 1,875 people aged 6 and older with type 1 diabetes who use the iLet Bionic Pancreas, an automated insulin delivery system. Over 12 months, researchers will track serious events like severe low blood sugar and diabetic ketoacidosis to see how the device pe…

This study is testing whether a continuous glucose monitor (CGM) can help older adults with type 2 diabetes who do not use insulin achieve better blood sugar control. Participants will either wear a CGM every two months or use standard finger-stick monitoring for six months. The …

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks …

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight the…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This early-stage trial tests an investigational drug called MWN105, given as a weekly injection for 8 weeks, in Chinese adults who are overweight or obese but do not have diabetes. The study aims to see if the drug is safe and tolerable, and how it moves through the body. Partici…

This study tests whether a four-week education program can help adults with type 1 diabetes dose mealtime insulin using continuous glucose monitor (CGM) data instead of traditional carbohydrate counting. Participants are randomly assigned to either the C-Carbs program or usual ca…

This Phase 2 trial tests a drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing some insulin, reducing the need for injected insulin. 66 participants will receive either the dr…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This trial tests whether verapamil, a blood pressure drug, can protect the pancreas cells that make insulin in children and teens newly diagnosed with type 1 diabetes. Participants aged 10 to 18 will take verapamil or a placebo daily for 24 weeks. Researchers will measure how muc…

This study tests whether baricitinib, a pill, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to under 36) will take either baricitinib or a placebo for 60 weeks. The goal is to see i…

This phase 2 trial tests whether photobiomodulation, a type of light therapy, can improve healing of foot ulcers in people with diabetes. Researchers will compare standard wound care alone against standard care plus light therapy applied to the ulcer and to blood vessels. The stu…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study helps older adults with type 2 diabetes talk to their doctors about switching from sulfonylurea drugs, which can cause dangerous low blood sugar and heart problems, to newer, safer options. About 220 participants will get either a simple question sheet to guide their n…

This trial tests two oral diabetes drugs, metformin and glyburide, in pregnant women with gestational diabetes who need medication to control blood sugar. The study asks whether one drug leads to fewer treatment failures, meaning blood sugar stays in a healthy range. Researchers …

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This trial tests whether the type and intensity of exercise affect blood sugar control in pregnant women with gestational diabetes. Participants will complete four separate exercise sessions: low-intensity resistance training, low-intensity aerobic training, moderate-intensity re…

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This trial is testing whether an investigational wound gel called VES-0-D can help heal mild-to-moderate diabetic foot ulcers better than standard wound care. Adults with type 1 or type 2 diabetes and a foot ulcer will receive either the gel or a standard dressing, applied every …

This study tests a drug called maridebart cafraglutide (MariTide) in people who are overweight or obese and also have type 2 diabetes. The goal is to see if the drug can help with long-term weight loss and blood sugar control, and to check its safety over time. Participants recei…

This trial tests whether a 12-week Nordic walking program, which uses poles to engage more muscles and burn more calories than regular walking, improves cardiovascular fitness in overweight or obese adults with type 2 diabetes and recent heart problems. Participants are randomly …

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This study tests whether giving a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to under 21 who were recently diagnosed with type 1 diabetes. The main goal is to see if th…

This trial tests whether trained community health workers can help adults with high blood pressure, diabetes, or high cholesterol address social needs like transportation, healthy food, housing, and job opportunities. Participants from clinics will be connected to a health worker…

This study tests a smartphone app called DailyDose that gives personalized advice on insulin doses and carbohydrate intake for people with type 1 diabetes who use multiple daily injections. The app uses data from continuous glucose monitors and insulin pens. Researchers want to s…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether giving pasteurized donor human milk to full-term babies of mothers with diabetes during the first five days of life can reduce the number of infants admitted to the neonatal unit for low blood sugar. About 1,444 mothers and their newborns will be randomly…

This trial tests whether applying perinatal tissue allografts to chronic diabetic foot ulcers, along with standard wound care, leads to more ulcers healing completely within 12 weeks compared to standard care alone. Adults with type 1 or 2 diabetes who have a nonhealing foot ulce…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This trial compares an experimental once-weekly injection, zenagamtide, with a standard daily insulin injection, insulin glargine, in adults with type 2 diabetes who also have higher cardiovascular risk. Participants are already taking 1 to 3 oral diabetes medications but need be…

This phase 2 trial tests whether adding an experimental drug called AT673 to the standard diabetes medication semaglutide leads to greater weight loss and better blood sugar control in adults with type 2 diabetes who are overweight or obese. Participants receive either a low or h…

This study tests a treatment called VX-880 for people with type 1 diabetes who have dangerous low blood sugar episodes. The therapy uses donor cells that can produce insulin, aiming to let participants stop taking insulin shots and avoid severe hypoglycemia. About 52 adults with …

This study tests an experimental drug called elecoglipron, taken alone or together with the existing medication dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled. About 800 participants will receive either the new drug, a placebo, or a combina…

This phase 3 study tests whether taking two diabetes medications together—elecoglipron and dapagliflozin—works better than either drug alone for controlling blood sugar in adults with type 2 diabetes. The trial enrolls about 2,000 people whose diabetes is not well managed by life…

This study tests a drug called dorzagliatin in 15 adults with cystic fibrosis who have trouble controlling their blood sugar. Participants take the drug or a placebo for 7 days each, in a crossover design. The goal is to see if dorzagliatin improves glucose tolerance and insulin …

This study tests whether group care—where patients meet together with health workers for education and check-ups—can improve control of high blood pressure and diabetes in Nepal. Over 1,100 adults from 37 health facilities will be assigned to standard care, low-intensity group ca…

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This study is testing a new tool called MODI, which is a smart algorithm that helps people with diabetes figure out the right amount of insulin to take. About 100 adults with type 1 or type 2 diabetes will use the MODI system along with a continuous glucose monitor for 13 weeks. …

This phase 3 trial is testing whether an experimental once-daily tablet called elecoglipron can help Asian adults with obesity or overweight lose weight, when combined with diet and exercise. The study includes people with or without type 2 diabetes. Participants will receive eit…

This trial tests a mobile health program called The 3Ms 2.0 for primary caregivers of Black adolescents with type 1 diabetes. The program uses interactive online sessions, video clips, and text messages to encourage daily parental monitoring of diabetes care. Researchers will com…

This trial tests whether a silicone-based or a hydrocolloid patch placed under insulin pumps or glucose monitors can prevent contact dermatitis from coming back in children aged 2-18. Participants will use different patches and attend visits for skin exams, ultrasounds, and quest…

This study tests whether a structured, multidisciplinary obesity care program—which may include the weight-loss drug semaglutide—helps adults with obesity lose more weight than usual care. Adults aged 18-65 with a BMI of 30 or higher will be followed for 18 months to see if they …

This study looks at whether replacing some wheat flour with chickpea flour in bread can lower blood sugar rises after eating. Healthy adults and people with type 2 diabetes will eat bread made with finely or coarsely ground chickpea flour, and their blood sugar will be tracked co…

This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a c…

This study tests whether using a diabetes management app alongside personalized nutrition counseling from a dietitian can help adults with insulin-requiring diabetes improve their blood sugar control, cholesterol, physical activity, and overall quality of life. Participants will …

This trial asks whether empagliflozin, metformin, or a combination of both can improve how muscles produce energy and respond to blood flow in people newly diagnosed with type 2 diabetes. About 54 men with type 2 diabetes will be randomly assigned to one of three groups: empaglif…

This trial tests whether using a diabetes-specific questionnaire during annual check-ups can improve the quality of care for people with type 2 diabetes. About 2,000 adults with type 2 diabetes from 30 general practices in Denmark will take part. Half of the practices will use th…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This study tests whether an AI app called SnapD, which recognizes Thai food and estimates nutrition, can help people with type 2 diabetes and overweight improve their blood sugar control. Some participants will also use a continuous glucose monitor (CGM) that tracks sugar levels …

This study tests whether a 12-week program of supervised foot and ankle exercises can help people with diabetes who have nerve damage in their feet. The exercises are done in groups at primary care clinics. Researchers will measure changes in symptoms, foot movement, and quality …

This trial tests whether 16 weeks of exercise training, liraglutide treatment, or both can improve blood vessel function and insulin sensitivity in adults with type 2 diabetes. Participants are randomly assigned to one of three groups and are studied before and after the interven…

This trial tests whether a mobile app called NutriSteppe can improve blood sugar control and weight loss in adults with type 2 diabetes or obesity who are already taking GLP-1 medications like semaglutide. Over 12 weeks, half the participants will use the app for personalized mea…

This trial tests whether a smartphone app called SPARK can help women with gestational diabetes manage their condition. Participants receive standard care, and some also use the app to support healthy eating, physical activity, and blood sugar tracking. The study looks at blood s…

This trial tests three different ways to reconnect the digestive tract after stomach cancer surgery to see which one best controls blood sugar in people who also have type 2 diabetes. Participants will be randomly assigned to one of three surgical procedures. The main goal is to …

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This trial tests whether a low-calorie diet combined with intensive lifestyle coaching can help adults with type 2 diabetes achieve remission—meaning blood sugar levels return to normal without medication. Participants are randomly assigned to either the intervention or standard …

This study tests whether a behavioral program that reduces evening light exposure and encourages finishing meals at least four hours before bedtime can improve how the body handles sugar. Overweight adults aged 18-45 who habitually sleep less than 6.5 hours per night will be rand…

This study tests whether helping people with diabetes find local resources (like food or housing help) and pairing them with a peer supporter can improve blood sugar and blood pressure. About 694 adults with diabetes who have trouble controlling their condition will be randomly a…

This trial tests whether an educational program using continuous glucose monitors (CGMs) can help older adults with type 2 diabetes use insulin more safely. Participants aged 75 and older who are at high risk for low blood sugar will either attend group education sessions with CG…

This phase 3 study tests whether a new oral drug called elecoglipron can help adults with type 2 diabetes better manage their blood sugar when added to their current insulin and other diabetes medications. About 600 participants will receive either elecoglipron or a placebo daily…

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study tests a new automatic insulin pump (Omnipod M) in 350 adults with type 2 diabetes who already use insulin. The pump adjusts insulin delivery on its own to keep blood sugar in a healthy range. The goal is to see if it improves blood sugar control and is safe to use.

This study tests two diabetes medications, pioglitazone and empagliflozin, to see which one better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 with this type of diabetes will take one of the drugs,…

This study tests whether a hybrid closed-loop insulin pump (MiniMed 780) can help people with diabetes after pancreas removal achieve better blood sugar control. About 24 adults will use the pump for 3 months and then their usual treatment for 3 months, with results compared. The…

This study investigates whether combining bariatric surgery with a GLP-1 receptor agonist (semaglutide) leads to greater and more sustained weight loss than surgery alone in people with obesity. Researchers will follow 400 participants across multiple centers in China for up to t…

This study tests whether a special nutritional supplement, designed using artificial intelligence, can help adults with type 2 diabetes lower their blood sugar over 24 weeks. One hundred participants will receive either the active supplement or a placebo, alongside their usual di…

This study will test whether a 4-month digital coaching program (Noom) helps adults who recently started GLP-1 medications improve their diet and physical activity. About 220 participants will use the app to track food and exercise, get coaching, and learn about managing challeng…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This study tests a 10-week virtual program called Acceptance Based Coping (ABaCo) for Hispanic/Latinx military patients with type 2 diabetes. The program, delivered by a bilingual health coach, teaches skills to cope with diabetes-related stress and improve self-care. Researchers…

This trial tests whether GlycoQuest, a video game that connects to a continuous glucose monitor and adapts using artificial intelligence, can help children aged 6 to 17 who were diagnosed with type 1 diabetes in the past three months. The game includes a glucose-responsive avatar…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This trial tests whether adding an antibiotic-impregnated bone graft substitute (Cerament G) to standard surgery improves healing of heel bone infections (calcaneal osteomyelitis) in people with diabetes. Thirty participants will be randomly assigned to receive either partial rem…

This study tests whether a structured exercise and nutrition program can slow the loss of muscle mass, strength, and function in adults aged 65 and older with type 2 diabetes and obesity who are taking semaglutide. Participants receive either standard health advice or a 26-week p…

This study tests a web-based program called Web-SUCCEED that helps veterans with chronic illness and their informal caregivers work together to manage the condition. The program includes three weekly online modules and brief phone calls with staff, focusing on stress coping and c…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This study tests whether an investigational drug called HTD1801 can slow the worsening of kidney disease in adults who have both type 2 diabetes and chronic kidney disease. About 75 participants will take either HTD1801 or a placebo twice daily for 12 weeks. Researchers will meas…

This trial compares two ways of monitoring blood sugar in adults recently diagnosed with type 2 diabetes (within the last 3 months). Half of the 80 participants use a real-time continuous glucose monitor (CGM) that provides constant feedback, while the other half use standard fin…

This trial investigates whether time-restricted eating (TRE) — eating all food within an 8-10 hour window each day — can improve kidney function in people with type 2 diabetes who have elevated protein in their urine (microalbuminuria). All 25 participants follow the same TRE sch…

This trial tests whether inclisiran, an injectable medication, can lower LDL cholesterol in patients who have multiple health conditions and take many drugs that interfere with standard statin therapy. Participants must be taking five or more prescription medications and have con…

This study explores whether a short-term low-energy diet (using meal replacements) can help adolescents aged 12–17 with obesity and type 2 diabetes lose weight and potentially achieve diabetes remission. Participants follow the diet for 12 weeks, then gradually reintroduce food o…

This trial investigates whether exosomes—tiny particles from human umbilical cord stem cells—can safely improve blood sugar control in adults with type 2 diabetes. Participants receive weekly intravenous infusions of the exosome product or a control for eight weeks. The study mea…

This study tests whether regularly screening for diabetes-related emotional distress and offering support can improve blood sugar control in adults with type 2 diabetes. About 1,250 participants with high blood sugar (A1C over 8%) will take part. The goal is to see if addressing …

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This study looks at whether adding GLP-1 receptor agonists or SGLT inhibitors to insulin helps adults with type 1 diabetes manage their blood sugar better. Researchers will track 300 participants for one year, measuring changes in HbA1c and other health markers. The goal is to se…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study will give 800 pregnant women biweekly food kits with fruits, vegetables, and other healthy foods to see if it improves their diet and pregnancy outcomes. Participants will be followed from early pregnancy through birth. The goal is to learn whether providing healthy fo…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a fully closed-loop insulin system (which automatically adjusts insulin delivery) works better than a standard insulin pump for people with type 2 diabetes. Eighty adults who have used an insulin pump for at least six months will try both methods for 12 w…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood su…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This study compares two different strength training schedules—non-linear and linear periodization—in people with type 2 diabetes. Over 8 weeks, 48 participants will do supervised workouts three times a week or receive usual care. Researchers will measure changes in exercise capac…

This study compares two digital approaches—live video classes and simple text messages—against traditional in-person classes to help 150 Hispanic/Latino adults with type 2 diabetes better manage their condition. The goal is to see if these digital tools can improve blood sugar co…

This study tests whether peer coaching can help older adults (55+) with uncontrolled type 2 diabetes in rural Kentucky better manage their condition. Participants are paired with trained peer coaches who call them weekly or bi-weekly to discuss self-care and goals. The study will…

This study tests if leg exercise (like pedaling) is better than arm exercise for controlling blood sugar, weight, and stress in pregnant women with gestational diabetes. 108 women in their second trimester will exercise three times a week for eight weeks. The goal is to find a sa…

This study tests whether regular phone calls from a trained peer coach can help older adults (55+) with type 2 diabetes in rural Kentucky improve their self-care. Participants are divided into groups that receive weekly or bi-weekly coaching calls to discuss goal-setting and diab…

This study tests whether a continuous glucose monitor (CGM) can improve pregnancy outcomes for women with gestational diabetes compared to standard finger-prick testing. About 386 women from Belgium and Australia will be randomly assigned to use either a CGM or a regular glucomet…

This study is tracking 145 adults with type 2 diabetes in Argentina who are starting semaglutide (either as a pill or injection) as part of their normal care. Researchers will measure changes in blood sugar, weight, waist size, and grip strength over 12 months, along with how sat…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study compares two types of IV fluids—saline and Ringer lactate—in 300 adults with severe diabetic ketoacidosis (DKA) admitted to the ICU. The goal is to see which fluid helps resolve DKA faster within 24 hours. Current guidelines recommend saline, but it may cause side effe…

This study compares two ways to place heart stents in people with diabetes: one using special imaging (IVUS or OCT) and the other using standard X-ray. The goal is to see if the imaging method reduces heart-related deaths, heart attacks, or the need for repeat procedures. About 1…

This study looks at how well the drug tirzepatide works in everyday life for people with obesity (without diabetes) or type 2 diabetes (with or without obesity). About 160 adults in Paraguay will take the drug as part of their regular care and be followed for 52 weeks. Researcher…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study tests whether semaglutide, a diabetes drug, can help heal foot ulcers in people with type 2 diabetes. About 52 adults will receive either semaglutide or a placebo for 20 weeks. The main goal is to see if more ulcers heal completely with the drug. This is an early-phase…

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

This study tests whether breathing a special mix of low and high oxygen air (called intermittent hypoxic-hyperoxic training) can help lower blood sugar in people with type 2 diabetes. About 250 adults aged 50-74 will be split into groups receiving either a 3-day or 10-day course …

This pilot study tests whether canagliflozin, a diabetes medication, can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. Researchers will compare the drug to a placebo over 6 months in 16 participants. The main goal is to mea…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This pilot study is testing whether a 12-week combination of two common diabetes drugs—dapagliflozin (Farxiga) and semaglutide (Ozempic)—is safe and helpful for people who have received a kidney transplant. The 20 participants will take both drugs and be monitored for changes in …

This study tests whether starting two diabetes drugs early—metformin plus either oral semaglutide or empagliflozin—controls blood sugar better than metformin alone in adults recently diagnosed with type 2 diabetes. About 90 participants will take the combination or just metformin…

This study is observing 300 adults with type 2 diabetes who are already taking luseogliflozin as part of their routine care. Researchers will track changes in blood sugar levels, body weight, and side effects over time. The goal is to see how well the drug works in real-world set…

This study is looking at how semaglutide, a drug used for diabetes and weight loss, changes the amount of fat stored inside the heart and leg muscles. Researchers want to see if semaglutide can shift fat away from these organs, which might improve health beyond just lowering bloo…

This study tests whether a total diet replacement of just 850 calories per day for 3 months, followed by weight maintenance, can help people with type 2 diabetes achieve remission. Participants are randomly assigned to follow-up via an eHealth app or in-person visits. The goal is…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This study tests a new drug called dorzagliatin in 44 adults with a rare, inherited form of diabetes (GCK-MODY). The drug works by activating a key enzyme to help the body better control blood sugar. Participants will receive both the drug and a placebo at different times to see …

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests a single pill containing three diabetes drugs (empagliflozin, linagliptin, and metformin) in 800 adults with type 2 diabetes. The goal is to see if the triple combination improves blood sugar control, weight, quality of life, and treatment satisfaction compared t…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study tests a program called Glycemic Excursion Minimization (GEM) for people newly diagnosed with type 2 diabetes. Participants use a continuous glucose monitor to see how food and activity affect their blood sugar, then make personalized changes. The goal is to lower blood…

This study tests whether a daily tablet called sotagliflozin can improve quality of life for people with both type 1 diabetes and heart failure. Researchers will give 320 participants either the drug or a placebo for 4 months, then compare symptoms like breathlessness and tiredne…

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This early study is testing a new treatment for type 2 diabetes. Doctors will take a small amount of fat from each patient, use a special laser to prepare it, and then inject it into the lining of the small intestine. The goal is to see if this can safely improve blood sugar cont…

This study tests a new type of shoe, called the LEEF-shoe, designed to prevent foot ulcers in people with diabetes and nerve damage. About 30 adults will wear both the LEEF-shoe and standard orthopedic shoes for several weeks to compare how well they relieve pressure on the feet.…

This study tests a smartphone app called StenoFood that gives dietary advice and self-monitoring tools to people with type 2 diabetes and early kidney disease. The goal is to see if the app helps them follow low-sodium and moderate-protein diet guidelines. About 104 participants …

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study tests whether adding SMS reminders with diet and exercise advice to a standard lifestyle program helps people with prediabetes lose more weight. 300 participants in Réunion will be split into two groups: one gets the standard program alone, the other also receives 72 t…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests whether a combination insulin drug (iGlarLixi) works better than standard insulin (Gla-100) at keeping blood sugar within a healthy range throughout the day. About 678 Chinese adults with type 2 diabetes who are not well controlled on oral medications will use a …

This study is testing whether a high-fiber supplement called Trimtab can help preserve beta-cell function in children aged 6 to 12 who were recently diagnosed with type 1 diabetes. For 12 weeks, participants will take the supplement daily, and researchers will measure C-peptide l…

This study tests a once-weekly injection called tirzepatide in about 2,500 adults with obesity or overweight who do not have type 2 diabetes. Participants receive either the drug or a placebo, along with diet and exercise advice. The main goal is to see how much weight they lose …

This study tests whether 12 weeks of high-intensity interval training (HIIT) can improve how muscles store sugar (glycogen) and use insulin in people with type 2 diabetes. Researchers will also check if HIIT reduces liver fat. The trial involves 36 overweight or obese adults aged…

This study tests whether a fully closed-loop insulin delivery system (an "artificial pancreas") can better control blood sugar in adults with type 2 diabetes who use insulin, compared to their usual insulin therapy with a continuous glucose monitor. About 224 participants will us…

This study looks at whether empagliflozin, a medicine used for diabetes, can help blood vessels and heart muscle recover after a heart attack. About 80 people who had a severe heart attack will either receive empagliflozin or standard care. Researchers will measure artery stiffne…

This study tests whether a 15-minute brisk walk, taken right after a missed insulin dose, can prevent high blood sugar in people with type 1 diabetes. Researchers will compare blood sugar levels in 30 adults aged 18-24 who either take insulin before a meal, after a meal, or after…

This large phase 3 trial is testing whether colchicine (a gout medication) and low-dose aspirin, taken together or alone, can prevent heart attacks, strokes, and cardiac death in 10,000 high-risk people with type 2 diabetes who have not yet had a heart-related event. Participants…

This study tests whether weekly diabetes education videos sent by text message, plus help from a community health worker, can improve blood sugar control in Chinese immigrants with type 2 diabetes. 270 participants in New York City will be randomly assigned to receive the program…

This phase 3 trial is testing whether semaglutide, a drug already used for type 2 diabetes and weight loss, can improve heart and kidney function in adults with type 1 diabetes. The study will measure artery stiffness, insulin sensitivity, and kidney blood flow in 60 participants…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This Phase 2 trial tests dapansutrile, an oral drug that reduces inflammation, in 300 adults with type 2 diabetes. The goal is to see if it improves blood sugar control and lowers the risk of diabetes-related complications. Participants are randomly assigned to receive either the…

This study tests whether an artificial pancreas system can improve blood sugar control and, in turn, reduce heart disease risk in people with type 1 diabetes. The system combines an insulin pump with a continuous glucose monitor to mimic a healthy pancreas. Researchers will measu…

Researchers at Ankara Etlik City Hospital are studying whether the perfusion index, a blood-flow reading taken with a standard pulse oximeter, can predict the severity of diabetic ketoacidosis in adults arriving at the emergency department. The study will follow 140 patients aged…

Researchers on Réunion Island are measuring blood sugar levels in 2,000 adults to estimate how many people have diabetes or pre-diabetes. Participants give a fasting blood sample and drink a 75g glucose solution, then give a second blood sample two hours later. The study also che…

This study is testing whether a combined autoantibody test on a drop of blood from a finger prick (dried on special paper) can detect type 1 diabetes as accurately as the standard blood draw from a vein. The researchers will enroll 106 children newly diagnosed with type 1 diabete…

This study tests a new way to measure the maximum amount of insulin a person's pancreas can produce. Participants first undergo the standard hyperglycemic clamp, then take a single dose of alpelisib and consume a standardized meal to see if the simpler test gives similar results.…

This trial tests whether adding an AI analysis of eye photos, an eye pressure check, and a virtual reality visual field test to standard diabetic eye screening can help detect glaucoma. About 2,000 people with diabetes who are already getting AI-based screening for diabetic eye d…

This study tests whether a continuous glucose monitor (CGM) worn on the arm can diagnose gestational diabetes as well as the standard oral glucose tolerance test (OGTT). Pregnant women of Chinese or Indian ethnicity will wear the sensor for up to 10 days and also undergo the OGTT…

This trial is testing whether an artificial intelligence (AI) model, called MONA DR, can accurately detect diabetic retinopathy—a common eye complication of diabetes that can lead to blindness—from retinal photographs. The study will enroll 100 adults with diabetes and compare th…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study collects blood samples from healthy people, those with benign diseases, and cancer patients to develop a multi-analyte blood test. The test looks for DNA methylation markers that may indicate the presence of various cancers, especially liver cancer. Researchers aim to …

This study explores whether a simple finger-prick blood sugar test done during a routine dental visit can help find people with advanced gum disease who have undetected high blood sugar. Adults with severe periodontitis but no known diabetes will be tested at the dental clinic an…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study is testing a new laser-based blood test that uses nanoparticles to detect pancreatic cancer early. Researchers will enroll 400 people, including those with diabetes, pancreatic cysts, or pancreatic cancer, to see if the test can accurately identify cancer. The goal is …

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study collects breath samples from 235 people with type 2 diabetes or obesity to improve a device that estimates blood sugar from exhaled air. Participants breathe into a portable analyzer that measures volatile organic compounds. The goal is to gather data to refine the dev…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study is testing whether whole genome sequencing (a complete scan of a person's DNA) can help doctors identify the cause of atypical diabetes—unusual cases that don't fit typical type 1 or type 2 diabetes. Researchers will compare this advanced genetic test to the current st…

This study is testing a new blood test called Avantect to see if it can find pancreatic cancer early in people who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 adults aged 50-84 will give blood samples and fill out anxiety questionnaires over a year. The…

Researchers are testing a weekly family-based lifestyle program called Family DPP+ to see if it helps parents with prediabetes lose weight and adopt healthier habits. The trial enrolls African American and Hispanic parents and their children in Georgia. Parents attend sessions fo…

Researchers in Pakistan are testing whether a mobile app that uses artificial intelligence to send personalized heat-risk alerts can reduce heat-related illness symptoms in adults with chronic conditions such as hypertension, diabetes, kidney disease, heart disease, or obesity. T…

This pilot study will test whether teaching people aged 50 to 75 how to cook healthy meals can reduce their risk of type 2 diabetes and dementia. Forty participants at higher risk will either attend weekly cooking classes with at-home practice or receive nutrition handouts. The s…

This phase II trial tests whether a special form of nicotinic acid (a B vitamin) can reverse prediabetes and prevent type 2 diabetes. About 390 adults with prediabetes will take either a low or high dose of the drug or a placebo daily for 26 weeks, along with lifestyle advice. Th…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

Researchers are testing whether adding dapagliflozin to a lifestyle program can normalize blood sugar in people with prediabetes and protect their kidneys. The trial enrolls 170 adults aged 35 to 75 with prediabetes. Participants receive either dapagliflozin or a placebo for six …

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet improves blood sugar control better than diet alone in women with prediabetes. Thirty women will be split into three groups based on their current blood sugar levels. They will follow the die…

Researchers test whether lowering systolic blood pressure to below 120 mm Hg prevents major cardiovascular events in adults with type 2 diabetes and high-normal blood pressure. The trial enrolls about 11,400 people aged 45 to 79. Participants receive either intensive treatment wi…

This study aims to develop a better system to support breastfeeding for women who had gestational diabetes, with the goal of preventing type 2 diabetes later. Researchers will work with patients, healthcare providers, and hospital leaders to design a practical strategy. Only 10 p…

This study tests whether giving adults at risk for type 2 diabetes free fresh fruits and vegetables, along with a proven lifestyle program, can help them lower blood sugar and lose weight. One hundred adults with prediabetes will either get the standard diabetes prevention progra…

This study tests whether the drug baricitinib can delay the onset of type 1 diabetes in children aged 1 to 36 months who are at high risk. Participants take baricitinib or a placebo daily for up to 5 years. The goal is to see if the drug can push back or prevent the need for insu…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This study tests whether regular, personalized health coaching—delivered virtually and during community screenings—can reduce the 10-year risk of heart attack or stroke in adults aged 40-75 who have at least one cardiometabolic risk factor like high blood pressure, high cholester…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

This trial tests a 4-week diet and exercise program called Small Steps for Big Changes in adults with prediabetes. Participants will attend supervised exercise sessions and learn to cut sugar and refined carbs while increasing vegetables. The study aims to see if this program can…

This trial compares two blood-thinning drugs—aspirin and cilostazol—to see which one better prevents major heart and blood vessel events in people with type 2 diabetes who are already at high risk. About 1,200 participants will be randomly assigned to take one of the two medicati…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study adapts a diabetes prevention program for Hispanic adolescents aged 12-16 with obesity, delivering it via telehealth using a Fitbit, chatbot, and online lessons. The goal is to see if this approach is feasible and acceptable for reducing type 2 diabetes risk. Researcher…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This pilot study tests whether a family-centered health and wellness coaching program can help prevent type 2 diabetes in South Asian and Black African/Caribbean families in Ontario, Canada. Each family dyad includes an adult caregiver and a youth aged 14–24. Participants receive…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study looks at whether adding brewer's spent grain (a beer-making byproduct) to cookies can help control blood sugar after eating. Twenty healthy adults will eat regular cookies and special high-fiber cookies on different days, and their blood sugar will be checked over two …

This study tests whether teaching basic carbohydrate counting can lower blood sugar levels in people with prediabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Researchers will check HbA1c levels at 3 and 6 m…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study tests whether intensive diet and physical activity counseling from 3 months to 2 years of age can protect the pancreas in infants with a genetic risk for Type 1 diabetes. About 1,244 babies will be randomly assigned to receive the counseling or standard care, and resea…

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-generated health videos can help people with prediabetes control their blood sugar. Fifty adults aged 35 and older with prediabetes will wear a CGM and receive smartphone feedback. The goal is to …

This study tests a new way to screen for heart failure risk in people with type 2 diabetes. Doctors use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then offer early prevention treatments. About 300 patients are taking part. The goal is to see if this…

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

People with type 2 diabetes often develop stiff ankles, pain, and walking problems. This trial compares two physiotherapy approaches: Mulligan Mobilization with Movement, where a therapist applies a gentle glide to the ankle during active movement, and conventional physiotherapy …

Researchers test whether adding a predictive app to a continuous glucose monitor changes fear of low blood sugar, sleep quality, and diabetes distress in adults with type 1 or insulin-treated type 2 diabetes. Participants use the monitor alone for two weeks, then with the app for…

Researchers are testing SugarVita 2.0, a digital game that lets players make nutrition, activity, and medication decisions while a glucose simulator shows the results. The 12-week pilot enrolls 30 adults with type 2 diabetes and an HbA1c above 55 mmol/mol. The study measures chan…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have eating disorders. Participants will be randomly assigned to ACT, supportive diabetes counseling, or a waitlist. The goal is to see if …

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This pilot study will test whether a 6-week program of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and blood sugar control in 30 adults aged 40+ with type 2 diabetes and chronic insomnia. Participants are randomly assigned to CBT-I or usual care, and outco…

This trial tests whether adding nanoparticles to the standard disinfection during root canal retreatment reduces post-operative pain in people with type II diabetes. Participants are adults aged 18 to 40 with a failed root canal in a front tooth and an active infection at the roo…

This study tests a mobile health program called R2D2 designed to reduce diabetes distress in children aged 8-12 with type 1 diabetes and their parents. The program uses cognitive behavioral therapy, mindfulness, and behavioral strategies to help families cope. Researchers will me…

This study looks at whether giving a carbohydrate drink before coronary artery bypass surgery can improve insulin sensitivity and recovery in people with type 2 diabetes. About 50 participants will be enrolled. The goal is to see if this simple step can reduce complications and s…

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study looks at whether a common diabetes medication (GLP-1 RA) can improve muscle strength and bone health in women over 65 with type 2 diabetes. About 20 participants will take the drug as part of their regular care and undergo tests like grip strength and bone density scan…

This trial tests whether taking Ceylon cinnamon supplements for six months can reduce pain and improve blood sugar, cholesterol, and body weight in adults with painful diabetic peripheral neuropathy. Participants are randomly assigned to receive either cinnamon capsules or a plac…

This study looks at whether eating a small handful of almonds (about 18 grams) 30 minutes before a meal can reduce the rise in blood sugar after eating. Researchers will test 25 adults with prediabetes, comparing blood sugar levels after meals with and without almonds. They also …

This study tests whether pairing teens with type 1 diabetes with a young adult peer mentor can help them become more physically active and improve their quality of life. The 12-week program includes in-person, virtual, and text-based support. Researchers will measure how well the…

This study looks at whether counseling sessions can help people with type 2 diabetes become more physically active and sit less. Researchers will compare standard care with informational sessions on exercise benefits, with or without practical guidance from a kinesiologist. The g…

This study tests whether natural cervical ripening methods can help labor start on its own in pregnant women with diet-controlled gestational diabetes. About 74 participants will try these methods starting at 37 weeks to see if they can avoid a medically induced labor. The goal i…

This study tests an 8-week program that combines positive psychology and motivational interviewing to help people with type 2 diabetes increase their physical activity. The program is delivered remotely via phone and text messages. Researchers will measure changes in activity lev…

This study tests a group-based psychological program called ACTnow for emerging adults (ages 18-35) with type 1 diabetes who feel overwhelmed by their condition. The program includes six bi-weekly sessions led by a psychologist and nurse, focusing on mindfulness and acceptance st…

This study looks at whether drinking whey protein twice a day can improve blood sugar and insulin levels in people with prediabetes or type 2 diabetes. Researchers will measure blood sugar control and appetite in 40 adults aged 50-70 over two 7-day periods. The goal is to see if …

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This study tests whether a combination of sensory-motor exercises (like pelvic rocking and strength training) can reduce pain and improve balance in postmenopausal women with polyneuropathy. One hundred women with type 2 diabetes and numbness in their arms and legs will be random…

This study looks at how a supplement called nicotinamide riboside (NR) and a low-carb, high-fat 'ketogenic' diet affect the way the body burns fat and uses energy. Researchers will measure changes in metabolism in 100 overweight or obese adults. Participants will eat a standard d…

This study looks at how losing sleep and having a disrupted body clock (like shift workers) can make the body less responsive to insulin, a key step toward obesity and type 2 diabetes. Researchers will test 48 healthy adults aged 18-45 to see how the timing of the stress hormone …

Researchers are investigating how mitochondria, the energy-producing structures inside muscle cells, relate to frailty in older adults. The study includes about 120 people: older adults with type 2 diabetes, healthy older adults, and healthy young adults. Everyone does a six-week…

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

Researchers want to learn how the body's own remaining insulin production, measured by a marker called C-peptide, affects quality of life and health outcomes in people with insulin-treated diabetes. The study follows about 700 adults, including some from a previous diabetes study…

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study will follow 2,000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress and lead to complications. Researchers will track health records, nutrition, and physical function to find key factors that affect long-term outcomes. …

Researchers in Guangzhou, China, are following 20,000 pregnant women and their children to study how the mix of bacteria in the mother's body during pregnancy and in the baby's gut early in life relates to health outcomes later on. The study tracks conditions such as obesity, ast…

This study tests how a single injection of HRS-4729 behaves in people with mild, moderate, or severe kidney impairment compared with healthy people. Researchers measure drug levels in the blood over time to see if kidney function affects how the body processes the drug. The trial…

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study looks at how fear of low blood sugar (hypoglycemia) affects how well people with diabetes follow their diet and take their medication. Researchers will measure fear levels, medication adherence, and diet adherence in 100 adults with diabetes who have had at least one l…

This early-stage trial is testing how well different tablet versions of the experimental drug elecoglipron are absorbed by the body. Healthy volunteers receive a single dose of one formulation, and researchers measure drug levels in the blood over time. The goal is to compare the…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study explores whether stem cells from taste buds can be turned into insulin-making cells. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells in a lab. The goal is to see if this is possible in humans, which …

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

This pilot study looks at how sleep, physical activity, and meal timing in early pregnancy relate to blood sugar patterns and the risk of gestational diabetes. Researchers will track 140 pregnant women using wearable devices and an AI food-logging app. The goal is to see if real-…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

Researchers want to understand how well people with diabetes in Reunion Island and mainland France can find, understand, and use health information. About 1,350 patients with type 1, type 2, or gestational diabetes who receive hospital care complete a one-time questionnaire calle…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study looks at how certain natural chemicals (endocannabinoids) influence the development of fat cells from stem cells found in belly fat. Researchers will take small fat samples from 30 people undergoing abdominal surgery, including healthy controls, people with obesity, an…

Researchers are studying whether the mix of bacteria in the gut helps explain why people with obesity and type 2 diabetes get chronic infections more often. The study follows 80 adults, some with ongoing infections and some without, for 12 months. Participants give blood, stool, …

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and open foot ulcers. The goal is to develop a tool that helps doct…

Researchers are building a large, diverse group of adults with varying body sizes, ethnicities, and diabetes risk. They will collect blood, stool, and fat tissue samples to study how obesity relates to diabetes and other health issues. The goal is to create a rich resource for fu…

Researchers at Mayo Clinic are studying how the pancreas changes during and after pregnancy in women with gestational diabetes. The trial involves pregnant women who have completed their second-trimester screening and are classified as having gestational diabetes or not. After de…

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study will follow about 579 adults who need surgery to remove part or all of their pancreas but do not have diabetes before the operation. Researchers want to see how often new diabetes develops after surgery and whether the amount of pancreas removed changes that risk. The …

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study investigates why women with type 1 diabetes (T1D) frequently develop polycystic ovary syndrome (PCOS), a condition of high androgen levels. Researchers will compare five groups of 12 participants each, including women with T1D and PCOS, women with T1D alone, men with T…

This early-stage trial is testing a new drug called ACI-19764 in 78 healthy adults to see if it is safe and how the body handles it. The drug targets a protein in the brain linked to inflammation. Participants will receive either the drug or a placebo, and researchers will monito…

This study looks at whether a new tool helps young adults (ages 18-30) with type 1 diabetes and their doctors work together better to make care plans that fit daily life. Researchers will compare usual doctor visits with visits using the tool, and interview participants afterward…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This observational study tests whether continuous glucose monitors (CGMs) worn from about 12 weeks of pregnancy can detect subtle blood sugar changes that might indicate a higher risk of gestational diabetes, before the usual screening at 24-28 weeks. Researchers will follow 48 p…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study uses continuous glucose monitors (CGMs) to track blood sugar levels in the days right after a kidney transplant. It compares three groups of recipients: those with diabetes, those with pre-diabetes, and those without diabetes. The goal is to see if glucose patterns dif…

This study is collecting blood, stool, genetic information, and health records from 1,200 Medicaid patients in South Carolina — some with type 2 diabetes and some without. Researchers will analyze this data to find patterns that could predict chronic kidney disease, a common comp…

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver disease. Researchers will measure liver sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise hel…

This study is looking at whether a specific genetic variation, called SLC16A11, influences how well the common diabetes drug metformin lowers blood sugar. Adults with type 2 diabetes will be grouped by whether they carry this gene variant and will take extended-release metformin …

This study investigates whether a key channel in insulin-producing cells becomes less active as type 2 diabetes progresses. Researchers will give a single 10 mg dose of glipizide, a drug that blocks this channel, to people with and without type 2 diabetes and measure their insuli…

This study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …

This study is investigating how immune cells called macrophages in fat tissue handle fat and influence metabolism. Researchers will compare people with obesity and related metabolic issues to lean individuals, using imaging, blood tests, and tissue biopsies. The goal is to unders…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study reviews medical records of 400 adults aged 40-70 who were recently diagnosed with type 2 diabetes in five Southeast Asian countries. Researchers will look at health data from before and after diagnosis to understand how heart disease risk is distributed. No new treatme…

This observational study follows 1,000 pregnant people with type 1 diabetes who use either a commercial or an open-source automated insulin delivery (AID) system. Researchers aim to compare maternal and neonatal outcomes, blood sugar control, and emotional well-being between the …

This study investigates whether genetic differences influence how people respond to semaglutide, a GLP-1 drug used for weight loss and diabetes. Overweight or obese volunteers of Amish descent will receive weekly semaglutide injections for six weeks. Before and after treatment, r…

This study explores whether a person's psychological profile — Type A (competitive, ambitious) or Type B (relaxed, less stress-prone) — affects the healing of diabetic foot wounds. Researchers will compare Bortner questionnaire scores between people whose wounds heal and those wh…

This study investigates whether proteins released by muscles, called myokines, can serve as early warning signs or even causes of muscle loss (sarcopenia) in people with metabolic or endocrine conditions like diabetes, obesity, and Cushing syndrome. Researchers will measure myoki…

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes a 14-day course of the drug and measure blood sugar, insulin, and other factors after a s…

This study follows 600 Indigenous families in Manitoba to understand how maternal health, genetics, and early-life environment contribute to obesity and type 2 diabetes in children. Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes are enrolled, and their …

This study investigates how two days of forearm immobilization (keeping the arm in a cast or sling) changes the way muscles take up glucose and amino acids. Researchers will compare these effects in people with type 2 diabetes and healthy volunteers. The goal is to understand why…

This study investigates how muscle fiber type and protein makeup relate to early insulin resistance, a key step before type 2 diabetes develops. Researchers will follow 250 healthy adults aged 20-30 for up to 20 years, using muscle biopsies, scans, and wearable sensors. The goal …

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study is testing a new device that combines an insulin pump with a continuous glucose monitor in one unit for adults with type 1 diabetes. The goal is to see how insulin delivery near the sensor affects glucose readings and to gather data to improve the design. About 40 part…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This trial is studying a medical device that has not been approved by the U.S. FDA. The purpose and specific details are not publicly available. It likely involves a small group of participants to gather initial safety or effectiveness data.

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study is collecting health data from 1,500 adults with diabetes in Switzerland to see how well current treatments work in everyday life. Researchers will track complications, quality of life, and survival over time. The goal is to find out what's working and what needs impro…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study looks at whether improving sleep and circadian timing can reduce heart disease risk in adolescents with type 1 diabetes who typically sleep less than 7 hours per night. Fifty teens will follow a one-month program that includes a longer sleep schedule, a low dose of mel…

This study tests whether a low-added-sugar, high-fat diet can reduce diabetes risk in adults with cystic fibrosis (CF). Sixty participants will receive either a low-sugar or standard CF diet for 8 weeks. Researchers will measure changes in insulin production, body fat, and blood …

This study follows 140 pregnant women who conceived while still breastfeeding. Researchers want to see if breastfeeding lowers the chance of developing gestational diabetes in the new pregnancy. They will track blood sugar levels and baby growth to find out.

This study looks at whether treating gestational diabetes early (before 24 weeks) is better than waiting until the standard 24-28 week screening. About 2,010 pregnant women with mild early high blood sugar will be randomly assigned to either start intensive treatment right away o…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study is checking how accurate the Dexcom G7 continuous glucose monitor is for patients in the intensive care unit after major abdominal surgery or organ transplant. Researchers will place two sensors on each patient—one that is calibrated and used to guide insulin dosing, a…

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study follows 500 American Indian adults with early kidney disease to learn how their condition progresses and what factors affect heart health. Researchers will measure kidney function and track heart events like heart attacks and strokes. The goal is to fill knowledge gaps…

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at whether exercising before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Over 12 weeks, 20 participants will do combined resistance and aerobic training three times a week. Researchers will track insulin doses and blood …

This study follows 3,600 overweight or obese teenagers who are at high risk for developing type 2 diabetes. Researchers will monitor changes in blood sugar, insulin, and other factors over time to learn how the disease starts. No treatments or medications are given—the goal is si…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at whether the standard A1C blood sugar test works correctly in people with a Left Ventricular Assist Device (LVAD), a type of heart pump. Researchers will compare A1C results with continuous glucose monitor (CGM) readings over 3 months in 20 adults with type 2 d…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study looks at how well the pancreas can produce insulin in people with type 2 diabetes. Participants drink a meal replacement shake, and blood is taken five times over two hours to measure insulin and blood sugar levels. The goal is to understand differences in insulin prod…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the normal function of HDL, or 'good' cholesterol. Researchers will compare 80 patients with poorly controlled diabetes who receive standard intensive therapy to 63 healthy people…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study looks at how a 12-week exercise program affects the way older adults (over 65) with type 2 diabetes use protein from their diet. Thirty participants will do moderate-to-vigorous aerobic and strength training, and researchers will measure changes in protein balance, gut…

This study looks at how certain diabetes medications (semaglutide, liraglutide, and tirzepatide) affect blood flow and oxygen use in the eyes of people with diabetes. Researchers will use special cameras to measure eye blood vessels and oxygen levels in 20 adults before and after…

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study follows 800 pregnant women—some healthy, some with obesity or diabetes—to understand how these conditions affect both mother and baby during pregnancy and after birth. Researchers will track body composition, blood sugar, blood pressure, and other health markers throug…

This study looks at whether people aged 50+ who are newly diagnosed with diabetes (or whose diabetes gets worse) might have early-stage pancreatic cancer. Researchers will use MRI scans and collect blood samples over time to find cancer or pre-cancerous changes. The goal is to de…

This study follows 400 pregnant women diagnosed with gestational diabetes to understand how it affects their health and their baby's health. Researchers will track things like blood sugar, blood pressure, and body fat during pregnancy and after birth. The goal is to learn more ab…

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have type 1 diabetes, are at high genetic risk, or are healthy. Researchers will collect blood and gut samples from 180 children to understand these interactions. The g…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at whether routine blood sugar tests (like fasting glucose and HbA1c) can predict gestational diabetes in pregnant women who have had bariatric surgery and cannot tolerate the standard sugary drink test. Researchers will follow 84 women throughout pregnancy to se…

This study aims to better predict which kidney transplant patients who develop diabetes will later suffer serious complications like heart disease or kidney failure. Researchers will use machine learning and genetic analysis to find new markers in blood, urine, and kidney tissue.…

This study looks at how the metabolism of both parents during pregnancy may change the baby's epigenetics—chemical marks on DNA—in gestational diabetes. Researchers will test 80 pregnant women and their partners, analyzing blood and fetal cell-free DNA. The goal is to better unde…

This observational study will examine how the pancreas works in 310 adults with type 2 diabetes. Researchers will use blood tests, stool samples, and ultrasound to measure both hormone and digestive functions. The goal is to identify a different form of diabetes called pancreatog…

This study follows over 500 adults with type 2 diabetes who had a heart CT scan years ago. Researchers will repeat the scan to see how plaque builds up in heart arteries over time and identify factors that increase risk. The goal is to better understand heart disease in diabetes,…

This study looks at how different exercise intensities affect the brain in people with type 2 diabetes. 75 inactive adults aged 30-75 will do supervised cycling at high or moderate intensity for 6 months, three times a week. Researchers will use brain scans, cognitive tests, and …

This study looks at how long people with type 2 diabetes need to stop taking GLP-1 medications (like semaglutide) before surgery to make sure their stomach is empty. These drugs slow down digestion, which can increase the risk of food or liquid entering the lungs during anesthesi…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This study is creating a large digital registry to find and understand rare forms of diabetes caused by a single gene (monogenic diabetes). Researchers will enroll up to 5,000 people in China who were diagnosed with diabetes at a young age and test their DNA. The goal is to learn…

This study observes 80 adults with and without diabetes to see how long-term blood sugar control (measured by HbA1c) affects brain oxygen levels during urologic surgery. Researchers use a special light device (NIRS) to measure brain oxygen and track recovery after surgery. The go…

This study looks at how people with type 2 diabetes break down polyphenols—natural compounds found in plants—compared to healthy individuals of the same age. Researchers will measure polyphenol levels in urine after participants take a special pill. The goal is to understand how …

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and see how it relates to the cells that make insulin. The goal is to better u…

This study aims to better understand how blood flow and sugar use in the brain are altered in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use advanced PET scans to measure these changes in 60 participants across three groups: people w…

This study follows 36 people with type 1 diabetes who have received a pancreatic islet transplant. Researchers will use continuous glucose monitors to see if a measure called 'Time in Tight Range' can detect early loss of graft function. The goal is to find a simple way to spot p…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to vision loss. Researchers will use advanced eye scans and imaging to track changes in the retina over two years. The goal is to find better ways to pre…

This study is looking for new, less invasive ways to diagnose and track Parkinson's disease, Alzheimer's disease, and type 2 diabetes. Researchers will study 500 participants using blood tests, brain scans, and genetic analysis to find early signs of these conditions. The goal is…

This study aims to identify different subgroups among people with type 1 diabetes by analyzing their health data using artificial intelligence. Researchers will look at clinical records and glucose monitoring information from 800 adults. Participants do not need to do anything ex…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study looks at how blood sugar levels change during the menstrual cycle in women with type 1 diabetes. Researchers will track 86 women in Canada using continuous glucose monitors, insulin data, ovulation kits, and activity trackers. The goal is to understand why insulin need…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This pilot study is testing whether wearing a continuous glucose monitor (CGM) for just 24 hours after giving birth can help predict a woman's long-term risk of developing type 2 diabetes. The study involves 50 women who had gestational diabetes and will wear the CGM immediately …

This observational study examines kidney tissue from adults with diabetic kidney disease who are already having a kidney biopsy or surgery as part of their regular care. Researchers want to see if people taking SGLT2 inhibitors (a type of diabetes medicine) show different biologi…

This observational study will follow 1,000 people with type 2 diabetes for one year to see if changes in the eye's blood vessels and tissues can predict worsening diabetic retinopathy and related heart problems. Researchers will use advanced imaging and medical records to track e…

This study is testing whether it's practical to screen thousands of children for type 1 diabetes and celiac disease during their regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 and follow them for about 5 years. The goal is to see if paren…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study is collecting kidney tissue, blood, urine, and genetic samples from 400 adults with diabetes who are already scheduled for a kidney biopsy. Researchers will compare people whose kidney function declines quickly versus slowly to find molecular clues. The goal is to bett…

This study is surveying 500 adults with type 2 diabetes to see how much they know about nutrition and how closely they follow the Mediterranean diet. Researchers will also measure blood sugar, cholesterol, and muscle strength. The goal is to understand the link between diet knowl…