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Simple blood test could spot hidden pancreatic cancer in new diabetes patients

NCT ID NCT06803771

Diagnosis Sponsor: University Hospital Southampton NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a new blood test called Avantect to see if it can find pancreatic cancer early in people who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 adults aged 50-84 will give blood samples and fill out anxiety questionnaires over a year. The goal is to catch cancer at an earlier, more treatable stage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 84 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth) * Haemoglobin A1c (HbA1c) ≥ 48 or 6.5% and/or confirmed type II DM diagnosed within the last 180 days (+20 days flexibility allowance) * Willing to provide up to 30 mL of blood for each study visit * Willing and eligible to undergo MRI scan (or CT scan if MRI is contraindicated) * Understands the study process and is willing to take part in the study and sign the informed consent form Exclusion Criteria: * Prior type I or type II DM diagnosis \> 6 months * A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis * Under investigation for pancreatic cancer / pancreatic cyst * Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months * Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years * Current chronic or acute oral or systemic steroid use within 3 months of initial HbA1c or diabetes diagnosis (estimate rather than accurate) * Blood transfusion within 1 month * Solid organ transplant recipient * Currently pregnant * Needing dialysis

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Conditions

The condition(s) this trial relates to.

diabetes mellitus malignant pancreatic neoplasm Pancreatic cancer, adult pancreatic neoplasm type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus Pancreatic cancer, adult

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    31 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ashfields Primary Care Centre

    RECRUITING

    Sandbach, Cheshire, CW11 1EQ, United Kingdom

  • Ashton Medical Group

    RECRUITING

    Ashton-under-Lyne, OL6 6HD, United Kingdom

  • Balance Street Health Centre

    RECRUITING

    Uttoxeter, Kent, ST14 8JG, United Kingdom

  • Bodey Medical Centre

    RECRUITING

    Manchester, M14 6WP, United Kingdom

  • Bournemouth Research Hub

    RECRUITING

    Bournemouth, BH7 7DW, United Kingdom

  • Bowland Medical Practice

    RECRUITING

    Manchester, M23 1JX, United Kingdom

  • Brockwood Medical Practice

    RECRUITING

    Brockham, Surrey, RH3 7NJ, United Kingdom

  • Civic Centre

    RECRUITING

    Uxbridge, UB8 1UW, United Kingdom

  • Eastham Group Practice

    RECRUITING

    Bromborough, CH62 6EE, United Kingdom

  • Forest Medical Group

    RECRUITING

    Leicester, Leicester Forest East, LE3 3LW, United Kingdom

  • Hazelvalley Family Practice

    RECRUITING

    Rossendale, BB4 5SL, United Kingdom

  • Integrated Care Partnership/ The Old Cottage Hospital

    RECRUITING

    Epsom, Surrey, KT17 4BL, United Kingdom

  • King's Mill Hospital (Sherwood Forest) Research Van

    RECRUITING

    Nottingham, NG17 4JL, United Kingdom

  • Kingswinford Medical Practice

    RECRUITING

    Kingswinford, Staffordshire, DY6 8DN, United Kingdom

  • Maidstone and Tunbridge Wells NHS Trust

    RECRUITING

    Maidstone, Kent, ME16 9QQ, United Kingdom

  • Moorgreen Hospital

    RECRUITING

    Southampton, SO30 3JB, United Kingdom

  • Park Medical Centre

    RECRUITING

    Leek, Staffordshire, ST13 6QR, United Kingdom

  • Peel Croft Surgery

    RECRUITING

    Burton-on-Trent, Staffordshire, DE14 3RH, United Kingdom

  • Pembroke Centre (Hillingdon)

    RECRUITING

    Ruislip, HA4 8NX, United Kingdom

  • Portsmouth Research Hub

    RECRUITING

    Portsmouth, PO1 3HN, United Kingdom

  • Quinton Practice

    RECRUITING

    Walsall, WS6 6EW, United Kingdom

  • South Leicestershire Medical Group

    RECRUITING

    Kibworth Beauchamp, Leicestershire, LE8 0LG, United Kingdom

  • South Westminster Centre

    RECRUITING

    London, SW1P 2PF, United Kingdom

  • Southampton Research Hub (Shirley Research Hub)

    RECRUITING

    Southampton, SO15 33UA, United Kingdom

  • The Cuckoo Lane Practice

    RECRUITING

    London, W7 1DR, United Kingdom

  • The Maples Medical Centre

    RECRUITING

    Manchester, M23 2SY, United Kingdom

  • Trinity Court Surgery

    RECRUITING

    Stratford-upon-Avon, Staffordshire, CV37 6HJ, United Kingdom

  • Warlingham Green Medical Practice

    RECRUITING

    Warlingham, Surrey, CR6 9NW, United Kingdom

  • Weymouth Research Hub

    RECRUITING

    Weymouth, DT4 0QE, United Kingdom

  • Willesden Medical Centre

    RECRUITING

    London, NW10 2PT, United Kingdom

  • Yardley Wood Health Centre

    RECRUITING

    Birmingham, B14 4DU, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.