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Could baking soda fight fatigue in kidney disease?

NCT ID NCT04984226

Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a placebo for 8 weeks, then switch. Researchers will measure muscle metabolism, exercise capacity, and fatigue levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sodium bicarbonate
What this could lead to
If it works, this could point toward a simple, cheap treatment to reduce fatigue and improve physical function in people with chronic kidney disease.
What could go wrong
This is a small, early-phase trial (80 people) testing a common substance, so the benefits may be modest or not confirmed in larger studies. Sodium bicarbonate can cause stomach upset or electrolyte imbalances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Moderate-severe CKD determined by eGFR \<50ml/min per 1.73m2 by CKD EPI equation on at least 2 consecutive occasions. * Metabolic acidosis defined as bicarbonate level\<24 on two consecutive occasions. Bicarbonate level of 24 or less allowed if eGFR\<=45ml/min per 1.73m2 * Age 21 to 85 years old Exclusion Criteria: * Type 1 diabetes * Poorly controlled diabetes (HgbA1c\>10%) * History of persistent hyperkalemia (K\>5.4) * History of persistent hypokalemia (K\<3.3) * Uncontrolled blood pressure (\>170/100) * Chronic treatment with renal replacement therapy * History of aortic dissection or severe valvular heart disease * Exercise induced angina * Uncontrolled cardiac dysrhythmia * Oxygen dependent chronic obstructive pulmonary disease (COPD) * Symptomatic claudication * End stage liver disease * Mobility disability defined as inability to walk without human assistance * Dementia or psychosis * Patients who cannot consent * Active use of intraveneous drugs * Non-english speaking * History of transplant * Implants that prohibit MRI measurements or trauma involving metal fragments * Pacemaker * Expectation to start dialysis during the course of study. * Women who are breastfeeding, pregnant, or are wanting to become pregnant * Any condition which in the judgement of the clinical investigator places the participant at risk from participation in the study. Exclusion criteria for optional muscle biopsy * Drugs- anticoagulants or antiplatelets: * Anticoagulants, any 1 (coumadin, rivaroxaban, apixaban, dabigatran, edoxaban) * Antiplatelets, any 2 (aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticragrelor, ticlopidine, vorapaxar) * Platelet count \<100,000 * International normalized ratio (INR)\>1.4

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Conditions

The condition(s) this trial relates to.

Acidosis chronic kidney disease chronic renal failure syndrome diabetes mellitus Fatigue Insulin Resistance metabolic acidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney diseases Diabetes Fatigue Insulin resistance Metabolic acidosis Mitochondrial energetics Physical endurance

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of California Davis Health

    RECRUITING

    Sacramento, California, 95817, United States

  • Vanderbilt University Medical Center

    NOT_YET_RECRUITING

    Nashville, Tennessee, 37232, United States

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