Could baking soda fight fatigue in kidney disease?
NCT ID NCT04984226
First seen May 09, 2026 · Last updated Jun 22, 2026 · Updated 11 times
Summary
This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a placebo for 8 weeks, then switch. Researchers will measure muscle metabolism, exercise capacity, and fatigue levels.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of California Davis Health
RECRUITINGSacramento, California, 95817, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sodium bicarbonate
What this could lead to
If it works, this could point toward a simple, cheap treatment to reduce fatigue and improve physical function in people with chronic kidney disease.
What could go wrong
This is a small, early-phase trial (80 people) testing a common substance, so the benefits may be modest or not confirmed in larger studies. Sodium bicarbonate can cause stomach upset or electrolyte imbalances.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.