INSULIN RESISTANCE

This study is testing whether a 10-week exercise program delivered through video calls (telemedicine) can improve heart and lung fitness and insulin sensitivity in Asian children who have low fitness levels. Researchers will compare the online program to standard activity recomme…

This study is testing if metformin, a common diabetes medication, can help with weight loss and reduce heart disease risk in obese people who do not have diabetes. It focuses on Black Nigerians to see if the drug works the same way in this population as it has in others. Particip…

This study is testing whether drinking a cranberry beverage for 12 weeks can improve blood sugar control, cholesterol levels, and the balance of gut bacteria in overweight or obese adults. Participants will drink either the cranberry drink or a placebo for two separate periods, w…

This study is testing if combining a fiber supplement with the medication metformin works better than either alone to help teens with severe obesity and insulin resistance. Over 12 months, researchers will measure changes in weight, blood sugar control, and gut bacteria in 90 par…

This study is testing whether replacing sugary sodas with unsweetened, flavored sparkling water can help teens who love sweet drinks cut down on added sugar and improve their health. Researchers will work with 63 Black/African American and Latine adolescents who have obesity and …

This 8-week study is testing whether a dietary supplement called Sabroxy® can help improve both blood sugar control and memory in adults. Researchers will enroll 120 adults aged 40-80 who have mild memory concerns and insulin resistance. Participants will take either the suppleme…

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This study is testing whether taking glutamine, a common amino acid, as a powder for 8 weeks can help improve blood sugar control and ease irritable bowel syndrome (IBS) symptoms in people with obesity. It will involve 110 participants who will be randomly assigned to receive eit…

This study is testing whether a 6-month physical activity program can improve hormone health and lower the risk of developing diabetes in girls aged 8-12 who are at higher risk. It compares a full program with health coaching and text messages to a lighter program with just text …

This study is testing whether short, frequent bursts of activity ('exercise snacks') are as effective as standard 30-minute workouts at controlling blood sugar in breast cancer survivors. Researchers will compare these approaches in 24 sedentary women who have had breast cancer a…

This study aims to learn more about how the hormone insulin works in people with obesity and high insulin levels. Researchers will give participants a short course of a drug called diazoxide, which lowers insulin production, and check their daily blood sugar and insulin levels. T…

This study aims to understand how being overweight and having early blood sugar changes might affect brain development in teenagers at risk for type 2 diabetes. Researchers will follow 117 teens aged 12-17 for nearly two years, comparing brain scans and thinking tests across thre…

This study is testing a new, safe imaging technology to look at 'brown fat,' a type of fat that burns calories for heat. Researchers want to see if this scan can measure how brown fat works and spot differences between healthy people and those with metabolic syndrome. Participant…

This study aims to understand how the hormone insulin works differently in healthy people compared to those at risk for type 2 diabetes and fatty liver disease. Researchers will give a single dose of a drug called alpelisib or a placebo to 32 participants during two separate over…

This study is testing whether taking a daily supplement of linoleic acid-rich oil for 8 weeks can improve insulin sensitivity in adults with insulin resistance. Researchers will compare this oil against a control blend oil in 120 participants while they maintain their usual diet …

This study aims to understand why women taking antipsychotic medications often develop serious metabolic side effects like weight gain and diabetes. Researchers will use MRI brain scans on 15 healthy young women to see how a common antipsychotic (olanzapine) and intranasal insuli…

This study aims to understand why people with type 2 diabetes are more likely to develop heart failure. Researchers will observe 500 participants with heart failure, some with and some without diabetes, to see how their heart cells produce energy. The goal is to gather knowledge …

This study aims to understand if taking ketone supplements can improve how the body processes sugar and uses energy, particularly for people who are overweight. Ten healthy overweight adults aged 55-70 will test different combinations of a ketone drink and a hormone infusion duri…

This study aims to understand how gut bacteria process food and how that process is different in young people with obesity and insulin resistance. Researchers will measure how the body breaks down fat and makes sugar after participants ingest a special carbohydrate. The goal is t…

This study aims to understand how aging changes the way our bodies respond to exercise, especially for older adults with prediabetes or related heart and metabolic risks. It will enroll 26 people who previously completed an exercise study to participate in a new 6-month aerobic e…

This study aims to understand how a person's genes affect how their immune cells respond to potential threats. Researchers will collect blood from healthy volunteers to grow immune cells in a lab and test their reactions. The goal is to learn if certain genetic patterns make peop…

This study aims to understand what happens in the body during a long water fast. Researchers will enroll 15 healthy adults to fast and then analyze their blood. They will test if the changes in the blood can affect models of diseases like cancer or diabetes in lab-grown cells.

This study aims to understand how just five days of strict bedrest affects muscle size, strength, and the body's ability to process sugar in healthy young adults. Researchers will measure changes in leg muscles, strength, and insulin sensitivity before and after a 5-day bedrest p…

This study aims to understand how different types of fats delivered to the gut affect muscle cells and contribute to insulin resistance, a key problem in obesity and type 2 diabetes. Researchers will compare two fat infusions (palm oil and Intralipid) against a saline control in …

This is a small, early-stage study to test a new procedure for measuring how the hormone insulin works in the body. Researchers want to understand how much insulin is actually needed to keep blood sugar normal. They will test this new method, called a Graded Insulin Suppression T…

This study aims to better understand how blood sugar levels vary in women with different types of polycystic ovary syndrome (PCOS). Researchers will use continuous glucose monitors to track sugar levels in 80 women with PCOS. The goal is to see if certain PCOS types have healthie…

This study aims to learn if eating foods rich in specific 'slow' and 'resistant' starches can help control blood sugar and improve health in people with insulin resistance. For two months, 40 participants will follow a special diet while researchers track their blood sugar, infla…

This study aims to understand how different types of insulin resistance affect the liver's production of triglycerides, a type of fat in the blood. Researchers will compare people with insulin resistance in different body tissues and test if a short bout of exercise before a meal…